@mastersthesis{MTMT:32160444,
	title = {A PACAP protektív szerepének vizsgálata a vesében in vitro és in vivo},
	url = {https://m2.mtmt.hu/api/publication/32160444},
	author = {László, Eszter},
	publisher = {PTE ÁOK},
	unique-id = {32160444},
	abstract = {Az ischaemia-reperfusiós vesekárosodás komoly problémát jelent a klinikai gyakorlatban, az acut veseelégtelenség fontos kiváltója lehet, chronicus vesekárosodás kifejlődéséhez vezethet, vagy a már fennálló vesekárosodás végstádiumú veseelégtelenséggé történő progresszióját segítheti elő. Az ischaemiareperfusio kiváltotta vesekárosodás pathofiziológiája rendkívül komplex, melyben egyaránt szerepet kapnak apoptoticus, inflammatoricus folyamatok, valamint az oxidatív stressz. A vese ischaemia-reperfusio egy inflammatoricus kaszkád elindulásához vezet, a gyulladás fő mediátorai chemokinek, melyek a proinflammatoricus citokineket, adhéziós molekulákat, valamint a leukocyták aktivációját szabályozzák. Számos leukocyta-szubtípus aggregatiója kimutatható a peritubularis kapillárisokban, az interstitiumban és a tubulusokban.},
	year = {2021}
}

@article{MTMT:30321888,
	title = {Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats : Gender Differences},
	url = {https://m2.mtmt.hu/api/publication/30321888},
	author = {László, Eszter and Juhász, Tamás and Varga, Ádám and Czibere, Bernadett and Kovács, Krisztina and Degrell, Peter and Horváth-Opper, Gabriella and Jancsó, Gábor and Szakály, Péter and Tamás, Andrea and Reglődi, Dóra},
	doi = {10.1007/s12031-018-1207-y},
	journal-iso = {J MOL NEUROSCI},
	journal = {JOURNAL OF MOLECULAR NEUROSCIENCE},
	volume = {68},
	unique-id = {30321888},
	issn = {0895-8696},
	abstract = {Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts general cytoprotective effects, including protection in different kidney disorders. The aim of our study was to investigate the ischemia/reperfusion-induced kidney injury of male and female rats to confirm the protective effects of PACAP in the kidney and to reveal possible gender differences.Male and female Wistar rats underwent unilateral renal artery clamping followed by 24-h, 48-h, or 14-day reperfusion. PACAP was administered intravenously before arterial clamping in half of the rats. Tubular damage, cytokine expression pattern, oxidative stress marker, antioxidative status and signaling pathways were evaluated using histology, immunohistology, cytokine array, PCR, and Western blot. Tubular damage was significantly less severe in the PACAP-treated male and female rats compared to controls. Results of female animals were significantly better in both treated and untreated groups. Cytokine expression, oxidative stress marker and antioxidative status confirmed the histological results. We also revealed that PACAP counteracted the decreased PKA phosphorylation, influenced the expression of BMP2 and BMP4, and increased the expression of the protein Smad1.We conclude that PACAP is protective in ischemia/reperfusion-induced kidney injury in both sexes, but females had markedly less pronounced injury after ischemia/reperfusion, possibly also involving further protective factors, the investigation of which could have future therapeutic value in treating ischemic kidney injuries.},
	keywords = {PACAP; BONE MORPHOGENETIC PROTEIN; Superoxide dismutase; CYTOKINE EXPRESSION; Ischemia/reperfusion; Tubular damage},
	year = {2019},
	eissn = {1559-1166},
	pages = {408-419}
}

@article{MTMT:3320609,
	title = {Effects of Pituitary Adenylate Cyclase Activating Polypeptide in Human Proximal Tubule Cells Against Gentamicin Toxicity},
	url = {https://m2.mtmt.hu/api/publication/3320609},
	author = {Horváth-Opper, Gabriella and Reglődi, Dóra and Czétány, Péter and Illés, Anita and Rémán, Gyöngyvér Éva and Fekete, Andrea and Tóth, Gábor and László, Eszter and Opper, Balázs},
	doi = {10.1007/s10989-017-9666-5},
	journal-iso = {INT J PEPT RES THER},
	journal = {INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS},
	volume = {25},
	unique-id = {3320609},
	issn = {1573-3149},
	year = {2019},
	eissn = {1573-3904},
	pages = {257-264},
	orcid-numbers = {Fekete, Andrea/0000-0002-0210-153X; Tóth, Gábor/0000-0002-3604-4385}
}

@article{MTMT:2940061,
	title = {Ischemia/reperfusion-induced Kidney Injury in Heterozygous PACAP-deficient Mice.},
	url = {https://m2.mtmt.hu/api/publication/2940061},
	author = {László, Eszter and Varga, Ádám and Kovács, Krisztina and Jancsó, Gábor and Kiss, Péter and Tamás, Andrea and Szakály, Péter and Fülöp, Balázs Dániel and Reglődi, Dóra},
	doi = {10.1016/j.transproceed.2015.07.027},
	journal-iso = {TRANSPLANT PROC},
	journal = {TRANSPLANTATION PROCEEDINGS},
	volume = {47},
	unique-id = {2940061},
	issn = {0041-1345},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with very diverse distribution and functions. Among others, PACAP is a potent cytoprotective peptide due to its antiapoptotic, anti-inflammatory, and antioxidant actions. This also has been shown in different kidney pathologies, including ischemia/reperfusion-induced kidney injury. Similar protective effects of the endogenous PACAP are confirmed by the increased vulnerability of PACAP-deficient mice to different harmful stimuli. Kidneys of homozygous PACAP-deficient mice have more severe damages in renal ischemia/reperfusion and kidney cell cultures isolated from these mice show increased sensitivity to renal oxidative stress. In our present study we raised the question of whether the partial lack of the PACAP gene is also deleterious, i.e. whether heterozygous PACAP-deficient mice also display more severe damage after renal ischemia/reperfusion. Mice underwent 45 or 60 minutes of ischemia followed by 2 weeks reperfusion. Histological evaluation of the kidneys was performed and individual histopathological parameters were graded. Furthermore, we investigated apoptotic markers, cytokine expression, and the activity of superoxide dismutase (SOD) enzyme 24 hours after 60 minutes of renal ischemia/reperfusion. We found no difference between the intact kidneys of wild-type and heterozygous mice, but marked differences could be observed following ischemia/reperfusion. Heterozygous PACAP-deficient mice had more severe histological alterations, with significantly higher histopathological scores for most of the tested parameters. Higher level of the proapoptotic pp38 MAPK and of some proinflammatory cytokines, as well as lower activity of the antioxidant SOD could be found in these mice. In conclusion, the partial lack of the PACAP gene results in worse outcomes in cases of renal ischemia/reperfusion, confirming that PACAP functions as an endogenous protective factor in the kidney.},
	year = {2015},
	eissn = {1873-2623},
	pages = {2210-2215}
}

@article{MTMT:2788820,
	title = {The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion.},
	url = {https://m2.mtmt.hu/api/publication/2788820},
	author = {László, Eszter and Kiss, Péter and Horváth-Opper, Gabriella and Szakály, Péter and Tamás, Andrea and Reglődi, Dóra},
	doi = {10.1556/ABiol.65.2014.4.1},
	journal-iso = {ACTA BIOL HUNG},
	journal = {ACTA BIOLOGICA HUNGARICA (1983-2018)},
	volume = {65},
	unique-id = {2788820},
	issn = {0236-5383},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP ) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycin- and cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.},
	year = {2014},
	eissn = {1588-256X},
	pages = {369-378}
}

@article{MTMT:2521248,
	title = {The role of endogenous PACAP in the kidney during ischaemia-reperfusion},
	url = {https://m2.mtmt.hu/api/publication/2521248},
	author = {László, Eszter and Kiss, P and Szakály, Péter and Kovács, K and Varga, Ádám and Degrell, P and Jancsó, Gábor and Horváth, G and Hashimoto, H and Lubics, Andrea and Tamás, Andrea and Reglődi, Dóra},
	journal-iso = {J MOL NEUROSCI},
	journal = {JOURNAL OF MOLECULAR NEUROSCIENCE},
	volume = {51},
	unique-id = {2521248},
	issn = {0895-8696},
	year = {2013},
	eissn = {1559-1166},
	pages = {215}
}

@article{MTMT:1947674,
	title = {PACAP is an endogenous protective factor - insights from PACAP-deficient mice},
	url = {https://m2.mtmt.hu/api/publication/1947674},
	author = {Reglődi, Dóra and Kiss, Péter and Szabadfi, Krisztina and Atlasz, Tamás and Gábriel, Róbert and Horváth-Opper, Gabriella and Szakály, Péter and Sándor, Balázs Attila and Lubics, Andrea and László, Eszter and Farkas, József and Matkovits, Attila and Brubel, Réka and Hashimoto, H and Ferencz, Andrea and Vincze, András and Helyes, Zsuzsanna and Welke, L and Lakatos, A and Tamás, Andrea},
	doi = {10.1007/s12031-012-9762-0},
	journal-iso = {J MOL NEUROSCI},
	journal = {JOURNAL OF MOLECULAR NEUROSCIENCE},
	volume = {48},
	unique-id = {1947674},
	issn = {0895-8696},
	abstract = {Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 
		widespread neuropeptide with a diverse array of biological 
		functions. Not surprisingly, the lack of endogenous PACAP 
		therefore results in a variety of abnormalities. One of the 
		important effects of PACAP is its neuroprotective and general 
		cytoprotective role. PACAP protects neurons and other tissues 
		against ischemic, toxic, and traumatic lesions. Data obtained 
		from PACAP-deficient mice provide evidence that endogenous 
		PACAP also has protective functions. Mice lacking PACAP are more 
		vulnerable to different in vitro and in vivo insults. The 
		present review summarizes data on the increased sensitivity of 
		PACAP-deficient mice against harmful stimuli. Mice lacking PACAP 
		respond with a higher degree of injury in cerebral ischemia, 
		autoimmune encephalomyelitis, and axonal lesion. Retinal 
		ischemic and excitotoxic injuries also produce increased cell 
		loss in PACAP-deficient mice. In peripheral organs, kidney cell 
		cultures from PACAP-deficient mice are more sensitive to 
		oxidative stress and in vitro hypoxia. In vivo, PACAP-deficient 
		mice have a negative histological outcome and altered cytokine 
		response in kidney and small intestine ischemia/reperfusion 
		injury. Large intestinal inflammation, toxic lesion of the 
		pancreas, and doxorubicin-induced cardiomyopathy are also more 
		severe with a lack of endogenous PACAP. Finally, an increased 
		inflammatory response has been described in subacute endotoxin-
		induced airway inflammation and in an oxazolone-induced allergic 
		contact dermatitis model. In summary, lack of endogenous PACAP 
		leads to higher vulnerability in a number of injuries in the 
		nervous system and peripheral organs, supporting the hypothesis 
		that PACAP is part of the endogenous cytoprotective machinery.},
	year = {2012},
	eissn = {1559-1166},
	pages = {482-492},
	orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633; Gábriel, Róbert/0000-0001-9323-8795; Ferencz, Andrea/0000-0002-1623-9783}
}

@article{MTMT:1708851,
	title = {Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney},
	url = {https://m2.mtmt.hu/api/publication/1708851},
	author = {Reglődi, Dóra and Kiss, Péter and Horváth-Opper, Gabriella and Lubics, Andrea and László, Eszter and Tamás, Andrea and Rácz, Boglárka and Szakály, Péter},
	doi = {10.1016/j.npep.2011.05.001},
	journal-iso = {NEUROPEPTIDES},
	journal = {NEUROPEPTIDES},
	volume = {46},
	unique-id = {1708851},
	issn = {0143-4179},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP) is a 
		widespread neuropeptide with 
		diverse effects in the nervous system and peripheral organs. One 
		of the most well-studied 
		effects of PACAP is its cytoprotective action, against different 
		harmful stimuli in a wide 
		variety of cells and tissues. PACAP occurs in the urinary 
		system, from the kidney to the lower 
		urinary tract. The present review focuses on the 
		nephroprotective effects of PACAP and 
		summarizes data obtained regarding the protective effects of 
		PACAP in different models of 
		kidney pathologies. In vitro data show that PACAP protects 
		tubular cells against oxidative 
		stress, myeloma light chain, cisplatin, cyclosporine-A and 
		hypoxia. In vivo data provide 
		evidence for its protective effects in ischemia/reperfusion, 
		cisplatin, cyclosporine-A, myeloma 
		kidney injury, diabetic nephropathy and gentamicin-induced 
		kidney damage. Results accumulated 
		on the renoprotective effects of PACAP suggest that PACAP is an 
		emerging candidate for 
		treatment of human kidney pathologies.},
	year = {2012},
	eissn = {1532-2785},
	pages = {61-70}
}

@article{MTMT:1740501,
	title = {Effects of in vivo renal ischemia/reperfusion in heterozygous PACAP deficient mice.},
	url = {https://m2.mtmt.hu/api/publication/1740501},
	author = {László, Eszter and Kiss, Péter and Reglődi, Dóra and Horváth-Opper, Gabriella and Lubics, Andrea and Tamás, Andrea and Brubel, Réka and Opper, Balázs and Baba, A and Hashimoto, H and Farkas, József and Matkovics, A and Magyarlaki, Tamás and Helyes, Zsuzsanna and Szakály, Péter},
	journal-iso = {ACTA PHYSIOL},
	journal = {ACTA PHYSIOLOGICA},
	volume = {202},
	unique-id = {1740501},
	issn = {1748-1708},
	year = {2011},
	eissn = {1748-1716},
	pages = {68-68}
}

@article{MTMT:1740497,
	title = {Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury.},
	url = {https://m2.mtmt.hu/api/publication/1740497},
	author = {Horváth-Opper, Gabriella and Szakály, Péter and László, Eszter and Kovács, Krisztina and Rácz, Boglárka and Ferencz, Andrea and Lubics, Andrea and Kiss, Péter and Tamás, Andrea and Brubel, Réka and Opper, Balázs and Baba, A and Hashimoto, H and Farkas, József and Matkovits, Attila and Magyarlaki, Tamás and Helyes, Zsuzsanna and Reglődi, Dóra},
	journal-iso = {ACTA PHYSIOL},
	journal = {ACTA PHYSIOLOGICA},
	volume = {202},
	unique-id = {1740497},
	issn = {1748-1708},
	year = {2011},
	eissn = {1748-1716},
	pages = {44},
	orcid-numbers = {Ferencz, Andrea/0000-0002-1623-9783}
}