@book{MTMT:34323209, title = {Ophthalmogy Practice Notes}, url = {https://m2.mtmt.hu/api/publication/34323209}, author = {Fodor, Mariann and Takács, Lili and Kettesy, Andrea Beáta and Kolozsvári, Bence Lajos and Nagy, Annamária and Steiber, Zita and Pásztor, Dorottya and Surányi, Éva and Széll, Noémi and Beáta, Bajdik and Balla, Szabolcs and Aranyosi, János and Mátyás, Hankovszky and Sára, Makhoul and Dorottya, Lilla Nagy and Orsolya, Pásztor and Anett, Porempovics and Ujhelyi, Bernadett}, publisher = {University of Debrecen}, unique-id = {34323209}, year = {2023} } @article{MTMT:33578444, title = {Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy}, url = {https://m2.mtmt.hu/api/publication/33578444}, author = {Galgóczi, Erika and Katkó, Mónika and Papp, Fruzsina Réka and Csiki, Róbert and Bak-Csiha, Sára and Erdei, Annamária and Bodor, Miklós and Ujhelyi, Bernadett and Steiber, Zita and Győry, Ferenc and Nagy, Endre}, doi = {10.3390/molecules28010015}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {33578444}, issn = {1420-3049}, abstract = {Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA) production of orbital (OF) and dermal (DF) fibroblasts. HA production of GO OFs (n = 4), NON-GO OFs (n = 4) and DFs (n = 4) was measured by ELISA. mRNA expression of enzymes of HA metabolism and fibroblast proliferation was examined by RT-PCR and BrdU incorporation, respectively. After 24 h of GC treatment (1µM) HA production decreased by an average of 67.9 ± 3.11% (p < 0.0001) in all cell cultures. HAS2, HAS3 and HYAL1 expression in OFs also decreased (p = 0.009, p = 0.0005 and p = 0.015, respectively). Ten ng/mL PDGF-BB increased HA production and fibroblast proliferation in all cell lines (p < 0.0001); GC treatment remained effective and reduced HA production under PDGF-BB-stimulated conditions (p < 0.0001). MP and DEX reduced (p < 0.001, p = 0.002, respectively) PDGF-BB-induced HAS2 expression in OFs. MP and DEX treatment decreased PDGF-BB stimulated HAS3 expression (p = 0.035 and p = 0.029, respectively). None of the GCs tested reduced the PDGF-BB stimulated proliferation rate. Our results confirm that GCs directly reduce the HA production of OFs, which may contribute to the beneficial effect of GCs in GO.}, year = {2023}, eissn = {1420-3049} } @article{MTMT:33211389, title = {The effect of glucocorticoids on hyaluronan production of orbital fibroblasts}, url = {https://m2.mtmt.hu/api/publication/33211389}, author = {Galgóczi, Erika and Katko, Monika and Erdei, Annamária and Bodor, Miklós and Ujhelyi, Bernadett and Steiber, Zita and Győry, Ferenc and Nagy, Endre}, doi = {10.1530/endoabs.84.PS2-07-64}, journal-iso = {ENDOCR ABSTR}, journal = {ENDOCRINE ABSTRACTS}, volume = {84}, unique-id = {33211389}, issn = {1470-3947}, year = {2022}, eissn = {1479-6848} } @article{MTMT:33032320, title = {Non-surgical orbital decompression using diuresis in dysthyroid optic neuropathy: a case report}, url = {https://m2.mtmt.hu/api/publication/33032320}, author = {Erdei, Annamária and Gazdag, Annamária and Ujhelyi, Bernadett and Nagy, Edit B and Berényi, Ervin László and Berta, Eszter and Steiber, Zita and Barna, Sándor Kristóf and Mezősi, Emese and Bodor, Miklós and Nagy, Endre}, doi = {10.1530/ETJ-22-0078}, journal-iso = {EUR THYROID J}, journal = {EUROPEAN THYROID JOURNAL}, volume = {11}, unique-id = {33032320}, issn = {2235-0640}, abstract = {Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 ml followed by furosemide 40 mg 6 hours later, administered daily, were initiated on the day of admission. Visual function by ophthalmology methods, and orbital compartment volumes and water content by MRI were followed. Intravenous diuretics resulted in immediate therapeutic response. Visual acuity improved from 20/50 to 20/25 after two days of treatment. MRI revealed decreasing water content of both the muscle and connective tissue compartments without any volume changes. Subsequently, corticosteroids and orbital irradiation were started. Orbital decompression surgery was not required.Edematous swelling of orbital tissues is an established contributor of local pressure increase in thyroid eye disease. Diuretics reduce orbital pressure and, if confirmed by others, may be useful additions to the standard of care in sight threatening DON.}, year = {2022}, eissn = {2235-0802}, orcid-numbers = {Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:32866680, title = {Different Effects of Cigarette Smoke, Heated Tobacco Product and E-Cigarette Vapour on Orbital Fibroblasts in Graves’ Orbitopathy; a Study by Real Time Cell Electronic Sensing}, url = {https://m2.mtmt.hu/api/publication/32866680}, author = {Aranyosi, János and Galgóczi, Erika and Erdei, Annamária and Katkó, Mónika and Fodor, Mariann and Ujhelyi, Zoltán and Bácskay, Ildikó and Nagy, Endre and Ujhelyi, Bernadett}, doi = {10.3390/molecules27093001}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {27}, unique-id = {32866680}, issn = {1420-3049}, year = {2022}, eissn = {1420-3049} } @article{MTMT:32035348, title = {The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease}, url = {https://m2.mtmt.hu/api/publication/32035348}, author = {Katkó, Mónika and Galgóczi, Erika and Erdei, Annamária and Gazdag, Annamária and Berta, Eszter and Bodor, Miklós and Seres, Ildiko and Hircsu, Ildiko and Badics, Arpad and Ujhelyi, Bernadett and Sira, Livia and Bhattoa Harjit, Pál and Nagy, Endre}, doi = {10.2147/JIR.S307046}, journal-iso = {J INFLAMM RES}, journal = {JOURNAL OF INFLAMMATION RESEARCH}, volume = {14}, unique-id = {32035348}, year = {2021}, eissn = {1178-7031}, pages = {1883-1890}, orcid-numbers = {Bhattoa Harjit, Pál/0000-0002-4909-0065} } @article{MTMT:31746464, title = {Analysis of intravitreal bevacizumab treatment for macular oedema due to retinal vein occlusion}, url = {https://m2.mtmt.hu/api/publication/31746464}, author = {Balla, Szabolcs and Zöld, Eszter and Potor, László and Lukucz, Balazs and Vajas, Attila and Ujhelyi, Bernadett and Nagy, Valéria}, doi = {10.1177/1120672120962051}, journal-iso = {EUR J OPHTHALMOL}, journal = {EUROPEAN JOURNAL OF OPHTHALMOLOGY}, volume = {31}, unique-id = {31746464}, issn = {1120-6721}, abstract = {Purpose: Our aim was to analyse the clinical effect of intravitreal bevacizumab treatment for macular oedema due to central/branch retinal vein occlusion (CRVO/BRVO). The end points were final best-corrected visual acuity (BCVA), BCVA improvement, final central 1-mm macular subfield thickness (CST) and change in CST. Methods: Our study included 34 CRVO and 25 BRVO patients. Patients received intravitreal bevacizumab (IVB) treatment at our department. Our control group consisted of 50 CRVO and 30 BRVO patients, who had not received this treatment because their disease developed before the anti-VEGF treatment became available. For statistical analysis, two-samplet-test, Pearson's correlation, and ANOVA were used. The level of significance was defined atp < 0.05. Results: With the two-sample t-test we found significant improvement of BCVA in the IVB-treated group (CRVO: 0.171 +/- 0.270, p1 = 3.25x10-4; BRVO: 0.215 +/- 0.282, p2 = 5.52x10-4). The difference in BCVA improvement was also significant compared to the control group (CRVO: p1 = 3.46x10-4; BRVO: p2 = 0.003). Significant decrease was observed in the CST in the treated group (CRVO: -345.114 +/- 280.577, p1 = 6.94x10-9; BRVO: -151.875 +/- 174.341, p2 = 1.67x10-4). In case of BRVO patients the final BCVA was significantly better in the treated group (0.617 +/- 0.334) compared to the control group (0.406 +/- 0.357),p = 0.016. Conclusion: IVB treatment results in significantly better final visual acuity and leads to significantly increased BCVA improvement compared to patients with RVO-induced macular oedema receiving no treatment.}, keywords = {Retina; Retina; CME; medical therapies; techniques of retinal examination; venous occlusive disease}, year = {2021}, eissn = {1724-6016}, pages = {2528-2534}, orcid-numbers = {Potor, László/0000-0001-9336-8637} } @article{MTMT:32020498, title = {Unusual onset of thyroid associated orbitopathy during pregnancy: case report and review of literature}, url = {https://m2.mtmt.hu/api/publication/32020498}, author = {Aranyosi, Janos K. and Deli, Tamás and Erdei, Annamária and Toth, Geza and Jakab, Attila and Fodor, Mariann and Nagy, Endre and Ujhelyi, Bernadett}, doi = {10.1186/s12902-020-00663-9}, journal-iso = {BMC ENDOCR DISORD}, journal = {BMC ENDOCRINE DISORDERS}, volume = {20}, unique-id = {32020498}, issn = {1472-6823}, year = {2020}, eissn = {1472-6823}, orcid-numbers = {Ujhelyi, Bernadett/0000-0002-5760-3350} } @article{MTMT:31805981, title = {Az endokrin orbitopathia korszerű kezelése}, url = {https://m2.mtmt.hu/api/publication/31805981}, author = {Steiber, Zita and Erdei, Annamária and Nagy, Endre and Ujhelyi, Bernadett}, journal-iso = {SZEMÉSZET}, journal = {SZEMÉSZET}, volume = {157}, unique-id = {31805981}, issn = {0039-8101}, year = {2020}, pages = {19-23} } @article{MTMT:31805965, title = {A szemfelszín betegségeinek sebészi kezelése amnionmembrán-transzplantációval}, url = {https://m2.mtmt.hu/api/publication/31805965}, author = {Ujhelyi, Bernadett and Aranyosi, János and Módis, László}, journal-iso = {SZEMÉSZET}, journal = {SZEMÉSZET}, volume = {157}, unique-id = {31805965}, issn = {0039-8101}, year = {2020}, pages = {82-88} }