@article{MTMT:3148677,
	title = {Identifying non-toxic doses of manganese for manganese-enhanced magnetic resonance imaging to map brain areas activated by operant behavior in trained rats.},
	url = {https://m2.mtmt.hu/api/publication/3148677},
	author = {Gálosi, Rita and Szalay, László Csaba and Aradi, Mihály and Perlaki, Gábor and Pál, József and Steier, Roy and Lénárd, László and Karádi, Zoltán György},
	doi = {10.1016/j.mri.2016.11.017},
	journal-iso = {MAGN RESON IMAGING},
	journal = {MAGNETIC RESONANCE IMAGING},
	volume = {37},
	unique-id = {3148677},
	issn = {0730-725X},
	abstract = {Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl2, at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels. Neurological examination was also carried out. The animals were tested in visual cue discriminated operant task. Imaging was performed using a 3T clinical MR scanner. T1 values were determined before and after MnCl2 administrations. Manganese-enhanced images of each animal were subtracted from their baseline images to calculate decrease in the T1 value (DeltaT1) voxel by voxel. The subtracted T1 maps of trained animals performing visual cue discriminated operant task, and those of naive rats were compared. The dose of 60mg/kg MnCl2 showed hepatotoxic effect, but even these animals did not exhibit neurological symptoms. The dose of 20 and 40mg/kg MnCl2 increased the number of omissions and did not affect the accuracy of performing the visual cue discriminated operant task. Using the accumulated dose of 40mg/kg, voxels with a significant enhanced DeltaT1 value were detected in the following brain areas of the visual cue discriminated operant behavior performed animals compared to those in the controls: the visual, somatosensory, motor and premotor cortices, the insula, cingulate, ectorhinal, entorhinal, perirhinal and piriform cortices, hippocampus, amygdala with amygdalohippocampal areas, dorsal striatum, nucleus accumbens core, substantia nigra, and retrorubral field. In conclusion, the MEMRI proved to be a reliable method to accomplish brain activity mapping in correlation with the operant behavior of freely moving rodents.},
	year = {2017},
	eissn = {1873-5894},
	pages = {122-133}
}

@CONFERENCE{MTMT:3079594,
	title = {Application of activation induced manganese-enhanced magnetic resonance imaging (MEMRI) for mapping of brain structures involved in operant responses in rats.},
	url = {https://m2.mtmt.hu/api/publication/3079594},
	author = {Gálosi, Rita and Szalay, László Csaba and Aradi, Mihály and Pál, József and Perlaki, Gábor and Karádi, Zoltán György and Lénárd, László},
	booktitle = {FAMÉ 2016},
	unique-id = {3079594},
	year = {2016}
}

@article{MTMT:2811986,
	title = {Pain-Related Autonomic Response Is Modulated By The Medial Prefrontal Cortex: An ECG-FMRI Study In Men},
	url = {https://m2.mtmt.hu/api/publication/2811986},
	author = {Perlaki, Gábor and Orsi, Gergely and Schwarcz, Attila and BODI, P and Plózer, Enikő and BICZO, K and Aradi, Mihály and Dóczi, Tamás Péter and Komoly, Sámuel and Hejjel, László and Kovács, Norbert and Janszky, József Vladimír},
	doi = {10.1016/j.jns.2015.01.019},
	journal-iso = {J NEUROL SCI},
	journal = {JOURNAL OF THE NEUROLOGICAL SCIENCES},
	volume = {349},
	unique-id = {2811986},
	issn = {0022-510X},
	year = {2015},
	eissn = {1878-5883},
	pages = {202-208},
	orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X}
}

@article{MTMT:2758889,
	title = {Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study.},
	url = {https://m2.mtmt.hu/api/publication/2758889},
	author = {Erdélyi-Bótor, Szilvia and Aradi, Mihály and Kamson Olayinka, Dávid and Kovács, Norbert and Perlaki, Gábor and Orsi, Gergely and Nagy, Szilvia Anett and Schwarcz, Attila and Dóczi, Tamás Péter and Komoly, Sámuel and Deli, Gabriella and Trauninger, Anita and Pfund, Zoltán},
	doi = {10.1111/head.12459},
	journal-iso = {HEADACHE},
	journal = {HEADACHE},
	volume = {55},
	unique-id = {2758889},
	issn = {0017-8748},
	abstract = {OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3-year long follow-up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. METHODS: The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0-Tesla clinical MRI scanner. Beyond the routine T1-, T2-weighted, and fluid-attenuated inversion recovery imaging, diffusion and perfusion-weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow-up studies were compared with each other. RESULTS: The follow-up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N-acetyl-aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P < .001) and volume (median values 0.896 vs 1.140 mL, P < .001) of hyperintensities were significantly higher in the follow-up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5, P = .004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (<.034 mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: -0.517, P = .034). CONCLUSIONS: This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging.},
	year = {2015},
	eissn = {1526-4610},
	pages = {55-70},
	orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:2598820,
	title = {Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements.},
	url = {https://m2.mtmt.hu/api/publication/2598820},
	author = {Orsi, Gergely and Aradi, Mihály and Nagy, Szilvia Anett and Perlaki, Gábor and Trauninger, Anita and Bogner, Péter and Janszky, József Vladimír and Illés, Zsolt László and Dóczi, Tamás Péter and Pfund, Zoltán and Schwarcz, Attila},
	doi = {10.1002/jmri.24580},
	journal-iso = {JMRI - J MAGN RESON IM},
	journal = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
	volume = {41},
	unique-id = {2598820},
	issn = {1053-1807},
	abstract = {PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements. MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm2 ) and biexponential (0-5000 s/mm2 ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls. RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 x 10-4 mm2 /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10-4 mm2 /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively). CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.J. Magn. Reson. Imaging 2014. (c) 2014 Wiley Periodicals, Inc.},
	year = {2015},
	eissn = {1522-2586},
	pages = {676-683},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Janszky, József Vladimír/0000-0001-6100-832X; Illés, Zsolt László/0000-0001-9655-0450}
}

@CONFERENCE{MTMT:2715253,
	title = {Hemispheric lateralization of sentence intonation in left handed subjects with typical and atypical language lateralization: An fMRI study},
	url = {https://m2.mtmt.hu/api/publication/2715253},
	author = {Varga, Eszter and Schnell, Zsuzsanna and Perlaki, Gábor and Orsi, Gergely and Aradi, Mihály and Auer, T and John, F and Dóczi, Tamás Péter and Komoly, Sámuel and Kovács, Norbert and Schwarcz, Attila and Tényi, Tamás and Herold, Róbert and Janszky, József Vladimír and Horváth, Réka},
	booktitle = {7th International Conference on Speech Prosody, SP 2014},
	unique-id = {2715253},
	abstract = {Prosody (as the melody of speech) is an important component of human social interactions. More specifically, linguistic prosody conveys meaning of speech through syllable, word, or sentence level stress and intonation. In the modern neuroimaging era the hemispheric representation of sentence intonation is widely investigated. Most of these studies suggest bilateral activations predominantly in the perisylvian language areas and in the subdominant homologues. However, there are some inconsistencies about the hemispheric representation and lateralization of linguistic prosody. These inconsistencies could be due to the lack of attention on the language lateralization of the subjects. The present study aims to investigate the hemispheric representation and lateralization of linguistic prosody with a sentence intonation task in two groups of left handed subjects with typical and atypical language lateralization. Functional MRI was used to test the assumption that - according to the functional lateralization hypothesis - the representation of sentence intonation is predominantly lateralized within the language dominant hemisphere and the lateralization of sentence intonation is associated with language lateralization in both groups. Left handers were examined to create two groups of subjects with typical and atypical language lateralization. In all, 32 healthy subjects were evaluated with a standard verbal fluency task with fMRI in order to assess functional hemispheric language lateralization. In our final investigation the atypical group consisted of 8 subjects with right hemispheric language dominance (LI<-0.2) and the typical group also consisted of 8 subjects with left hemispheric language dominance (LI>0.2). Sentence intonation task was utilized to test linguistic prosody skills with fMRI. 49 pairs of sentences (18 pairs of neutral-neutral sentences, 10 pairs of interrogativeinterrogative sentences, and 1 pair of interrogative-neutral sentence) were presented with an event-related design. Sentences were matched in terms of syntactic structure, semantic complexity and length and all were affectively neutral. In the fMRI data analysis interrogative pairs were compared to neutral pairs. One of the main findings of our study is that subjects with typical language lateralization activated the middle temporal gyrus (MTG) on the right side. The activation of the MTG in the right hemisphere is classically associated with the encoding of prosodic information. Furthermore, both groups recruited the frontal and temporal language areas predominantly in the language-dominant hemisphere. Moreover, between-group comparison showed significantly stronger activations in subjects with typical language lateralization only in left sided language areas: pars triangularis of the inferior frontal gyrus, the superior frontal gyrus and the inferior parietal lobule. This finding is in accordance with the functional lateralization hypothesis of prosody, and suggests a correlation between linguistic prosody lateralization and language lateralization.},
	keywords = {Semantics; Chemical activation; Speech; neuroimaging; FMRI; LATERALIZATION; LANGUAGE LATERALIZATION; linguistics; INFERIOR FRONTAL GYRUS; Left-handers; Sentence intonation; Verbal fluency task; Inferior parietal lobules; Human social interactions},
	year = {2014},
	pages = {1130-1133},
	orcid-numbers = {Schnell, Zsuzsanna/0000-0002-4207-5698; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X}
}

@CONFERENCE{MTMT:2533570,
	title = {A quantitative approach in characterization of epidermoid cyst and middle ear cholesteatoma: T1 and T2 mapping},
	url = {https://m2.mtmt.hu/api/publication/2533570},
	author = {Horváth, Andrea and Nagy, Szilvia Anett and Perlaki, Gábor and Tóth, A and Orsi, Gergely and Aradi, Mihály and Komáromy, H and Dóczi, Tamás Péter and Bogner, Péter},
	booktitle = {European Congress of Radiology, ECR 2014},
	doi = {10.1594/ecr2014/C-1947},
	unique-id = {2533570},
	year = {2014},
	orcid-numbers = {Horváth, Andrea/0000-0002-0396-2446; Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@misc{MTMT:3228173,
	title = {Differentiating White Matter Lesions in Multiple Sclerosis and Migraine Using Monoexponential and Biexponential Diffusion Measurements},
	url = {https://m2.mtmt.hu/api/publication/3228173},
	author = {Orsi, Gergely and Aradi, Mihály and Nagy, Szilvia Anett and Perlaki, Gábor and Trauninger, A and Bogner, Péter and Janszky, József Vladimír and Illes, Zs and Dóczi, Tamás Péter and Pfund, Zoltán and Schwarcz, A},
	unique-id = {3228173},
	year = {2013},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Janszky, József Vladimír/0000-0001-6100-832X}
}

@misc{MTMT:3013125,
	title = {Biexponenciális diffúziós jelcsökkenés migrénben és sclerosis multiplexben},
	url = {https://m2.mtmt.hu/api/publication/3013125},
	author = {Orsi, Gergely and Aradi, Mihály and Nagy, Szilvia Anett and Bogner, Péter and Janszky, József Vladimír and Illés, Zsolt László and Perlaki, Gábor and Dóczi, Tamás Péter and Pfund, Zoltán and Schwarcz, Attila},
	unique-id = {3013125},
	year = {2013},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Janszky, József Vladimír/0000-0001-6100-832X; Illés, Zsolt László/0000-0001-9655-0450}
}

@article{MTMT:2533567,
	title = {A kómás agy strukturális és funkcionális vizsgálata multiparametrikus MR-technikával},
	url = {https://m2.mtmt.hu/api/publication/2533567},
	author = {Horváth, Andrea and Aradi, Mihály and Perlaki, Gábor and Orsi, Gergely and Szalay, Csaba and Schwarcz, Attila and Büki, András and Kövér, Ferenc and Dóczi, Tamás Péter and Bogner, Péter},
	journal-iso = {MAGYAR RADIOLÓGIA},
	journal = {MAGYAR RADIOLÓGIA},
	volume = {87},
	unique-id = {2533567},
	issn = {0025-0287},
	year = {2013},
	pages = {32-39},
	orcid-numbers = {Horváth, Andrea/0000-0002-0396-2446}
}