TY  - JOUR
AU  - Christofi, A
AU  - Kormányos, Árpád
AU  - Kalapos, Anita
AU  - Domsik, Péter
AU  - Gyenes, Nándor
AU  - Ambrus, Nóra
AU  - Gavallér, Edit Henriette
AU  - Csajbók, Éva
AU  - Julesz, János
AU  - Forster, Tamás
AU  - Csanády, Miklós
AU  - Horváth, Á
AU  - Lengyel, Csaba Attila
AU  - Nemes, Attila
AU  - Valkusz, Zsuzsanna
TI  - A NÖVEKEDÉSI HORMON HATÁSA A SZÍV FIZIOLÓGIÁJÁRA
JF  - MAGYAR BELORVOSI ARCHIVUM
J2  - MBA
VL  - 76
PY  - 2023
IS  - 5-6
SP  - 303
EP  - 303
PG  - 1
SN  - 0133-5464
UR  - https://m2.mtmt.hu/api/publication/34559525
ID  - 34559525
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lee, B.R.
AU  - Dalley, R.
AU  - Miller, J.A.
AU  - Chartrand, T.
AU  - Close, J.
AU  - Mann, R.
AU  - Mukora, A.
AU  - Ng, L.
AU  - Alfiler, L.
AU  - Baker, K.
AU  - Bertagnolli, D.
AU  - Brouner, K.
AU  - Casper, T.
AU  - Csajbók, Éva
AU  - Donadio, N.
AU  - Driessens, S.L.W.
AU  - Egdorf, T.
AU  - Enstrom, R.
AU  - Galakhova, A.A.
AU  - Gary, A.
AU  - Gelfand, E.
AU  - Goldy, J.
AU  - Hadley, K.
AU  - Heistek, T.S.
AU  - Hill, D.
AU  - Hou, W.-H.
AU  - Johansen, N.
AU  - Jorstad, N.
AU  - Kim, L.
AU  - Kocsis, Ágnes Katalin
AU  - Kruse, L.
AU  - Kunst, M.
AU  - León, G.
AU  - Long, B.
AU  - Mallory, M.
AU  - Maxwell, M.
AU  - McGraw, M.
AU  - McMillen, D.
AU  - Melief, E.J.
AU  - Molnár, Gábor
AU  - Mortrud, M.T.
AU  - Newman, D.
AU  - Nyhus, J.
AU  - Opitz-Araya, X.
AU  - Ozsvár, A.
AU  - Pham, T.
AU  - Pom, A.
AU  - Potekhina, L.
AU  - Rajanbabu, R.
AU  - Ruiz, A.
AU  - Sunkin, S.M.
AU  - Szöts, Ildikó
AU  - Taskin, N.
AU  - Thyagarajan, B.
AU  - Tieu, M.
AU  - Trinh, J.
AU  - Vargas, S.
AU  - Vumbaco, D.
AU  - Waleboer, F.
AU  - Walling-Bell, S.
AU  - Weed, N.
AU  - Williams, G.
AU  - Wilson, J.
AU  - Yao, S.
AU  - Zhou, T.
ED  - Barzó, Pál / Collaborator
AU  - Bakken, T.
AU  - Cobbs, C.
AU  - Dee, N.
AU  - Ellenbogen, R.G.
AU  - Esposito, L.
AU  - Ferreira, M.
AU  - Gouwens, N.W.
AU  - Grannan, B.
AU  - Gwinn, R.P.
AU  - Hauptman, J.S.
AU  - Hodge, R.
AU  - Jarsky, T.
AU  - Keene, C.D.
AU  - Ko, A.L.
AU  - Korshoej, A.R.
AU  - Levi, B.P.
AU  - Meier, K.
AU  - Ojemann, J.G.
AU  - Patel, A.
AU  - Ruzevick, J.
AU  - Silbergeld, D.L.
AU  - Smith, K.
AU  - Sørensen, J.C.
AU  - Waters, J.
AU  - Zeng, H.
AU  - Berg, J.
AU  - Capogna, M.
AU  - Goriounova, N.A.
AU  - Kalmbach, B.
AU  - de, Kock C.P.J.
AU  - Mansvelder, H.D.
AU  - Sorensen, S.A.
AU  - Tamás, Gábor
AU  - Lein, E.S.
AU  - Ting, J.T.
TI  - Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
JF  - SCIENCE
J2  - SCIENCE
VL  - 382
PY  - 2023
IS  - 6667
PG  - 16
SN  - 0036-8075
DO  - 10.1126/science.adf6484
UR  - https://m2.mtmt.hu/api/publication/34289826
ID  - 34289826
N1  - Allen Institute for Brain Science, Seattle, WA 98109, USA            
            Allen Institute for Neural Dynamics, Seattle, WA 98109, USA            
            MTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, Neuroscience, University of Szeged, Szeged, 6726, Hungary            
            Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, 1081 HV, Netherlands            
            Department of Biomedicine, Aarhus University, Denmark            
            Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA            
            Department of Neurosurgery, University of Szeged, Szeged, 6725, Hungary            
            Swedish Neuroscience Institute, Seattle, WA 98122, USA            
            Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA            
            Department of Neurosurgery, Aarhus University Hospital, Denmark            
            Department of Anesthesiology, Aarhus University Hospital, Denmark            
            Center for Experimental Neuroscience, Aarhus University Hospital, Denmark            
            Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA            
            Export Date: 10 November 2023; Cited By: 0
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chartrand, Thomas
AU  - Dalley, Rachel
AU  - Close, Jennie
AU  - Goriounova, Natalia A.
AU  - Lee, Brian R.
AU  - Mann, Rusty
AU  - Miller, Jeremy A.
AU  - Molnár, Gábor
AU  - Mukora, Alice
AU  - Alfiler, Lauren
AU  - Baker, Katherine
AU  - Bakken, Trygve E.
AU  - Berg, Jim
AU  - Bertagnolli, Darren
AU  - Braun, Thomas
AU  - Brouner, Krissy
AU  - Casper, Tamara
AU  - Csajbók, Éva
AU  - Dee, Nick
AU  - Egdorf, Tom
AU  - Enstrom, Rachel
AU  - Galakhova, Anna A.
AU  - Gary, Amanda
AU  - Gelfand, Emily
AU  - Goldy, Jeff
AU  - Hadley, Kristen
AU  - Heistek, Tim S.
AU  - Hill, DiJon
AU  - Jorstad, Nik
AU  - Kim, Lisa
AU  - Kocsis, Ágnes Katalin
AU  - Kruse, Lauren
AU  - Kunst, Michael
AU  - Leon, Gabriela
AU  - Long, Brian
AU  - Mallory, Matthew
AU  - McGraw, Medea
AU  - McMillen, Delissa
AU  - Melief, Erica J.
AU  - Mihut, Norbert
AU  - Ng, Lindsay
AU  - Nyhus, Julie
AU  - Oláh, Gáspár
AU  - Ozsvár, Attila
AU  - Omstead, Victoria
AU  - Péterfi, Zoltán Attila
AU  - Pom, Alice
AU  - Potekhina, Lydia
AU  - Rajanbabu, Ramkumar
AU  - Rózsa, Márton
AU  - Ruiz, Augustin
AU  - Sandle, Joanna Grace
AU  - Sunkin, Susan M.
AU  - Szöts, Ildikó
AU  - Tieu, Michael
AU  - Tóth, Martin
AU  - Trinh, Jessica
AU  - Vargas, Sara
AU  - Vumbaco, David
AU  - Williams, Grace
AU  - Wilson, Julia
AU  - Yao, Zizhen
AU  - Barzó, Pál
AU  - Cobbs, Charles
AU  - Ellenbogen, Richard G.
AU  - Esposito, Luke
AU  - Ferreira, Manuel
AU  - Gouwens, Nathan W.
AU  - Grannan, Benjamin
AU  - Gwinn, Ryder P.
AU  - Hauptman, Jason S.
AU  - Jarsky, Tim
AU  - Keene, C. Dirk
AU  - Ko, Andrew L.
AU  - Koch, Christof
AU  - Ojemann, Jeffrey G.
AU  - Patel, Anoop
AU  - Ruzevick, Jacob
AU  - Silbergeld, Daniel L.
AU  - Smith, Kimberly
AU  - Sorensen, Staci A.
AU  - Tasic, Bosiljka
AU  - Ting, Jonathan T.
AU  - Waters, Jack
AU  - de Kock, Christiaan P.J.
AU  - Mansvelder, Huib D.
AU  - Tamás, Gábor
AU  - Zeng, Hongkui
AU  - Kalmbach, Brian
AU  - Lein, Ed S.
TI  - Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
JF  - SCIENCE
J2  - SCIENCE
VL  - 382
PY  - 2023
IS  - 6667
PG  - 19
SN  - 0036-8075
DO  - 10.1126/science.adf0805
UR  - https://m2.mtmt.hu/api/publication/34196545
ID  - 34196545
N1  - Allen Institute for Brain Science, Seattle, WA, United States            
            Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands            
            Research Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary            
            byte physics, Berlin, Germany            
            Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States            
            Department of Neurosurgery, University of Szeged, Szeged, Hungary            
            Swedish Neuroscience Institute, Seattle, WA, United States            
            Department of Neurological Surgery, University of Washington, Seattle, WA, United States            
            Department of Physiology and Biophysics, University of Washington, Seattle, WA, United States            
            Washington National Primate Research Center, University of Washington, Seattle, WA, United States            
            Export Date: 10 November 2023; Cited By: 0
AB  - Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Vágvölgyi, Anna
AU  - Csajbók, Éva
AU  - König, C
ED  - Vágvölgyi, Anna
ED  - Vámos, Máté
TI  - Untersuchungen bei endokrinologischen Erkrankungen
T2  - Klinische Undersuchung in der Inneren Medizin
PB  - Szegedi Tudományegyetem Általános Orvostudományi Kar
CY  - Szeged
SN  - 9789633069530
PY  - 2023
SP  - 69
EP  - 80
PG  - 12
UR  - https://m2.mtmt.hu/api/publication/34188161
ID  - 34188161
LA  - German
DB  - MTMT
ER  - 

TY  - CONF
AU  - Vágvölgyi, Anna
AU  - Maróti, Á
AU  - Szűcs, Mónika
AU  - Póczik, Cs
AU  - Urbán-Pap, D
AU  - Baczkó, István
AU  - Orosz, Andrea
AU  - Nemes, Attila
AU  - Csajbók, Éva
AU  - Sepp, Krisztián
AU  - Kempler, Péter
AU  - Várkonyi, Tamás
AU  - Lengyel, Csaba Attila
TI  - Evaluation of the autonomic and peripheral sensory nervous system function in young patients with type 1 diabetes at the time of the transition from pediatric to adult-oriented health care system
T2  - NEURODIAB 2021
PY  - 2021
SP  - 74
EP  - 74
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/32507483
ID  - 32507483
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vágvölgyi, Anna
AU  - Maróti, Ágnes
AU  - Szűcs, Mónika
AU  - Póczik, Csongor
AU  - Urbán-Pap, Dóra
AU  - Baczkó, István
AU  - Orosz, Andrea
AU  - Nemes, Attila
AU  - Csajbók, Éva
AU  - Sepp, Krisztián
AU  - Kempler, Péter
AU  - Várkonyi, Tamás
AU  - Lengyel, Csaba Attila
TI  - 1-es típusú diabeteses betegek perifériás és autonóm idegrendszeri funkciójának felmérése a felnőttgondozásba kerülésük idején = Evaluation of the peripheral and autonomic state of young patients with type 1 diabetes at the time of transition from the child-centred to the adult-orientated health care system
JF  - DIABETOLOGIA HUNGARICA
J2  - DIABETOLOGIA HUNGARICA
VL  - 29
PY  - 2021
IS  - Suppl.1
SP  - 56
EP  - 57
PG  - 2
SN  - 1217-372X
DO  - 10.24121/dh.2021.S1.36
UR  - https://m2.mtmt.hu/api/publication/32208040
ID  - 32208040
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vágvölgyi, Anna
AU  - Maróti, Ágnes
AU  - Szűcs, Mónika
AU  - Póczik, Csongor
AU  - Urbán-Pap, Dóra
AU  - Baczkó, István
AU  - Nemes, Attila
AU  - Csajbók, Éva
AU  - Sepp, Krisztián
AU  - Kempler, Péter
AU  - Orosz, Andrea
AU  - Várkonyi, Tamás
AU  - Lengyel, Csaba Attila
TI  - Peripheral and autonomic neuropathy status of young patients with type 1 diabetes mellitus at the time of transition from pediatric care to adult-oriented diabetes care
JF  - FRONTIERS IN ENDOCRINOLOGY
J2  - FRONT ENDOCRINOL
VL  - 12
PY  - 2021
PG  - 12
SN  - 1664-2392
DO  - 10.3389/fendo.2021.719953
UR  - https://m2.mtmt.hu/api/publication/32186701
ID  - 32186701
N1  - Department of Medicine, University of Szeged, Szeged, Hungary            
            Department of Pediatrics and Pediatric Health Center, University of Szeged, Szeged, Hungary            
            Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary            
            Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary            
            Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary            
            Department of Oncology and Internal Medicine, Semmelweis University, Budapest, Hungary            
            Export Date: 29 September 2021            
            Correspondence Address: Orosz, A.; Department of Pharmacology and Pharmacotherapy, Hungary
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Csajbók, Éva
AU  - Dézsi, Lívia
AU  - Araujo-Vilar, David
TI  - Az első magyar – genetikailag is igazolt – parciális lipodisztrófiás eset. Az Európai Lipodisztrófia Konzorcium és Regiszter (EClip) jelentősége. The first Hungarian genetically identified partial lipodystrophy case, the importance of European Networking on Lipodystrophy.
JF  - DIABETOLOGIA HUNGARICA
J2  - DIABETOLOGIA HUNGARICA
VL  - 28
PY  - 2020
IS  - Suppl.1
SP  - 16
EP  - 17
PG  - 2
SN  - 1217-372X
DO  - 10.24121/dh.2020.S1.7
UR  - https://m2.mtmt.hu/api/publication/31680457
ID  - 31680457
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Csajbók, Éva
TI  - Expression of insulin and GLP-1 receptors in interneurons of the cerebral cortex
PB  - Szegedi Tudományegyetem (SZTE)
PY  - 2019
SP  - 44
UR  - https://m2.mtmt.hu/api/publication/31320715
ID  - 31320715
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Csajbók, Éva
AU  - Kocsis, Ágnes Katalin
AU  - Faragó, Nóra
AU  - Furdan, Szabina
AU  - Kovács, Balázs
AU  - Lovas, Sándor
AU  - Molnár, Gábor
AU  - Likó, István
AU  - Zvara, Ágnes
AU  - Puskás, László
AU  - Patócs, Attila Balázs
AU  - Tamás, Gábor
TI  - Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex
JF  - DIABETOLOGIA
J2  - DIABETOLOGIA
VL  - 62
PY  - 2019
IS  - 4
SP  - 717
EP  - 725
PG  - 9
SN  - 0012-186X
DO  - 10.1007/s00125-018-4803-z
UR  - https://m2.mtmt.hu/api/publication/30399139
ID  - 30399139
N1  - MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :1            
            Export Date: 28 January 2020            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8            
            Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council            
            Funding details: 20391-3/2018/FEKUSTRAT            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :1            
            Export Date: 15 February 2020            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8            
            Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council            
            Funding details: 20391-3/2018/FEKUSTRAT            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :2            
            Export Date: 9 April 2020            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council, ERC            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :2            
            Export Date: 15 April 2020            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council, ERC            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 28 January 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council, ERC            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 1 February 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding details: European Research Council, ERC            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 23 February 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 18 March 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 24 March 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 1 April 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 6 May 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :3            
            Export Date: 17 May 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :4            
            Export Date: 10 August 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary            
            1st Department of Internal Medicine, University of Szeged, Szeged, Hungary            
            Laboratory of Functional Genomics, Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary            
            Avidin Ltd, Szeged, Hungary            
            MTA Lendület Hereditary Endocrine Tumors Research Group, Semmelweis University, Budapest, Hungary            
            Cited By :4            
            Export Date: 8 September 2021            
            CODEN: DBTGA            
            Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Közép fasor 52, Hungary; email: gtamas@bio.u-szeged.hu            
            Chemicals/CAS: insulin, 9004-10-8; glucagon like peptide 1, 89750-14-1; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin            
            Funding details: European Research Council, ERC            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT            
            Funding details: Aeronautical Development Agency, ADA            
            Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155            
            Funding text 1: Funding This work was supported by the European Research Council INTERIMPACT project (GT), the Hungarian Academy of Sciences (GT), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), the Ministry of Human Capacities, Hungary (grant 20391-3/2018/FEKUSTRAT) and by the National Brain Research Program, Hungary (GT).            
            Funding text 2: The authors thank ?. T?th, M. V. V?rady and N. T?th for technical assistance (MTA-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary). Some of these data were presented as an abstract at the ADA 77th Scientific Sessions in 2017.
AB  - Aims/hypothesisGlucagon-like peptide 1 (GLP-1) receptors are expressed by pancreatic beta cells and GLP-1 receptor signalling promotes insulin secretion. GLP-1 receptor agonists have neural effects and are therapeutically promising for mild cognitive impairment and Alzheimer's disease. Our previous results showed that insulin is released by neurogliaform neurons in the cerebral cortex, but the expression of GLP-1 receptors on insulin-producing neocortical neurons has not been tested. In this study, we aimed to determine whether GLP-1 receptors are present in insulin-containing neurons.MethodsWe harvested the cytoplasm of electrophysiologically and anatomically identified neurogliaform interneurons during patch-clamp recordings performed in slices of rat neocortex. Using single-cell digital PCR, we determined copy numbers of Glp1r mRNA and other key genes in neurogliaform cells harvested in conditions corresponding to hypoglycaemia (0.5mmol/l glucose) and hyperglycaemia (10mmol/l glucose). In addition, we performed whole-cell patch-clamp recordings on neurogliaform cells to test the effects of GLP-1 receptor agonists for functional validation of single-cell digital PCR results.ResultsSingle-cell digital PCR revealed GLP-1 receptor expression in neurogliaform cells and showed that copy numbers of mRNA of the Glp1r gene in hyperglycaemia exceeded those in hypoglycaemia by 9.6 times (p<0.008). Moreover, single-cell digital PCR confirmed co-expression of Glp1r and Ins2 mRNA in neurogliaform cells. Functional expression of GLP-1 receptors was confirmed with whole-cell patch-clamp electrophysiology, showing a reversible effect of GLP-1 on neurogliaform cells. This effect was prevented by pre-treatment with the GLP-1 receptor-specific antagonist exendin-3(9-39) and was absent in hypoglycaemia. In addition, single-cell digital PCR of neurogliaform cells revealed that the expression of transcription factors (Pdx1, Isl1, Mafb) are important in beta cell development.Conclusions/interpretationOur results provide evidence for the functional expression of GLP-1 receptors in neurons known to release insulin in the cerebral cortex. Hyperglycaemia increases the expression of GLP-1 receptors in neurogliaform cells, suggesting that endogenous incretins and therapeutic GLP-1 receptor agonists might have effects on these neurons, similar to those in pancreatic beta cells.
LA  - English
DB  - MTMT
ER  -