@article{MTMT:34420912,
	title = {Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study},
	url = {https://m2.mtmt.hu/api/publication/34420912},
	author = {Áfra, Eszter and Janszky, József Vladimír and Perlaki, Gábor and Orsi, Gergely and Nagy, Szilvia Anett and Arató, Ákos and Szente, Anna Tímea and Alhour, Husamalddin Ali Mohammad and Kis-Jakab, Gréta and Darnai, Gergely},
	doi = {10.1007/s11682-023-00825-y},
	journal-iso = {BRAIN IMAGING BEHAV},
	journal = {BRAIN IMAGING AND BEHAVIOR},
	unique-id = {34420912},
	issn = {1931-7557},
	abstract = {Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n  = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning .},
	year = {2024},
	eissn = {1931-7565},
	orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Nagy, Szilvia Anett/0000-0001-6483-9209; Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652}
}

@article{MTMT:34113102,
	title = {Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People},
	url = {https://m2.mtmt.hu/api/publication/34113102},
	author = {Perlaki, Gábor and Darnai, Gergely and Arató, Ákos and Alhour, Husamalddin Ali Mohammad and Szente, Anna Tímea and Áfra, Eszter and Nagy, Szilvia Anett and Horváth, Réka and Kovács, Norbert and Dóczi, Tamás Péter and Orsi, Gergely and Janszky, József Vladimír},
	doi = {10.1002/jmri.28970},
	journal-iso = {JMRI - J MAGN RESON IM},
	journal = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
	volume = {59},
	unique-id = {34113102},
	issn = {1053-1807},
	abstract = {Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p  = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p  = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p  = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p  = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2  = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2  = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p  = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3.},
	keywords = {Brain; morphometry; cortical thickness; SARS-CoV-2},
	year = {2024},
	eissn = {1522-2586},
	pages = {2152-2161},
	orcid-numbers = {Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652; Nagy, Szilvia Anett/0000-0001-6483-9209; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X}
}

@article{MTMT:33742456,
	title = {Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats},
	url = {https://m2.mtmt.hu/api/publication/33742456},
	author = {Nagy, Szilvia Anett and Ivic, Ivan and Tóth, Péter József and Komoly, Sámuel and Kiss, Tamás and Pénzes, Máté and Málnási Csizmadia, András and Dóczi, Tamás Péter and Perlaki, Gábor and Orsi, Gergely},
	doi = {10.1038/s41598-023-32679-1},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33742456},
	issn = {2045-2322},
	abstract = {Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10-6), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Málnási Csizmadia, András/0000-0002-2430-8398}
}

@article{MTMT:33546835,
	title = {Emotional face expression recognition in problematic Internet use and excessive smartphone use : task-based fMRI study},
	url = {https://m2.mtmt.hu/api/publication/33546835},
	author = {Arató, Ákos and Nagy, Szilvia Anett and Perlaki, Gábor and Orsi, Gergely and Szente, Anna Tímea and Kis-Jakab, Gréta and Áfra, Eszter and Alhour, Husamalddin Ali Mohammad and Kovács, Norbert and Janszky, József Vladimír and Darnai, Gergely},
	doi = {10.1038/s41598-022-27172-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33546835},
	issn = {2045-2322},
	abstract = {Growing literature indicates that problematic Internet use (PIU) and excessive smartphone use (ESU) are associated with breakdown of functional brain networks. The effects of PIU&ESU on emotional face expression (EFE) recognition are not well understood, however behavioural investigations and fMRI studies of different addiction forms indicated the impairment of this function. The Facial Emotion Recognition Paradigm was used to probe cortico-limbic responses during EFE recognition. Combined fMRI and psychophysiological analysis were implemented to measure EFE-related functional brain changes in PIU&ESU. Self-reported questionnaires were used to assess PIU&ESU. Positive associations were found between the extent of PIU&ESU and functional connections related to emotional cognitive control and social brain networks. Our findings highlight the involvement of social functioning, especially EFE recognition in PIU&ESU. Therefore, we emphasize that besides the brain's executive and reward systems, the social brain network might be the next candidate to be involved in the pathogenesis of PIU&ESU.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X}
}

@article{MTMT:33334987,
	title = {The neural correlates of mental fatigue and reward processing: a task-based fMRI study},
	url = {https://m2.mtmt.hu/api/publication/33334987},
	author = {Darnai, Gergely and Matuz, András and Alhour, Husamalddin Ali Mohammad and Perlaki, Gábor and Orsi, Gergely and Arató, Ákos and Szente, Anna Tímea and Áfra, Eszter and Nagy, Szilvia Anett and Janszky, József Vladimír and Csathó, Árpád},
	doi = {10.1016/j.neuroimage.2022.119812},
	journal-iso = {NEUROIMAGE},
	journal = {NEUROIMAGE},
	volume = {265},
	unique-id = {33334987},
	issn = {1053-8119},
	abstract = {Increasing time spent on the task (i.e., the time-on-task (ToT) effect) often results in mental fatigue. Typical effects of ToT are decreasing levels of task-related motivation and the deterioration of cognitive performance. However, a massive body of research indicates that the detrimental effects can be reversed by extrinsic motivators, for example, providing rewards to fatigued participants. Although several attempts have been made to identify brain areas involved in mental fatigue and related reward processing, the neural correlates are still less understood. In this study, we used the psychomotor vigilance task to induce mental fatigue and blood oxygen-level-dependent functional magnetic resonance imaging to investigate the neural correlates of the ToT effect and the reward effect (i.e., providing extra monetary reward after fatigue induction) in a healthy young sample. Our results were interpreted in a recently proposed neurocognitive framework. The activation of the right middle frontal gyrus, right insula and right anterior cingulate gyrus decreased as fatigue emerged and the cognitive performance dropped. However, after providing an extra reward, the cognitive performance, as well as activation of these areas, increased. Moreover, the activation levels of all of the mentioned areas were negatively associated with reaction times. Our results confirm that the middle frontal gyrus, insula and anterior cingulate cortex play crucial roles in cost-benefit evaluations, a potential background mechanism underlying fatigue, as suggested by the neurocognitive framework.},
	year = {2023},
	eissn = {1095-9572},
	orcid-numbers = {Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652; Nagy, Szilvia Anett/0000-0001-6483-9209; Janszky, József Vladimír/0000-0001-6100-832X}
}

@{MTMT:34004909,
	title = {The effect of positive and negative life events on the brain using non contrast brain perfusion imaging},
	url = {https://m2.mtmt.hu/api/publication/34004909},
	author = {Sebők-Tornai, Bence and Nagy, Szilvia Anett},
	booktitle = {Abstract Book of the 1st International Conference of Biomedical Engineering and Innovation},
	unique-id = {34004909},
	year = {2022},
	pages = {27},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:33106083,
	title = {Investigating the Neurological Consequences of General Internet Addiction Using Resting State fMRI},
	url = {https://m2.mtmt.hu/api/publication/33106083},
	author = {Áfra, Eszter and Arató, Ákos and Szente, Anna and Nagy, Szilvia Anett and Perlaki, Gabor and Orsi, Gergely and Darnai, Gergely and Janszky, Jozsef},
	journal-iso = {J BEHAV ADDICT},
	journal = {JOURNAL OF BEHAVIORAL ADDICTIONS},
	volume = {11},
	unique-id = {33106083},
	issn = {2062-5871},
	keywords = {FMRI; general Internet addiction},
	year = {2022},
	eissn = {2063-5303},
	pages = {275-275},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:33106079,
	title = {Effects of problematic internet use and internet-based activities on brain structure},
	url = {https://m2.mtmt.hu/api/publication/33106079},
	author = {Szente, Anna Tímea and Arató, Ákos and Áfra, Eszter and Nagy, Szilvia Anett and Orsi, Gergely and Perlaki, Gabor and Darnai, Gergely and Janszky, Jozsef},
	journal-iso = {J BEHAV ADDICT},
	journal = {JOURNAL OF BEHAVIORAL ADDICTIONS},
	volume = {11},
	unique-id = {33106079},
	issn = {2062-5871},
	keywords = {MRI; PROBLEMATIC INTERNET USE},
	year = {2022},
	eissn = {2063-5303},
	pages = {274-274},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:32920165,
	title = {Emotional Face Expression Recognition in Internet Use Disorder: task-based fMRI study},
	url = {https://m2.mtmt.hu/api/publication/32920165},
	author = {Arató, Ákos and SZENTE, ANNA and Nagy, Szilvia Anett and PERLAKI, GÁBOR and ORSI, GERGELY and Áfra, Eszter and DÓCZI, TAMÁS and Darnai, Gergely and JANSZKY, JÓZSEF},
	journal-iso = {J BEHAV ADDICT},
	journal = {JOURNAL OF BEHAVIORAL ADDICTIONS},
	volume = {11},
	unique-id = {32920165},
	issn = {2062-5871},
	year = {2022},
	eissn = {2063-5303},
	pages = {223-223},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:32907490,
	title = {Language processing in Internet use disorder : Task-based fMRI study},
	url = {https://m2.mtmt.hu/api/publication/32907490},
	author = {Darnai, Gergely and Perlaki, Gábor and Orsi, Gergely and Arató, Ákos and Szente, Anna Tímea and Horváth, Réka and Áfra, Eszter and Nagy, Szilvia Anett and Kovács, Norbert and Dóczi, Tamás Péter and Janszky, József Vladimír},
	doi = {10.1371/journal.pone.0269979},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {17},
	unique-id = {32907490},
	issn = {1932-6203},
	abstract = {Internet use disorder (IUD) is generally conceptualized as a fast-growing behavioral addiction. Several structural and functional brain alterations have been revealed in this condition, but previous behavioral studies indicated that language systems may also be impaired. We used a silent word generation task to induce brain activation in Broca's area and other parts of the language system. Blood-oxygen-level-dependent activation analysis and psychophysiological interaction analysis were applied to assess functional brain changes. IUD was measured by the Problematic Internet Use Questionnaire and two additional questions concerning usage time and subjective rating of addiction. According to our key findings, areas strongly related to the default mode network were altered in IUD during the task. Moreover, Broca's area showed altered functional connectivity with other language network and occipital areas in IUD. These findings may address the neural background of decreased verbal fluency performance previously reported in the literature, and we emphasize that beside the brain's reward and inhibitory control systems, the language system is the next candidate to be involved in the pathogenesis of IUD.},
	year = {2022},
	eissn = {1932-6203},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X}
}