TY - JOUR AU - Szűcs, Gabriella AU - Szekanecz, Zoltán AU - Szamosi, Szilvia TI - Can we define difficult-to-treat systemic sclerosis? JF - EXPERT REVIEW OF CLINICAL IMMUNOLOGY J2 - EXPERT REV CLIN IMMUNOL PY - 2024 SP - 1 EP - 17 PG - 17 SN - 1744-666X DO - 10.1080/1744666X.2024.2352450 UR - https://m2.mtmt.hu/api/publication/34855342 ID - 34855342 LA - English DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Szamosi, Szilvia AU - Benkő, Szilvia AU - Szűcs, Gabriella TI - Monogénesen öröklődő és szerzett autoinflammatoricus betegségek JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 18 SP - 683 EP - 697 PG - 15 SN - 0030-6002 DO - 10.1556/650.2024.33038 UR - https://m2.mtmt.hu/api/publication/34845388 ID - 34845388 AB - Az autoinflammatio a természetes (innate) immunitás zavara, mely veleszületett, monogénes vagy szerzett lehet. A monogénes autoinflammatoricus kórképek közé tartoznak az inflammasomopathiák, az actinopathiák, az endoplazmatikus reticulum stresszt okozó mutációk, az NFκB-hez társult betegségek, az interferonopathiák, az endogén antagonisták génjeinek mutációi és a DADA2. A szerzett autoinflammatoricus betegségek közé számos gyulladásos reumatológiai kórképet, bél-, bőr- és csontbetegséget, valamint egyéb kórképeket (például VEXAS, IgG4-gyel társult betegség, recurrens pericarditis, 2-es típusú diabetes, interstitialis tüdőbetegség) sorolhatunk. Ebben az összefoglalóban áttekintjük az autoinflammatio koncepcióját és főbb mechanizmusait, a legfontosabb monogénes és szerzett autoinflammatoricus kórképeket, az immundeficientiák autoinflammatióban játszott szerepét, valamint a szóba jövő terápiás lehetőségeket. Autoinflammation is a disorder of natural (innate) immunity, which can be monogenic, or acquired. Monogenic autoinflammatory diseases include inflammasomopathies, actinopathies, endoplasmic reticulum stress mutations, NFκB-associated diseases, interferonopathies, mutations in endogenous antagonist genes, and DADA2. Acquired autoinflammatory diseases include numerous inflammatory rheumatological diseases, intestinal, skin and bone diseases, as well as other conditions (e.g., VEXAS, IgG4-related disease, recurrent pericarditis, type 2 diabetes, interstitial lung disease). In this summary, we review the concept and main mechanisms of autoinflammation, the most important monogenic and acquired autoinflammatory conditions, the role of inborn errors of immunity in autoinflammation, as well as the possible therapeutic options. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Szamosi, Szilvia AU - Benkő, Szilvia AU - Szűcs, Gabriella TI - Autoinflammatio és autoinflammatorikus kórképek JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE PY - 2024 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34836389 ID - 34836389 LA - English DB - MTMT ER - TY - JOUR AU - Geetha, Duvuru AU - Dua, Anisha AU - Yue, Huibin AU - Springer, Jason AU - Salvarani, Carlo AU - Jayne, David AU - Merkel, Peter AU - Szűcs, Gabriella TI - Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial JF - ANNALS OF THE RHEUMATIC DISEASES J2 - ANN RHEUM DIS VL - 83 PY - 2024 IS - 2 SP - 223 EP - 232 PG - 10 SN - 0003-4967 DO - 10.1136/ard-2023-224816 UR - https://m2.mtmt.hu/api/publication/34820283 ID - 34820283 LA - English DB - MTMT ER - TY - JOUR AU - Major, Tamás AU - Nagy, Gábor AU - Szabó, Judit AU - Mózes, Huba AU - Szűcs, Gabriella AU - Szekanecz, Zoltán AU - Szamosi, Szilvia TI - Granulomatosis with polyangiitis or its mimic? A case report JF - JOURNAL OF INTERNATIONAL MEDICAL RESEARCH J2 - J INT MED RES VL - 52 PY - 2024 IS - 4 SP - 1 EP - 8 PG - 8 SN - 0300-0605 DO - 10.1177/03000605241237876 UR - https://m2.mtmt.hu/api/publication/34788385 ID - 34788385 AB - Differentiation between granulomatosis with polyangiitis (GPA) limited to the upper airways and cocaine-induced midline destructive lesion (CIMDL) may be particularly difficult because of their common histopathologic features and antineutrophil cytoplasmic antibody (ANCA) profiles. We herein present a case involving a young woman with an initial diagnosis of GPA based on upper and lower airway manifestations and constitutional symptoms, histopathologic evidence of granulomas, a positive cytoplasmic ANCA indirect immunofluorescent test result, and proteinase 3 positivity by enzyme-linked immunosorbent assay (ELISA). CIMDL was confirmed based on the appearance of a hard palate perforation, positivity for methylecgonine on urine toxicology, a positive perinuclear ANCA indirect immunofluorescent test result, and subsequent human neutrophil elastase (HNE) ANCA positivity by ELISA. Finally, based on the coexistence of CIMDL, constitutional symptoms, and lower airway manifestations, the diagnosis was modified to cocaine-induced GPA mimic. Urine toxicology for cocaine and HNE ELISA are indicated in young patients with GPA who develop limited airway disease to check for the presence of CIMDL and cocaine-/levamisole-induced ANCA-associated vasculitis. Continued abstinence from cocaine is the first-choice therapy for both CIMDL and cocaine-induced GPA mimic. LA - English DB - MTMT ER - TY - JOUR AU - Simon, Diána AU - Kacsándi, Dorottya AU - Karancsiné Pusztai, Anita AU - Soós, Boglárka AU - Végh, Edit AU - Kerekes, György AU - Czókolyová, Monika AU - Szamosi, Szilvia AU - Szűcs, Gabriella AU - Prohászka, Zoltán AU - Németh, Péter AU - Berki, Tímea AU - Szekanecz, Zoltán TI - Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25063429 UR - https://m2.mtmt.hu/api/publication/34745209 ID - 34745209 N1 - * Megosztott szerzőség AB - Cardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM and IgG levels were determined by ELISA. Ultrasonography was performed to assess brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV). Other variables were also evaluated at baseline and 6 and 12 months after treatment initiation. Anti-TNF therapy improved FMD in RA and PWV in AS and stabilized ccIMT. TNF inhibition increased anti-CS IgM and IgG, and possibly also anti-TOPO-F4 IgG levels. Various correlation analyses revealed that nAAbs might be independently involved in autoimmunity as well as changes in inflammation and vascular pathology over time in biologic-treated patients (p < 0.05). We also found associations between anti-TOPO-F4 IgG and anti-Hsp60 IgG (p < 0.05). Baseline nAAb levels or nAAb level changes might determine changes in CRP, disease activity, FMD, PWV, and ccIMT over time (p < 0.05). The interplay between arthritis and inflammatory atherosclerosis, as well as the effects of anti-TNF biologics on these pathologies, might independently involve nAAbs. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Gábor AU - Földesi, Róza AU - Csípő, István AU - Tarr, Tünde AU - Szűcs, Gabriella AU - Szántó, Antónia AU - Bubán, Tamás AU - Szekanecz, Zoltán AU - Papp, Mária AU - Kappelmayer, János AU - Antal-Szalmás, Péter TI - A novel way to evaluate autoantibody interference in samples with mixed antinuclear antibody patterns in the HEp-2 cell based indirect immunofluorescence assay and comparison of conventional microscopic and computer-aided pattern recognition JF - CLINICA CHIMICA ACTA J2 - CLIN CHIM ACTA VL - 553 PY - 2024 SP - 117747 SN - 0009-8981 DO - 10.1016/j.cca.2023.117747 UR - https://m2.mtmt.hu/api/publication/34482910 ID - 34482910 LA - English DB - MTMT ER - TY - JOUR AU - Deibel, Elisabeth AU - Carreira, Patricia E. AU - Vonk, Madelon AU - del, Papa Nicoletta AU - Becvár, Radim AU - Guillén-Del-Castillo, Alfredo AU - Campochiaro, Corrado AU - Poormoghim, Hadi AU - Liem, Sophie AU - Lazzaroni, Maria-Grazia AU - Giollo, Alessandro AU - Mekinian, Arsene AU - de Vries-Bouwstra, Jeska AU - De Santis, Maria AU - Balbir-Gurman, Alexandra AU - Mihai, Carina AU - De Luca, Giacomo AU - Moiseev, Sergey AU - Zanatta, Elisabetta AU - Foti, Rosario AU - Rednic, Simona AU - Denton, Christopher AU - Cutolo, Maurizio AU - Belloli, Laura AU - Airo, Paolo AU - Garzanova, Liudmila AU - Moroncini, Gianluca AU - Inanc, Murat AU - Panopoulos, Stylianos AU - Tandaipan, Jose-Luis AU - Chatelus, Emmanuel AU - Rosato, Edoardo AU - Kuwana, Masataka AU - Yavuz, Sule AU - Alegre-Sancho, Juan J. AU - Smith, Vanessa AU - Szűcs, Gabriella AU - Henes, Joerg AU - Rodríguez-Pintó, Ignasi AU - Atzeni, Fabiola AU - Spierings, Julia AU - Truchetet, Marie-Elise AU - Milchert, Marcin AU - Brito, de Araujo Daniel AU - Riemekasten, Gabriela AU - Bernardino, Vera AU - Martin, Thierry AU - del, Galdo Francesco AU - Vacca, Alessandra AU - Mendoza, Fabian AU - Midtvedt, Øyvind AU - Murdaca, Giuseppe AU - Santiago, Tania AU - Codullo, Veronica AU - Cacciapaglia, Fabio AU - Walker, Ulrich AU - Brunborg, Cathrine AU - Tirelli, Francesca AU - Allanore, Yannick AU - Furst, Daniel E. AU - Matucci, Marco AU - Gabrielli, Armando AU - Distler, Oliver AU - Hoffmann-Vold, Anna-Maria TI - Does the impact of COVID-19 on patients with systemic sclerosis change over time? JF - ARTHRITIS CARE & RESEARCH J2 - ARTHRIT CARE RES VL - 76 PY - 2024 IS - 1 SP - 88 EP - 97 PG - 10 SN - 2151-464X DO - 10.1002/acr.25226 UR - https://m2.mtmt.hu/api/publication/34391704 ID - 34391704 LA - English DB - MTMT ER - TY - JOUR AU - Zanatta, Elisabetta AU - Moccaldi, Beatrice AU - Szűcs, Gabriella AU - Spagnolo, Paolo TI - Should we use nintedanib as early therapy in patients with SSc-ILD? JF - AUTOIMMUNITY REVIEWS J2 - AUTOIMMUN REV PY - 2024 SN - 1568-9972 DO - 10.1016/j.autrev.2023.103463 UR - https://m2.mtmt.hu/api/publication/34391645 ID - 34391645 LA - English DB - MTMT ER - TY - JOUR AU - Kerekes, György AU - Bodoki, Levente AU - Hamar, Attila AU - Karancsiné Pusztai, Anita AU - Tajti, Gábor AU - Katkó, Mónika AU - Végh, Edit AU - Pethő, Zsófia AU - Bodnár, Nóra AU - Horváth, Ágnes AU - Soós, B. AU - Szamosi, Szilvia AU - Hascsi, Z. AU - Harangi, Mariann AU - Panyi, György AU - Szűcs, Gabriella AU - Szekanecz, Zoltán TI - AB0237 EFFECTS OF ONE-YEAR TOFACITINIB THERAPY ON ANGIOGENIC BIOMARKERS IN RHEUMATOID ARTHRITIS JF - ANNALS OF THE RHEUMATIC DISEASES J2 - ANN RHEUM DIS VL - 82 PY - 2023 IS - S1 SP - 1303 EP - 1303 PG - 1 SN - 0003-4967 DO - 10.1136/annrheumdis-2023-eular.2331 UR - https://m2.mtmt.hu/api/publication/34775337 ID - 34775337 LA - English DB - MTMT ER -