TY - JOUR AU - Kocsis, Ádám László AU - Mezőlaki, Noémi AU - Porkoláb, Dorottya AU - Mohos, Gábor AU - Kis, Erika AU - Varga, János AU - Baltás, Eszter AU - Ócsai, Henriette AU - Korom, Irma AU - Varga, Erika AU - Németh, István Balázs AU - Kemény, Lajos AU - Oláh, Judit Magdolna TI - Az őrszemnyirokcsomó-áttét kimutatása 4 mm-nél vastagabb melanomában esélyt ad ígéretes adjuváns kezelésre [Detection of sentinel lymph node metastasis in thick melanoma provides promising adjuvant treatment] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 161 PY - 2020 IS - 39 SP - 1675 EP - 1680 PG - 6 SN - 0030-6002 DO - 10.1556/650.2020.31835 UR - https://m2.mtmt.hu/api/publication/31640438 ID - 31640438 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kocsis, Ádám László AU - Karsko, L AU - Kurgyis, Zsuzsanna AU - Besenyi, Zsuzsanna AU - Pávics, László AU - Viharosné Dósa-Rácz, Éva AU - Kis, Erika AU - Baltás, Eszter AU - Ócsai, Henriette AU - Varga, Erika AU - Bende, Balázs AU - Varga, Ákos AU - Mohos, Gábor AU - Korom, Irma AU - Varga, János AU - Kemény, Lajos AU - Németh, István Balázs AU - Oláh, Judit Magdolna TI - Is it Necessary to Perform Sentinel Lymph Node Biopsy in Thin Melanoma?. A Retrospective Single Center Analysis TS - A Retrospective Single Center Analysis JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 26 PY - 2020 IS - 3 SP - 1861 EP - 1868 PG - 8 SN - 1219-4956 DO - 10.1007/s12253-019-00769-z UR - https://m2.mtmt.hu/api/publication/31067970 ID - 31067970 N1 - Funding Agency and Grant Number: University of Szeged (SZTE); Bolyai Scholarship Hungarian Academy of Science; NKFI (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K-125509, GINOP_2.3.2-15-2016-00020] Funding text: Open access funding provided by University of Szeged (SZTE). This research was supported by NKFI (OTKA) K-125509, GINOP_2.3.2-15-2016-00020 grant and Bolyai Scholarship Hungarian Academy of Science. AB - Sentinel lymph node biopsy (SLNB) is a standard procedure for regional lymph node staging and still has the most important prognostic value for the outcome of patients with thin melanoma. In addition to ulceration, SLNB had to be considered even for a single mitotic figure in thin (<1 mm) melanoma according to AJCC7th guideline, therefore, a retrospective review was conducted involving 403 pT1 melanoma patients. Among them, 152 patients suffered from pT1b ulcerated or mitotic rate ≥ 1/ mm2 melanomas according to the AJCC7th staging system. SLNB was performed in 78 cases, of which nine (11.5%) showed SLN positivity. From them, interestingly, we found a relatively high positive sentinel rate (6/78-8%) in the case of thin primary melanomas ˂0.8 mm. Moreover, the presence of regression increased the probability of sentinel positivity by 5.796 fold. After reassessing pT stage based on the new AJCC8th, 37 pT1b cases were reordered into pT1a category. There was no significant relation between other characteristics examined (age, gender, Breslow, Clark level, and mitosis index) and sentinel node positivity. Based on our data, we suggest that mitotic rate alone is not a sufficiently powerful predictor of SLN status in thin melanomas. If strict histopathological definition criteria are applied, regression might be an additional adverse feature that aids in identifying T1 patients most likely to be SLN-positive. After reassessing of pT1b cases according to AJCC8th regression proved to be independent prognostic factor on sentinel lymph node positivity. Our results propose that sentinel lymph node biopsy might also be considered at patients with regressive thin (˂0.8 mm) melanomas. LA - English DB - MTMT ER - TY - JOUR AU - Mohos, Gábor AU - Kocsis, Ádám László AU - Erős, Gábor AU - Korponyai, Csilla AU - Varga, Ákos AU - Bende, Balázs AU - Varga, János TI - Reconstruction of Alar-Perialar Defects with a Combined Subcutaneous and Cutaneous Pedicled Rotation-Advancement Nasolabial Flap JF - JOURNAL OF INVESTIGATIVE SURGERY J2 - J INVEST SURG VL - 33 PY - 2020 IS - 7 SP - 666 EP - 672 PG - 7 SN - 0894-1939 DO - 10.1080/08941939.2018.1538397 UR - https://m2.mtmt.hu/api/publication/30634855 ID - 30634855 AB - During the reconstruction of alar defects involving the upper lip, reconstructive surgeons face the need for various thicknesses of tissues crucial to preserving the facial sulcus which is important for a cosmetically acceptable result. Our aim was to reconstruct the deep perialar and thinner lateral nasal alar defect in a single step procedure with a suitable flap which is reliable, has appropriate blood supply and provides an esthetically good result.Extended alar defect was reconstructed with a combined flap in 10 cases. During the procedure, a subcutaneous pedicle was created and the proximal part of the flap was rotated into the defect as a rotational flap. The procedure and the follow-up have been photo-documented in all cases. Furthermore, the perfusion of the flaps was monitored by means of laser Doppler flowmetry. Postoperative complications were evaluated with a semi-quantitative score and the patients completed a patient satisfaction questionnaire, too.An optimal esthetic result was obtained in all cases after the operation. The lateral nasal alar part of the defect was reconstructed with the thinner proximal part of the flap while the deeper perialar region involving the upper lip was covered with the thicker distal part. The flaps have shown sufficient blood flow after the operation. There was no significant pin cushioning or "trap-door" effect in any case. Mild erythema and edema was found in few cases. The patients were satisfied with the cosmetic result of the intervention.The flap is suitable for the reconstruction of alar defects involving the perialar region. It has the advantage of covering the deeper perialar and the thinner alar defects, whilst eliminating the pin cushioning effect of the conventional subcutaneous island pedicle flaps. LA - English DB - MTMT ER - TY - THES AU - Mohos, Gábor TI - Reconstruction of different tissue defects by means of various flaps in plastic surgery PB - Szegedi Tudományegyetem (SZTE) PY - 2019 SP - 45 DO - 10.14232/phd.10201 UR - https://m2.mtmt.hu/api/publication/31152157 ID - 31152157 LA - English DB - MTMT ER - TY - JOUR AU - Varga, János AU - Bende, Balázs AU - Altmayer, Anita AU - Gaál, Magdolna AU - Kis, Erika AU - Kocsis, Ádám László AU - Mohos, Gábor AU - Varga, Ákos AU - Vas, Krisztina AU - Veréb, Zoltán AU - Kemény, Lajos TI - Új terápiás lehetőségek a plasztikai sebészet és a dermatológia határterületén JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 95 PY - 2019 IS - 2 SP - 69 EP - 73 PG - 5 SN - 0006-7768 DO - 10.7188/bvsz.2019.95.2.7 UR - https://m2.mtmt.hu/api/publication/30729353 ID - 30729353 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, János AU - Mohos, Gábor AU - Varga, Ákos AU - Erős, Gábor AU - Bende, Balázs AU - Németh, István Balázs AU - Kocsis, Ádám László TI - A Possible Technique for the Complex Reconstruction of Exposed Breast Implant: Applicability and Microcirculation of the Capsule Flap JF - JOURNAL OF INVESTIGATIVE SURGERY J2 - J INVEST SURG VL - 32 PY - 2019 IS - 6 SP - 530 EP - 535 PG - 6 SN - 0894-1939 DO - 10.1080/08941939.2018.1442532 UR - https://m2.mtmt.hu/api/publication/3347287 ID - 3347287 AB - AIM OF THE STUDY: Immediate breast reconstruction is often applied after mastectomy. However, inappropriate surgical technique, postoperative radiotherapy and infection may lead to tissue necrosis and implant protrusion. Traditional therapies frequently fail. However, previous data suggested that capsule flaps may be appropriate for the salvage of implants. Our goal was to investigate the usefulness of capsuloplasty in patients with exposed breast implant and to monitor the blood supply of capsule flaps during the operation. MATERIALS AND METHODS: Capsuloplasty was performed in 19 patients with exposed implant. After removal of necrotic tissue, capsulotomy was performed, the planned flap was dissected free, the implant was covered with the flap and the wound was then closed. During operation, the blood flow of the flap was determined by means of laser Doppler flowmetry. Moreover, tissue samples were taken for histology and immunostaining for CD34. RESULTS: The postoperative follow-up showed that capsule flaps survived in each case: no complications were found. The blood flow of the flaps did not change significantly during the intervention as compared with the baseline values. The histology and the immunohistochemistry revealed considerable vascularization and angiogenesis in the flap. CONCLUSIONS: Capsule flaps seem to be appropriate for the salvage of exposed implants and for enhancement of implant cover in the case of thin and injured tissue. LA - English DB - MTMT ER - TY - JOUR AU - Korponyai, Csilla AU - Szél, Edit AU - Behany, Z AU - Varga, Erika AU - Mohos, Gábor AU - Dura, A AU - Dikstein, S AU - Kemény, Lajos AU - Erős, Gábor TI - The effects of locally applied glycerol and xylitol on the hydration, barrier function and morphological parameters of the skin JF - ACTA DERMATO-VENEREOLOGICA J2 - ACTA DERM-VENEREOL VL - 97 PY - 2017 IS - 2 SP - 182 EP - 187 PG - 6 SN - 0001-5555 DO - 10.2340/00015555-2493 UR - https://m2.mtmt.hu/api/publication/3097079 ID - 3097079 N1 - Megjegyzés-26581988 Megjegyzés-27128742 OA gold Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Central Pharmacy, University of Szeged, Szeged, Hungary Unit of Cell Pharmacology, School of Pharmacy, The Hebrew University, Jerusalem, Israel MTA-SZTE Dermatological Research Group, Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Cited By :8 Export Date: 28 August 2019 CODEN: ADVEA Correspondence Address: Korponyai, C.; Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6., Hungary; email: csillakorponyai81@gmail.com Chemicals/CAS: glycerol, 56-81-5; interstitial collagenase, 9001-12-1; xylitol, 87-99-0; filaggrin; Gels; Glycerol; Intermediate Filament Proteins; Matrix Metalloproteinase 1; Xylitol Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Central Pharmacy, University of Szeged, Szeged, Hungary Unit of Cell Pharmacology, School of Pharmacy, The Hebrew University, Jerusalem, Israel MTA-SZTE Dermatological Research Group, Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Cited By :14 Export Date: 29 August 2020 CODEN: ADVEA Correspondence Address: Korponyai, C.; Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6., Hungary; email: csillakorponyai81@gmail.com Chemicals/CAS: glycerol, 56-81-5; interstitial collagenase, 9001-12-1; xylitol, 87-99-0; filaggrin; Gels; Glycerol; Intermediate Filament Proteins; Matrix Metalloproteinase 1; Xylitol Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Central Pharmacy, University of Szeged, Szeged, Hungary Unit of Cell Pharmacology, School of Pharmacy, The Hebrew University, Jerusalem, Israel MTA-SZTE Dermatological Research Group, Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Cited By :18 Export Date: 12 March 2021 CODEN: ADVEA Correspondence Address: Korponyai, C.; Department of Dermatology and Allergology, Korányi fasor 6., Hungary; email: csillakorponyai81@gmail.com Chemicals/CAS: glycerol, 56-81-5; interstitial collagenase, 9001-12-1; xylitol, 87-99-0; filaggrin; Gels; Glycerol; Intermediate Filament Proteins; Matrix Metalloproteinase 1; Xylitol AB - Glycerol and xylitol hydrate the skin and improve its barrier function over a short period. We studied the effects of glycerol and xylitol on the physiological properties and morphology of the skin after longer-term application. Twelve volunteers with dry skin were examined. Three areas on the arms were determined. Area 1 served as untreated control. The vehicle was applied to area 2, while area 3 was treated twice daily with a formulation containing glycerol (5%) and xylitol (5%) for 14 days. Transepidermal water loss (TEWL), hydration and biomechanical properties of the skin were monitored. Biopsies were taken for routine histology and immunohistochemistry for filaggrin and matrix metalloproteinase-1 (MMP-1). The polyols increased the skin hydration and protein quantity of filaggrin, elevated the interdigitaion index, decreased the TEWL and improved the biomechanical properties of the skin, but did not change the protein expression of MMP-1. A combination of glycerol and xylitol can be useful additional therapy for dry skin. LA - English DB - MTMT ER - TY - JOUR AU - Vass, Gábor AU - Mohos, Gábor AU - Bere, Zsófia AU - Iván, László AU - Varga, János AU - Piffkó, József AU - Rovó, László TI - Secondary correction of nasal deformities in cleft lip and palate patients. surgical technique and outcome evaluation TS - surgical technique and outcome evaluation JF - HEAD AND FACE MEDICINE J2 - HEAD FACE MED VL - 12 PY - 2016 IS - 1 PG - 5 SN - 1746-160X DO - 10.1186/s13005-016-0132-y UR - https://m2.mtmt.hu/api/publication/3157301 ID - 3157301 AB - BACKGROUND: Nasal deformity associated with cleft lip and palate is a highly challenging reconstructive problem in rhinoplasty. In the literature, several operative solutions and evaluation methods have been described, however these do not offer a standard procedure for the surgeon. Our aim was to standardize our surgical technique-as much as the uniqueness of each case allowed it-based on the most frequent deformities we had faced; and to evaluate our results via a postoperative patient satisfaction questionnaire. Between 2012 and 2014 12 consecutive patients with combined cleft lip and palate deformities underwent secondary nasal and septal correction surgery with the same method by the same surgeon. The indications of surgery were, on one hand, difficult nasal breathing and altered nasal function (tendency for chronic rhinosinusitis) and on the other hand the aesthetic look of the nose. No exclusion criteria were stated. In our follow-up study we evaluated our results by using a modified Rhinoplasty Outcome Evaluation (ROE) questionnaire: patients answered the same four questions pre- and postoperatively. Data were statistically analyzed by t-test. RESULTS: Based on the questionnaire, all patients experienced improvement of nasal breathing function, improved appearance of the nose and less stigmatization from the society. According to the t-test, all scores of the four questions improved significantly in the postoperative 4-6 months, compared with the preoperative scores. CONCLUSIONS: In our opinion with our standardized surgical steps satisfactory aesthetic and functional results can be achieved. We think the modified ROE questionnaire is an adequate and simple method for the evaluation of our surgical results. LA - English DB - MTMT ER - TY - JOUR AU - Vass, Gábor AU - Mohos, Gábor AU - Paczona, Róbert AU - Varga, János AU - Iván, László AU - Rovó, László TI - Ajtószárny lebenyek speciális felhasználási lehetőségei fej-nyaki tumoros beteganyagunkon JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 58 PY - 2015 IS - 4 SP - 257 EP - 265 PG - 9 SN - 1217-3231 DO - 10.21755/MTO.2015.058.0004.006 UR - https://m2.mtmt.hu/api/publication/3062399 ID - 3062399 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, János AU - Kis, Erika AU - Mohos, Gábor AU - Kocsis, Ádám László AU - Bende, Balázs AU - Varga, Ákos AU - Kemény, Lajos TI - Hidradenitis Suppurativa sebészi kezelése JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 91 PY - 2015 IS - 6 SP - 211 EP - 212 PG - 2 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/3014802 ID - 3014802 LA - Hungarian DB - MTMT ER -