TY - JOUR AU - Pál, Dániel AU - Szilágyi, Brigitta AU - Berczeli, Márton AU - Szalay, Csaba Imre AU - Sárdy, Balázs AU - Oláh, Zoltán AU - Székely, Tamás AU - Rácz, Gergely AU - Banga, Péter AU - Czinege, Zsófia AU - Sótonyi, Péter TI - Ruptured Aortic Aneurysm and Dissection Related Death: an Autopsy Database Analysis JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 26 PY - 2020 IS - 4 SP - 2391 EP - 2399 PG - 9 SN - 1219-4956 DO - 10.1007/s12253-020-00835-x UR - https://m2.mtmt.hu/api/publication/31376140 ID - 31376140 LA - English DB - MTMT ER - TY - JOUR AU - Rusz, Orsolya AU - Papp, O AU - Vízkeleti, Laura AU - Molnar, BA AU - Bende, KC AU - Lotz, Gábor AU - Ács, Balázs AU - Kahán, Zsuzsanna AU - Székely, Tamás AU - Bathori, A AU - Szundi, C AU - Kulka, Janina AU - Szállási, Zoltán AU - Tőkés, Anna-Mária TI - LAPTM4B gene copy number gain is associated with inferior response to anthracycline-based chemotherapy in hormone receptor negative breast carcinomas JF - CANCER CHEMOTHERAPY AND PHARMACOLOGY J2 - CANCER CHEMOTH PHARM VL - 82 PY - 2018 IS - 1 SP - 139 EP - 147 PG - 9 SN - 0344-5704 DO - 10.1007/s00280-018-3602-z UR - https://m2.mtmt.hu/api/publication/3376691 ID - 3376691 AB - PURPOSE: To determine the associations between lysosomal-associated transmembrane protein 4b (LAPTM4B) gene copy number and response to different chemotherapy regimens in hormone receptor negative (HR-) primary breast carcinomas. PATIENTS AND METHODS: Two cohorts were analyzed: (1) 69 core biopsies from HR-breast carcinomas treated with neoadjuvant chemotherapy (anthracycline based in 72.5% of patients and non-anthracycline based in 27.5% of patients). (2) Tissue microarray (TMA) of 74 HR-breast carcinomas treated with adjuvant therapy (77.0% of the patients received anthracycline, 17.6% of the patients non-anthracycline-based therapy, and in 5.4% of the cases, no treatment data are available). Interphase FISH technique was applied on pretreatment core biopsies (cohort I) and on TMAs (cohort II) using custom-made dual-labelled FISH probes (LAPTM4B/CEN8q FISH probe Abnova Corp.). RESULTS: In the neoadjuvant cohort in the anthracycline-treated group, we observed a significant difference (p = 0.029) of average LAPTM4B copy number between the non-responder and pathological complete responder groups (4.1 +/- 1.1 vs. 2.6 +/- 0.1). In the adjuvant setting, the anthracycline-treated group of metastatic breast carcinomas was characterized by higher LAPTM4B copy number comparing to the non-metastatic ones (p = 0.046). In contrast, in the non-anthracycline-treated group of patients, we did not find any LAPTM4B gene copy number differences between responder vs. non-responder groups or between metastatic vs. non-metastatic groups. CONCLUSION: Our results confirm the possible role of the LAPTM4B gene in anthracycline resistance in HR- breast cancer. Analyzing LAPTM4B copy number pattern may support future treatment decision. LA - English DB - MTMT ER - TY - JOUR AU - Halászlaki, Csaba AU - Tóbiás, Bálint AU - Balla, Bernadett AU - Kósa, János AU - Horányi, János AU - Bölöny, E AU - Nagy, Zsolt AU - Speer, Gábor AU - Járay, Balázs AU - Székely, Eszter AU - Istók, Roland AU - Székely, Tamás AU - Putz, Zsuzsanna AU - Dank, Magdolna AU - Lakatos, Péter AU - Takács, István TI - Predictive value of somatic mutations for the development of malignancy in thyroid nodules benign by cytopathology JF - ENDOCRINE PRACTICE J2 - ENDOCR PRACT VL - 22 PY - 2016 IS - 9 SP - 1081 EP - 1087 PG - 7 SN - 1530-891X DO - 10.4158/EP151057.OR UR - https://m2.mtmt.hu/api/publication/3068409 ID - 3068409 LA - English DB - MTMT ER - TY - JOUR AU - Ács, Balázs AU - Szekely, N AU - Szász, Attila Marcell AU - Lotz, Gábor AU - Székely, Tamás AU - Istók, Roland AU - Székely, Eszter AU - Madaras, Lilla AU - Kulka, Janina AU - Járay, Balázs TI - Reliability of immunocytochemistry and fluorescence in situ hybridization on fine-needle aspiration cytology samples of breast cancers: A comparative study JF - DIAGNOSTIC CYTOPATHOLOGY J2 - DIAGN CYTOPATHOL VL - 44 PY - 2016 IS - 6 SP - 466 EP - 471 PG - 6 SN - 8755-1039 DO - 10.1002/dc.23463 UR - https://m2.mtmt.hu/api/publication/3040245 ID - 3040245 AB - INTRODUCTION: To characterize breast tumors and metastases, fine-needle aspiration cytology (FNAB) can be a favorable first choice. However, the diagnostic accuracy of ancillary tests applied to FNAB samples is yet to be validated. PATIENTS AND METHODS: We examined 110 breast cancer patients' paired cytological and surgical resection specimens evaluated between 2005 and 2014. Comparison of ER and Her2 immunocytochemical (ICC) and immunohistochemical (IHC) staining and HER2 fluorescence in situ hybridization (FISH) was performed. RESULTS: Significant difference (p < 0.001) and moderate correlation (kappa = 0.446) were noted between results of 97 paired ICC an IHC reactions for ER expression. ICC for ER status had a sensitivity of 75%, specificity of 100%, positive predictive value (PPV) of 100%, and negative predictive value (NPV) of 38.2%. Significant difference (p = 0.012) and moderate correlation (kappa = 0.541) were found between results of 77 paired ICC an IHC reactions for Her2 expression. The Her2 ICC had a sensitivity of 54%, specificity of 95.4%, PPV of 66.7%, and NPV of 92.6%. The results of FISH carried out on 23 paired samples of FNAB and surgical specimens indicated perfect correlation (kappa = 1.000) and no significant difference (p = 1.000). FISH performed on FNAB has sensitivity, specificity, PPV, and NPV of 100%. CONCLUSION: The correlation of ICC and IHC is moderate regarding ER and Her2 expression of the same tumor. FISH performed on FNAB samples is suitable to categorize primary and metastatic breast cancer in regard of HER2 gene amplification status and can be used as a predictive test in respect of therapies targeting HER2. Diagn. Cytopathol. 2016. (c) 2016 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Benczik, Márta AU - Galamb, Ádám AU - Koiss, R AU - Kovacs, A AU - Járay, Balázs AU - Székely, Tamás AU - Szekerczés, Tímea AU - Schaff, Zsuzsa AU - Sobel, Gábor AU - Jeney, Csaba TI - Claudin-1 as a Biomarker of Cervical Cytology and Histology JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 22 PY - 2016 IS - 1 SP - 179 EP - 188 PG - 10 SN - 1219-4956 DO - 10.1007/s12253-015-9990-z UR - https://m2.mtmt.hu/api/publication/2963615 ID - 2963615 N1 - Gábor Sobel and Csaba Jeney equally contributed. Cellcall Ltd., Röppentyű u. 48, Budapest, 1134, Hungary 2nd Department of Obstetrics and Gynecology, Semmelweis University, Üllői út 78/a, Budapest, 1082, Hungary Combined Szent István and Szent László Hospital, Nagyvárad tér 1, Budapest, 1097, Hungary 2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, 1091, Hungary Synlab Hungary Ltd., Bajcsy-Zsilinszky út 53, Budapest, 1065, Hungary Department of Medical Microbiology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Cited By :6 Export Date: 14 February 2020 CODEN: POREF Correspondence Address: Jeney, C.; Cellcall Ltd., Röppentyű u. 48, Hungary; email: csjeney@gmail.com AB - Several immunochemistry tests are used for triaging human papilloma virus (HPV) and cytology positive cases in cervical cancer screening and as an adjunct test to diagnose cervical cancer. Claudin-1 (CLDN1) protein is a major component of the tight junction, shown to have altered expression in cervical cancer. In this study, value of CLDN1 was analysed as a screening and triage immunochemistry test compared to cytology and HPV testing. A population of 352 women attending colposcopic referral visits resulting in cervical conisation and a second population of 150 women attending routine gynaecological visits with negative cervical cytology were enrolled in a multi-centre clinical study in Hungary. Cytology and HPV (Genoid Full Spectrum HPV Amplification and Detection System) testing were carried out along with immunocytochemistry for CLDN1, and as a reference, using CINtec p16 Cytology Kit. Three different evaluation protocols were used which assessed immunostaining characteristics with or without cytological readings. High correlation observable between p16INK4a and CLDN1 established CLDN1 as a competing marker in cervical cancer. Concordance of CLDN1 immunostaining of cervical intraepithelial neoplasia 2 and above (CIN2+) positives was 84.0 % (73.8-89.3); concordance of CIN2+ negatives was 69.0 % (59.6-75.8). In conclusion, CLDN1 has similar diagnostic potential as p16INK4a, our results established it as a histological and cytological biomarker with the potential to improve the clinical performance of cervical cytology and histology. LA - English DB - MTMT ER - TY - JOUR AU - Tóbiás, Bálint AU - Halászlaki, Csaba AU - Balla, Bernadett AU - Kósa, János AU - Árvai, Kristóf AU - Horváth, Péter AU - Takács, István AU - Nagy, Zsolt AU - Horváth, Evelin AU - Horányi, János AU - Járay, Balázs AU - Székely, Eszter AU - Székely, Tamás AU - Győri, Gabriella AU - Putz, Zsuzsanna AU - Dank, Magdolna AU - Valkusz, Zsuzsanna AU - Vasas, Béla AU - Iványi, Béla AU - Lakatos, Péter TI - Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 22 PY - 2016 IS - 1 SP - 27 EP - 33 PG - 7 SN - 1219-4956 DO - 10.1007/s12253-015-9969-9 UR - https://m2.mtmt.hu/api/publication/2927668 ID - 2927668 N1 - Bálint Tobiás and Csaba Halászlaki equally contributed to this work. AB - The incidence of thyroid cancers is increasing worldwide. Some somatic oncogene mutations (BRAF, NRAS, HRAS, KRAS) as well as gene translocations (RET/PTC, PAX8/PPAR-gamma) have been associated with the development of thyroid cancer. In our study, we analyzed these genetic alterations in 394 thyroid tissue samples (197 papillary carcinomas and 197 healthy). The somatic mutations and translocations were detected by Light Cycler melting method and Real-Time Polymerase Chain Reaction techniques, respectively. In tumorous samples, 86 BRAF (44.2 %), 5 NRAS (3.1 %), 2 HRAS (1.0 %) and 1 KRAS (0.5 %) mutations were found, as well as 9 RET/PTC1 (4.6 %) and 1 RET/PTC3 (0.5 %) translocations. No genetic alteration was seen in the non tumorous control thyroid tissues. No correlation was detected between the genetic variants and the pathological subtypes of papillary cancer as well as the severity of the disease. Our results are only partly concordant with the data found in the literature. LA - English DB - MTMT ER - TY - JOUR AU - Székely, Eszter AU - Istók, Roland AU - Székely, Tamás AU - Kovács, I AU - Somorácz, Áron AU - Járay, Balázs TI - Az aspirációs citológia szerepe a daganatdiagnosztikában. JF - MAGYAR ONKOLÓGIA J2 - MAGYAR ONKOLÓGIA VL - 58 PY - 2014 IS - 4 SP - 311 EP - 323 PG - 13 SN - 0025-0244 UR - https://m2.mtmt.hu/api/publication/2958331 ID - 2958331 AB - Fine needle aspiration biopsy (FNAB) of focal lesions is a quick, relatively simple and cost-effective diagnostic method. However, performing aspirations and interpreting smears require skill and experience. Before initiating an aspiration the doctor needs to be aware of the limits of cytology as it is vital to know what kind of diagnostic issues can be answered upon a smear and what kind of questions cannot. Traditionally FNAB was performed without radiologic guidance, and therefore almost only palpable lesions were aspirated. Since ultrasound (US) has become widely used in medicine, it is axiomatical that FNAB is ideally performed with US guidance not only for the protection of the patients but also for targeting the lesion more safely. Several cytologists find US guidance unnecessary as a routinely used examination, which may lead to unsatisfactory smears and false negative results. This means not only a loss for the patient, but leads to a negative judgement of this diagnostic method. Our interventional cytology diagnostic team developed a working method resulting in excellent statistical results. In the followings we would like to share our experience refined the past two decades to restore the reputation of this diagnostic method. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóbiás, Bálint AU - Balla, Bernadett AU - Kósa, János AU - Horányi, János AU - Takács, István AU - Nagy, Zsolt AU - Horváth, Péter AU - Járay, Balázs AU - Székely, Eszter AU - Istók, Roland AU - Székely, Tamás AU - Lakatos, Péter TI - Detecting somatic oncogene mutations in FNA samples of cold nodules in Hungary JF - ENDOCRINE ABSTRACTS J2 - ENDOCR ABSTR VL - 32 PY - 2013 SN - 1470-3947 DO - 10.1530/endoabs.32.P1108 UR - https://m2.mtmt.hu/api/publication/2336120 ID - 2336120 N1 - 15th European Congress of Endocrinology, Copenhagen, Denmark 2013.04.27- 05.01. LA - English DB - MTMT ER - TY - JOUR AU - Székely, Eszter AU - Törzsök, Péter AU - Riesz, Péter AU - Korompay, Anna AU - Fintha, Attila AU - Székely, Tamás AU - Lotz, Gábor AU - Nyirády, Péter AU - Romics, Imre AU - Tímár, József AU - Schaff, Zsuzsa AU - Kiss, András TI - Expression of claudins and their prognostic significance in non-invasive urothelial neoplasms of the human urinary bladder JF - JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY J2 - J HISTOCHEM CYTOCHEM VL - 59 PY - 2011 IS - 10 SP - 932 EP - 941 PG - 10 SN - 0022-1554 DO - 10.1369/0022155411418829 UR - https://m2.mtmt.hu/api/publication/1632012 ID - 1632012 LA - English DB - MTMT ER - TY - JOUR AU - Riesz, Péter AU - Székely, Eszter AU - Török, V AU - Székely, Tamás AU - Romics, Imre TI - E-cadherin-expresszió vizsgálata hólyagrákban JF - MAGYAR UROLÓGIA J2 - MAGYAR UROLÓGIA VL - 19 PY - 2007 IS - 3 SP - 159 EP - 163 PG - 5 SN - 0864-8921 UR - https://m2.mtmt.hu/api/publication/1781927 ID - 1781927 LA - Hungarian DB - MTMT ER -