TY  - JOUR
AU  - Wéber, Edit
AU  - Hetényi, Anasztázia
AU  - Váczi, Balázs
AU  - Szolnoki, Éva Tünde
AU  - Fajka-Boja, Roberta
AU  - Tubak, Vilmos
AU  - Monostori, Éva
AU  - Martinek, Tamás
TI  - Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein
JF  - CHEMBIOCHEM
J2  - CHEMBIOCHEM
VL  - 11
PY  - 2010
IS  - 2
SP  - 228
EP  - 234
PG  - 7
SN  - 1439-4227
DO  - 10.1002/cbic.200900502
UR  - https://m2.mtmt.hu/api/publication/1321061
ID  - 1321061
N1  - Chemicals/CAS: galectin 1, 258495-34-0; tyrosine, 16870-43-2, 55520-40-6, 60-18-4; Asialoglycoproteins; Galectin 1; Glycoproteins; Peptides; Recombinant Proteins; Tyrosine, 55520-40-6; alpha-Fetoproteins; asialofetuin
Funding Agency and Grant Number: Hungarian Academy of Sciences; Hungarian Scientific Research Fund [K 69047, PD 75938]; NKTH-OTKA [CK 78188]; OTKA NF [69316]\n Funding text: A.H. and T.A.M. acknowledge the award of Janos Bolyai Research Fellowships by the Hungarian Academy of Sciences. This work was supported by grants from the Hungarian Scientific Research Fund (OTKA K 69047, PD 75938, NKTH-OTKA CK 78188, and OTKA NF 69316).\n
AB  - Galectin-1 (Gal-1), a ubiquitous P-galactoside-binding protein expressed by various normal and pathological tissues, has been implicated in cancer and autoimmune/inflammatory diseases in consequence of its regulatory role in adhesion, cell viability, proliferation, and angiogenesis. The functions of Gal-1 depend on its affinity for P-galactoside-containing glycoconjugates; accordingly, the inhibition of sugar binding blocks its functions, hence promising potential therapeutic tools. The Tyr-Xxx-Tyr peptide motifs have been reported to be glycomimetic sequences, mainly on the basis of their inhibitory effect on the Gal-1-asialofetuin (ASF) interaction. However, the results regarding the efficacy of the Tyr-Xxx-Tyr motif as a glycomimetic inhibitor are still controversial. The present STD and trNOE NMR experiments reveal that the Tyr-Xxx-Tyr peptides studied do not bind to Gal-1, whereas their binding to ASF is clearly detected. N-15,H-1 HSQC titrations with N-15-labeled Gal-1 confirm the absence of any peptide-Gal-1 interaction. These data indicate that the Tyr-Xxx-Tyr peptides tested in this work are not glycomimetics as they interact with ASF via an unrevealed molecular linkage.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kurucz, Judit Éva
AU  - Váczi, Balázs
AU  - Márkus, Róbert
AU  - Laurinyecz, Barbara
AU  - Vilmos, Péter
AU  - Zsámboki, János
AU  - Csorba, Kinga
AU  - Gateff, E
AU  - Hultmark, D
AU  - Andó, István
TI  - Definition of Drosophila hemocyte subsets by cell-type specific antigens
JF  - ACTA BIOLOGICA HUNGARICA (1983-2018)
J2  - ACTA BIOL HUNG
VL  - 58
PY  - 2007
IS  - Suppl. 1
SP  - 95
EP  - 111
PG  - 17
SN  - 0236-5383
DO  - 10.1556/ABiol.58.2007.Suppl.8
UR  - https://m2.mtmt.hu/api/publication/1915261
ID  - 1915261
AB  - We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Andó, István
AU  - Laurinyecz, Barbara
AU  - Márkus, Róbert
AU  - Rus, Florentina
AU  - Váczi, Balázs
AU  - Zsámboki, János
AU  - Kurucz, Judit Éva
TI  - Ősi örökségünk a veleszületett immunitás : a Drosophila immunrendszere
JF  - MAGYAR TUDOMÁNY
J2  - MAGYAR TUDOMÁNY
VL  - 111
PY  - 2004
SP  - 1080
EP  - 1089
PG  - 10
SN  - 0025-0325
UR  - https://m2.mtmt.hu/api/publication/1913689
ID  - 1913689
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Andó, István
AU  - Laurinyecz, Barbara
AU  - Nagy, István
AU  - Márkus, Róbert
AU  - FLORENTINA, R
AU  - Váczi, Balázs
AU  - Zsámboki, János
AU  - FEHER, L
AU  - GATEFF, E
AU  - Kurucz, Judit Éva
TI  - Ősi örökségünk a veleszületett immunitás. A Drosophila immunrendszere
JF  - MAGYAR IMMUNOLÓGIA
J2  - MAGYAR IMMUNOLÓGIA
VL  - 2
PY  - 2003
IS  - 4
SP  - 39
EP  - 45
PG  - 7
SN  - 1588-3280
UR  - https://m2.mtmt.hu/api/publication/1912996
ID  - 1912996
LA  - Hungarian
DB  - MTMT
ER  -