@article{MTMT:34844873, title = {Spontaneous and Treatment-Related Changes of Serum Calcitonin in Medullary Thyroid Cancer: Long-Term Experience in a Patient With Multiple Endocrine Neoplasia Type 2B}, url = {https://m2.mtmt.hu/api/publication/34844873}, author = {Réti, Zsuzsanna and Tabák, Ádám and Garami, Miklós and Kalina, Ildikó and Kiss, Gergely and Sápi, Zoltán and Tóth, Miklós and Tőke, Judit}, doi = {10.1200/PO.23.00675}, journal-iso = {JCO PRECIS ONCOL}, journal = {JCO PRECISION ONCOLOGY}, volume = {8}, unique-id = {34844873}, year = {2024}, eissn = {2473-4284}, orcid-numbers = {Réti, Zsuzsanna/0000-0003-1095-5030; Tabák, Ádám/0000-0002-6234-3936; Garami, Miklós/0000-0003-4298-2746; Kalina, Ildikó/0000-0002-2647-9123; Tóth, Miklós/0000-0002-8701-408X} } @article{MTMT:34830215, title = {Diagnosis rates, therapeutic characteristics, lifestyle, and cancer screening habits of patients with diabetes mellitus in a highly deprived region in Hungary: a cross-sectional analysis}, url = {https://m2.mtmt.hu/api/publication/34830215}, author = {Pártos, Katalin and Major, Dávid and Dósa, Norbert Sándor and Fazekas-Pongor, Vince and Tabák, Ádám and Ungvári, Zoltán István and Horváth, Ildikó and Barta, Ildikó and Pozsgai, Éva and Bodnár, Tamás and Fehér, Gergely and Lenkey, Zsófia and Fekete, Mónika and Springó, Zsolt}, doi = {10.3389/fendo.2024.1299148}, journal-iso = {FRONT ENDOCRINOL}, journal = {FRONTIERS IN ENDOCRINOLOGY}, volume = {15}, unique-id = {34830215}, issn = {1664-2392}, year = {2024}, eissn = {1664-2392}, orcid-numbers = {Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tabák, Ádám/0000-0002-6234-3936; Ungvári, Zoltán István/0000-0002-6035-6039; Horváth, Ildikó/0000-0001-6891-1044; Fekete, Mónika/0000-0001-8632-2120} } @article{MTMT:34826851, title = {Treatment of type 2 diabetes mellitus in the elderly – Special considerations}, url = {https://m2.mtmt.hu/api/publication/34826851}, author = {Gadó, Klára and Tabák, Ádám and Vingender, István and Domján, Gyula and Bednárikné Dörnyei, Gabriella}, doi = {10.1556/2060.2024.00317}, journal-iso = {PHYSIOL INT}, journal = {PHYSIOLOGY INTERNATIONAL}, volume = {in press}, unique-id = {34826851}, issn = {2498-602X}, abstract = {Type 2 diabetes is a frequent chronic disease. Given its strong positive association with older age, it is a significant public health issue in elderly populations. Furthermore, the aging of the population, driven by increasing life expectancy in high and middle-income countries leads to an increasing prevalence of diabetes.}, year = {2024}, eissn = {2677-0164}, orcid-numbers = {Gadó, Klára/0000-0003-2253-5826; Tabák, Ádám/0000-0002-6234-3936; Domján, Gyula/0000-0003-0722-1538; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252} } @{MTMT:34804963, title = {Hypoglykaemiák}, url = {https://m2.mtmt.hu/api/publication/34804963}, author = {Tabák, Ádám}, booktitle = {Belgyógyászat 1 tantárgyi jegyzet}, unique-id = {34804963}, year = {2024}, pages = {145-147}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936} } @{MTMT:34804957, title = {Ketoacidosis, hyperosmolaris coma}, url = {https://m2.mtmt.hu/api/publication/34804957}, author = {Tabák, Ádám}, booktitle = {Belgyógyászat 1 tantárgyi jegyzet}, unique-id = {34804957}, year = {2024}, pages = {142-145}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936} } @{MTMT:34804467, title = {Nephropathia diabetica}, url = {https://m2.mtmt.hu/api/publication/34804467}, author = {Ferencz, Viktória and Tabák, Ádám}, booktitle = {Belgyógyászat 1 tantárgyi jegyzet}, unique-id = {34804467}, year = {2024}, pages = {139-139}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936} } @article{MTMT:34797483, title = {Birthweight trends and their explanatory factors in Hungary between 1999 and 2018. an analysis of the Hungarian Tauffer registry}, url = {https://m2.mtmt.hu/api/publication/34797483}, author = {Zsirai, László and Kun, Attila and Visolyi, Gergely and Svébis, Márk Márton and Domján, Beatrix Annamária and Tabák, Ádám}, doi = {10.1186/s12978-024-01787-0}, journal-iso = {REPROD HEALTH}, journal = {REPRODUCTIVE HEALTH}, volume = {21}, unique-id = {34797483}, abstract = {The increasing birthweight trend stopped and even reversed in several high income countries in the last 20 years, however the reason for these changes is not well characterized. We aimed to describe birthweight trends of term deliveries in Hungary between 1999 and 2018 and to investigate potential maternal and foetal variables that could drive these changes.We analysed data from the Hungarian Tauffer registry, a compulsory anonymized data collection of each delivery. We included all singleton term deliveries in 1999-2018 (n = 1,591,932). We modelled birthweight trends separately in 1999-2008 and 2008-2018 in hierarchical multiple linear regression models adjusted for calendar year, newborn sex, maternal age, gestational age at delivery, and other important determinants.Median birthweights increased from 3250/3400 g (girl/boy) to 3300/3440 g from 1999 to 2008 and decreased to 3260/3400 g in 2018. When we adjusted for gestational age at delivery the increase in the first period became more pronounced (5.4 g/year). During the second period, similar adjustment substantially decreased the rate of decline from 2.5 to 1.4 g/year. Further adjustment for maternal age halved the rate of increase to 2.4 g/year in the first period. During the second period, adjustment for maternal age had little effect on the estimate.Our findings of an increasing birthweight trend (mostly related to the aging of the mothers) in 1999-2008 may forecast an increased risk of cardiometabolic diseases in offsprings born in this period. In contrast, the decreasing birthweight trends after 2008 may reflect some beneficial effects on perinatal morbidity. However, the long-term effect cannot be predicted, as the trend is mostly explained by the shorter pregnancies.}, keywords = {pregnancy; Gestational Age; parity; Maternal Age; Caesarean section; labor induction; Population-based study; birthweight; Obstetrical database; Week of delivery}, year = {2024}, eissn = {1742-4755}, orcid-numbers = {Visolyi, Gergely/0000-0003-3677-7682; Svébis, Márk Márton/0000-0002-6624-9621; Tabák, Ádám/0000-0002-6234-3936} } @article{MTMT:34741829, title = {Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel.}, url = {https://m2.mtmt.hu/api/publication/34741829}, author = {Tabák, Ádám and Kempler, Péter and Guja, Cristian and Eldor, Roy and Haluzik, Martin and Klupa, Tomasz and Papanas, Nikolaos and Stoian, Anca Pantea and Mankovsky, Boris}, doi = {10.1007/s13300-024-01556-z}, journal-iso = {DIABTHERAP}, journal = {DIABETES THERAPY}, volume = {15}, unique-id = {34741829}, issn = {1869-6953}, abstract = {Despite the availability of various antihyperglycaemic therapies and comprehensive guidelines, glycaemic control in diabetes management has not improved significantly during the last decade in the real-world clinical setting. Treatment inertia arising from a complex interplay among patient-, clinician- and healthcare-system-related factors is the prime reason for this suboptimal glycaemic control. Also, the key factor leading to inadequate glycaemic levels remains limited communication between healthcare professionals (HCPs) and people with type 2 diabetes (PwT2D). Early insulin administration has several advantages including reduced glucotoxicity, high efficacy and preserved β-cell mass/function, leading to lowering the risk of diabetes complications. The current publication is based on consensus of experts from the South-Eastern European region and Israel who reviewed the existing evidence and guidelines for the treatment of PwT2D. Herein, the experts emphasised the timely use of insulin, preferably second-generation basal insulin (BI) analogues and intensification using basal-plus therapy, as the most-potent glucose-lowering treatment choice in the real-world clinical setting. Despite an increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the experts urged timely insulin initiation for inadequate glycaemic control in PwT2D. Furthermore, the combination of BI and GLP-1 RA addressing both fasting plasma glucose and post-prandial excursions as a free- or fixed-ratio combination was identified to reduce treatment complexity and burden. To minimise discontinuation and improve adherence, the experts reiterated quality, regular interactions and discussions between HCPs and PwT2D/carers for their involvement in the diabetes management decision-making process. Clinicians and HCPs should consider the opinions of the experts in accordance with the most recent recommendations for diabetes management.}, keywords = {ISRAEL; clinical practice; Titration; Type 2 diabetes; INTENSIFICATION; Insulin initiation; South-Eastern European region}, year = {2024}, eissn = {1869-6961}, pages = {897-915}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936; Kempler, Péter/0000-0002-6072-8832} } @article{MTMT:34425939, title = {The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging}, url = {https://m2.mtmt.hu/api/publication/34425939}, author = {Ungvári, Zoltán István and Tabák, Ádám and Ádány, Róza and Purebl, György and Kaposvári, Csilla and Fazekas-Pongor, Vince and Csípő, Tamás and Szarvas, Zsófia and Horváth, Krisztián and Mukli, Péter and Balog, Piroska and Bódizs, Róbert and Ujma, Przemyslaw Péter and Stauder, Adrienne and Belsky, Daniel W. and Kovács, Illés and Yabluchanskiy, Andriy and Maier, Andrea B. and Moizs, Mariann and Östlin, Piroska and Yon, Yongjie and Varga, Péter and Vokó, Zoltán and Papp, Magor Csongor and Takács, István and Vásárhelyi, Barna and Torzsa, Péter and Ferdinandy, Péter and Csiszar, Anna and Benyó, Zoltán and Szabó, Attila and Bednárikné Dörnyei, Gabriella and Kivimäki, Mika and Kellermayer, Miklós and Merkely, Béla Péter}, doi = {10.1007/s11357-023-01018-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34425939}, issn = {2509-2715}, abstract = {The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.}, year = {2024}, eissn = {2509-2723}, pages = {191-218}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tabák, Ádám/0000-0002-6234-3936; Purebl, György/0000-0002-9750-2001; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Mukli, Péter/0000-0003-4355-8103; Balog, Piroska/0000-0001-5025-8649; Bódizs, Róbert/0000-0001-5341-060X; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Stauder, Adrienne/0000-0002-0358-3657; Kovács, Illés/0000-0001-5763-0482; Vokó, Zoltán/0000-0002-1004-1848; Takács, István/0000-0002-7810-4833; Vásárhelyi, Barna/0000-0003-0055-7346; Torzsa, Péter/0000-0002-8148-4961; Ferdinandy, Péter/0000-0002-6424-6806; Benyó, Zoltán/0000-0001-6015-0359; Szabó, Attila/0000-0001-7321-9861; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Kellermayer, Miklós/0000-0002-5553-6553; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:34163215, title = {The effect of COVID-19 vaccination status on all-cause mortality in patients hospitalised with COVID-19 in Hungary during the delta wave of the pandemic}, url = {https://m2.mtmt.hu/api/publication/34163215}, author = {Horváth, Viktor József and Békeffy, Magdolna Zsófia and Németh, Zsuzsanna and Szelke, Emese and Fazekas-Pongor, Vince and Hajdú, Noémi and Svébis, Márk Márton and Pintér, József and Domján, Beatrix Annamária and Mészáros, Szilvia and Körei, Anna Erzsébet and Kézdi, Árpád and Kocsis, Ibolya and Kristóf, Katalin and Kempler, Péter and Rozgonyi, Ferenc and Takács, István and Tabák, Ádám}, doi = {10.1007/s11357-023-00931-1}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34163215}, issn = {2509-2715}, abstract = {The high mortality of patients with coronavirus disease 2019 (COVID-19) is effectively reduced by vaccination. However, the effect of vaccination on mortality among hospitalised patients is under-researched. Thus, we investigated the effect of a full primary or an additional booster vaccination on in-hospital mortality among patients hospitalised with COVID-19 during the delta wave of the pandemic. This retrospective cohort included all patients (n = 430) admitted with COVID-19 at Semmelweis University Department of Medicine and Oncology in 01/OCT/2021–15/DEC/2021. Logistic regression models were built with COVID-19-associated in-hospital/30 day-mortality as outcome with hierarchical entry of predictors of vaccination, vaccination status, measures of disease severity, and chronic comorbidities. Deceased COVID-19 patients were older and presented more frequently with cardiac complications, chronic kidney disease, and active malignancy, as well as higher levels of inflammatory markers, serum creatinine, and lower albumin compared to surviving patients (all p < 0.05). However, the rates of vaccination were similar (52–55%) in both groups. Based on the fully adjusted model, there was a linear decrease of mortality from no/incomplete vaccination (ref) through full primary (OR 0.69, 95% CI: 0.39–1.23) to booster vaccination (OR 0.31, 95% CI 0.13–0.72, p = 0.006). Although unadjusted mortality was similar among vaccinated and unvaccinated patients, this was explained by differences in comorbidities and disease severity. In adjusted models, a full primary and especially a booster vaccination improved survival of patients hospitalised with COVID-19 during the delta wave of the pandemic. Our findings may improve the quality of patient provider discussions at the time of admission.}, year = {2024}, eissn = {2509-2723}, pages = {1881-1894}, orcid-numbers = {Horváth, Viktor József/0000-0002-7888-2651; Békeffy, Magdolna Zsófia/0009-0005-5659-9758; Németh, Zsuzsanna/0000-0003-2586-6639; Szelke, Emese/0000-0002-8514-3451; Fazekas-Pongor, Vince/0000-0002-6405-4003; Svébis, Márk Márton/0000-0002-6624-9621; Mészáros, Szilvia/0000-0002-4871-6986; Körei, Anna Erzsébet/0000-0001-6201-2961; Kocsis, Ibolya/0000-0003-3128-2832; Kristóf, Katalin/0000-0002-5189-4636; Kempler, Péter/0000-0002-6072-8832; Takács, István/0000-0002-7810-4833; Tabák, Ádám/0000-0002-6234-3936} }