@article{MTMT:34879306, title = {Effectiveness and tolerability of rectal ointment and suppositories containing sucralfate for hemorrhoidal symptoms: a prospective, observational study}, url = {https://m2.mtmt.hu/api/publication/34879306}, author = {Marik, A.R. and Miklós, I. and Csukly, Gábor and Hársfalvi, P. and Novák, A.}, doi = {10.1007/s00384-024-04642-7}, journal-iso = {INT J COLORECTAL DIS}, journal = {INTERNATIONAL JOURNAL OF COLORECTAL DISEASE}, volume = {39}, unique-id = {34879306}, issn = {0179-1958}, year = {2024}, eissn = {1432-1262}, orcid-numbers = {Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34877513, title = {EEG connectivity and network analyses predict outcome in patients with disorders of consciousness – A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34877513}, author = {Szirmai, Danuta and Zabihi, A. and Kói, Tamás and Hegyi, Péter and Wenning, A.S. and Engh, Marie Anne and Molnár, Zsolt and Csukly, Gábor and Horváth, András Attila}, doi = {10.1016/j.heliyon.2024.e31277}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34877513}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Engh, Marie Anne/0000-0003-4269-5130; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34850748, title = {Minimum spanning tree analysis of EEG resting-state functional networks in schizophrenia}, url = {https://m2.mtmt.hu/api/publication/34850748}, author = {Becske, Melinda and Marosi, Csilla and Molnár, Hajnalka and Fodor, Zsuzsanna and Farkas, Kinga and Rácz, Frigyes Sámuel and Baradits, Máté and Csukly, Gábor}, doi = {10.1038/s41598-024-61316-8}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34850748}, issn = {2045-2322}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Becske, Melinda/0000-0002-3265-4039; Marosi, Csilla/0000-0001-6467-175X; Molnár, Hajnalka/0000-0002-3555-1692; Fodor, Zsuzsanna/0000-0001-9335-4921; Farkas, Kinga/0000-0002-1125-3957; Rácz, Frigyes Sámuel/0000-0001-9077-498X; Baradits, Máté/0000-0003-1131-4550; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34804337, title = {Theta-burst rTMS in schizophrenia to ameliorate negative and cognitive symptoms: study protocol for a double-blind, sham-controlled, randomized clinical trial}, url = {https://m2.mtmt.hu/api/publication/34804337}, author = {Csukly, Gábor and Orbán-Szigeti, Boglárka and Suri, Karolin Mária and Zsigmond, Réka Ildikó and Hermán, Levente and Simon, Viktória and Kabaji, Anita and Bata, Barnabás and Hársfalvi, Péter and Vass, Edit and Csibri, Éva and Farkas, Kinga and Réthelyi, János}, doi = {10.1186/s13063-024-08106-9}, journal-iso = {TRIALS}, journal = {TRIALS}, volume = {25}, unique-id = {34804337}, issn = {1745-6215}, year = {2024}, eissn = {1745-6215}, orcid-numbers = {Csukly, Gábor/0000-0002-5006-9407; Orbán-Szigeti, Boglárka/0000-0001-9744-4393; Zsigmond, Réka Ildikó/0000-0002-7019-6761; Hermán, Levente/0000-0002-1376-5366; Vass, Edit/0000-0002-8858-7277; Farkas, Kinga/0000-0002-1125-3957; Réthelyi, János/0000-0002-3641-012X} } @article{MTMT:34797928, title = {Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology : a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34797928}, author = {Huszár, Zsolt and Engh, Marie Anne and Pavlekovics, Márk and Sato, Tomoya and Steenkamp, Yalea and Hanseeuw, Bernard and Terebessy, Tamás and Molnár, Zsolt and Hegyi, Péter and Csukly, Gábor}, doi = {10.1186/s13195-024-01455-2}, journal-iso = {ALZHEIMERS RES THER}, journal = {ALZHEIMERS RESEARCH & THERAPY}, volume = {16}, unique-id = {34797928}, issn = {1758-9193}, abstract = {Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the presence of these protein changes (A+ and T+) remains unclear. By performing a systematic review and meta-analysis, we investigated the risk of mild cognitive impairment (MCI) or dementia in the non-demented population with A+ and A- alone and in combination with T+ and T- as confirmed by PET or cerebrospinal fluid examination.A systematic search of prospective and retrospective studies investigating the association of Aβ and p-tau with cognitive decline was performed in three databases (MEDLINE via PubMed, EMBASE, and CENTRAL) on January 9, 2024. The risk of bias was assessed using the Cochrane QUIPS tool. Odds ratios (OR) and Hazard Ratios (HR) were pooled using a random-effects model. The effect of neurodegeneration was not studied due to its non-specific nature.A total of 18,162 records were found, and at the end of the selection process, data from 36 cohorts were pooled (n= 7,793). Compared to the unexposed group, the odds ratio (OR) for conversion to dementia in A+ MCI patients was 5.18 [95% CI 3.93; 6.81]. In A+ CU subjects, the OR for conversion to MCI or dementia was 5.79 [95% CI 2.88; 11.64]. Cerebrospinal fluid Aβ42 or Aβ42/40 analysis and amyloid PET imaging showed consistent results. The OR for conversion in A+T+ MCI subjects (11.60 [95% CI 7.96; 16.91]) was significantly higher than in A+T- subjects (2.73 [95% CI 1.65; 4.52]). The OR for A-T+ MCI subjects was non-significant (1.47 [95% CI 0.55; 3.92]). CU subjects with A+T+ status had a significantly higher OR for conversion (13.46 [95% CI 3.69; 49.11]) than A+T- subjects (2.04 [95% CI 0.70; 5.97]). Meta-regression showed that the ORs for Aβ exposure decreased with age in MCI. (beta = -0.04 [95% CI -0.03 to -0.083]).Identifying Aβ-positive individuals, irrespective of the measurement technique employed (CSF or PET), enables the detection of the most at-risk population before disease onset, or at least at a mild stage. The inclusion of tau status in addition to Aβ, especially in A+T+ cases, further refines the risk assessment. Notably, the higher odds ratio associated with Aβ decreases with age.The study was registered in PROSPERO (ID: CRD42021288100).}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1758-9193}, orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Terebessy, Tamás/0000-0002-7494-6064; Hegyi, Péter/0000-0003-0399-7259; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34774958, title = {Low Functional network integrity in cognitively unimpaired and MCI subjects with depressive symptoms. results from a multi-center fMRI study.}, url = {https://m2.mtmt.hu/api/publication/34774958}, author = {Csukly, Gábor and Tombor, László and Hidasi, Zoltán and Csibri, Eva and Fullajtár, Máté and Huszár, Zsolt and Koszovácz, Vanda and Lányi, Orsolya and Vass, Edit and Koleszár, Boróka and Kóbor, István and Farkas, Katalin and Rosenfeld, Viktória and Berente, Dalida Borbála and Bolla, Gergő Levente and Kiss, Mate and Kamondi, Anita and Horváth, András Attila}, doi = {10.1038/s41398-024-02891-2}, journal-iso = {TRANSL PSYCHIAT}, journal = {TRANSLATIONAL PSYCHIATRY}, volume = {14}, unique-id = {34774958}, issn = {2158-3188}, abstract = {Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using a Minimum Spanning Tree as a graph-theoretical approach. Furthermore, we examined functional connectivity in the Default Mode Network, the Frontolimbic Network (FLN), the Salience Network, and the Cognitive Control Network. All 183 elderly subjects underwent a comprehensive neuropsychological evaluation and a 3 Tesla brain MRI scan. To assess the potential presence of depressive symptoms, the 13-item version of the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) was utilized. Participants were assigned into three groups based on their cognitive status: amnestic mild cognitive impairment (MCI), non-amnestic MCI, and healthy controls. Regarding affective symptoms, subjects were categorized into depressed and non-depressed groups. An increased mean eccentricity and network diameter were found in patients with depressive symptoms relative to non-depressed ones, and both measures showed correlations with depressive symptom severity. In patients with depressive symptoms, a functional hypoconnectivity was detected between the Anterior Cingulate Cortex (ACC) and the right amygdala in the FLN, which impairment correlated with depressive symptom severity. While no structural difference was found in subjects with depressive symptoms, the volume of the hippocampus and the thickness of the precuneus and the entorhinal cortex were decreased in subjects with MCI, especially in amnestic MCI. The increase in eccentricity and diameter indicates a more path-like functional network configuration that may lead to an impaired functional integration in depression, a possible cause of depressive symptomatology in the elderly.}, year = {2024}, eissn = {2158-3188}, orcid-numbers = {Csukly, Gábor/0000-0002-5006-9407; Tombor, László/0000-0001-9410-5732; Hidasi, Zoltán/0000-0002-7798-0145; Fullajtár, Máté/0000-0003-4786-2735; Koszovácz, Vanda/0000-0003-0668-0185; Vass, Edit/0000-0002-8858-7277; Kóbor, István/0000-0002-9123-5766; Rosenfeld, Viktória/0009-0001-3599-7803; Kamondi, Anita/0000-0001-9860-730X} } @article{MTMT:34545815, title = {Lifestyle and behavioural changes in older adults during the Covid-19 pandemic are associated with subjective cognitive complaints}, url = {https://m2.mtmt.hu/api/publication/34545815}, author = {Zsuffa, János and Katz, Sándor László and Koszovácz, Vanda and Berente, Dalida Borbála and Kamondi, Anita and Csukly, Gábor and Mangialasche, Francesca and Rocha, Ana Sabsil Lopez and Kivipelto, Miia and Horváth, András Attila}, doi = {10.1038/s41598-024-52856-0}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34545815}, issn = {2045-2322}, abstract = {Subjective cognitive complaints (SCC) is a self-reported experience of persistently impaired cognitive functions which could be the earliest red flag of neurocognitive disorders. The COVID-19 pandemic and related restriction measures changed the lifestyle and behaviour of older adults. The aim of this study was to assess the relation of these changes and SCC status in Hungary. This cross-sectional study analysed the data of 359 elderly Hungarians who filled out the WW-FINGERS-SARS-CoV2 survey. A quarter of the respondents (n:88) reported SCC in connection with the pandemic. We compared sociodemographic features, health status, lifestyle, and social life parameters between subjects with reported SCC and without. To eliminate the potential interrelation across group differences, stepwise logistic regression was applied. Participants with SCC showed the following characteristics, compared to individuals without: (1) they were older; (2) they were more likely to be women; (3) they had a higher number of chronic disorders; (4) showed more prominent impairment in physical mobility; (5) had worse sleep quality; (6) spent less time with family; and (7) used internet more frequently during the pandemic (all p ’s < 0.001). Logistic regression highlighted that only two parameters were related to SCC status independently, the physical mobility (ability to walk 500 m without difficulties; OR = 1.186; p < 0.001; 95%CI = 1.101, 1.270) and changes in time spent with grandchildren (OR = 1.04; p = 0.015; 95%CI = 1.008, 1.073). Our study draws attention to the importance of physical mobility and quality time with family as key factors in the cognitive well-being of elderly people.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Koszovácz, Vanda/0000-0003-0668-0185; Kamondi, Anita/0000-0001-9860-730X; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34523124, title = {A comparison of visual and acoustic mismatch negativity as potential biomarkers in schizophrenia}, url = {https://m2.mtmt.hu/api/publication/34523124}, author = {Molnár, Hajnalka and Marosi, Csilla and Becske, Melinda and Békési, E. and Farkas, Kinga and Stefanics, G. and Czigler, István and Csukly, Gábor}, doi = {10.1038/s41598-023-49983-5}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34523124}, issn = {2045-2322}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Molnár, Hajnalka/0000-0002-3555-1692; Marosi, Csilla/0000-0001-6467-175X; Becske, Melinda/0000-0002-3265-4039; Farkas, Kinga/0000-0002-1125-3957; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34501793, title = {Domain-specific cognitive impairment in multiple sclerosis : A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34501793}, author = {Lugosi, Katalin and Engh, Marie Anne and Huszár, Zsolt and Hegyi, Péter and Mátrai, Péter and Csukly, Gábor and Molnár, Zsolt and Horváth, Klaudia and Mátis, Dóra and Mezei, Zsolt}, doi = {10.1002/acn3.51976}, journal-iso = {ANN CLIN TRANSL NEUROL}, journal = {ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY}, volume = {11}, unique-id = {34501793}, issn = {2328-9503}, abstract = {Methods of cognitive measurements in multiple sclerosis (MS) are not standardized. We aimed to identify the prevalence of cognitive domain-specific impairment (DSI) in MS by using subtests of the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) with analyzing different cutoff values.The systematic review and meta-analysis were registered on PROSPERO (ID: CRD42021287004). The systematic literature search was performed via PubMed, Embase, and CENTRAL on 24 October 2021. Inclusion criteria were adults of different MS subtypes (CIS, RRMS, PPMS, and SPMS) with the condition of distinct DSI measured by BRB-N. Pediatric MS, computerized versions of BRB-N, and patients receiving steroids were excluded. Primary outcome was pooled prevalence rates of impaired patients within each cutoff and MS subtype, with 95% confidence interval, I-squared statistics for heterogeneity, and chi-squared test for subgroup differences. Risk of bias was assessed using the "JBI Quality Assessment Tool for Prevalence Studies."In 48 eligible observational studies (n = 3431 patients), the three most prevalent thresholds were the 2.0 SD and 1.5 SD below the mean of normative values, and the score below the fifth percentile of the normative values. A progressively increasing worsening of the overall DSI was observed from CIS, moving toward RRMS, PPMS, and SPMS.Cognitive impairment is observed in all MS phenotypes, with varying degrees. Due to several potential influencing factors, our comprehensive literature review has not revealed consistent findings, and we, therefore, recommend considering a more sophisticated, "individual referencing" approach, acknowledging the diverse clinical and sociodemographic characteristics among populations and disparities in cognitive testing.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2328-9503}, pages = {564-576}, orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Hegyi, Péter/0000-0003-0399-7259; Csukly, Gábor/0000-0002-5006-9407; Mezei, Zsolt/0000-0002-3797-2191} } @article{MTMT:34452906, title = {IS THE BALINT GROUP AN OPPORTUNITY TO MENTALIZE?}, url = {https://m2.mtmt.hu/api/publication/34452906}, author = {Farkas, Kinga and Csukly, Gábor and Fonagy, P.}, doi = {10.1111/bjp.12880}, journal-iso = {BR J PSYCHOTHER}, journal = {BRITISH JOURNAL OF PSYCHOTHERAPY}, volume = {40}, unique-id = {34452906}, issn = {0265-9883}, year = {2024}, eissn = {1752-0118}, pages = {55-75}, orcid-numbers = {Farkas, Kinga/0000-0002-1125-3957; Csukly, Gábor/0000-0002-5006-9407} }