@article{MTMT:34780699,
	title = {Klinikai táplálás az intenzív osztályon: az EuroPN-vizsgálat magyarországi eredményei},
	url = {https://m2.mtmt.hu/api/publication/34780699},
	author = {Csomós, Ákos and Klicsu, László and László, István and Bobek, Ilona and Sárkány, Ágnes and Gál, Béla},
	doi = {10.1556/650.2024.33017},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34780699},
	issn = {0030-6002},
	abstract = {Bevezetés: A kritikus állapotú betegek mesterséges táplálásának jelentősége jól ismert, hiányában a folyamatos fehérjelebontás miatt romlik a sebgyógyulás, valamint emelkedik a lélegeztetőgépen töltött napok száma. Célkitűzés: A korábban publikált EuroPN nemzetközi vizsgálat célja az volt, hogy európai összehasonlításban felmérje a részt vevő intenzív osztályok aktuális táplálási gyakorlatát, és megvizsgálja a kalória-, illetve fehérjebevitel hatását a lélegeztetőgépről való leszoktatásban és a 90 napos halálozásban. A jelen kézirat a vizsgálatban részt vevő magyarországi osztályok eredményeit elemzi. Módszer: Vizsgálatunkba azokat a betegeket vontuk be, akiket legalább 5 napja kezeltek az intenzív osztályon. A klinikai és a táplálási adatokat napokra bontva gyűjtöttük az intenzív osztályos felvételt követő első 5 napban retrospektíven, majd azt követően maximum 15 napon át (vagy az elbocsátás/elhalálozás napjáig) prospektíven. A betegkimeneteli adatokat a 15., a 30. és a 90. napon rögzítettük. Eredmények: Magyarországról 6 intenzív osztályról összesen 111 beteget vontunk be a vizsgálatba. A kumulatív kalória- és fehérjebevitel tekintetében a magyarországi betegek nagyobb arányban kapták meg az ESPEN-célértékeket: kalória esetében az előírt kalória 92%-át (95% CI 68; 118) sikerült biztosítani ( vs. 83% Európában [95% CI 59; 107]); fehérje esetében pedig még jelentősebb a különbség: Magyarországon 83% (95%CI 57; 121), ezzel szemben Európában 65% (95% CI 41; 91) volt a bevitel és az ESPEN-célérték aránya. Megbeszélés és következtetés: A nemzetközi EuroPN-adatelemzésben a nagyobb kumulatív kalória- és fehérjebevitel csökkentette a lélegeztetőgépről való leszoktatás időtartamát. A magyarországi betegek esetében gyorsabban értük el ezeket a célértékeket, köszönhetően annak, hogy a kiegészítő parenteralis táplálást nagyobb arányban alkalmaztuk. Orv Hetil. 2024; 165(14): 531–537.},
	year = {2024},
	eissn = {1788-6120},
	pages = {531-537}
}

@article{MTMT:33091847,
	title = {Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN)},
	url = {https://m2.mtmt.hu/api/publication/33091847},
	author = {Matejovic, Martin and Huet, Olivier and Dams, Karolien and Elke, Gunnar and Vaquerizo Alonso, Clara and Csomós, Ákos and Krzych, Łukasz J. and Tetamo, Romano and Puthucheary, Zudin and Rooyackers, Olav and Tjäder, Inga and Kuechenhoff, Helmut and Hartl, Wolfgang H. and Hiesmayr, Michael},
	doi = {10.1186/s13054-022-03997-z},
	journal-iso = {CRIT CARE},
	journal = {CRITICAL CARE},
	volume = {26},
	unique-id = {33091847},
	issn = {1364-8535},
	year = {2022},
	eissn = {1466-609X}
}

@article{MTMT:32764995,
	title = {Hospitals with and without neurosurgery: a comparative study evaluating the outcome of patients with traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/32764995},
	author = {Giugni, Aimone and Gamberini, Lorenzo and Carrara, Greta and Antiga, Luca and Brissy, Obou and Buldini, Virginia and Calamai, Italo and Csomós, Ákos and De Luca, Alessandra and Ferri, Enrico and Fleming, Joanne M. and Gradisek, Primoz and Kaps, Rafael and Kyprianou, Theodoros and Lagomarsino, Silvia and Lazar, Isaac and Martino, Costanza and Mikaszewska-Sokolewicz, Malgorzata and Montis, Andrea and Nardai, Gábor and Nattino, Giovanni and Nattino, Giuseppe and Paci, Giulia and Portolani, Laila and Xirouchaki, Nektaria and Chieregato, Arturo and Bertolini, Guido and Ágnes, Sárkány and Agostini, Fulvio and Ajmone-Cat, Claudio and Bassi, Giovanni and Bekos, Vasileios and Bellin, Marzia and Bocci, Maria Grazia and Bonato, Valeria and Bonato, Alfeo and Bonizzoli, Manuela and Bonucci, Paola and Bottazzi, Andrea and Calicchio, Giuseppe and Carlin, Fabrizia and Casagli, Sergio and Castioni, Carlo Alberto and Ciceri, Rita and Cocciolo, Francesco and Crestan, Ezio and Cseplo, Peter and Csomos, Akos and Curto, Francesco and Dąbrowski, Wojciech and De Cristofaro, Anna and De Luca, Alessandra and Duda, Izabela and Duek, Or and Bakó, Blanka Emoke and Fagoni, Nazzareno and Fassini, Paola and Ferri, Enrico and Filekovic, Suada and Fiore, Gilberto and Gamberini, Emiliano and Gattari, Diego and Gianni, Massimo and Dessena, Maria Giovanna and Giuntini, Romano and Guido, Stefania and Gyulai, Rita and Hadash, Amir and Hribar, Renata and Ilia, Stavroula and Jankovic, Vesna Novak and Jurekovic, Vlado and Jereb, Mateja and Kapias, Maciej and Karadzic, Dragica and Kasnik, Darja and Kioulpalis, Anastasios and Szaszi, Adrienn Kitti and Kompan, Janez and Kyriakides, Eraclis and Lamborghini, Sara and Livigni, Sergio and Malacarne, Paolo and Martelli, Maria and Martin, Marina Alessandra and Marudi, Andrea and Melis, Martina and Mengoli, Francesca and Mirkovic, Tomislav and Mizak, Wiktoria and Munari, Marina and Nascimben, Ennio and Natalini, Giuseppe and Negro, Giancarlo and Nemes, Csaba and Bernasconi, Mara Olga and Pagani, Michele and Parrini, Vieri and Partala, Panagio and Pastorelli, Mauro and Pellicioli, Isabella and Bert, Paolo Perino and Petrucci, Nicola and Piva, Simone and Poole, Daniele and Radrizzani, Danilo and Rekas, Anna and Robak, Paweł and Rosano, Antonio and Ruggeri, Patrizia and Sacchi, Marco and Skoti, Mara and Skrt, Alja and Spagarino, Ermanno and Sulkowski, Wiktor and Szedlák, Balázs and Terzitta, Marina and Tinturini, Rebecca and Tofani, Rossella and Tselioti, Paraskevi and Vecchiarelli, Ada and Venturini, Elisabetta and Visconti, Salvatore and Xirouchaki, Nektaria and Zompanti, Valeria and Zoppellari, Roberto},
	doi = {10.1186/s13049-021-00959-2},
	journal-iso = {SCAND J TRAUMA RESUS},
	journal = {SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION AND EMERGENCY MEDICINE},
	volume = {29},
	unique-id = {32764995},
	issn = {1757-7241},
	year = {2021},
	eissn = {1757-7241},
	orcid-numbers = {Nattino, Giovanni/0000-0002-3034-6251}
}

@article{MTMT:32236838,
	title = {Protocol for a prospective cohort study on the use of clinical nutrition and assessment of long-term clinical and functional outcomes in critically ill adult patients},
	url = {https://m2.mtmt.hu/api/publication/32236838},
	author = {Hiesmayr, M. and Csomós, Ákos and Dams, K. and Elke, G. and Hartl, W. and Huet, O. and Krzych, L.J. and Kuechenhoff, H. and Matejovic, M. and Puthucheary, Z.A. and Rooyackers, O. and Tetamo, R. and Tjäder, I. and Vaquerizo, C.},
	doi = {10.1016/j.clnesp.2021.01.048},
	journal-iso = {CLINICAL NUTRITION ESPEN},
	journal = {CLINICAL NUTRITION ESPEN},
	volume = {43},
	unique-id = {32236838},
	issn = {2405-4577},
	year = {2021},
	pages = {104-110}
}

@article{MTMT:32193801,
	title = {Prognostic Value of a Combination of Circulating Biomarkers in Critically Ill Patients with Traumatic Brain Injury: Results from the European CREACTIVE Study},
	url = {https://m2.mtmt.hu/api/publication/32193801},
	author = {Gradisek, Primoz and Carrara, Greta and Antiga, Luca and Bottazzi, Barbara and Chieregato, Arturo and Csomós, Ákos and Fainardi, Enrico and Filekovic, Suada and Fleming, Joanne and Hadjisavvas, Andreas and Kaps, Rafael and Kyprianou, Theodoros and Latini, Roberto and Lazar, Isaac and Masson, Serge and Mikaszewska-Sokolewicz, Malgorzata and Novelli, Deborah and Paci, Giulia and Xirouchaki, Nektaria and Zanier, Elisa and Nattino, Giovanni and Bertolini, Guido},
	doi = {10.1089/neu.2021.0066},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {38},
	unique-id = {32193801},
	issn = {0897-7151},
	abstract = {Individualized patient care is essential to reduce the global burden of traumatic brain injury (TBI). This pilot study focused on TBI patients admitted to intensive care units (ICUs) and aimed at identifying patterns of circulating biomarkers associated with the disability level at 6 months from injury, measured by the extended Glasgow Outcome Scale (GOS-E). The concentration of 107 biomarkers, including proteins related to inflammation, innate immunity, TBI, and central nervous system, were quantified in blood samples collected on ICU admission from 80 patients. Patients were randomly selected among those prospectively enrolled in the Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe (CREACTIVE) observational study. Six biomarkers were selected to be associated with indicators of primary or secondary brain injury: three glial proteins (glial cell-derived neurotrophic factor, glial fibrillary acidic protein, and S100 calcium-binding protein B) and three cytokines (stem cell factor, fibroblast growth factor [FGF] 23 and FGF19). The subjects were grouped into three clusters according to the expression of these proteins. The distribution of the 6-month GOS-E was significantly different across clusters (p < 0.001). In two clusters, the number of 6-month deaths or vegetative states was significantly lower than expected, as calculated according to a customization of the corticosteroid randomization after significant head injury (CRASH) scores (observed/expected [O/E] events = 0.00, 95% confidence interval [CI]: 0.00-0.90 and 0.00, 95% CI: 0.00-0.94). In one cluster, less-than-expected unfavorable outcomes (O/E = 0.50, 95% CI: 0.05-0.95) and more-than-expected good recoveries (O/E = 1.55, 95% CI: 1.05-2.06) were observed. The improved prognostic accuracy of the pattern of these six circulating biomarkers at ICU admission upon established clinical parameters and computed tomography results needs validation in larger, independent cohorts. Nonetheless, the results of this pilot study are promising and will prompt further research in personalized medicine for TBI patients.},
	keywords = {PROTEIN; Cluster Analysis; Glasgow Outcome Scale; Clinical Neurology; Critical Care Medicine; circulating biomarkers; C-TERMINAL HYDROLASE-L1},
	year = {2021},
	eissn = {1557-9042},
	pages = {2667-2676},
	orcid-numbers = {Kyprianou, Theodoros/0000-0001-8272-7630}
}

@article{MTMT:32236858,
	title = {PROSAFE: a European endeavor to improve quality of critical care medicine in seven countries},
	url = {https://m2.mtmt.hu/api/publication/32236858},
	author = {Finazzi, Stefano and Paci, Giulia and Antiga, Luca and Brissy, Obou and Carrara, Greta and Crespi, Daniele and Csato, Gabor and Csomós, Ákos and Duek, Or and Facchinetti, Sara and Fleming, Joanne and Garbero, Elena and Gianni, Massimo and Gradisek, Primoz and Kaps, Rafael and Kyprianou, Theodoros and Lazar, Isaac and Mikaszewska-Sokolewicz, Malgorzata and Mondini, Matteo and Nattino, Giovanni and Olivieri, Carlo and Poole, Daniele and Previtali, Claudio and Radrizzani, Danilo and Rossi, Carlotta and Skurzak, Stefano and Tavola, Mario and Xirouchaki, Nektaria and Bertolini, Guido},
	doi = {10.23736/S0375-9393.20.14112-9},
	journal-iso = {MINERVA ANESTESIOL},
	journal = {MINERVA ANESTESIOLOGICA},
	volume = {86},
	unique-id = {32236858},
	issn = {0375-9393},
	year = {2020},
	eissn = {1827-1596},
	pages = {1305}
}

@article{MTMT:3381212,
	title = {A levoszimendán perioperatív alkalmazása a szívsebészetben. Magyar ajánlás},
	url = {https://m2.mtmt.hu/api/publication/3381212},
	author = {Szudi, László János and Szekely, László and Sápi, Erzsébet and Prodán, Zsolt and Szolnoky, Jenő and Csomós, Ákos and Nyolczas, Noémi and Paulovich, Erzsébet and Németh, Endre and Hartyánszky, István and Zima, Endre István and Sax, Balázs and Bertalan, Andrea and Hejjel, László and Bogáts, Gábor and Babik, Barna and Gombocz, K and Szerafin, Tamás and Koszta, György and Molnár, Andrea},
	doi = {10.1556/650.2018.31083},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {159},
	unique-id = {3381212},
	issn = {0030-6002},
	abstract = {Low output syndrome significantly increases morbidity and mortality of cardiac surgery and lengthens the durations of intensive care unit and hospital stays. Its treatment by catecholamines can lead to undesirable systemic and cardiac complications. Levosimendan is a calcium sensitiser and adenosine triphosphate (ATP)-sensitive potassium channel (IK,ATP) opener agent. Due to these effects, it improves myocardium performance, does not influence adversely the balance between O2 supply and demand, and possesses cardioprotective and organ protective properties as well. Based on the scientific literature and experts' opinions, a European recommendation was published on the perioperative use of levosimendan in cardiac surgery in 2015. Along this line, and also taking into consideration cardiac surgeon, anaesthesiologist and cardiologist representatives of the seven Hungarian heart centres and the children heart centre, the Hungarian recommendation has been formulated that is based on two pillars: literature evidence and Hungarian expert opinions. The reviewed fields are: coronary and valvular surgery, assist device implantation, heart transplantation both in adult and pediatric cardiologic practice. Orv Hetil. 2018; 159(22): 870-877.},
	year = {2018},
	eissn = {1788-6120},
	pages = {870-877},
	orcid-numbers = {Nyolczas, Noémi/0000-0001-9466-0939; Németh, Endre/0000-0001-6033-4297; Hartyánszky, István/0000-0003-1909-6500; Zima, Endre István/0000-0001-5132-6009; Babik, Barna/0000-0003-3739-8879}
}

@article{MTMT:3297422,
	title = {Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research.},
	url = {https://m2.mtmt.hu/api/publication/3297422},
	author = {Maas, AIR and Menon, DK and Adelson, PD and Andelic, N and Bell, MJ and Belli, A and Bragge, P and Brazinova, A and Büki, András and Chesnut, RM and Citerio, G and Coburn, M and Cooper, DJ and Crowder, AT and Czeiter, Endre and Czosnyka, M and Diaz-Arrastia, R and Dreier, JP and Duhaime, AC and Ercole, A and van Essen, TA and Feigin, VL and Gao, G and Giacino, J and Gonzalez-Lara, LE and Gruen, RL and Gupta, D and Hartings, JA and Hill, S and Jiang, JY and Ketharanathan, N and Kompanje, EJO and Lanyon, L and Laureys, S and Lecky, F and Levin, H and Lingsma, HF and Maegele, M and Majdan, M and Manley, G and Marsteller, J and Mascia, L and McFadyen, C and Mondello, S and Newcombe, V and Palotie, A and Parizel, PM and Peul, W and Piercy, J and Polinder, S and Puybasset, L and Rasmussen, TE and Rossaint, R and Smielewski, P and Soderberg, J and Stanworth, SJ and Stein, MB and von Steinbuchel, N and Stewart, W and Steyerberg, EW and Stocchetti, N and Synnot, A and Te, Ao B and Tenovuo, O and Theadom, A and Tibboel, D and Videtta, W and Wang, KKW and Williams, WH and Wilson, L and Yaffe, K},
	doi = {10.1016/S1474-4422(17)30371-X},
	journal-iso = {LANCET NEUROL},
	journal = {LANCET NEUROLOGY},
	volume = {16},
	unique-id = {3297422},
	issn = {1474-4422},
	abstract = {Executive summary
		A  concerted  effort  to  tackle  the  global  health  problem  posed  by  traumatic  brain  injury  (TBI)  is  long  overdue.  TBI is a public health challenge of vast, but insufficiently recognised,     proportions.     Worldwide,     more     than     50 million people have a TBI each year, and it is estimated that  about  half  the  world’s  population  will  have  one  or  more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability   across   all   ages   in   all   countries,   with   a   disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has  been  estimated  that  TBI  costs  the  global  economy  approximately  $US400  billion  annually.  Deficiencies  in  prevention,   care,   and   research   urgently   need   to   be   addressed  to  reduce  the  huge  burden  and  societal  costs  of   TBI.   This   Commission   highlights   priorities   and   provides expert recommendations for all stakeholders—policy    makers,    funders,    health-care    professionals,    researchers, and patient representatives—on clinical and research  strategies  to  reduce  this  growing  public  health  problem and improve the lives of people with TBI.},
	year = {2017},
	eissn = {1474-4465},
	pages = {987-1048},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:3256264,
	title = {Intensive care in 2050: healthcare expenditure.},
	url = {https://m2.mtmt.hu/api/publication/3256264},
	author = {Guidet, B and van der Voort, PHJ and Csomós, Ákos},
	doi = {10.1007/s00134-017-4679-2},
	journal-iso = {INTENS CARE MED},
	journal = {INTENSIVE CARE MEDICINE},
	volume = {43},
	unique-id = {3256264},
	issn = {0342-4642},
	year = {2017},
	eissn = {1432-1238},
	pages = {1141-1143}
}

@article{MTMT:3255774,
	title = {Worldwide Survey of the "Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Empowerment" (ABCDEF) Bundle.},
	url = {https://m2.mtmt.hu/api/publication/3255774},
	author = {Morandi, A and Piva, S and Ely, EW and Myatra, SN and Salluh, JIF and Amare, D and Azoulay, E and Bellelli, G and Csomós, Ákos and Fan, E and Fagoni, N and Girard, TD and Heras, La Calle G and Inoue, S and Lim, CM and Kaps, R and Kotfis, K and Koh, Y and Misango, D and Pandharipande, PP and Permpikul, C and Cheng, Tan C and Wang, DX and Sharshar, T and Shehabi, Y and Skrobik, Y and Singh, JM and Slooter, A and Smith, M and Tsuruta, R and Latronico, N},
	doi = {10.1097/CCM.0000000000002640},
	journal-iso = {CRIT CARE MED},
	journal = {CRITICAL CARE MEDICINE},
	volume = {45},
	unique-id = {3255774},
	issn = {0090-3493},
	abstract = {OBJECTIVES: To assess the knowledge and use of the Assessment, prevention, and management of pain; spontaneous awakening and breathing trials; Choice of analgesia and sedation; Delirium assessment; Early mobility and exercise; and Family engagement and empowerment (ABCDEF) bundle to implement the Pain, Agitation, Delirium guidelines. DESIGN: Worldwide online survey. SETTING: Intensive care. INTERVENTION: A cross-sectional online survey using the Delphi method was administered to intensivists worldwide, to assess the knowledge and use of all aspects of the ABCDEF bundle. MEASUREMENT AND MAIN RESULTS: There were 1,521 respondents from 47 countries, 57% had implemented the ABCDEF bundle, with varying degrees of compliance across continents. Most of the respondents (83%) used a scale to evaluate pain. Spontaneous awakening trials and spontaneous breathing trials are performed in 66% and 67% of the responder ICUs, respectively. Sedation scale was used in 89% of ICUs. Delirium monitoring was implemented in 70% of ICUs, but only 42% used a validated delirium tool. Likewise, early mobilization was "prescribed" by most, but 69% had no mobility team and 79% used no formal mobility scale. Only 36% of the respondents assessed ICU-acquired weakness. Family members were actively involved in 67% of ICUs; however, only 33% used dedicated staff to support families and only 35% reported that their unit was open 24 hr/d for family visits. CONCLUSIONS: The current implementation of the ABCDEF bundle varies across individual components and regions. We identified specific targets for quality improvement and adoption of the ABCDEF bundle. Our data reflect a significant but incomplete shift toward patient- and family-centered ICU care in accordance with the Pain, Agitation, Delirium guidelines.},
	year = {2017},
	eissn = {1530-0293},
	pages = {e1111-e1122}
}