@article{MTMT:34693196,
	title = {Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness},
	url = {https://m2.mtmt.hu/api/publication/34693196},
	author = {Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1111/acel.14101},
	journal-iso = {AGING CELL},
	journal = {AGING CELL},
	unique-id = {34693196},
	issn = {1474-9718},
	abstract = {Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.},
	year = {2024},
	eissn = {1474-9726},
	orcid-numbers = {Kerepesi, Csaba/0000-0001-9541-246X; Bábszky, Gergely/0000-0002-5939-8434; Koltai, Erika/0000-0002-1370-2955; Horvath, Steve/0000-0002-4110-3589; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34539479,
	title = {PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/34539479},
	author = {Mozaffaritabar, Soroosh and Koltai, Erika and Zhou, Lei and Bori, Zoltán and Kolonics, Attila and Kujach, Sylwester and Gu, Yaodong and Koike, Atsuko and Boros, Anita and Radák, Zsolt},
	doi = {10.1007/s13105-024-01006-1},
	journal-iso = {J PHYSIOL BIOCHEM},
	journal = {JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY},
	volume = {2024},
	unique-id = {34539479},
	issn = {1138-7548},
	abstract = {The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.},
	keywords = {skeletal muscle; lipid metabolism; Exercise; Mitochondrial function; PGC-1α overexpression},
	year = {2024},
	eissn = {1877-8755},
	orcid-numbers = {Mozaffaritabar, Soroosh/0000-0003-1052-7140; Koltai, Erika/0000-0002-1370-2955; Zhou, Lei/0000-0002-8152-7896; Bori, Zoltán/0000-0003-1253-060X; Kolonics, Attila/0000-0003-3990-5336; Kujach, Sylwester/0000-0001-5520-1748; Koike, Atsuko/0009-0002-2668-7114; Boros, Anita/0000-0001-5330-9050; Radák, Zsolt/0000-0003-1297-6804}
}

@CONFERENCE{MTMT:34053803,
	title = {The role of PGC1-A in inter-muscular lipid metabolism in exercised mice},
	url = {https://m2.mtmt.hu/api/publication/34053803},
	author = {Soroosh, Mozafffaritabar and Koltai, Erika and Radák, Zsolt},
	booktitle = {VIII. Sporttudományi PhD Szimpózium},
	unique-id = {34053803},
	year = {2023},
	pages = {47-48},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:33866054,
	title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation},
	url = {https://m2.mtmt.hu/api/publication/33866054},
	author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1007/s11357-023-00826-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {33866054},
	issn = {2509-2715},
	abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ  = 0.2, p  = 6.4E − 4, r  = 0.19, p  = 1.2E − 3), Jumpmax ( p  = 0.11, p  = 5.5E − 2, r  = 0.13, p  = 2.8E − 2), Gripmax ( ρ  = 0.17, p  = 3.5E − 3, r  = 0.16, p  = 5.6E − 3), and HDL levels ( ρ  = 0.18, p  = 1.95E − 3, r  = 0.19, p  = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p  = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.},
	year = {2023},
	eissn = {2509-2723},
	pages = {2805-2817},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:33745909,
	title = {Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33745909},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey V. and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00791-1},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {2023},
	unique-id = {33745909},
	year = {2023},
	eissn = {2522-5812},
	pages = {495},
	orcid-numbers = {Cikes, Domagoj/0000-0003-0350-5672; Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey V./0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@article{MTMT:33712726,
	title = {PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing},
	url = {https://m2.mtmt.hu/api/publication/33712726},
	author = {Cikes, Domagoj and Elsayad, Kareem and Sezgin, Erdinc and Koltai, Erika and Torma, Ferenc Gergely and Orthofer, Michael and Yarwood, Rebecca and Heinz, Leonhard X. and Sedlyarov, Vitaly and Miranda, Nasser Darwish and Taylor, Adrian and Grapentine, Sophie and al-Murshedi, Fathiya and Abot, Anne and Weidinger, Adelheid and Kutchukian, Candice and Sanchez, Colline and Cronin, Shane J. F. and Novatchkova, Maria and Kavirayani, Anoop and Schuetz, Thomas and Haubner, Bernhard and Haas, Lisa and Hagelkruys, Astrid and Jackowski, Suzanne and Kozlov, Andrey and Jacquemond, Vincent and Knauf, Claude and Superti-Furga, Giulio and Rullman, Eric and Gustafsson, Thomas and McDermot, John and Lowe, Martin and Radák, Zsolt and Chamberlain, Jeffrey S. and Bakovic, Marica and Banka, Siddharth and Penninger, Josef M.},
	doi = {10.1038/s42255-023-00766-2},
	journal-iso = {NAT METAB},
	journal = {NATURE METABOLISM},
	volume = {5},
	unique-id = {33712726},
	abstract = {Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.},
	keywords = {disease model; Ageing; Gene Therapy},
	year = {2023},
	eissn = {2522-5812},
	pages = {495-515},
	orcid-numbers = {Sezgin, Erdinc/0000-0002-4915-388X; Koltai, Erika/0000-0002-1370-2955; Miranda, Nasser Darwish/0000-0002-8821-8236; Grapentine, Sophie/0000-0003-2307-4363; Weidinger, Adelheid/0000-0002-2759-211X; Kutchukian, Candice/0000-0003-1142-7109; Kavirayani, Anoop/0000-0003-3874-3101; Schuetz, Thomas/0000-0001-9211-8345; Hagelkruys, Astrid/0000-0003-3015-4038; Kozlov, Andrey/0000-0002-0834-4997; Jacquemond, Vincent/0000-0003-4944-270X; Knauf, Claude/0000-0001-5213-5378; Superti-Furga, Giulio/0000-0002-0570-1768; Rullman, Eric/0000-0003-2854-7262; Radák, Zsolt/0000-0003-1297-6804; Chamberlain, Jeffrey S./0000-0001-5299-0059; Banka, Siddharth/0000-0002-8527-2210; Penninger, Josef M./0000-0002-8194-3777}
}

@CONFERENCE{MTMT:33022430,
	title = {A több évtizedes testedzés hatása a humán vérből izolált extracelluláris vezikulák tartalmára},
	url = {https://m2.mtmt.hu/api/publication/33022430},
	author = {György, Bernadett and Pálóczi, Krisztina and Buzás, Edit and Koltai, Erika and Radák, Zsolt},
	booktitle = {VII. SPORTTUDOMÁNYI PHD SZIMPÓZIUM - PROGRAM- ÉS ABSZTRAKTFÜZET},
	unique-id = {33022430},
	year = {2022},
	pages = {24-24},
	orcid-numbers = {György, Bernadett/0000-0002-3787-7338; Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:32259162,
	title = {Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes},
	url = {https://m2.mtmt.hu/api/publication/32259162},
	author = {Ireland, Alex and Mittag, Uwe and Degens, Hans and Felsenberg, Dieter and Heinonen, Ari and Koltai, Erika and Korhonen, Marko T. and McPhee, Jamie S. and Mekjavic, Igor and Pisot, Rado and Rawer, Rainer and Radák, Zsolt and Simunic, Bostjan and Suominen, Harri and Rittweger, Jörn},
	doi = {10.1007/s00223-021-00907-3},
	journal-iso = {CALCIFIED TISSUE INT},
	journal = {CALCIFIED TISSUE INTERNATIONAL},
	volume = {110},
	unique-id = {32259162},
	issn = {0171-967X},
	year = {2022},
	eissn = {1432-0827},
	pages = {196-203},
	orcid-numbers = {Ireland, Alex/0000-0003-1094-9183; Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804}
}

@CONFERENCE{MTMT:32234984,
	title = {Koordinációs képességek mérésének lehetséges módszere magyar elit sportolói mintán},
	url = {https://m2.mtmt.hu/api/publication/32234984},
	author = {Adorjánné Olajos, Andrea and Koltai, Erika},
	booktitle = {IV. Sport és Innováció Nemzetközi Konferencia, SPORTINNO 2021: Programfüzet absztraktokkal},
	unique-id = {32234984},
	year = {2021},
	pages = {99-100},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:32113803,
	title = {Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.},
	url = {https://m2.mtmt.hu/api/publication/32113803},
	author = {Gombos, Zoltán and Koltai, Erika and Torma, Ferenc Gergely and Bakonyi, Péter and Kolonics, Attila and Aczél, Dóra Tímea and Ditrói, Tamás and Nagy, Péter and Kawamura, Takuji and Radák, Zsolt},
	doi = {10.3390/ijms22147588},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32113803},
	issn = {1661-6596},
	abstract = {Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H2S levels of this overload-induced hypertrophy were studied. Fourteen days of overload resulted in a significant 43% (p < 0.01) increase in the mass of plantaris muscle compared to sham operated animals. Cystathionine-β-synthase (CBS) activities and bioavailable H2S levels were not modified by overload. On the other hand, overload-induced hypertrophy of skeletal muscle was associated with increased SIRT1 (p < 0.01), Akt (p < 0.01), mTOR, S6 (p < 0.01) and suppressed sestrin 2 levels (p < 0.01), which are mostly responsible for anabolic signaling. Decreased FOXO1 and SIRT3 signaling (p < 0.01) suggest downregulation of protein breakdown and mitophagy. Decreased levels of NAD+, sestrin2, OGG1 (p < 0.01) indicate that the redox milieu of skeletal muscle after 14 days of overloading is reduced. The present investigation revealed novel cellular interactions that regulate anabolic and catabolic processes in the hypertrophy of skeletal muscle.},
	keywords = {skeletal muscle; Redox regulation; anabolic signaling pathways; overload-induced hypertrophy},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bakonyi, Péter/0000-0002-6120-3384; Kolonics, Attila/0000-0003-3990-5336; Nagy, Péter/0000-0003-3393-235X; Radák, Zsolt/0000-0003-1297-6804}
}