@article{MTMT:2883904, title = {Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats}, url = {https://m2.mtmt.hu/api/publication/2883904}, author = {Mosaferi Ziaaldini, Mohammad and Koltai, Erika and Csende, Zsolt and Goto, Sataro and Boldogh, Istvan and Taylor, Albert W and Radák, Zsolt}, doi = {10.1016/j.exger.2015.04.008}, journal-iso = {EXP GERONTOL}, journal = {EXPERIMENTAL GERONTOLOGY}, volume = {67}, unique-id = {2883904}, issn = {0531-5565}, abstract = {Abstract Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.}, keywords = {FOLLISTATIN; MYOSTATIN; skeletal muscle; Aging; Exercise; Reactive oxygen species}, year = {2015}, eissn = {1873-6815}, pages = {9-14}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:2704733, title = {Prediction of jumping distance using a short approach model}, url = {https://m2.mtmt.hu/api/publication/2704733}, author = {Béres, Sándor and Csende, Zsolt and Adrian, Lees and Tihanyi, József}, journal-iso = {KINESIOLOGY}, journal = {KINESIOLOGY}, volume = {46}, unique-id = {2704733}, issn = {1331-1441}, abstract = {Recent evidence has suggested that relationship between approach speed and distance jumped may not be linear. The aims of this study were (1) to test the hypothesis that using a short approach (6-8-10-12 strides) of increasing length, performance variables will be non-linearly related to distance jumped, (2) to investigate the nature of these relationships for a group of long jumpers and individuals within the group, and (3) to use the regression analysis to determine the optimum number of run-up strides and predict the jumping distance that would be achieved with an optimum length run-up for an individual jumper. Eight male long jumpers with different skill levels (body mass: 75.2±2.2 kg and body height: 188.0±4.2 cm) performed a series of short-approach maximal jumps and the full-length approach in a competition. Kinematic data were collected from video analysis. The relationship between the number of approach strides and velocity, and distance jumped were shown to be best represented by second order polynomial equations. When applied on an individual basis, the predicted jump distances (6.95±.61 m) agreed very well with those found in actual competition (6.96±.58m). As a result, these individual relationships were used to comment on individual optimal approach lengths and to evaluate an individual’s potential for performance in the long jump event. It was concluded that the short approach model of performance is a valuable paradigm for investigating long jump behaviour and the performance potential of individuals. The findings also supported the simplified mathematical model proposed in the literature for the study of long jump performance.}, year = {2014}, eissn = {1848-638X}, pages = {88-96} } @article{MTMT:2597018, title = {Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance}, url = {https://m2.mtmt.hu/api/publication/2597018}, author = {Hart, Nikolett and Szűcs (Sárga), Linda and Csende, Zsolt and Koch, Lauren G and Britton, Steven L and Davies, Kelvin J A and Radák, Zsolt}, doi = {10.2203/dose-response.13-010.Radak}, journal-iso = {DOSE RESP}, journal = {DOSE-RESPONSE}, volume = {12}, unique-id = {2597018}, issn = {1559-3258}, year = {2014}, eissn = {1559-3258}, pages = {57-71}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:2530023, title = {Stretch-shortening cycle characteristics during vertical jumps carried out with small and large range of motion.}, url = {https://m2.mtmt.hu/api/publication/2530023}, author = {Kopper, Bence and Csende, Zsolt and Trzaskoma, Lukasz and Tihanyi, József}, doi = {10.1016/j.jelekin.2014.01.001}, journal-iso = {J ELECTROMYOGR KINES}, journal = {JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY}, volume = {24}, unique-id = {2530023}, issn = {1050-6411}, abstract = {In the present study we investigated kinematical characteristics of the knee and ankle extensors to estimate the length change properties of the contractile and the passive elements in countermovement jumps (CMJ) and drop jumps (DJ) performed with small (40 degrees ) and large (80 degrees ) range of joint motion (SRM and LRM). At SRM the accelerations at maximal muscle lengths compared with the last phase of joint flexion were greater for the gastrocnemius and the soleus (124.9% and 79.4%) and also were greater than at the beginning of joint extension, while no difference was measured at LRM. The differences suggest that at LRM the length change of the serial passive elements from the end of joint flexion to the beginning of joint extension is minimal and simultaneously the length change of the contractile elements is significant, but at SRM - especially in the plantar flexors - the length change of the contractile elements is minimal while in the passive elements significant. It can be presumed that for SRM at the end of joint flexion significant elastic energy is stored and at the beginning of joint extension reused, while for LRM elastic energy storage is not dominant.}, year = {2014}, eissn = {1873-5711}, pages = {233-239} } @article{MTMT:2237194, title = {Resveratrol enhances exercise training responses in rats selectively bred for high running performance}, url = {https://m2.mtmt.hu/api/publication/2237194}, author = {Hart, Nikolett and Szűcs (Sárga), Linda and Csende, Zsolt and Koltai, Erika and Koch, LG and Britton, SL and Davies, KJA and Kouretas, D and Wessner, B and Radák, Zsolt}, doi = {10.1016/j.fct.2013.01.051}, journal-iso = {FOOD CHEM TOXICOL}, journal = {FOOD AND CHEMICAL TOXICOLOGY}, volume = {61}, unique-id = {2237194}, issn = {0278-6915}, abstract = {High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p<0.05). The changes in mitochondrial fission/fusion and Lon protease/HSP78 levels suggest that exercise training does not significantly induce damage of proteins. Moreover, neither exercise training nor resveratrol supplementation altered the content of protein carbonyls. Changes in the levels of forkhead transcription factor 1 and SIRT4 could suggest increased fat utilization and improved insulin sensitivity. These data indicate, that resveratrol supplementation enhances aerobic performance due to the activation of the AMPK-SIRT1-PGC-1alpha pathway.}, year = {2013}, eissn = {1873-6351}, pages = {53-59}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:2137602, title = {Muscle activation history at different vertical jumps and its influence on vertical velocity}, url = {https://m2.mtmt.hu/api/publication/2137602}, author = {Kopper, Bence and Csende, Zsolt and Sáfár, Sándor and Hortobágyi, Tibor and Tihanyi, József}, doi = {10.1016/j.jelekin.2012.09.005}, journal-iso = {J ELECTROMYOGR KINES}, journal = {JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY}, volume = {23}, unique-id = {2137602}, issn = {1050-6411}, abstract = {In the present study we investigated displacement, time, velocity and acceleration history of center of mass (COM) and electrical activity of knee extensors to estimate the dominance of the factors influencing the vertical velocity in squat jumps (SJs), countermovement jumps (CMJs) and drop jumps (DJs) performed with small (40°) and large (80°) range of joint motion (SROM and LROM). The maximum vertical velocity (v4) was 23.4% (CMJ) and 7.8% (DJ) greater when the jumps were performed with LROM compared with SROM (p < 0.05). These differences are considerably less than it could be expected from the greater COM and knee angular displacement and duration of active state. This small difference can be attributed to the greater deceleration during eccentric phase (CMJ:32.1%, DJ:91.5%) in SROM than that in LROM. v4 was greater for SJ in LROM than for SJ in SROM indicating the significance of the longer active state and greater activation level (p < 0.001). The difference in v4 was greater between SJ and CMJ in SROM (38.6%) than in LROM (9.0%), suggesting that elastic energy storage and re-use can be a dominant factor in the enhancement of vertical velocity of CMJ and DJ compared with SJ performed with SROM. © 2012 Elsevier Ltd. All rights reserved.}, keywords = {Electromyography; Elastic energy; Pretension; Active state; Activation level}, year = {2013}, eissn = {1873-5711}, pages = {132-139}, orcid-numbers = {Hortobágyi, Tibor/0000-0001-5732-7942} } @article{MTMT:1881645, title = {Mechanical, Biochemical, and Electromyographic Responses to Short-term Eccentric-Concentric Knee Extensor Training in Humans}, url = {https://m2.mtmt.hu/api/publication/1881645}, author = {Váczi, Márk and Tihanyi, József and Hortobágyi, Tibor and Rácz, Levente and Csende, Zsolt and Costa, Andreas and Pucsok, József}, doi = {10.1519/JSC.0b013e3181c1fa47}, journal-iso = {J STRENGTH CONDIT RES}, journal = {JOURNAL OF STRENGTH AND CONDITIONING RESEARCH}, volume = {25}, unique-id = {1881645}, issn = {1064-8011}, abstract = {The article describes a study that examined the effects that short-term eccentric-concentric knee extensor training in humans had on their biomechanical and biochemical variables, muscle soreness, and electromyographic activity. It was found that the training caused immediate reductions in maximal voluntary force.}, keywords = {Electromyography; research; MUSCLE DAMAGE; *Biomechanics; High-intensity; Acute resistance training; *ELECTROMYOGRAPHY; *MYALGIA; *BIOCHEMISTRY; *LEG exercises}, year = {2011}, eissn = {1533-4287}, pages = {922-932}, orcid-numbers = {Hortobágyi, Tibor/0000-0001-5732-7942} } @article{MTMT:1815999, title = {ROR1 expression is not a unique marker of CLL}, url = {https://m2.mtmt.hu/api/publication/1815999}, author = {Barna, Gábor and Mihalik, Rudolf and Timár, Botond and Tombol, J and Csende, Zsolt and Sebestyén, Anna and Bödör, Csaba and Csernus, Balázs and Reiniger, Lilla and Peták, István and Matolcsy, András}, doi = {10.1002/hon.948}, journal-iso = {HEMATOL ONCOL}, journal = {HEMATOLOGICAL ONCOLOGY}, volume = {29}, unique-id = {1815999}, issn = {0278-0232}, year = {2011}, eissn = {1099-1069}, pages = {17-21}, orcid-numbers = {Barna, Gábor/0000-0003-1960-5061; Timár, Botond/0000-0001-6210-8154; Sebestyén, Anna/0000-0001-8814-4794; Bödör, Csaba/0000-0002-0729-692X; Reiniger, Lilla/0000-0003-2248-4264; Peták, István/0000-0003-0422-9286; Matolcsy, András/0000-0002-5382-2150} } @article{MTMT:1713490, title = {Adaptation to altered balance conditions in unilateral amputees due to atherosclerosis: A randomized controlled study}, url = {https://m2.mtmt.hu/api/publication/1713490}, author = {Mayer, Ágnes Andrea and Tihanyi, József and Bretz, Károly and Csende, Zsolt and Bretz, É and Horváth, Mónika}, doi = {10.1186/1471-2474-12-118}, journal-iso = {BMC MUSCULOSKEL DIS}, journal = {BMC MUSCULOSKELETAL DISORDERS}, volume = {12}, unique-id = {1713490}, issn = {1471-2474}, abstract = {Background: Amputation impairs the ability to balance. We examined adaptation strategies in balance following dysvascularity-induced unilateral tibial amputation in skilled prosthetic users (SPU) and first fitted amputees (FFA) (N = 28). Methods. Excursions of center of pressure (COP) were determined during 20 s quiet standing using a stabilometry system with eyes-open on both legs or on the non-affected leg(s). Main measures: COP trajectories and time functions; distribution of reaction forces between the two legs; inclination angles obtained through second order regression analysis using stabilogram data. Results: FFA vs SPU demonstrated 27.8% greater postural sway in bilateral stance (p = 0.0004). Postural sway area was smaller in FFA standing on the non-affected leg compared with SPU (p = 0.028). The slope of the regression line indicating postural stability was nearly identical in FFA and SPU and the direction of regression line was opposite for the left and right leg amputees. Conclusion: Of the two adaptation strategies in balance, the first appears before amputation due to pain and fatigue in the affected leg. This strategy appears in the form of reduced postural sway while standing on the non-affected leg. The second adaptation occurs during rehabilitation and regular use of the prosthesis resulting in normal weightbearing associated with reduced postural sway on two legs and return to the normal postural stability on one leg. © 2011 Mayer et al; licensee BioMed Central Ltd.}, keywords = {Female; Male; ATHEROSCLEROSIS; PAIN; ARTICLE; human; ADAPTATION; clinical article; fatigue; Tibia; body posture; Eye; bone prosthesis; weight bearing; disabled person; standing; stabilography; leg pain; leg amputation; below knee amputation; balance disorder}, year = {2011}, eissn = {1471-2474}, orcid-numbers = {Mayer, Ágnes Andrea/0000-0003-0184-0792} } @article{MTMT:1822327, title = {ROR1 EXPRESSION IS NOT A UNIQUE MARKER OF CLL}, url = {https://m2.mtmt.hu/api/publication/1822327}, author = {Barna, Gábor and Mihalik, Rudolf and Timár, Botond and Csende, Zsolt and Sebestyén, Anna and Tombol, J and Bödör, Csaba and Csernus, Balázs and Matolcsy, András}, journal-iso = {CYTOM PART B-CLIN CY}, journal = {CYTOMETRY PART B-CLINICAL CYTOMETRY}, volume = {78B}, unique-id = {1822327}, issn = {1552-4949}, year = {2010}, eissn = {1552-4957}, pages = {436-436}, orcid-numbers = {Barna, Gábor/0000-0003-1960-5061; Timár, Botond/0000-0001-6210-8154; Sebestyén, Anna/0000-0001-8814-4794; Bödör, Csaba/0000-0002-0729-692X; Matolcsy, András/0000-0002-5382-2150} }