@article{MTMT:2923890, title = {Synthesis and structure of novel ferrocene-containing β-carbolines including polycondensed derivatives with the elements of planar-, central- and conformational chirality}, url = {https://m2.mtmt.hu/api/publication/2923890}, author = {Kovács, Z and Jernei, Tamás and Katona, D and Kocsis, László and Csámpai, Antal}, doi = {10.1016/j.jorganchem.2015.07.004}, journal-iso = {J ORGANOMET CHEM}, journal = {JOURNAL OF ORGANOMETALLIC CHEMISTRY}, volume = {794}, unique-id = {2923890}, issn = {0022-328X}, abstract = {Abstract Employing tryptamine or tryptophane methylester hydrochloride and (Sp)-2-formylferrocene-1-carboxylate as precursors by means of Pictet-Spengler reactions and subsequent intramolecular acylation effected by cyanuricfluoride or carbonyldiimidazole (CDI), the first representatives of ferrocene-containing β-carboline derivatives including polycyclic ferroceno/fused lactames, were prepared. In the course of CDI-mediated tandem cyclization of a tryptophane-derived carboxyferrocenyl-substituted β-carboline, a ring enlargement simultaneously taking place with the loss of the η5-C5H5Fe+ fragment of the fused ferrocene moiety, effected by the coordinating imidazole released from the reagent, led to a 4H-cyclopenta[7,8]azonino[5,4-b]indole as a minor product. The constitution and relative configuration of the new compounds with the elements of planar-, central- and conformational chirality were established by NMR methods including HMQC, HMBC and NOESY measurements supported by DFT modeling studies. © 2015 Published by Elsevier B.V.}, keywords = {NMR spectroscopy; Planar chirality; β-carboline; Tandem diastereoselective cyclization; Loss of iron from ferrocene; DFT modeling; Conformational chirality; Condensed ferrocene}, year = {2015}, eissn = {1872-8561}, pages = {125-135}, orcid-numbers = {Csámpai, Antal/0000-0003-2107-7309} } @CONFERENCE{MTMT:2893991, title = {Synthesis and invitro cytostaticeffect of diverseferrocene-conjugateson human celllines}, url = {https://m2.mtmt.hu/api/publication/2893991}, author = {Szabó, Ildikó and Bősze, Szilvia and Kocsis, László and Hudecz, Ferenc and Csámpai, Antal}, booktitle = {13th Ferrocene Colloquium}, unique-id = {2893991}, year = {2015}, pages = {76}, orcid-numbers = {Szabó, Ildikó/0000-0002-9844-7841; Hudecz, Ferenc/0000-0001-5128-9498; Csámpai, Antal/0000-0003-2107-7309} } @CONFERENCE{MTMT:2893986, title = {Synthesis of ferrocene - based bis heterocycles with biological relevance employing sequential degradation and reconstruction of the metallocene structure}, url = {https://m2.mtmt.hu/api/publication/2893986}, author = {Csámpai, Antal and Kovács, Zoltán and Csókás, Dániel and Gyömöre, Ádám and Jernei, Tamás and Kocsis, László and Szabó, Ildikó and Bősze, Szilvia and Hudecz, Ferenc}, booktitle = {13th Ferrocene Colloquium}, unique-id = {2893986}, year = {2015}, pages = {20}, orcid-numbers = {Csámpai, Antal/0000-0003-2107-7309; Szabó, Ildikó/0000-0002-9844-7841; Hudecz, Ferenc/0000-0001-5128-9498} } @article{MTMT:2863245, title = {Electrochemical and Photometric Detection of Plasmin by Specific Peptide Substrate.}, url = {https://m2.mtmt.hu/api/publication/2863245}, author = {Castillo, G and Pribransky, Kinga and Mező, Gábor and Kocsis, László and Csámpai, Antal and Németh, Krisztina and Keresztes, Zsófia and Hianik, T}, doi = {10.1002/elan.201400622}, journal-iso = {ELECTROANAL}, journal = {ELECTROANALYSIS}, volume = {27}, unique-id = {2863245}, issn = {1040-0397}, abstract = {We report a comparative analysis of plasmin detection by means of electrochemical biosensor and photometric assays. The biosensor has been based on ferrocene-modified peptide (Fc-P) specific to plasmin. Fc-P substrate is enzymatically cleaved by plasmin and the short fragment of peptide contained Fc is released causing decrease of redox current measured by cyclic voltammetry. The biosensor was tested in the range 1–20 nM of freshly prepared plasmin and it was highly selective (LOD=0.56±0.03 nM) demonstrating lower reaction to other proteins such as thrombin and β-casein. The concentration of plasmin has been determined also by a photometric analysis based on UV-vis spectroscopy (LOD=3.68±0.04 nM). The assay has been validated in milk samples.}, year = {2015}, eissn = {1521-4109}, pages = {789-798}, orcid-numbers = {Mező, Gábor/0000-0002-7618-7954; Csámpai, Antal/0000-0003-2107-7309; Keresztes, Zsófia/0000-0002-1126-4779} } @{MTMT:2730897, title = {Shynthesis of novel ferrocene, chalcone and triazole containing molecules with promising results in anticancer chemotherapy}, url = {https://m2.mtmt.hu/api/publication/2730897}, author = {Kocsis, László and Patik, Márta and Szabó, Ildikó and Bősze, Szilvia and Csámpai, Antal and Hudecz, Ferenc}, booktitle = {COST Action - Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells}, unique-id = {2730897}, year = {2014}, orcid-numbers = {Szabó, Ildikó/0000-0002-9844-7841; Csámpai, Antal/0000-0003-2107-7309; Hudecz, Ferenc/0000-0001-5128-9498} } @CONFERENCE{MTMT:2525033, title = {2-Arylideneferroceno[e]cyclohexanones and related 3-aryl-3,3a,4,5-tetrahydroferroceno[g]indazoles: synthesis, NMR-, DFT- and x-ray analysis}, url = {https://m2.mtmt.hu/api/publication/2525033}, author = {Kolos, Kiss and Kocsis, László and Holczbauer, Tamás and Mátyás, Czugler and Luminita, Silaghi-Dumitrescu and Antal, Csámpai}, booktitle = {2-Arylideneferroceno[e]cyclohexanones and related 3-aryl-3,3a,4,5-tetrahydroferroceno[g]indazoles: synthesis, NMR-, DFT- and x-ray analysis}, unique-id = {2525033}, year = {2013}, pages = {4-4} } @CONFERENCE{MTMT:2525044, title = {Synthesis and Spectroscopic Structure Analysis of Novel C2-Chiral Diphenothiazinyl- Salen Complexes}, url = {https://m2.mtmt.hu/api/publication/2525044}, author = {Kocsis, László and Kolos, KISS and Kinga, FODOR and Antal, CSÁMPAI and Luminiţa, SILAGHI-DUMITRESCU}, booktitle = {XVIII. Nemzetközi Vegyészkonferencia}, unique-id = {2525044}, year = {2012}, pages = {22-22} } @CONFERENCE{MTMT:2525036, title = {Synthesis and Characterization of New Phenothiazine Derivatives}, url = {https://m2.mtmt.hu/api/publication/2525036}, author = {Kocsis, László and Kiss, Kolos and FODOR, Kinga and KÁROLYI, Benedek-Imre and CSÁMPAI, Antal and LOVÁSZ, Tamás and SILAGHI-DUMITRESCU, Lum ini ţ a}, booktitle = {17th International Conference on Chemistry}, unique-id = {2525036}, year = {2011} } @CONFERENCE{MTMT:2525041, title = {Aszimmetrikus kobalt(III)-komplexek etil-metil-dioximmal}, url = {https://m2.mtmt.hu/api/publication/2525041}, author = {ifj, VÁRHELYI Csaba and Pokol, György and Izvekov, Vladiszlav and GÖMÖRY, Ágnes and VÁRHELYI, Csaba and Kocsis, László}, booktitle = {XV. Nemzetközi Vegyészkonferencia}, unique-id = {2525041}, year = {2009}, orcid-numbers = {Pokol, György/0000-0003-1597-9808} } @article{MTMT:1626916, title = {Endomorphin synthesis in rat brain from intracerebroventricularly injected [H-3]-Tyr-Pro: A possible biosynthetic route for endomorphins}, url = {https://m2.mtmt.hu/api/publication/1626916}, author = {Rónai, András and Szemenyei, Erzsébet and Kató, Erzsébet and Kocsis, László and Orosz, György and Al-Khrasani, Mahmoud and Tóth, Géza}, doi = {10.1016/j.regpep.2005.12.004}, journal-iso = {REGUL PEPTIDES}, journal = {REGULATORY PEPTIDES}, volume = {134}, unique-id = {1626916}, issn = {0167-0115}, abstract = {in spite of concentrated efforts, the biosynthetic route of mu-opioid receptor agonist brain tetrapeptide endomorphins (Tyr-Pro-Trp-Phe-NH2 and Tyr-Pro-Phe-Phe-NH2), discovered in 1997, is still obscure. We report presently that 30 min after intracerebroventricular injection of 20 or 200 mu Ci [H-3]Tyr-Pro (49.9 Ci mmol(-1)) the incorporated radioactivity was found in endomorphin-related tetra- and tripeptides in rat brain extracts. As detected by the combination of HPLC with radiodetection, a peak corresponding to endomorphin-2-OH could be identified in two of four extracts of "20 mu Ci" series. Radioactive peaks in position of Tyr, Tyr-Pro, Tyr-Pro-Phe or Tyr-Pro-Trp appeared regularly in both series and also in the "tetrapeptide cluster" constituted by endomorphins and their free carboxylic forms. In one of the four extracts in the "200 mu Ci" series a robust active peak in the position of endomorphin 2 could be detected. Intracerebroventricularly injected 100 mmol, but not 10 or 1000 nmol cold Tyr-Pro (devoid of opioid activity in vitro), caused a naloxone-reversible prolongation of tail-flick latency in rats, peaking between 15 and 30 min. We suggest that Tyr-Pro may serve as a biosynthetic precursor to endomorphin synthesis. (C) 2006 Elsevier B.V. All rights reserved.}, keywords = {HPLC; CELLS; LOCALIZATION; IMMUNOREACTIVITY; SPINAL-CORD; PAIN; ANALGESIA; DEGRADATION; MU-OPIOID RECEPTOR; DIPEPTIDYL-PEPTIDASE IV; ALPHA-AMIDATING MONOOXYGENASE; radiodetection; Tyr-Pro substrate; endomorphin de novo biosynthesis}, year = {2006}, eissn = {1873-1686}, pages = {54-60}, orcid-numbers = {Kató, Erzsébet/0000-0001-5786-0405; Al-Khrasani, Mahmoud/0000-0001-8488-3266} }