TY - JOUR AU - Kállai-Szabó, Nikolett AU - Farkas, Dóra AU - Lengyel, Miléna AU - Basa, Bálint AU - Fleck, C. AU - Antal, István TI - Microparticles and multi-unit systems for advanced drug delivery JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 194 PY - 2024 PG - 25 SN - 0928-0987 DO - 10.1016/j.ejps.2024.106704 UR - https://m2.mtmt.hu/api/publication/34631071 ID - 34631071 N1 - Export Date: 28 February 2024 CODEN: EPSCE Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Vlahovic, Kristina AU - Gordon, Péter AU - Kállai-Szabó, Nikolett AU - Zelkó, Romána AU - Antal, István AU - Farkas, Dóra TI - Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 12 PG - 48 SN - 1424-8247 DO - 10.3390/ph16121658 UR - https://m2.mtmt.hu/api/publication/34405975 ID - 34405975 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, H-1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, H-1111, Hungary Department of Pharmacy Administration, Semmelweis University, Hőgyes Str. 7–9, Budapest, H-1092, Hungary Export Date: 14 March 2024 Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu Correspondence Address: Farkas, D.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: farkas.dora@semmelweis.hu AB - In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gergő D. AU - Kállai-Szabó, Nikolett AU - Lengyel, Miléna AU - Süvegh, Károly AU - Ender, Ferenc AU - Katona, Gábor AU - Nochta-Kazsoki, Adrienn Katalin AU - Zelkó, Romána AU - Antal, István AU - Balogh, György Tibor AU - Balogh Weiser, Diána TI - Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 389 PY - 2023 PG - 13 SN - 0167-7322 DO - 10.1016/j.molliq.2023.122819 UR - https://m2.mtmt.hu/api/publication/34096036 ID - 34096036 N1 - Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Eötvös Loránd University Laboratory of Nuclear Chemistry, P.O. Box 32, Budapest, H-1518, Hungary Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Spinsplit Llc., Vend u. 17, Budapest, H-1025, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary University Pharmacy, Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Budapest, H-1111, Hungary Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Export Date: 20 February 2024 CODEN: JMLID Correspondence Address: Antal, I.; Department of Pharmaceutical Chemistry, Hőgyes E. Street 7–9, Hungary; email: antal.istvan@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Pápay, Zsófia Edit AU - Szalkai, Petra AU - Niczinger, Noémi AU - Kijima, S. AU - Sugibayashi, K. AU - Antal, István AU - Kállai-Szabó, Nikolett TI - Viscoelasticity of Liposomal Dispersions JF - NANOMATERIALS J2 - NANOMATERIALS-BASEL VL - 13 PY - 2023 IS - 16 PG - 14 SN - 2079-4991 DO - 10.3390/nano13162340 UR - https://m2.mtmt.hu/api/publication/34096011 ID - 34096011 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, 1092, Hungary Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Saitama, Sakado, 350-0295, Japan Export Date: 21 November 2023 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: antal.istvan@semmelweis.hu Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Ficzere, Máté AU - Mészáros, Lilla Alexandra AU - Kállai-Szabó, Nikolett AU - Kovács, Andrea AU - Antal, István AU - Nagy, Zsombor Kristóf AU - Galata, Dorián László TI - Real-time coating thickness measurement and defect recognition of film coated tablets with machine vision and deep learning JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 623 PY - 2022 PG - 8 SN - 0378-5173 DO - 10.1016/j.ijpharm.2022.121957 UR - https://m2.mtmt.hu/api/publication/32912550 ID - 32912550 N1 - Funding Agency and Grant Number: OTKA grant [FK-132133]; Ministry for Innovation and Technology Funding text: This work was supported by OTKA grant FK-132133. The research reported in this paper and carried out at BME has been supported by the National Laboratory of Artificial Intelligence funded by the NRDIO under the auspices of the Ministry for Innovation and Technology. AB - This paper presents a system, where images acquired with a digital camera are coupled with image analysis and deep learning to identify and categorize film coating defects and to measure the film coating thickness of tablets. There were 5 different classes of defective tablets, and the YOLOv5 algorithm was utilized to recognize defects, the accuracy of the classification was 98.2%. In order to characterize coating thickness, the diameter of the tablets in pixels was measured, which was used to measure the coating thickness of the tablets. The proposed system can be easily scaled up to match the production capability of continuous film coaters. With the developed technique, the complete screening of the produced tablets can be achieved in real-time resulting in the improvement of quality control. LA - English DB - MTMT ER - TY - JOUR AU - Kállai-Szabó, Nikolett AU - Lengyel, Miléna AU - Farkas, Dóra AU - Barna, Ádám Tibor AU - Fleck, Christian AU - Basa, Bálint AU - Antal, István TI - Review on Starter Pellets: Inert and Functional Cores JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 6 PG - 30 SN - 1999-4923 DO - 10.3390/pharmaceutics14061299 UR - https://m2.mtmt.hu/api/publication/32898525 ID - 32898525 N1 - Export Date: 23 September 2022 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7–9, Hungary; email: antal.istvan@pharma.semmelweis‐univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Király, Márton AU - Sántha, Konrád AU - Kállai-Szabó, Barnabás AU - Pencz, Kriszta Mariann AU - Ludányi, Krisztina AU - Kállai-Szabó, Nikolett AU - Antal, István TI - Development and Dissolution Study of a β-Galactosidase Containing Drinking Straw JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 4 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics14040769 UR - https://m2.mtmt.hu/api/publication/32770821 ID - 32770821 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7–9, Budapest, 1092, Hungary ViteCer Ltd., Ipartelepi Street 8/b, Cegled, 2700, Hungary Cited By :3 Export Date: 29 February 2024 Correspondence Address: Ludányi, K.; Department of Pharmaceutics, Hőgyes E. Street 7–9, Hungary; email: ludanyi.krisztina@pharma.semmelweis-univ.hu Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes E. Street 7–9, Hungary; email: kallai.nikolett@pharma.semmelweis-univ.hu Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7–9, Hungary; email: antal.istvan@pharma.sesmmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Kleiner, Dénes AU - Kondor, Miklós AU - Sebők, Szilvia AU - Bartus, Gábor AU - Kállai-Szabó, Nikolett AU - Szalkai, Petra AU - Mirzahosseini, Arash AU - Zelkó, Romána TI - DMSO tartalmú topikális készítmények formulálásaés stabilitásának vizsgálata JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 SP - S17 EP - S17 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/32502731 ID - 32502731 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Király, Márton AU - Sántha, Konrád AU - Kállai-Szabó, Barnabás AU - Kállai-Szabó, Nikolett AU - Antal, István AU - Ludányi, Krisztina TI - β-galactosidase Containing Innovative Drug Delivery System JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 253 EP - 254 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.253-254 UR - https://m2.mtmt.hu/api/publication/32496864 ID - 32496864 N1 - Poster-45 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Borbás, Bence AU - Kállai-Szabó, Nikolett AU - Basa, Bálint AU - Antal, István TI - Study on 3D Printed Innovative Modified Release Formulation JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 189 EP - 190 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.189-190 UR - https://m2.mtmt.hu/api/publication/32496840 ID - 32496840 N1 - Poster-14 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER -