@article{MTMT:36078935, title = {Interdiszciplináris konszenzus-állásfoglalás a krónikus fáradtság szindróma/myalgiás encephalomyelopathia diagnosztikájáról és kezeléséről}, url = {https://m2.mtmt.hu/api/publication/36078935}, author = {Simonyi, Gábor and Bedros, Jonathán Róbert and Réthelyi, János and Polgár, Anna and Kiss, Emese Virág}, doi = {10.1556/650.2025.33259}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {166}, unique-id = {36078935}, issn = {0030-6002}, abstract = {A krónikus fáradtság szindróma/myalgiás encephalomyelitis (újabban encephalomyelopathia) olyan betegségentitás, amely az elmúlt évtizedekben vált ismertté a nemzetközi szakirodalomban, a hazai orvosi irodalomban pedig még kevéssé ismert. Tünettana szerteágazó, szomatikus, kognitív, pszichológiai és funkcionális érintettséggel, az etiológiájára vonatkozó elképzelések ellentmondásosak. Ugyanakkor foglalkozni szükséges a kérdéssel, mert számos páciens kerül az egészségügyi rendszer látókörébe ezekkel a panaszokkal. Összefoglaló tanulmányunkban a fenti kérdéseket járjuk körül a nemzetközi szakirodalom és irányelvek bemutatása révén, célunk a hazai ellátórendszerben dolgozó szakemberek – orvosok, pszichológusok, gyógytornászok, dietetikusok – számára megfelelő információ biztosítása. A krónikus fáradtság szindróma/myalgiás encephalomyelopathia kezelésének lehetőségeire is javaslatot teszünk.}, year = {2025}, eissn = {1788-6120}, pages = {523-531}, orcid-numbers = {Simonyi, Gábor/0000-0002-5205-3820; Réthelyi, János/0000-0002-3641-012X; Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:36142638, title = {Az antifoszfolipid szindróma aktualitásai}, url = {https://m2.mtmt.hu/api/publication/36142638}, author = {Takács, Júlia and Végh, Judit and Kiss, Emese Virág}, doi = {10.33616/lam.35.0188}, journal-iso = {LEGE ART MED}, journal = {LEGE ARTIS MEDICINAE}, volume = {35}, unique-id = {36142638}, issn = {0866-4811}, abstract = {Az antifoszfolipid szindróma szerzett thrombophilia, a szisztémás autoimmun betegségek közé tartozó thromboinflammatoricus kórkép. Patomechanizmusa komplex folyamat, mely intenzív kutatások tárgyát képezi. Involválja az immun-, komplementés véralvadási rendszer számos elemét, aktív szerepet töltenek be a thrombocyták, endothelsejtek. A neutrophil extracelluláris hálók prokoaguláns hatása és a β2-glikoprotein-I központi szerepet töltenek be patogenezisében. 2023 őszén új ACR/EULAR klasszifikációs kritériumrendszert vezettek be, mely segít egységesíteni a kórkép szerteágazó klinikai és laboratóriumi megnyilvánulásait. Az antitestprofilok meghatározásával lehetőség nyílik az antifoszfolipid szindróma kezelési intenzitásának megválasztására. Kezelésének célja a vérrögképződés megelőzése, a szövődmények csökkentése és a betegek életminőségének javítása. A hosszú távú antithromboticus kezelés jelenleg az egyetlen olyan kezelés, amely bizonyítottan csökkenti az antifoszfolipid szindróma érrendszeri szövődményeit, emellett egyre több esetben alkalmazunk immunmoduláns/immunszuppresszív kezelést, melynek célja a betegség hosszú távú kórlefolyásának modulálása, a krónikus szövődmények megelőzése. A terápiás megközelítések közé tartozik a tartós Bsejt-gátlás rituximab, belimumab és az abatacept segítségével, az immunmoduláns hydroxychloroquin, intravénás immunglobulin vagy plazmaferézis alkalmazása.}, year = {2025}, eissn = {2063-4161}, pages = {188-198}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:34512365, title = {A B12-vitamin, vas, folsav, a homocisztein, valamint a D3-vitamin szérumszintek lehetséges összefüggései szájszárazságban és/vagy Sjögren-szindrómában szenvedő hazai betegpopulációban}, url = {https://m2.mtmt.hu/api/publication/34512365}, author = {Tóth, György and Erdei, Csilla and Dézsi, Anna and Németh, Orsolya and Kovács, Alexandra and Kiss, Emese Virág and Márton, Krisztina}, doi = {10.1556/650.2024.32951}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34512365}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {147-154}, orcid-numbers = {Tóth, György/0000-0001-7544-3971; Erdei, Csilla/0000-0003-1110-9645; Dézsi, Anna/0000-0001-5139-1580; Németh, Orsolya/0000-0002-4714-1463; Kovács, Alexandra/0000-0001-5831-4983; Kiss, Emese Virág/0000-0002-5399-2379; Márton, Krisztina/0000-0002-6525-2511} } @article{MTMT:34889522, title = {A felnőttkori Still-betegség patogenezise, klinikai jellemzői és terápiás lehetősége. Rövid áttekintés.}, url = {https://m2.mtmt.hu/api/publication/34889522}, author = {Tóth, Klaudia and Bazsó, Anna and Kiss, Emese Virág}, journal-iso = {MAGYAR REUMATOL}, journal = {MAGYAR REUMATOLÓGIA}, volume = {65}, unique-id = {34889522}, issn = {0139-4495}, year = {2024}, pages = {4-10}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:35223434, title = {Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review}, url = {https://m2.mtmt.hu/api/publication/35223434}, author = {Bazsó, Anna and Szodoray, Peter and Shoenfeld, Yehuda and Kiss, Emese Virág}, doi = {10.1007/s10067-024-07123-y}, journal-iso = {CLIN RHEUMATOL}, journal = {CLINICAL RHEUMATOLOGY}, volume = {43}, unique-id = {35223434}, issn = {0770-3198}, abstract = {Systemic sclerosis (SSc) is a progressive autoimmune disorder that mainly affects the skin. There are other clinical manifestations as renal, pulmonary, cardiovascular, and gastrointestinal tract involvements. Based on the skin involvement there are two subtypes of SSc, as limited cutaneous SSc (lSSc) which involves the acral part of the body and diffuse cutaneous SSc (dSSc) resulting in significant skin thickening of the body. Despite of the extensive research the pathomechanism is not fully clarified, how Ssc develops, moreover identifying biomarkers to predict the clinical outcome and prognosis still remains challenging. Circulating biomarkers can be crucial to define the diagnosis, to predict the prognosis and monitor the clinical course. However, only some patients are responsive to the therapy in SSc, and there is a need to reach the ideal therapy for any individual to prevent or slow down the progression in early stages of the disease. In this narrative review, our purpose was to summarize the potential biomarkers in Ssc, describe their role in the diagnosis, pathomechanism, clinical course, organ manifestations, as well as the response to the therapy. Biomarkers assessment aids in the evaluation of disease progression, and disease outcome.}, keywords = {EXPRESSION; ASSOCIATION; GROWTH-FACTOR-BETA; Prognosis; Biomarkers; INTERSTITIAL LUNG-DISEASE; scleroderma; PULMONARY-HYPERTENSION; SERUM-LEVELS; DIGITAL ULCERS; RNA POLYMERASE-III; organ manifestations}, year = {2024}, eissn = {1434-9949}, pages = {3055-3072}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:35277519, title = {Oral Mucosal Human Papillomavirus and Epstein-Bar Virus Rates in Patients with Dry Mouth and/or Sjögren's Syndrome in a Hungarian Cohort.}, url = {https://m2.mtmt.hu/api/publication/35277519}, author = {Erdei, Csilla and Heizer, Ágnes and Mensch, Károly and Szarka, Krisztina Zsuzsanna and Kiss, Emese Virág and Márton, Krisztina}, doi = {10.3290/j.ohpd.b5718350}, journal-iso = {ORAL HLTH PREV DENT}, journal = {ORAL HEALTH & PREVENTIVE DENTISTRY}, volume = {22}, unique-id = {35277519}, issn = {1602-1622}, abstract = {To find an association between oral mucosal human papilloma- and/or Epstein-Barr (HPV, EBV) virus infection in patients with dry mouth and/or Sjögren's syndrome (SS) compared to healthy controls and to find connections with salivary gland histopathological alterations.Ninety-two participants were divided into four groups: 1. healthy controls (n = 32); 2. xerostomia (n = 28); 3. hyposalivation (n = 22); and 4. SS groups (n = 10). To detect virus infection brush biopsy was outlined in all groups. Detections of virus-specific sequences were achieved with polymerase chain reaction (PCR). Lip biopsy and histopathological assessment was performed in groups 2, 3 and 4.HPV positivity of oral mucosal cells was shown in group 1: 1 (3.12%); group 2: 3 (10.7%); group 3: 2 (8.26%); and in group 4: 0 of the samples. EBV was present in group 1: 14 (43.7%); group 2: 17 (60.7%); group 3: 6 (27.3%); and in group 4: 5 (50%) of the cases. There was no statistically significant difference between the attributes. Intact salivary gland in 28.2%, chronic sialadenitis in 28.2%, stromal fibrosis in 6.5%, lipomatous atrophy in 8.6%, fibrous atrophy in 6.5% and positive focus score (SS) in 26.1% were found in the subjects. Neither HPV nor EBV infection caused statistically significantly more histological abnormalities.Orofacial mucosal HPV and/or EBV DNA rates did not differ statistically significantly in patients with xerostomia or hyposalivation or SS compared to healthy controls, therefore, it cannot prove the provocative role of these viruses in dry mouth and/or SS. Neither dry mouth nor SS were accompanied by statistically significantly more salivary gland alterations in HPV- and/or EBV-positive subjects; these alterations are frequent in the virus-negative cases too.}, keywords = {EPSTEIN-BARR VIRUS; Sjogren's Syndrome; oral mucosa; human papillomavirus; Dry mouth}, year = {2024}, eissn = {1757-9996}, pages = {443-452}, orcid-numbers = {Erdei, Csilla/0000-0003-1110-9645; Mensch, Károly/0000-0002-7764-1944; Kiss, Emese Virág/0000-0002-5399-2379; Márton, Krisztina/0000-0002-6525-2511} } @article{MTMT:35428023, title = {Correction: Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review (Clinical Rheumatology, (2024), 10.1007/s10067-024-07123-y)}, url = {https://m2.mtmt.hu/api/publication/35428023}, author = {Bazsó, Anna and Szodoray, P. and Shoenfeld, Y. and Kiss, Emese Virág}, doi = {10.1007/s10067-024-07147-4}, journal-iso = {CLIN RHEUMATOL}, journal = {CLINICAL RHEUMATOLOGY}, volume = {43}, unique-id = {35428023}, issn = {0770-3198}, year = {2024}, eissn = {1434-9949}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:35704781, title = {RITKA DIFFERENCIÁLDIAGNOSZTIKAI ESET AZ IMMUNOLÓGIÁBAN}, url = {https://m2.mtmt.hu/api/publication/35704781}, author = {Balogh, Dóra Marietta and Kiss, Emese Virág}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {77}, unique-id = {35704781}, issn = {0133-5464}, year = {2024}, pages = {328-328}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} } @article{MTMT:32847862, title = {Prevalence of Sjögren’s Syndrome in Patients with Dry Mouth in the Region of Central Hungary}, url = {https://m2.mtmt.hu/api/publication/32847862}, author = {Dézsi, Anna and Erdei, Csilla and Demeter, Tamás and Kovács, Alexandra and Nagy, Gábor and Mensch, Károly and Németh, Orsolya and Hermann, Péter and Tóth, György and Füst, Ágnes and Kiss, Emese Virág and Kőhidai, László and Zalatnai, Attila and Márton, Krisztina}, doi = {10.1111/odi.14264}, journal-iso = {ORAL DIS}, journal = {ORAL DISEASES}, volume = {29}, unique-id = {32847862}, issn = {1354-523X}, abstract = {Abstract Objective One third of the Hungarian population suffers from xerostomia. Since there is no evidence on the actual prevalence of Sjögren?s syndrome (SS) in Hungary, this study aimed to evaluate the same. Materials and Methods Data were collected from the Faculty of Dentistry, Semmelweis University from 2008 to 2015. A diagnosis of SS was established based on the American College of Rheumatology and European League Against Rheumatism criteria. Results Of the 1,076 patients examined with sicca symptoms, 188 patients, had confirmed SS. Primary SS (pSS) was diagnosed in 135 patients, secondary SS (sSS) was confirmed in 53 patients. According to the available statistical records of the public health service of Hungary, there were an average of 16 (0.0014%, 5-26) newly diagnosed SS cases in the entire population and 141 SS patient-practitioner consultations (49-232) per 100,000 inhabitants in the country over the past 10?years (based on the past 10?years: 2011-2020). Conclusion Results revealed that approximately 1/5th?1/6th of patients with sicca symptoms have SS, among whom 72% and 285 have pSS and sSS, respectively. Global Hungarian records simultaneously revealed that the number of both new diagnoses and doctor-SS patient encounters has significantly decreased (by 50%) yearly over the last decade.}, keywords = {Hungary; Sjogren's Syndrome; sicca syndrome}, year = {2023}, eissn = {1601-0825}, pages = {2756-2764}, orcid-numbers = {Dézsi, Anna/0000-0001-5139-1580; Erdei, Csilla/0000-0003-1110-9645; Demeter, Tamás/0000-0003-3385-3344; Kovács, Alexandra/0000-0001-5831-4983; Nagy, Gábor/0000-0001-5510-7903; Mensch, Károly/0000-0002-7764-1944; Németh, Orsolya/0000-0002-4714-1463; Hermann, Péter/0000-0002-9148-0139; Tóth, György/0000-0001-7544-3971; Füst, Ágnes/0000-0002-5725-4461; Kiss, Emese Virág/0000-0002-5399-2379; Kőhidai, László/0000-0002-9002-0296; Zalatnai, Attila/0000-0001-6334-8336; Márton, Krisztina/0000-0002-6525-2511} } @article{MTMT:34889523, title = {Nagyér-vasculitis és spondylitis ankylopoetica társulása}, url = {https://m2.mtmt.hu/api/publication/34889523}, author = {Bazsó, Anna and Szabó, Nóra Anna and Kiss, Emese Virág}, journal-iso = {MAGYAR REUMATOL}, journal = {MAGYAR REUMATOLÓGIA}, volume = {64}, unique-id = {34889523}, issn = {0139-4495}, year = {2023}, pages = {91-95}, orcid-numbers = {Kiss, Emese Virág/0000-0002-5399-2379} }