@article{MTMT:32598373, title = {Egy 70 éves intézmény}, url = {https://m2.mtmt.hu/api/publication/32598373}, author = {Szabó, Zoltán and Forgács, József and Kertész, Éva and Bagoly, Gabriella and Kálmánczhelyiné, Sipos Anikó and Leskovicsné, Meszesán Katalin and Cs., Nagy Gábor and Kiss, Tamás}, journal-iso = {MAGY KEM LAP}, journal = {MAGYAR KÉMIKUSOK LAPJA}, volume = {76}, unique-id = {32598373}, issn = {0025-0163}, year = {2021}, eissn = {1588-1199}, pages = {367-379} } @misc{MTMT:30427692, title = {Quadruplex forming of oligonucleotides containing 2'-deoxy-5-hydroxyuridine}, url = {https://m2.mtmt.hu/api/publication/30427692}, author = {Balázs, Csaba and Kupihár, Zoltán and Kele, Zoltán and Szabó, Zoltán and Ferenc, Györgyi and Kovács, Lajos}, unique-id = {30427692}, year = {2018}, orcid-numbers = {Ferenc, Györgyi/0000-0002-3456-319X; Kovács, Lajos/0000-0002-0331-3980} } @CONFERENCE{MTMT:30426990, title = {Study of the quadruplex-forming properties of 2’-deoxy-5-hydroxyuridine-containing oligonucleotides}, url = {https://m2.mtmt.hu/api/publication/30426990}, author = {Ferenc, Györgyi and Balázs, Csaba and Paragi, Gábor and Kupihár, Zoltán and Kele, Zoltán and Szabó, Zoltán and Kovács, Lajos}, booktitle = {Straub-Napok}, unique-id = {30426990}, year = {2018}, pages = {22}, orcid-numbers = {Ferenc, Györgyi/0000-0002-3456-319X; Paragi, Gábor/0000-0001-5408-1748; Kupihár, Zoltán/0000-0001-5499-7617; Kele, Zoltán/0000-0002-4401-0302; Kovács, Lajos/0000-0002-0331-3980} } @article{MTMT:1615481, title = {Rapid High-Resolution Characterization of Functionally Important Monoclonal Antibody N-Glycans by Capillary Electrophoresis}, url = {https://m2.mtmt.hu/api/publication/1615481}, author = {Szabó, Zoltán and Guttman, András and Bones, Jonathan and Karger, Barry L}, doi = {10.1021/ac2007587}, journal-iso = {ANAL CHEM}, journal = {ANALYTICAL CHEMISTRY}, volume = {83}, unique-id = {1615481}, issn = {0003-2700}, abstract = {Characterization of the N-glycosylation present in the Fc region of therapeutic monoclonal antibodies requires rapid, high-resolution separation methods to guarantee product safety and efficacy during all stages of process development. Determination of fucosylated oligosaccharides is particularly important during clone selection, product characterization, and lot release as fucose has been shown to adversely affect the ability of mAbs to induce antibody dependent cellular cytotoxicity (ADCC). Here, we apply a general capillary electrophoresis optimization strategy to separate functionally relevant fucosylated and afucosylated glycans on mononclonal antibody products in the presence of several high mannose oligosaccharides. The N-glycans chosen represent those most commonly reported on CHO cell derived therapeutic antibodies. A rapid (<7 min) high-resolution separation of 12 commonly reported and functionally important IgG glycans was developed by systematically evaluating the effects of selectivity (boric acid) and efficiency (linear polyacrylamide) enhancing additives. The approach can be used to rapidly optimize capillary electrophoresis separation of other glycan mixtures. Following optimization, the method was applied to overnight sample processing for automated 96 well plate-based glycosylation analyses of two nonproprietary therapeutic monoclonal antibodies, demonstrating ruggedness and suitability for high-throughput process and product monitoring applications.}, year = {2011}, eissn = {1520-6882}, pages = {5329-5336}, orcid-numbers = {Guttman, András/0000-0002-7838-082X} } @article{MTMT:1401397, title = {Structural variability of endotoxins from R-type isogenic mutants of Shigella sonnei}, url = {https://m2.mtmt.hu/api/publication/1401397}, author = {Kilár, Anikó and Dörnyei, Ágnes and Bui, Annamária and Szabó, Zoltán and Kocsis, Béla and Kilár, Ferenc}, doi = {10.1002/jms.1863}, journal-iso = {J MASS SPECTROM}, journal = {JOURNAL OF MASS SPECTROMETRY}, volume = {46}, unique-id = {1401397}, issn = {1076-5174}, year = {2011}, eissn = {1096-9888}, pages = {61-70}, orcid-numbers = {Dörnyei, Ágnes/0000-0002-6552-8522; Kilár, Ferenc/0000-0001-5737-5514} } @misc{MTMT:2450564, title = {MALDI TOF Analysis of an Ancient Bone Cancer}, url = {https://m2.mtmt.hu/api/publication/2450564}, author = {Jámbor, Éva and Böddi, Katalin and Németh, V and Tóth, G and Tóth, Cs and Szabó, Zoltán and Márk, László}, unique-id = {2450564}, year = {2010}, orcid-numbers = {Márk, László/0000-0002-9301-8159} } @misc{MTMT:2450557, title = {Protein Identification from Submandibular Salivary Stones w ith MALDI TOF Mass Spectrometry}, url = {https://m2.mtmt.hu/api/publication/2450557}, author = {Böddi, Katalin and Brochmann, AS and Szalma, József and Lempel, Edina and Szabó, Zoltán and Takátsy, Anikó}, unique-id = {2450557}, year = {2010}, orcid-numbers = {Szalma, József/0000-0002-6006-8758} } @article{MTMT:1615480, title = {Rapid Release of N-Linked Glycans from Glycoproteins by Pressure-Cycling Technology}, url = {https://m2.mtmt.hu/api/publication/1615480}, author = {Szabó, Zoltán and Guttman, András and Karger, Barry L}, doi = {10.1021/ac100098e}, journal-iso = {ANAL CHEM}, journal = {ANALYTICAL CHEMISTRY}, volume = {82}, unique-id = {1615480}, issn = {0003-2700}, year = {2010}, eissn = {1520-6882}, pages = {2588-2593}, orcid-numbers = {Guttman, András/0000-0002-7838-082X} } @article{MTMT:1615479, title = {Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MS}, url = {https://m2.mtmt.hu/api/publication/1615479}, author = {Szabó, Zoltán and Guttman, András and Rejtar, Tomas and Karger, Barry L}, doi = {10.1002/elps.201000037}, journal-iso = {ELECTROPHORESIS}, journal = {ELECTROPHORESIS}, volume = {31}, unique-id = {1615479}, issn = {0173-0835}, year = {2010}, eissn = {1522-2683}, pages = {1389-1395}, orcid-numbers = {Guttman, András/0000-0002-7838-082X} } @article{MTMT:1425162, title = {Laser desorption/ionization mass spectrometric analysis of small molecules using fullerene-derivatized silica as energy-absorbing material}, url = {https://m2.mtmt.hu/api/publication/1425162}, author = {Szabó, Zoltán and Vallant, RM and Takátsy, Anikó and Bakry, R and Najam-ul-Haq, M and Rainer, M and Huck, CW and Bonn, GK}, doi = {10.1002/jms.1740}, journal-iso = {J MASS SPECTROM}, journal = {JOURNAL OF MASS SPECTROMETRY}, volume = {45}, unique-id = {1425162}, issn = {1076-5174}, abstract = {In spite of the growing acceptance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the analysis of a wide variety of compounds, including polymers and proteins, its use in analyzing low-molecular-weight molecules (<1000 m/z) is still limited. This is mainly due to the interference of matrix molecules in the low-mass range. Here the derivatized fullerenes covalently bound to silica particles with different pore sizes are applied as thin layer for laser desorption/ionization (LDI) mass spectrometric analysis. Thus, an interference of intrinsic matrix ions can be eliminated or minimized in comparison with the state-of-the-art weak organic acid matrices. The desorption/ionization ability of the developed fullerene-silica materials depends on the applied laser power, sample preparation and pore size of the silica particles. Thus, fullerene-silica serves as an LDI support for mass spectrometric analysis of molecules (<1500 Da). The performance of the fullerene-silica is demonstrated by the mass analysis of variety of small molecules such as carbohydrates, amino acids, peptides, phospholipids and drugs. Copyright (C) 2010 John Wiley & Sons, Ltd.}, year = {2010}, eissn = {1096-9888}, pages = {545-552} }