@article{MTMT:34763930,
	title = {Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties},
	url = {https://m2.mtmt.hu/api/publication/34763930},
	author = {Farkas, Gyula and Nagy, Sándor and Dévay, Attila and Széchenyi, Aleksandar and Pál, Szilárd},
	doi = {10.3390/pharmaceutics16030405},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {34763930},
	issn = {1999-4923},
	abstract = {The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes.},
	keywords = {Flow properties; flow time; flow curve; conical section; static angle of repose},
	year = {2024},
	eissn = {1999-4923},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:34212245,
	title = {Development of a novel multi-target drug candidate for neuropathic pain: preclinical and phase I clinical studies},
	url = {https://m2.mtmt.hu/api/publication/34212245},
	author = {Helyes, Zsuzsanna and Horvath, Adam Istvan and Szentes, Nikolett and Tekus, Valeria and Kálai, Tamás and Pál, Szilárd and Szoke, Eva and Matyus, Peter},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {180},
	unique-id = {34212245},
	issn = {0007-1188},
	year = {2023},
	eissn = {1476-5381},
	pages = {433-434}
}

@article{MTMT:33588242,
	title = {Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer},
	url = {https://m2.mtmt.hu/api/publication/33588242},
	author = {Varga, Adorján and Makszin, Lilla and Bufa, Anita and Sipos, Dávid and Kása, Péter and Pál, Szilárd and Rosenstiel, Philip and Sommer, Felix and Kocsis, Béla and Péterfi, Zoltán},
	doi = {10.3389/fcimb.2023.1041384},
	journal-iso = {FRONT CELL INFECT MI},
	journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY},
	volume = {13},
	unique-id = {33588242},
	issn = {2235-2988},
	year = {2023},
	eissn = {2235-2988},
	orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763; Kása, Péter/0000-0002-6134-0928; Péterfi, Zoltán/0000-0001-9658-153X}
}

@article{MTMT:32623813,
	title = {Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection},
	url = {https://m2.mtmt.hu/api/publication/32623813},
	author = {Vörös-Horváth, Barbara and Zivkovic, Pavo and Bánfai, Krisztina and Bovári-Biri, Judit and Pongrácz, Judit and Bálint, Gábor and Pál, Szilárd and Széchenyi, Aleksandar},
	doi = {10.1021/acsomega.1c05149},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {7},
	unique-id = {32623813},
	issn = {2470-1343},
	abstract = {The COVID-19 virus is spread by pulmonary droplets. Its high infectivity is caused by the high-affinity binding of the viral spike protein to the ACE2 receptors on the surface of respiratory epithelial cell membranes. The proper hydration of nasal mucosa plays an essential role in defense of bacterial and viral infections. Therefore, a nasal formulation, which can moisture the nasal mucosa and contains the ACE2 receptor inhibitor, can reduce the risk of COVID-19 infection. This article presents a systematic study of the preparation of chitosan hydrogels with dicarboxylic acids (malic and glutaric acid) and their detailed characterization (Fourier transform infrared spectroscopy, deter-mination of cross-linking efficiency, rheological studies, thermal analysis, and swelling kinetics). The results confirm that chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The adsorption capacity of hydrogels for three different ACE2 inhibitors, as APIs, has also been investigated. The API content of hydrogels and their mucoadhesive property can provide an excellent basis to use the hydrogels for the development of a nasal formulation in order to reduce the risk of SARS-CoV 2 infection.},
	keywords = {DERIVATIVES; PROTEIN; antiviral activity; DRUG-DELIVERY; Chitin; Inserts; SARS coronavirus},
	year = {2022},
	eissn = {2470-1343},
	pages = {3240-3253},
	orcid-numbers = {Pongrácz, Judit/0000-0002-0278-5556; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@{MTMT:32474355,
	title = {Muskotályzsálya (Salvia sclarea L.) szuperkritikus fluid extraktumok biológiai aktivitásának optimalizálása válaszfelület modellezés segítségével},
	url = {https://m2.mtmt.hu/api/publication/32474355},
	author = {Bakó, Csongor and Balázs, Viktória Lilla and Takács, Gyöngyi and Pallos, József Péter and Pál, Szilárd and Kocsis, Béla and Pethő, Dóra and Horváth, Györgyi},
	booktitle = {METT25 a Magyar Elválasztástudományi Társaság jubileumi konferenciája},
	unique-id = {32474355},
	year = {2021},
	orcid-numbers = {Horváth, Györgyi/0000-0001-5344-0294}
}

@article{MTMT:32471114,
	title = {Combination of Analytical and Statistical Methods in Order to Optimize Antibacterial Activity of Clary Sage Supercritical Fluid Extracts},
	url = {https://m2.mtmt.hu/api/publication/32471114},
	author = {Bakó, Csongor and Balázs, Viktória Lilla and Takács, Gyöngyi and Pallos, József Péter and Pál, Szilárd and Kocsis, Béla and Pethő, Dóra and Horváth, Györgyi},
	doi = {10.3390/molecules26216449},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {26},
	unique-id = {32471114},
	issn = {1420-3049},
	year = {2021},
	eissn = {1420-3049},
	orcid-numbers = {Horváth, Györgyi/0000-0001-5344-0294}
}

@article{MTMT:32084429,
	title = {Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain},
	url = {https://m2.mtmt.hu/api/publication/32084429},
	author = {Horváth, Ádám István and Szentes, Nikolett and Tékus, Valéria and Payrits, Maja and Szőke, Éva and Pótóné Oláh, Emőke and Garami, András and Fliszár-Nyúl, Eszter and Poór, Miklós and Pápayné Sár, Cecília and Kálai, Tamás and Pál, Szilárd and Percze, Krisztina and Nagyné Scholz, Éva and Mészáros, Tamás and Tóth, Blanka and Mátyus, Péter and Helyes, Zsuzsanna},
	doi = {10.3390/biomedicines9070749},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {9},
	unique-id = {32084429},
	year = {2021},
	eissn = {2227-9059},
	orcid-numbers = {Garami, András/0000-0003-2493-0571; Fliszár-Nyúl, Eszter/0000-0003-0923-0059; Percze, Krisztina/0000-0002-4124-1893; Mészáros, Tamás/0000-0002-7396-9678; Mátyus, Péter/0000-0003-3963-9445}
}

@article{MTMT:32056248,
	title = {How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods},
	url = {https://m2.mtmt.hu/api/publication/32056248},
	author = {Varga, Adorján and Kocsis, Béla and Sipos, Dávid and Kása, Péter and Vigvári, Szabolcs József and Pál, Szilárd and Dembrovszky, Fanni and Borbásné Farkas, Kornélia and Péterfi, Zoltán},
	doi = {10.3389/fcimb.2021.657320},
	journal-iso = {FRONT CELL INFECT MI},
	journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY},
	volume = {11},
	unique-id = {32056248},
	issn = {2235-2988},
	year = {2021},
	eissn = {2235-2988},
	orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Dembrovszky, Fanni/0000-0001-6953-3591; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Péterfi, Zoltán/0000-0001-9658-153X}
}

@article{MTMT:31905073,
	title = {Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals},
	url = {https://m2.mtmt.hu/api/publication/31905073},
	author = {Salem, Ala' and Takácsi-Nagy, Anna Erzsébet and Nagy, Sándor and Hagymási, Alexandra and Gősi, Fruzsina and Vörös-Horváth, Barbara and Balić, Tomislav and Pál, Szilárd and Széchenyi, Aleksandar},
	doi = {10.3390/pharmaceutics13020277},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {13},
	unique-id = {31905073},
	issn = {1999-4923},
	abstract = {Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.},
	keywords = {COCRYSTALS; High-pressure homogenization; Sulfamethazine; 4-aminosalicylic acid; high-power ultrasound; nano-drugs},
	year = {2021},
	eissn = {1999-4923},
	orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:31646675,
	title = {Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control},
	url = {https://m2.mtmt.hu/api/publication/31646675},
	author = {Salem, Ala' and Hagymási, A. and Vörös-Horváth, Barbara and Šafarik, T. and Balić, T. and Szabó, Péter and Gősi, F. and Nagy, Sándor and Pál, Szilárd and Kunsági-Máté, Sándor and Széchenyi, Aleksandar},
	doi = {10.1016/j.ejps.2020.105599},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {156},
	unique-id = {31646675},
	issn = {0928-0987},
	year = {2021},
	eissn = {1879-0720},
	orcid-numbers = {Szabó, Péter/0000-0003-0827-3583; Széchenyi, Aleksandar/0000-0001-9207-2551}
}