@article{MTMT:34718768,
	title = {Quantifying the effect of subthalamic stimulation on bradykinesia using digitized spiral drawings in Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/34718768},
	author = {Berki, A. and Palotai, M. and Muthuraman, M. and Ding, H. and Halasz, L. and Eross, L. and Fekete, G. and Bognár, László and Pichner, E. and Tamas, G.},
	journal-iso = {EUR J NEUROL},
	journal = {EUROPEAN JOURNAL OF NEUROLOGY},
	volume = {30},
	unique-id = {34718768},
	issn = {1351-5101},
	year = {2023},
	eissn = {1468-1331},
	pages = {231-231}
}

@article{MTMT:33118864,
	title = {Clinical parameters predict the effect of bilateral subthalamic stimulation on dynamic balance parameters during gait in Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/33118864},
	author = {Kelemen, Andrea Judit and Halász, László and Muthuraman, Muthuraman and Erőss, Loránd and Barsi, Péter and Zádori, Dénes and Laczó, Bence and Kis, Dávid and Klivényi, Péter and Fekete, Gábor and Bognár, László and Bereczki, Dániel and Tamás, Gertrúd},
	doi = {10.3389/fneur.2022.917187},
	journal-iso = {FRONT NEUR},
	journal = {FRONTIERS IN NEUROLOGY},
	volume = {13},
	unique-id = {33118864},
	issn = {1664-2295},
	abstract = {We investigated the effect of deep brain stimulation on dynamic balance during gait in Parkinson's disease with motion sensor measurements and predicted their values from disease-related factors. We recruited twenty patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least 12 months and 24 healthy controls. Six monitors with three-dimensional gyroscopes and accelerometers were placed on the chest, the lumbar region, the two wrists, and the shins. Patients performed the instrumented Timed Up and Go test in stimulation OFF, stimulation ON, and right- and left-sided stimulation ON conditions. Gait parameters and dynamic balance parameters such as double support, peak turn velocity, and the trunk's range of motion and velocity in three dimensions were analyzed. Age, disease duration, the time elapsed after implantation, the Hoehn-Yahr stage before and after the operation, the levodopa, and stimulation responsiveness were reported. We individually calculated the distance values of stimulation locations from the subthalamic motor center in three dimensions. Sway values of static balance were collected. We compared the gait parameters in the OFF and stimulation ON states and controls. With cluster analysis and a machine-learning-based multiple regression method, we explored the predictive clinical factors for each dynamic balance parameter (with age as a confounder). The arm movements improved the most among gait parameters due to stimulation and the horizontal and sagittal trunk movements. Double support did not change after switching on the stimulation on the group level and did not differ from control values. Individual changes in double support and horizontal range of trunk motion due to stimulation could be predicted from the most disease-related factors and the severity of the disease; the latter also from the stimulation-related changes in the static balance parameters. Physiotherapy should focus on double support and horizontal trunk movements when treating patients with subthalamic deep brain stimulation.},
	year = {2022},
	eissn = {1664-2295},
	orcid-numbers = {Kelemen, Andrea Judit/0000-0002-7969-9197; Erőss, Loránd/0000-0002-5796-5546; Barsi, Péter/0000-0002-3574-9973; Zádori, Dénes/0000-0003-0749-7980; Klivényi, Péter/0000-0002-5389-3266; Bereczki, Dániel/0000-0002-8374-0500; Tamás, Gertrúd/0000-0001-8054-3678}
}

@article{MTMT:32704613,
	title = {Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study},
	url = {https://m2.mtmt.hu/api/publication/32704613},
	author = {Kelemen, Andrea Judit and Halász, László and Erőss, Loránd and Rudas, Gábor and Muthuraman, Muthuraman and Zádori, Dénes and Laczó, Bence and Kis, Dávid and Klivényi, Péter and Fekete, Gábor and Bognár, László and Bereczki, Dániel and Tamás, Gertrúd},
	doi = {10.1371/journal.pone.0264114},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {17},
	unique-id = {32704613},
	issn = {1932-6203},
	abstract = {Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least one year.We recruited 24 patients with Parkinson's disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine-learning-based multiple regression method.Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation.The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson's disease.},
	year = {2022},
	eissn = {1932-6203},
	orcid-numbers = {Kelemen, Andrea Judit/0000-0002-7969-9197; Erőss, Loránd/0000-0002-5796-5546; Zádori, Dénes/0000-0003-0749-7980; Klivényi, Péter/0000-0002-5389-3266; Bereczki, Dániel/0000-0002-8374-0500; Tamás, Gertrúd/0000-0001-8054-3678}
}

@article{MTMT:32528263,
	title = {Globus Pallidus Internus Deep Brain Stimulation For a Patient With Parkinson's Disease And Cerebral Developmental Venous Anomaly In The Region Of The Basal Ganglia},
	url = {https://m2.mtmt.hu/api/publication/32528263},
	author = {Fekete, Gábor and Tamás, Gertrúd and Novák, László and Bognár, László},
	doi = {10.4103/0028-3886.338678},
	journal-iso = {NEUROL INDIA},
	journal = {NEUROLOGY INDIA},
	volume = {70},
	unique-id = {32528263},
	issn = {0028-3886},
	year = {2022},
	eissn = {1998-4022},
	pages = {457-458},
	orcid-numbers = {Tamás, Gertrúd/0000-0001-8054-3678}
}

@article{MTMT:32461994,
	title = {Frequency-specific network activity predicts bradykinesia severity in Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/32461994},
	author = {Muthuraman, Muthuraman and Palotai, Marcell László and Jávor-Duray, Borbála and Kelemen, Andrea Judit and Koirala, Nabin and Halász, László and Erőss, Loránd and Fekete, Gábor and Bognár, László and Deuschl, Günther and Tamás, Gertrúd},
	doi = {10.1016/j.nicl.2021.102857},
	journal-iso = {NEUROIMAGE-CLIN},
	journal = {NEUROIMAGE-CLINICAL},
	volume = {32},
	unique-id = {32461994},
	issn = {2213-1582},
	abstract = {Bradykinesia has been associated with beta and gamma band interactions in the basal ganglia-thalamo-cortical circuit in Parkinson's disease. In this present cross-sectional study, we aimed to search for neural networks with electroencephalography whose frequency-specific actions may predict bradykinesia.Twenty Parkinsonian patients treated with bilateral subthalamic stimulation were first prescreened while we selected four levels of contralateral stimulation (0: OFF, 1-3: decreasing symptoms to ON state) individually, based on kinematics. In the screening period, we performed 64-channel electroencephalography measurements simultaneously with electromyography and motion detection during a resting state, finger tapping, hand grasping tasks, and pronation-supination of the arm, with the four levels of contralateral stimulation. We analyzed spectral power at the low (13-20 Hz) and high (21-30 Hz) beta frequency bands and low (31-60 Hz) and high (61-100 Hz) gamma frequency bands using the dynamic imaging of coherent sources. Structural equation modelling estimated causal relationships between the slope of changes in network beta and gamma activities and the slope of changes in bradykinesia measures.Activity in different subnetworks, including predominantly the primary motor and premotor cortex, the subthalamic nucleus predicted the slopes in amplitude and speed while switching between stimulation levels. These subnetwork dynamics on their preferred frequencies predicted distinct types and parameters of the movement only on the contralateral side.Concurrent subnetworks affected in bradykinesia and their activity changes in the different frequency bands are specific to the type and parameters of the movement; and the primary motor and premotor cortex are common nodes.},
	keywords = {Parkinson disease; GAMMA OSCILLATION; Deep brain stimulation; bradykinesia; beta oscillation},
	year = {2021},
	eissn = {2213-1582},
	orcid-numbers = {Jávor-Duray, Borbála/0000-0002-2042-7074; Kelemen, Andrea Judit/0000-0002-7969-9197; Erőss, Loránd/0000-0002-5796-5546; Tamás, Gertrúd/0000-0001-8054-3678}
}

@article{MTMT:32015389,
	title = {Cranial and ventricular size following shunting or endoscopic third ventriculostomy (ETV) in infants with aqueductal stenosis: further insights from the International Infant Hydrocephalus Study (IIHS)},
	url = {https://m2.mtmt.hu/api/publication/32015389},
	author = {Coulter, Ian C. and Kulkarni, Abhaya and Sgouros, Spyros and Constantini, Shlomi and Constantini, Shlomi and Sgouros, Spyros and Kulkarni, Abhaya and Leitner, Yael and Kestle, John R. W. and Cochrane, Douglas D. and Choux, Maurice and Gjerris, Fleming and Sherer, Adina and Akalan, Nejat and Bilginer, Burçak and Navarro, Ramon and Vujotic, Ljiljana and Haberl, Hannes and Thomale, Ulrich-Wilhelm and Zúccaro, Graciela and Jaimovitch, Roberto and Frim, David and Loftis, Lori and Swift, Dale M. and Robertson, Brian and Gargan, Lynn and Bognár, László and Cseke, Georgina and Cama, Armando and Ravegnani, Giuseppe Marcello and Preuß, Matthias and Schroeder, Henry W. and Fritsch, Michael and Baldauf, Joerg and Mandera, Marek and Luszawski, Jerzy and Skorupka, Patrycja and Mallucci, Conor and Williams, Dawn and Zakrzewski, Krzystof and Nowoslawska, Emilia and Srivastava, Chhitij and Mahapatra, Ashok K. and Kumar, Raj and Sahu, Rabi Narayan and Melikian, Armen G. and Korshunov, Anton and Galstyan, Anna and Suri, Ashish and Gupta, Deepak and Grotenhuis, J. André and Lindert, Erik J. van and Costa, Val José Aloysio da and Di, Rocco Concezio and Tamburrini, Gianpiero and Zymberg, Samuel Tau and Cavalheiro, Sergio and Jie, Ma and Feng, Jiang and Friedman, Orna and Rajmohamed, Naheeda and Roszkowski, Marcin and Barszcz, Slawomir and Jallo, George I. and Pincus, David W. and Richter, Bridget and Mehdorn, H. M. and Schultka, Susan and de, Ribaupierre Sandrine and Thompson, Dominic and Gatscher, Silvia and Wagner, Wolfgang and Koch, Dorothee and Cipri, Saverio and Zaccone, Claudio and McDonald, Patrick},
	doi = {10.1007/s00381-020-04503-y},
	journal-iso = {CHILD NERV SYST},
	journal = {CHILDS NERVOUS SYSTEM},
	volume = {36},
	unique-id = {32015389},
	issn = {0256-7040},
	year = {2020},
	eissn = {1433-0350},
	pages = {1407-1414}
}

@article{MTMT:31734995,
	title = {Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis},
	url = {https://m2.mtmt.hu/api/publication/31734995},
	author = {Chen, Carol C.L. and Deshmukh, Shriya and Jessa, Selin and Hadjadj, Djihad and Lisi, Véronique and Andrade, Augusto Faria and Faury, Damien and Jawhar, Wajih and Dali, Rola and Suzuki, Hiromichi and Pathania, Manav and A, Deli and Dubois, Frank and Woodward, Eleanor and Hébert, Steven and Coutelier, Marie and Karamchandani, Jason and Albrecht, Steffen and Brandner, Sebastian and De Jay, Nicolas and Gayden, Tenzin and Bajic, Andrea and Harutyunyan, Ashot S. and Marchione, Dylan M. and Mikael, Leonie G. and Juretic, Nikoleta and Zeinieh, Michele and Russo, Caterina and Maestro, Nicola and Bassenden, Angelia V. and Hauser, Péter and Virga, József and Bognár, László and Klekner, Álmos and Zapotocky, Michal and Vicha, Ales and Krskova, Lenka and Vanova, Katerina and Zamecnik, Josef and Sumerauer, David and Ekert, Paul G. and Ziegler, David S. and Ellezam, Benjamin and Filbin, Mariella G. and Blanchette, Mathieu and Hansford, Jordan R. and Khuong-Quang, Dong-Anh and Berghuis, Albert M. and Weil, Alexander G. and Garcia, Benjamin A. and Garzia, Livia and Mack, Stephen C. and Beroukhim, Rameen and Ligon, Keith L. and Taylor, Michael D. and Bandopadhayay, Pratiti and Kramm, Christoph and Pfister, Stefan M. and Korshunov, Andrey and Sturm, Dominik and Jones, David T.W. and Salomoni, Paolo and Kleinman, Claudia L. and Jabado, Nada},
	doi = {10.1016/j.cell.2020.11.012},
	journal-iso = {CELL},
	journal = {CELL},
	volume = {183},
	unique-id = {31734995},
	issn = {0092-8674},
	year = {2020},
	eissn = {1097-4172},
	pages = {1617-1633.e22},
	orcid-numbers = {Chen, Carol C.L./0000-0003-1022-5978; Deshmukh, Shriya/0000-0001-9086-3261; Jessa, Selin/0000-0003-4192-6523; Lisi, Véronique/0000-0001-5385-4219; Andrade, Augusto Faria/0000-0001-5866-0501; Faury, Damien/0000-0003-1584-599X; Jawhar, Wajih/0000-0002-2724-6401; Suzuki, Hiromichi/0000-0002-8858-0294; Pathania, Manav/0000-0001-5635-5028; A, Deli/0000-0002-9195-7507; Dubois, Frank/0000-0002-7654-6208; Hébert, Steven/0000-0001-6267-8595; Coutelier, Marie/0000-0002-0261-7210; Karamchandani, Jason/0000-0002-3906-5616; Bajic, Andrea/0000-0002-7177-5757; Harutyunyan, Ashot S./0000-0002-9050-9315; Marchione, Dylan M./0000-0001-6941-0604; Juretic, Nikoleta/0000-0001-8265-8305; Zeinieh, Michele/0000-0002-0875-2077; Bassenden, Angelia V./0000-0002-8266-4569; Hauser, Péter/0000-0002-8307-8975; Klekner, Álmos/0000-0003-2887-8918; Zapotocky, Michal/0000-0002-9013-2546}
}

@article{MTMT:31685444,
	title = {Intraoperative Electrophysiology in Children - Single Institute Experience of 96 Examinations},
	url = {https://m2.mtmt.hu/api/publication/31685444},
	author = {Fekete, Gábor and Bognár, László and Gutema, Emanuel and Novák, László},
	doi = {10.4103/0028-3886.284352},
	journal-iso = {NEUROL INDIA},
	journal = {NEUROLOGY INDIA},
	volume = {68},
	unique-id = {31685444},
	issn = {0028-3886},
	abstract = {Aim: To summarize our experience gathered during the use of different intraoperative electrophysiological modalities in children.Materials and Methods: We analyzed the data collected from 96 pediatric neurosurgical interventions. During the operations. we used a combination of intraoperative electrophysiological examinations tailored to the actual pathologies. The modalities included cortical and white matter mapping, cranial nerve and cranial nerve nucleus stimulation, motor evoked potential (MEP), somatosensory evoked potential (SSEP). peripheral nerve stimulation, bulbocavernosus reflex. and a special setup for selective dorsal rhizotomy.Results: The success ratio of the different modalities varied between 25% and 100%. All the applied methods could be used in children.Conclusion: Although the application of certain intraoperative techniques could be limited due to the ongoing developmental and maturation processes in childhood, we can not exclude the possibility of successful recording in any modality. Thus, we recommend to apply all the available methods in children bearing in mind that the success ratio might be lower than that in the adult population.},
	keywords = {Electrophysiology; Pediatric; neurosurgery; Intraoperative},
	year = {2020},
	eissn = {1998-4022},
	pages = {407-412}
}

@article{MTMT:31625559,
	title = {Az inváziós spektrum prognosztikai jelentősége glioblastomában},
	url = {https://m2.mtmt.hu/api/publication/31625559},
	author = {Szivos, László and Virga, József and Hortobágyi, Tibor and Zahuczky, Gábor and Uray, Iván and Jenei, Adrienn and Bognár, László and Árkosy, Péter and Klekner, Álmos},
	doi = {10.18071/ISZ.73.0317},
	journal-iso = {IDEGGYOGY SZEMLE},
	journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE},
	volume = {73},
	unique-id = {31625559},
	issn = {0019-1442},
	abstract = {A glioblastoma a leggyakoribb központi idegrendszeri rosszindulatú daganat; sebészi kezelése a da­ganatok invazív jellegénél fogva nem lehetséges, onko­te­rá­piája pedig csupán szerény eredményeket hoz – a bete­gek átlagos teljes túlélése (OS) 16–24 hónap. A betegek egy része alig reagál az alkalmazott kezelésre; a klinikumban jelenleg nincs olyan prognosztikai vagy prediktív marker, ami segítené a betegek túlélésében tapasztalható jelentős szórás érdemi feltérképezését és a kezelési algoritmus optimalizálását. Jelen kutatásban az invázióban sze­re­pet játszó extracelluláris mátrix (ECM-) molekulák expresszió­jának prognosztikai jelentőségét kívántuk meghatározni. Eltérő prognózisú betegcsoportokat létrehozva (A csoport OS < 16 hónap, B csoport OS > 16 hó­nap) vizsgáltuk meg glioblastomás betegek gyors­fa­gyasz­tott tu­mor­mintáiban a szakirodalom által jelenleg elismert mar­kerek (IDH1 mutációs és MGMT metilációs státusz) je­len­lé­tét, továbbá 46 inváziós ECM-molekula mRNS-szintjét. A DE KK Idegsebészeti Klinikán operált és az Onkológiai Klinikán utókezelt betegek klinikai adatai nem mutattak jelentős különbségeket a túlélési adatokat (progressziómentes és teljes túlélés) és a reoperációs arányt leszámítva. Minden minta IDH vad típusú volt. Je­len­tős különbség volt a jobb és a rosszabb túlélésű be­­te­gek kö­zött az MGMT promoter hipermetiláció arányá­ban (28,6% vs. 68,8%). Az inváziós ECM-molekulák expressziós mintá­zata, az inváziós spektrum szintén jelentős különbséget mutatott; szignifikáns különbség mutatkozott az integrin β2, kadhe­rin-12, FLT4/VEGFR-3, verzikán molekulák expressziójá­ban. Az inváziós spektrum megbízhatóságát statisztikai osz­tályozóval tesztelve a módszer a minták 83,3%-át sorolta a megfelelő prognosztikai csoportba (PPÉ: 0,93). A különböző túlélésű betegcsoportok összehasonlítása során a reoperációs arányban megfigyel­hető különbség az irodalmi adatokkal összevágó tény. Az MGMT promoter metiláltságának vizsgálata hazai ­ újdonság, az eredmény az eddigi ismereteket megerősítve sürgeti a vizsgálat rutinszerű bevezetését. Az inváziós spektrum vizsgálata többletinformációt ad a tumorról, prognosztikai markerként segíthet felismerni az ag­resszívabb tumorokat, továbbá felhívja a figyelmet az antiinvazív ágensek jövőbeni használatának szükségességére a GBM terápiájában.},
	keywords = {Prognózis; glioblastoma; Extracelluláris mátrix; MGMT; peritumoralis infiltráció},
	year = {2020},
	eissn = {2498-6208},
	pages = {317-325},
	orcid-numbers = {Szivos, László/0000-0001-8746-3726; Hortobágyi, Tibor/0000-0001-5732-7942}
}

@article{MTMT:31615186,
	title = {Elevated Pro-Inflammatory Cell-Free MicroRNA Levels in Cerebrospinal Fluid of Premature Infants after Intraventricular Hemorrhage},
	url = {https://m2.mtmt.hu/api/publication/31615186},
	author = {Fejes, Zsolt and Erdei, Judit Zsuzsa and Pócsi, Marianna and Takai, Jun and Jeney, Viktória and Nagy, Andrea and Varga, Aliz and Bácsi, Attila and Bognár, László and Novák, László and Kappelmayer, János and Nagy, Béla},
	doi = {10.3390/ijms21186870},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31615186},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067}
}