TY - JOUR AU - Gáborová, Mária AU - Vágvölgyi, Máté AU - Tayeb, Bizhar Ahmed AU - Minorics, Renáta AU - Zupkó, István AU - Jurček, Ondřej AU - Béni, Szabolcs AU - Kubínová, Renata AU - Balogh, György Tibor AU - Hunyadi, Attila TI - Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells JF - ACS OMEGA J2 - ACS OMEGA PY - 2024 SN - 2470-1343 DO - 10.1021/acsomega.4c00800 UR - https://m2.mtmt.hu/api/publication/34779108 ID - 34779108 LA - English DB - MTMT ER - TY - JOUR AU - Csorba, Anita AU - Katona, Gábor AU - Budai-Szűcs, Mária AU - Balogh Weiser, Diána AU - Molnár, P. AU - Maka, Erika AU - Nochta-Kazsoki, Adrienn Katalin AU - Vajna, Márton Antal AU - Zelkó, Romána AU - Nagy, Zoltán Zsolt AU - Balogh, György Tibor TI - A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25031623 UR - https://m2.mtmt.hu/api/publication/34538437 ID - 34538437 N1 - Department of Ophthalmology, Semmelweis University, Mária Street 39, Budapest, H-1085, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, Szeged, H-6720, Hungary Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Molteam Llc., Mélyfúró Street 4, Budapest, H-1151, Hungary University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Export Date: 23 February 2024 Correspondence Address: Csorba, A.; Department of Ophthalmology, Mária Street 39, Hungary; email: csorba.anita@semmelweis-univ.hu Correspondence Address: Balogh, G.T.; Department of Pharmaceutical Chemistry, Hőgyes Endre Street 7-9, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Safaa, Mohammed Omer AU - Nagy, Nándor AU - Szőcs, Emőke AU - Kádár, Szabina AU - Völgyi, Gergely AU - Pinke, Balázs AU - Mészáros, László AU - Katona, Gábor AU - Vincze, Anna AU - Dormán, Péter AU - Nagy, Zoltán Zsolt AU - Balogh, György Tibor AU - Nochta-Kazsoki, Adrienn Katalin AU - Zelkó, Romána TI - Development of innovative electrospun nepafenac-loaded nanofibers-based ophthalmic inserts JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 647 PY - 2023 PG - 13 SN - 0378-5173 DO - 10.1016/j.ijpharm.2023.123554 UR - https://m2.mtmt.hu/api/publication/34225112 ID - 34225112 N1 - University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Department of Anatomy, Histology and Embryology Semmelweis University, Tűzoltó Street 58, Budapest, H-1094, Hungary Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 9, Budapest, H-1092, Hungary Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, H-1111, Hungary Department of Ophthalmology, Semmelweis University, Ma ́ria Street 39, Budapest, 1085, Hungary Export Date: 1 March 2024 CODEN: IJPHD Correspondence Address: Kazsoki, A.; University Pharmacy Department of Pharmacy Administration, Hőgyes Endre Street 7-9, Hungary; email: kazsoki.adrienn@semmelweis.hu Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; nepafenac, 78281-72-8; poloxamer, 9003-11-6; polyvinyl alcohol, 37380-95-3, 9002-89-5 Tradenames: nevanac Manufacturers: TCI, Japan LA - English DB - MTMT ER - TY - CONF AU - Vincze, Anna AU - Balogh, György Tibor TI - In vitro and ex vivo test systems in the development of cyclodextrin-enabled eye drops T2 - EUROCD 2023 7th European Cyclodextrin Conference PY - 2023 UR - https://m2.mtmt.hu/api/publication/34165281 ID - 34165281 LA - English DB - MTMT ER - TY - CONF AU - Erdős, Dóra AU - D. Marton, András AU - Balogh, György Tibor TI - Ginkgo biloba EGb 761® extract in vitro permeability study T2 - EUROCD 2023 7th European Cyclodextrin Conference PY - 2023 UR - https://m2.mtmt.hu/api/publication/34163444 ID - 34163444 N1 - https://www.cyclodextrinconference.com/wp-content/uploads/2023/07/EuroCD-2023-Scientific-Program-5.pdf LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Ferenc AU - Huliák, Ildikó AU - Árva, Hédi AU - Csontné Kiricsi, Mónika AU - Erdős, Dóra AU - Kocsis, Marianna AU - Takács, Gergely AU - Balogh, György Tibor AU - Nagyné Frank, Éva TI - Medicinal Chemistry‐driven Approach to Novel 2‐Substituted Benzoxazole – Estradiol Chimeras: Synthesis, Anticancer Activity and Early ADME Profile JF - CHEMMEDCHEM J2 - CHEMMEDCHEM VL - 18 PY - 2023 IS - 22 PG - 9 SN - 1860-7179 DO - 10.1002/cmdc.202300352 UR - https://m2.mtmt.hu/api/publication/34147665 ID - 34147665 N1 - Department of Molecular and Analytical Chemistry, University of Szeged, Dóm tér 7–8, Szeged, 6720, Hungary Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, 1111, Hungary Mcule.com Kft., Bartók Béla út 105–113, Budapest, 1115, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. 9, Budapest, 1085, Hungary Export Date: 13 October 2023 CODEN: CHEMG Correspondence Address: Frank, É.; Department of Molecular and Analytical Chemistry, Dóm tér 7–8, Hungary; email: frank@chem.u-szeged.hu Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rkp. 3, Hungary; email: balogh.gyorgy.tibor@semmelwies.hu AB - The efficient synthesis of novel estradiol‐based A‐ring‐fused oxazole derivatives, which can be considered as benzoxazole‐steroid domain‐integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2‐aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection‐based t‐distributed stochastic neighbor embedding (t‐SNE), the novel molecules were proved to represent a new chemical space among steroid drugs. They were characterized based on critical physicochemical parameters using in silico and experimental data. The performance of the compounds to inhibit cell proliferation was tested on four human cancer cell lines and non‐cancerous cells. Further examinations were performed to reveal IC50 and lipophilic ligand efficiency (LLE) values, cancer cell selectivity, and apoptosis‐triggering features. Pharmacological tests and LLE metric revealed that some derivatives, especially the 2‐(4‐ethylpiperazin‐1‐yl)oxazole derivative exhibit strong anticancer activity and trigger the apoptosis of cancer cells with relatively low promiscuity risk similarly to the structurally most closely‐related and intensively studied anticancer agent, 2‐methoxy‐estradiol. LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Ádám AU - Ungor, Ditta Anita AU - Varga, Norbert AU - Katona, Gábor AU - Balogh, György Tibor AU - Csapó, Edit TI - Lipid-Based Nanocarriers for Delivery of Neuroprotective Kynurenic Acid: Preparation, Characterization, and BBB Transport JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 18 PG - 13 SN - 1661-6596 DO - 10.3390/ijms241814251 UR - https://m2.mtmt.hu/api/publication/34146936 ID - 34146936 AB - Encapsulation possibilities of an extensively investigated neuroprotective drug (kynurenic acid, KYNA) are studied via lipid-based nanocarriers to increase the blood–brain barrier (BBB) specific permeability. The outcomes of various preparation conditions such as stirring and sonication time, concentration of the lipid carriers and the drug, and the drug-to-lipid ratio are examined. Considering the experimentally determined encapsulation efficiency, hydrodynamic diameter, and ζ-potential values, the initial lipid and drug concentration as well as the stirring and sonication time of the preparation were optimized. The average hydrodynamic diameter of the prepared asolectin-(LIP) and water-soluble lipopolymer (WSLP)-based liposomes was found to be ca. 25 and 60 nm under physiological conditions. The physicochemical characterization of the colloidal carriers proves that the preparation of the drug-loaded liposomes was a successful process, and secondary interactions were indicated between the drug molecule and the polymer residues around the WSLP membrane. Dissolution profiles of the active molecule under physiological conditions were registered, and the release of the unformulated and encapsulated drug is very similar. In addition to this outcome, the in vitro polar brain lipid extract (porcine)-based permeability test proved the achievement of two- or fourfold higher BBB specific penetration and lipid membrane retention for KYNA in the liposomal carriers relative to the unformatted drug. LA - English DB - MTMT ER - TY - JOUR AU - Takács, Gergely AU - Havasi, Dávid AU - Sándor, Márk AU - Dohánics, Zsolt AU - Balogh, György Tibor AU - Kiss, Róbert TI - DIY Virtual Chemical Libraries - Novel Starting Points for Drug Discovery JF - ACS MEDICINAL CHEMISTRY LETTERS J2 - ACS MED CHEM LETT VL - 14 PY - 2023 IS - 9 SP - 1188 EP - 1197 PG - 10 SN - 1948-5875 DO - 10.1021/acsmedchemlett.3c00146 UR - https://m2.mtmt.hu/api/publication/34119941 ID - 34119941 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gergő D. AU - Kállai-Szabó, Nikolett AU - Lengyel, Miléna AU - Süvegh, Károly AU - Ender, Ferenc AU - Katona, Gábor AU - Nochta-Kazsoki, Adrienn Katalin AU - Zelkó, Romána AU - Antal, István AU - Balogh, György Tibor AU - Balogh Weiser, Diána TI - Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 389 PY - 2023 PG - 13 SN - 0167-7322 DO - 10.1016/j.molliq.2023.122819 UR - https://m2.mtmt.hu/api/publication/34096036 ID - 34096036 N1 - Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Eötvös Loránd University Laboratory of Nuclear Chemistry, P.O. Box 32, Budapest, H-1518, Hungary Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Spinsplit Llc., Vend u. 17, Budapest, H-1025, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary University Pharmacy, Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Semmelweis University, Hőgyes E. Street 7–9, Budapest, H-1092, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Budapest, H-1111, Hungary Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Export Date: 20 February 2024 CODEN: JMLID Correspondence Address: Antal, I.; Department of Pharmaceutical Chemistry, Hőgyes E. Street 7–9, Hungary; email: antal.istvan@semmelweis.hu LA - English DB - MTMT ER - TY - PAT AU - Balogh, György Tibor AU - Katona, Gábor AU - Csóka, Ildikó AU - Zupkó, István AU - Nagy, Zoltán Zsolt AU - Kiss, Huba AU - Takács, Ágnes AU - Csorba, Anita TI - Eye drop formulation. An ocular formulation comprising L-Ascorbic 6-palmitate (ASP) is provided. The formulation is useful in situation wherein the maintenance of corneal transparency is at risk e..g. during or after corneal surgeries TS - An ocular formulation comprising L-Ascorbic 6-palmitate (ASP) is provided. The formulation is useful in situation wherein the maintenance of corneal transparency is at risk e..g. during or after corneal surgeries PY - 2023 PG - 30 UR - https://m2.mtmt.hu/api/publication/34066167 ID - 34066167 LA - English DB - MTMT ER -