@article{MTMT:34729015, title = {Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/34729015}, author = {Szabó, Diána and Janovák, László and Abdelghafour, Mohamed M. and Takács, Tamás and Csanády, Miklós ifj. and Spengler, Gabriella and Szakács, László and Csanády, Miklós and Rovó, László}, doi = {10.1556/650.2024.32978}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34729015}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {370-378}, orcid-numbers = {Janovák, László/0000-0002-2066-319X; Abdelghafour, Mohamed M./0000-0002-7895-4555; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756} } @article{MTMT:34072590, title = {Invalidity of Tokyo guidelines in acute biliary pancreatitis : A multicenter cohort analysis of 944 pancreatitis cases}, url = {https://m2.mtmt.hu/api/publication/34072590}, author = {Juhász, Márk Félix and Tóháti, Rebeka and Jászai, Viktória Adrienn and Molnár, Regina and Borbásné Farkas, Kornélia and Czakó, László and Vincze, Áron and Erőss, Bálint Mihály and Szentesi, Andrea Ildikó and Izbéki, Ferenc and Papp, Mária and Hegyi, Péter and Párniczky, Andrea}, doi = {10.1002/ueg2.12402}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34072590}, issn = {2050-6406}, abstract = {There is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse.We aimed to assess the on-admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints.We conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n = 944) based on the on-admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP.27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%.Around 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific-AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted.}, keywords = {MORTALITY; Antibiotic use; cholangitis; endoscopic retrograde cholangiopancreatography; cholecystitis; ERCP; STONES; Biliary acute pancreatitis; 2018 Tokyo guidelines}, year = {2023}, eissn = {2050-6414}, pages = {767-774}, orcid-numbers = {Molnár, Regina/0009-0009-7067-1647; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Czakó, László/0000-0002-6331-0802; Vincze, Áron/0000-0003-2217-7686; Erőss, Bálint Mihály/0000-0003-3658-8427; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Hegyi, Péter/0000-0003-0399-7259; Váncsa, Szilárd/0000-0002-9347-8163; Márta, Katalin/0000-0002-2213-4865; Nagy, Rita/0000-0002-2663-4912; Imrei, Marcell/0000-0003-0175-7462; Maurovich-Horvat, Pál/0000-0003-0885-736X; Doros, Attila/0000-0002-6496-9895; Zubek, László/0000-0003-0583-3290; Gál, János/0000-0001-9160-6478} } @article{MTMT:34053506, title = {Importance of MUC17 in the bile-induced pancreatic cancer progression}, url = {https://m2.mtmt.hu/api/publication/34053506}, author = {Gál, Eleonóra and Menyhárt, I and Veréb, Z and Kemény, L and Tiszlavicz, L and Czakó, László and Takács, Tamás and Hegyi, P and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34053506}, year = {2023}, eissn = {2415-9107}, pages = {79-79}, orcid-numbers = {Czakó, László/0000-0002-6331-0802; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:33864451, title = {Detailed characteristics of post-discharge mortality in acute pancreatitis}, url = {https://m2.mtmt.hu/api/publication/33864451}, author = {Turcsiné Czapári, Dóra and Váradi, Alex and Borbásné Farkas, Kornélia and Nyári, Gergely Róbert and Márta, Katalin and Váncsa, Szilárd and Nagy, Rita and Teutsch, Brigitta and Bunduc, Stefania and Erőss, Bálint Mihály and Czakó, László and Vincze, Áron and Izbéki, Ferenc and Papp, Mária and Merkely, Béla Péter and Szentesi, Andrea Ildikó and Hegyi, Péter}, doi = {10.1053/j.gastro.2023.05.028}, journal-iso = {GASTROENTEROLOGY}, journal = {GASTROENTEROLOGY}, volume = {165}, unique-id = {33864451}, issn = {0016-5085}, abstract = {The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95-98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality.2,613, well-characterized patients from twenty-five centers were collected and followed by the Hungarian Pancreatic Study Group between 2012 and 2021. A general and a hospital-based population was used as the control group.After an AP episode patients have an approximately three-fold higher incidence rate of mortality than the general population (0.0404vs.0.0130 person-years). First-year mortality after discharge was almost double than in-hospital mortality (5.5%vs.3.5%), with 3.0% occurring in the first 90-day period. Age, comorbidities, and severity were the most significant independent risk factors for death following AP. Furthermore, multivariate analysis identified creatinine, glucose, and pleural fluid on admission as independent risk factors associated with post-discharge mortality. In the first 90-day period, cardiac failure and AP-related sepsis were among the main causes of death following discharge, while cancer-related cachexia and non-AP-related infection were the key causes in the later phase.Almost as many patients in our cohort die in the first 90-day period after discharge as during their hospital stay. Evaluation of cardiovascular status, follow-up of local complications, and cachexia-preventing oncological care should be an essential part of post-AP patient care. Future study protocols in AP must include at least a 90-day follow-up period after discharge.}, year = {2023}, eissn = {1528-0012}, pages = {682-695}, orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Márta, Katalin/0000-0002-2213-4865; Váncsa, Szilárd/0000-0002-9347-8163; Nagy, Rita/0000-0002-2663-4912; Teutsch, Brigitta/0000-0002-9530-7886; Erőss, Bálint Mihály/0000-0003-3658-8427; Czakó, László/0000-0002-6331-0802; Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Merkely, Béla Péter/0000-0001-6514-0723; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Imrei, Marcell/0000-0003-0175-7462; Németh, Balázs/0000-0001-5338-7577; Tiszlavicz, László/0000-0003-1134-6587; Oláh, Orsolya/0000-0002-5731-4030; Vitális, Zsuzsanna/0000-0001-8198-5312; Doros, Attila/0000-0002-6496-9895} } @article{MTMT:33761635, title = {Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry}, url = {https://m2.mtmt.hu/api/publication/33761635}, author = {Váncsa, Szilárd and Sipos, Zoltán and Váradi, Alex and Nagy, Rita and Ocskay, Klementina and Juhász, Márk Félix and Márta, Katalin and Teutsch, Brigitta and Mikó, Alexandra and Hegyi, Péter Jenő and Vincze, Áron and Izbéki, Ferenc and Czakó, László and Papp, Mária and Hamvas, József and Varga, Márta and Török, Imola and Mickevicius, Artautas and Erőss, Bálint Mihály and Párniczky, Andrea and Szentesi, Andrea Ildikó and Pár, Gabriella and Hegyi, Péter}, doi = {10.1002/ueg2.12389}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {33761635}, issn = {2050-6406}, abstract = {Non-alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic-associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP.We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in-hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis.MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate-to-severe AP (OR = 1.43, CI: 1.09-1.89). However, the odds of in-hospital mortality (OR = 0.89, CI: 0.42-1.89) and severe AP (OR = 1.70, CI: 0.97-3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39-5.09). In addition, the presence of one, two, and three diagnostic criteria dose-dependently increased the odds of moderate-to-severe AP (OR = 1.23, CI: 0.88-1.70, OR = 1.38, CI: 0.93-2.04, and OR = 3.04, CI: 1.63-5.70, respectively) and severe AP (OR = 1.13, CI: 0.54-2.27, OR = 2.08, CI: 0.97-4.35, and OR = 4.76, CI: 1.50-15.4, respectively). Furthermore, in patients with alcohol abuse and aged ≥60 years, the effect of MAFLD became insignificant.MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose-dependent effect on the outcomes of AP.}, keywords = {MORTALITY; Prognosis; metabolic syndrome; SEVERITY; Acute pancreatitis; STEATOSIS; Non-Alcoholic Fatty Liver Disease; NAFLD; MAFLD; Metabolic-associated fatty liver disease}, year = {2023}, eissn = {2050-6414}, pages = {371-382}, orcid-numbers = {Váncsa, Szilárd/0000-0002-9347-8163; Sipos, Zoltán/0000-0001-7845-8116; Váradi, Alex/0000-0001-8229-6340; Nagy, Rita/0000-0002-2663-4912; Ocskay, Klementina/0000-0001-5848-2506; Márta, Katalin/0000-0002-2213-4865; Teutsch, Brigitta/0000-0002-9530-7886; Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Czakó, László/0000-0002-6331-0802; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Imrei, Marcell/0000-0003-0175-7462; Németh, Balázs/0000-0001-5338-7577; Maurovich-Horvat, Pál/0000-0003-0885-736X; Doros, Attila/0000-0002-6496-9895; Zubek, László/0000-0003-0583-3290; Gál, János/0000-0001-9160-6478; Tari, Edina/0000-0002-8540-0614} } @article{MTMT:34014741, title = {Az antibakteriális oldattal történő szájöblítés hatása a post-ERCP-s cholangitis kialakulására}, url = {https://m2.mtmt.hu/api/publication/34014741}, author = {Szabó, Á. and Feró, E. and Gyömbér, E. and Göncz, M. and Soós, E. and Czakó, László and Takács, Tamás and Bor, Renáta and Szepes, Zoltán}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {34014741}, year = {2022}, eissn = {2415-9107}, pages = {101-101}, orcid-numbers = {Czakó, László/0000-0002-6331-0802; Bor, Renáta/0000-0001-9393-5240; Szepes, Zoltán/0000-0002-9466-8719} } @article{MTMT:34013125, title = {Endoscopic papillectomy for ampullary adenoma: are we good enough?}, url = {https://m2.mtmt.hu/api/publication/34013125}, author = {Gieszinger, G. and Tajti, M. and Karamya, Zain Alabedeen and Szepes, Zoltán and Takács, Tamás and Kui, Balázs and Illés, Dóra and Ivány, Emese and Czakó, László}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {34013125}, year = {2022}, eissn = {2415-9107}, pages = {78-78}, orcid-numbers = {Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802} } @article{MTMT:32991767, title = {Mutations in the 5’ upstream region of chymotrypsinogen C gene are not associated with chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/32991767}, author = {Németh, Balázs and Madarász, R and Nagy, A and Sándor, M and Stefanovics, R and Karamya, Z and Takács, Tamás and Farkas, G and Izbéki, F and Czakó, László and Szmola, R and Gervain, J and Gódi, S and Szentesi, A and Szücs, Á and Sahin-Tóth, M and Hegyi, P}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {32991767}, year = {2022}, eissn = {2415-9107}, pages = {93-94}, orcid-numbers = {Németh, Balázs/0000-0001-5338-7577; Czakó, László/0000-0002-6331-0802} } @article{MTMT:32991670, title = {A TRPV6 gén mutációinak szerepe krónikus hasnyálmirigy-gyulladásban}, url = {https://m2.mtmt.hu/api/publication/32991670}, author = {Pesei, Z and Hegede, R and Németh, Balázs and Takács, Tamás and Szentesi, A and Farkas, G and Czakó, László and Hegyi, P and Hegyi, E}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {32991670}, year = {2022}, eissn = {2415-9107}, pages = {98}, orcid-numbers = {Németh, Balázs/0000-0001-5338-7577; Czakó, László/0000-0002-6331-0802} } @article{MTMT:32843481, title = {The effect of bile on pancreatic cancer, the importance of mucins}, url = {https://m2.mtmt.hu/api/publication/32843481}, author = {Gál, Eleonóra and Veréb, Zoltán and Rakk, Dávid and Szekeres, András and Becskeházi, Eszter and Tiszlavicz, László and Czakó, László and Takács, Tamás and Hegyi, P and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {32843481}, year = {2022}, eissn = {2415-9107}, pages = {77-77}, orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155; Szekeres, András/0000-0003-1651-4623; Tiszlavicz, László/0000-0003-1134-6587; Czakó, László/0000-0002-6331-0802; Venglovecz, Viktória/0000-0002-2316-7247} }