@article{MTMT:34558800,
	title = {The oral microbiome of a family including Papillon-Lefèvre-syndrome patients and clinically healthy members},
	url = {https://m2.mtmt.hu/api/publication/34558800},
	author = {Vályi, Péter and Wirth, Roland and Minárovits, János and Strang, Orsolya and Maróti, Gergely and Kovács, Kornél Lajos},
	doi = {10.1186/s12903-024-03856-z},
	journal-iso = {BMC ORAL HEALTH},
	journal = {BMC ORAL HEALTH},
	volume = {24},
	unique-id = {34558800},
	issn = {1472-6831},
	abstract = {The oral microbiota composition of patients diagnosed with Papillon-Lefèvre-syndrome and treated for several years were compared to those existing in the oral cavity of the clinically healthy family members and a cohort of patients having various stages of chronic periodontitis.},
	year = {2024},
	eissn = {1472-6831},
	orcid-numbers = {Vályi, Péter/0000-0002-9594-2038; Wirth, Roland/0000-0002-2383-2323; Strang, Orsolya/0000-0002-0259-9091; Maróti, Gergely/0000-0002-3705-0461; Kovács, Kornél Lajos/0000-0002-3926-0497}
}

@article{MTMT:34860295,
	title = {Human tumor viruses: induction of three-dimensional alterations in the host genome structure},
	url = {https://m2.mtmt.hu/api/publication/34860295},
	author = {Minárovits, János},
	doi = {10.3389/fmicb.2023.1280210},
	journal-iso = {FRONT MICROBIOL},
	journal = {FRONTIERS IN MICROBIOLOGY},
	volume = {14},
	unique-id = {34860295},
	issn = {1664-302X},
	abstract = {Certain viruses called tumor viruses or oncoviruses are capable to change the gene expression pattern of distinct human or animal cell types in tissue culture, resulting in uncontrolled proliferation as well as a change in the social behavior of the infected cells: the oncovirus-transformed, immortalized cells are capable to form malignant neoplasms in suitable animal models. At present, seven human viruses are categorized as causative agents of distinct human malignancies. The genomes of human tumor viruses, typically encode viral oncoproteins and non- translated viral RNAs that affect the gene expression pattern of their target cells or induce genetic and epigenetic alterations contributing to oncogenesis. Recently, the application of chromatin conformation capture technologies and three-dimensional (3D) molecular imaging techniques revealed how the gene products or genomes of certain human tumor viruses interact with and induce alterations in the 3D host genome structure. This Mini Review aims to cover selected aspects of these developments. The papers, discussed briefly, describe how insertion of a novel viral binding site for the 3D genome organizer cellular protein CCCTC-binding factor (CTCF) into the DNA of T cells infected by human T-cell lymphotropic virus type 1 (HTLV-1) may contribute to lymphomagenesis, as well as how integration of high risk human papillomavirus genome into the host cell DNA may facilitate cervical carcinogenesis. Recent results regarding the interactions of cellular genomes with the episomal, chromatinized DNA genomes of oncogenic human herpesvirus, Epstein-Barr virus (EBV) will also be summarized, similarly to available data regarding contacts formed by episomal or integrated hepatitis B virus (HBV) DNA with host chromatin. Finally, a putative mechanism of hepatitis C virus (HCV) induced chromatin alterations will be presented, which may solve the riddle, how a cytoplasmic RNA virus without a viral oncogene could induce malingnant transfrormation of hepatocytes.},
	keywords = {MECHANISMS; TRANSFORMATION; PRINCIPLES; Oncogene; tumor virus; Chromatin loop; host cell genome; viral episome},
	year = {2023},
	eissn = {1664-302X}
}

@article{MTMT:34127552,
	title = {Interaction of biomolecules with anatase, rutile and amorphous TiO2 surfaces: A molecular dynamics study},
	url = {https://m2.mtmt.hu/api/publication/34127552},
	author = {Tarjányi, Tamás and Bogár, Ferenc and Minárovits, János and Gajdács, Márió and Tóth, Zsolt},
	doi = {10.1371/journal.pone.0289467},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {18},
	unique-id = {34127552},
	issn = {1932-6203},
	abstract = {The adhesion of biomolecules to dental and orthopedic implants is a fundamental step in the process of osseointegration. Short peptide motifs, such as RGD or KRSR, carried by extracellular matrix proteins or coated onto implant surfaces, accelerate cell adhesion and tissue formation. For this reason, understanding the binding mechanisms of adhesive peptides to oxidized surfaces of titanium implants is of paramount importance. We performed molecular dynamics simulations to compare the adhesion properties of 6 peptides, including the tripeptide RGD, its variants KGD and LGD, as well as the tetrapeptide KRSR, its variant LRSR and its truncated version RSR, on anatase, rutile, and amorphous titanium dioxide (TiO 2 ) surfaces. The migration of these molecules from the water phase to the surface was simulated in an aqueous environment. Based on these simulations, we calculated the residence time of each peptide bound to the three different TiO 2 structures. It was found that the presence of an N-terminal lysine or arginine amino acid residue resulted in more efficient surface binding. A pulling simulation was performed to detach the adhered molecules. The maximum pulling force and the binding energy were determined from the results of these simulations. The tri- and tetrapeptides had slightly greater adhesion affinity to the amorphous and anatase structure than to rutile in general, however specific surface and peptide binding characters could be detected. The binding energies obtained from our simulations allowed us to rank the adhesion strengths of the studied peptides.},
	year = {2023},
	eissn = {1932-6203},
	orcid-numbers = {Tarjányi, Tamás/0000-0002-9481-5977; Bogár, Ferenc/0000-0002-0611-1452; Gajdács, Márió/0000-0003-1270-0365}
}

@{MTMT:33562016,
	title = {Daganatvírusok},
	url = {https://m2.mtmt.hu/api/publication/33562016},
	author = {Minárovits, János},
	booktitle = {Orvosi virológia},
	unique-id = {33562016},
	year = {2022},
	pages = {502-506}
}

@CONFERENCE{MTMT:33162598,
	title = {Átvitt HIV gyógyszer-rezisztencia jelentősége a klinikai gyakorlatban},
	url = {https://m2.mtmt.hu/api/publication/33162598},
	author = {Áy, Éva and Adravecz, Lilla and Pocskay, Ágnes and Müller, Viktor and Lakatos, Botond and Szlávik, János and Pék, Tamás and Marschalkó, Márta and Tóth, Béla and Kárpáti, Sarolta and Mezei, Mária and Minárovits, János},
	booktitle = {Magyar Infektológiai és Klinikai Mikrobiológiai Társaság 49. Kongresszusa},
	unique-id = {33162598},
	year = {2022},
	pages = {62-62},
	orcid-numbers = {Pék, Tamás/0000-0001-5189-8656; Kárpáti, Sarolta/0000-0002-8472-0712}
}

@CONFERENCE{MTMT:33118459,
	title = {Osszeointegráció molekuláris megközelítésben: kristályos és amorf titán-oxid felületekkel kölcsönható biomolekulák},
	url = {https://m2.mtmt.hu/api/publication/33118459},
	author = {Tarjányi, Tamás and Bogár, Ferenc and Gajdács, Márió and Minárovits, János and Tóth, Zsolt},
	booktitle = {Szegedi Fogorvosnapok 2022. Szegedi Fogorvos Találkozó és Tudományos Konferencia, Magyar Gyermekfogászati és Fogszabályozási Társaság IX. Tóth Pál Vándorgyűlés},
	unique-id = {33118459},
	year = {2022},
	pages = {25-25},
	orcid-numbers = {Tarjányi, Tamás/0000-0002-9481-5977; Bogár, Ferenc/0000-0002-0611-1452; Gajdács, Márió/0000-0003-1270-0365}
}

@{MTMT:33094830,
	title = {Coronaviridae},
	url = {https://m2.mtmt.hu/api/publication/33094830},
	author = {Takács, Mária and Minárovits, János},
	booktitle = {Orvosi virológia},
	unique-id = {33094830},
	year = {2022},
	pages = {154-162}
}

@article{MTMT:32788115,
	title = {Megemlékezés Földes István mikrobiológus, az orvostudomány doktora születésének centenáriumán = A Tribute to István Földes, DSc, Microbiologist on the Centenary of his Birth},
	url = {https://m2.mtmt.hu/api/publication/32788115},
	author = {Minárovits, János},
	doi = {10.1556/2065.183.2022.2.12},
	journal-iso = {MAGYAR TUDOMÁNY},
	journal = {MAGYAR TUDOMÁNY},
	volume = {183},
	unique-id = {32788115},
	issn = {0025-0325},
	year = {2022},
	eissn = {1588-1245},
	pages = {247-249}
}

@article{MTMT:32581214,
	title = {Integrative profiling of Epstein–Barr virus transcriptome using a multiplatform approach},
	url = {https://m2.mtmt.hu/api/publication/32581214},
	author = {Fülöp, Ádám and Torma, Gábor and Moldován, Norbert and Szenthe, Kálmán and Bánáti, Ferenc and Almsarrhad, Islam and Csabai, Zsolt and Tombácz, Dóra and Minárovits, János and Boldogkői, Zsolt},
	doi = {10.1186/s12985-021-01734-6},
	journal-iso = {VIROL J},
	journal = {VIROLOGY JOURNAL},
	volume = {19},
	unique-id = {32581214},
	issn = {1743-422X},
	abstract = {Background Epstein-Barr virus (EBV) is an important human pathogenic gammaherpesvirus with carcinogenic potential. The EBV transcriptome has previously been analyzed using both Illumina-based short read-sequencing and Pacific Biosciences RS II-based long-read sequencing technologies. Since the various sequencing methods have distinct strengths and limitations, the use of multiplatform approaches have proven to be valuable. The aim of this study is to provide a more complete picture on the transcriptomic architecture of EBV. Methods In this work, we apply the Oxford Nanopore Technologies MinION (long-read sequencing) platform for the generation of novel transcriptomic data, and integrate these with other's data generated by another LRS approach, Pacific BioSciences RSII sequencing and Illumina CAGE-Seq and Poly(A)-Seq approaches. Both amplified and non-amplified cDNA sequencings were applied for the generation of sequencing reads, including both oligo-d(T) and random oligonucleotide-primed reverse transcription. EBV transcripts are identified and annotated using the LoRTIA software suite developed in our laboratory. Results This study detected novel genes embedded into longer host genes containing 5 '-truncated in-frame open reading frames, which potentially encode N-terminally truncated proteins. We also detected a number of novel non-coding RNAs and transcript length isoforms encoded by the same genes but differing in their start and/or end sites. This study also reports the discovery of novel splice isoforms, many of which may represent altered coding potential, and of novel replication-origin-associated transcripts. Additionally, novel mono- and multigenic transcripts were identified. An intricate meshwork of transcriptional overlaps was revealed. Conclusions An integrative approach applying multi-technique sequencing technologies is suitable for reliable identification of complex transcriptomes because each techniques has different advantages and limitations, and the they can be used for the validation of the results obtained by a particular approach.},
	keywords = {EPSTEIN-BARR VIRUS; Transcriptome; SPLICE VARIANT; Herpesvirus; transcription start site; Long-read sequencing; nanopore sequencing; PacBio sequencing; transcript isoform; Transcription end site},
	year = {2022},
	eissn = {1743-422X},
	orcid-numbers = {Torma, Gábor/0000-0003-3241-0955; Moldován, Norbert/0000-0003-4138-586X; Bánáti, Ferenc/0000-0002-8999-523X; Csabai, Zsolt/0000-0003-0031-0116; Tombácz, Dóra/0000-0001-5520-2978; Boldogkői, Zsolt/0000-0003-1184-7293}
}

@article{MTMT:32020395,
	title = {Microbiomes in supragingival biofilms and saliva of adolescents with gingivitis and gingival health},
	url = {https://m2.mtmt.hu/api/publication/32020395},
	author = {Wirth, Roland and Maróti, Gergely and Lipták, Lídia and Mester, Mónika Klára and Al Ayoubi, Alaa and Pap, Bernadett and Madléna, Melinda and Minárovits, János and Kovács, Kornél Lajos},
	doi = {10.1111/odi.13883},
	journal-iso = {ORAL DIS},
	journal = {ORAL DISEASES},
	volume = {28},
	unique-id = {32020395},
	issn = {1354-523X},
	abstract = {Background Important alterations exist in the microbiomes of supragingival biofilm and saliva samples from adolescent patients developing induced or spontaneous gingivitis relative to healthy controls. These and the relationships to dental health are not fully understood yet. Subjects and Methods Supragingival biofilm samples (n = 36) were collected from the teeth of 9 adolescents with gingivitis induced by orthodontic appliances, as well as dental plaques (n = 40) from 10 adolescents with spontaneous gingivitis, in addition to similar samples (n = 36) from 9 healthy controls. The bacterial metagenomes were analyzed by 16S rRNA gene amplicon sequencing. Salivary microbiomes of the same persons were characterized by shotgun metagenome sequencing. The data sets were examined using advanced bioinformatics workflows and two reference databases. Results The composition and diversity of bacterial communities did not differ extensively among the three study groups. Nevertheless, the relative abundances of the genera Fusobacterium, Akkermansia, Treponema, and Campylobacter were prominently higher in gingivitis patients versus controls. In contrast, the genera Lautropia, Kingella, Neisseria, Actinomyces, and Rothia were significantly more abundant in controls than in either of the two gingivitis groups. Conclusions The abundance pattern of certain taxa rather than individual strains shows characteristic features of potential diagnostic value. Stringent bioinformatics treatment of the sequencing data is mandatory to avoid unintentional misinterpretations.},
	year = {2022},
	eissn = {1601-0825},
	pages = {2000-2014},
	orcid-numbers = {Wirth, Roland/0000-0002-2383-2323; Maróti, Gergely/0000-0002-3705-0461; Madléna, Melinda/0000-0002-2154-3069; Kovács, Kornél Lajos/0000-0002-3926-0497}
}