@article{MTMT:34729573,
	title = {Automated high-throughput cell culture scratch assay identifies wound healing promoting and inhibiting compounds from a small compound library of redox active molecules},
	url = {https://m2.mtmt.hu/api/publication/34729573},
	author = {Virág, László and Hegedűs, Csaba and Kovács, Katalin and Polgár, Zsuzsanna and Kókai, Endre and Sturniolo, Isotta and Demény, Máté Ágoston and Virág, Bernadett and Szabó, Éva},
	doi = {10.1016/j.freeradbiomed.2023.10.328},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {208},
	unique-id = {34729573},
	issn = {0891-5849},
	year = {2023},
	eissn = {1873-4596},
	pages = {S144-S144}
}

@article{MTMT:34089348,
	title = {Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition},
	url = {https://m2.mtmt.hu/api/publication/34089348},
	author = {Ujlaki, Gyula and Kovács, Tünde and Vida, András and Kókai, Endre and Rauch, Boglárka and Schwarcz, Szandra and Mikó, Edit and Janka, Eszter and Sipos, Adrienn and Hegedűs, Csaba and Uray (Davis), Karen L. and Nagy, Péter and Bay, Péter},
	doi = {10.3390/molecules28155898},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34089348},
	issn = {1420-3049},
	abstract = {Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including the gut microbiome. Oncobiotic transformation of the gut microbiome impairs the production of antineoplastic bacterial metabolites. The goal of this study was to identify bacterial metabolites with antineoplastic properties. We constructed a 30-member bacterial metabolite library and screened the library compounds for effects on cell proliferation and epithelial-mesenchymal transition. The metabolites were applied to 4T1 murine breast cancer cells in concentrations corresponding to the reference serum concentrations. However, yric acid, glycolic acid, d-mannitol, 2,3-butanediol, and trans-ferulic acid exerted cytostatic effects, and 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, and vanillic acid exerted hyperproliferative effects. Furthermore, 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, 2,3-butanediol, and hydrocinnamic acid inhibited epithelial-to-mesenchymal (EMT) transition. We identified redox sets among the metabolites (d-mannitol—d-mannose, 1-butanol—butyric acid, ethylene glycol—glycolic acid—oxalic acid), wherein only one partner within the set (d-mannitol, butyric acid, glycolic acid) possessed bioactivity in our system, suggesting that changes to the local redox potential may affect the bacterial secretome. Of the nine bioactive metabolites, 2,3-butanediol was the only compound with both cytostatic and anti-EMT properties.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Janka, Eszter/0000-0003-0724-5281; Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:34082035,
	title = {Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7},
	url = {https://m2.mtmt.hu/api/publication/34082035},
	author = {Ráduly, Zsolt and Szabó, László and Dienes, Beatrix and Szentesi, Péter and Bana, Ágnes Viktória and Hajdú, Tibor and Kókai, Endre and Hegedűs, Csaba and Csernoch, László and Gönczi, Mónika},
	doi = {10.3390/cells12141825},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {12},
	unique-id = {34082035},
	abstract = {Septin7 as a unique member of the GTP binding protein family, is widely expressed in the eukaryotic cells and considered to be essential in the formation of hetero-oligomeric septin complexes. As a cytoskeletal component, Septin7 is involved in many important cellular processes. However, its contribution in striated muscle physiology is poorly described. In skeletal muscle, a highly orchestrated process of migration is crucial in the development of functional fibers and in regeneration. Here, we describe the pronounced appearance of Septin7 filaments and a continuous change of Septin7 protein architecture during the migration of myogenic cells. In Septin7 knockdown C2C12 cultures, the basic parameters of migration are significantly different, and the intracellular calcium concentration change in migrating cells are lower compared to that of scrambled cultures. Using a plant cytokinin, forchlorfenuron, to dampen septin dynamics, the altered behavior of the migrating cells is described, where Septin7-depleted cells are more resistant to the treatment. These results indicate the functional relevance of Septin7 in the migration of myoblasts, implying its contribution to muscle myogenesis and regeneration.},
	keywords = {INTRACELLULAR CALCIUM; regeneration; CYTOSKELETON; myogenesis; migration; septin7; forchlorfenuron (FCF)},
	year = {2023},
	eissn = {2073-4409},
	orcid-numbers = {Szentesi, Péter/0000-0003-2621-2282; Bana, Ágnes Viktória/0009-0001-6940-1692}
}

@article{MTMT:34020857,
	title = {Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages},
	url = {https://m2.mtmt.hu/api/publication/34020857},
	author = {Skopál, Adrienn and Ujlaki, Gyula and Gerencsér, Attila Tibor and Bankó, Csaba and Bacsó, Zsolt and Ciruela, Francisco and Virág, László and Haskó, György and Kókai, Endre},
	doi = {10.3390/cimb45060315},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {45},
	unique-id = {34020857},
	issn = {1467-3037},
	abstract = {Adenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann–Pick type C intracellular cholesterol transporter 1 (NPC1) protein. The NPC1 protein was identified to interact with the C-terminal tail of A2AR in RAW 264.7 and IPMФ cells by two independent and parallel proteomic approaches. The interaction between the NPC1 protein and the full-length A2AR was further validated in HEK-293 cells that permanently express the receptor and RAW264.7 cells that endogenously express A2AR. A2AR activation reduces the expression of NPC1 mRNA and protein density in LPS-activated mouse IPMФ cells. Additionally, stimulation of A2AR negatively regulates the cell surface expression of NPC1 in LPS-stimulated macrophages. Furthermore, stimulation of A2AR also altered the density of lysosome-associated membrane protein 2 (LAMP2) and early endosome antigen 1 (EEA1), two endosomal markers associated with the NPC1 protein. Collectively, these results suggested a putative A2AR-mediated regulation of NPC1 protein function in macrophages, potentially relevant for the Niemann–Pick type C disease when mutations in NPC1 protein result in the accumulation of cholesterol and other lipids in lysosomes.},
	year = {2023},
	eissn = {1467-3045},
	pages = {4948-4969},
	orcid-numbers = {Bacsó, Zsolt/0000-0001-6885-3796; Ciruela, Francisco/0000-0003-0832-3739}
}

@misc{MTMT:33806508,
	title = {Optimization of tumor cell killing by chimeric antigen receptor expressing macrophages},
	url = {https://m2.mtmt.hu/api/publication/33806508},
	author = {Gerencsér, A and Tóth, PÁ and Vígh, D and Kókai, Endre and Virág, László},
	unique-id = {33806508},
	year = {2023}
}

@article{MTMT:32799560,
	title = {Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signalling},
	url = {https://m2.mtmt.hu/api/publication/32799560},
	author = {Skopál, Adrienn and Kéki, T and Tóth, PÁ and Csóka, B and Koscsó, B and Német, ZH and Antonioli, L and Ivessa, A and Ciruela, F and Virág, László and Haskó, György and Kókai, Endre},
	doi = {10.1016/j.jbc.2022.101888},
	journal-iso = {J BIOL CHEM},
	journal = {JOURNAL OF BIOLOGICAL CHEMISTRY},
	volume = {298},
	unique-id = {32799560},
	issn = {0021-9258},
	year = {2022},
	eissn = {1083-351X}
}

@article{MTMT:31334758,
	title = {The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells},
	url = {https://m2.mtmt.hu/api/publication/31334758},
	author = {Mészáros, Beáta and Papp, Ferenc and Mocsár, Gábor and Kókai, Endre and Kovács, Katalin and Tajti, Gábor and Panyi, György},
	doi = {10.1038/s41598-020-63517-3},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {10},
	unique-id = {31334758},
	issn = {2045-2322},
	year = {2020},
	eissn = {2045-2322},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@CONFERENCE{MTMT:30477500,
	title = {PP2A szerepe a SOX9/CREB trnszkriciós faktorok és a RHAMM/CD44 interakciók szabályzásában humán melanoma sejtvonalakban},
	url = {https://m2.mtmt.hu/api/publication/30477500},
	author = {Katona, Éva and Juhász, Tamás and Hajdú, Tibor and Nagy, Gábor and Kókai, Endre and Trencsényi, György and Gergely, Pál and Zákány, Róza},
	booktitle = {48. Membrán-Transzport Konferencia},
	unique-id = {30477500},
	year = {2018},
	pages = {32},
	orcid-numbers = {Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:3406102,
	title = {Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae},
	url = {https://m2.mtmt.hu/api/publication/3406102},
	author = {Hegedüs, Éva and Kókai, Endre and Nánási, Péter Pál and Imre, László and Halász, László and Jossé, R and Antunovics, Zsuzsa and Webb, MR and Hage, AE and Pommier, Y and Székvölgyi, Lóránt and Dombrádi, Viktor Béla and Szabó, Gábor},
	doi = {10.1093/nar/gky743},
	journal-iso = {NUCLEIC ACIDS RES},
	journal = {NUCLEIC ACIDS RESEARCH},
	volume = {46},
	unique-id = {3406102},
	issn = {0305-1048},
	year = {2018},
	eissn = {1362-4962},
	pages = {10649-10668},
	orcid-numbers = {Halász, László/0000-0003-4726-7012}
}

@article{MTMT:3247963,
	title = {A2A adenosine receptors control pancreatic dysfunction in high-fat-diet induced obesity},
	url = {https://m2.mtmt.hu/api/publication/3247963},
	author = {Csóka, B and Törő, G and Vindeirinho, J and Varga, Zoltán and Koscsó, B and Németh, ZH and Kókai, Endre and Antonioli, L and Suleiman, M and Marchetti, P and Cseri, Karolina and Deák, Ádám and Virág, László and Pacher, Pál and Bay, Péter and Haskó, György},
	doi = {10.1096/fj.201700398R},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {31},
	unique-id = {3247963},
	issn = {0892-6638},
	keywords = {Animals; MICE; Mice, Knockout; Gene Expression Regulation/drug effects; Antigens, Differentiation/biosynthesis/genetics; Dietary Fats/*adverse effects/pharmacology; Receptor, Adenosine A2A/genetics/*metabolism; Pancreatic Diseases/chemically induced/genetics/*metabolism/pathology; Obesity/chemically induced/genetics/*metabolism/pathology; Insulin-Secreting Cells/*metabolism/pathology},
	year = {2017},
	eissn = {1530-6860},
	pages = {4985-4997},
	orcid-numbers = {Varga, Zoltán/0000-0002-2758-0784; Pacher, Pál/0000-0001-7036-8108}
}