@article{MTMT:34857077,
	title = {Weight loss treatment for COVID-19 in patients with NCDs. a pilot prospective clinical trial.},
	url = {https://m2.mtmt.hu/api/publication/34857077},
	author = {Oshakbayev, Kuat and Durmanova, Aigul and Zhankalova, Zulfiya and Idrisov, Alisher and Bedelbayeva, Gulnara and Gazaliyeva, Meruyert and Nabiyev, Altay and Tordai, Attila and Dukenbayeva, Bibazhar},
	doi = {10.1038/s41598-024-61703-1},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34857077},
	issn = {2045-2322},
	abstract = {COVID-19 comorbid with noncommunicable chronic diseases (NCDs) complicates the diagnosis, treatment, and prognosis, and increases the mortality rate. The aim is to evaluate the effects of a restricted diet on clinical/laboratory inflammation and metabolic profile, reactive oxygen species (ROS), and body composition in patients with COVID-19 comorbid with NCDs. We conducted a 6-week open, pilot prospective controlled clinical trial. The study included 70 adult patients with COVID-19 comorbid with type 2 diabetes (T2D), hypertension, or nonalcoholic steatohepatitis (NASH).a restricted diet including calorie restriction, hot water drinking, walking, and sexual self-restraint.COVID-19 diagnosis by detecting SARS-CoV-2 genome by RT-PCR; weight loss in Main group; body temperature; C-reactive protein. Secondary endpoints: the number of white blood cells; erythrocyte sedimentation rate; adverse effects during treatment; fasting blood glucose, glycosylated hemoglobin A1c (HbA1c), systolic/diastolic blood pressure (BP); blood lipids; ALT/AST, chest CT-scan. In Main group, patients with overweight lost weight from baseline (- 12.4%; P < 0.0001); 2.9% in Main group and 7.2% in Controls were positive for COVID-19 (RR: 0.41, CI: 0.04-4.31; P = 0.22) on the 14th day of treatment. Body temperature and C-reactive protein decreased significantly in Main group compared to Controls on day 14th of treatment (P < 0.025). Systolic/diastolic BP normalized (P < 0.025), glucose/lipids metabolism (P < 0.025); ALT/AST normalized (P < 0.025), platelets increased from baseline (P < 0.025), chest CT (P < 0.025) in Main group at 14 day of treatment. The previous antidiabetic, antihypertensive, anti-inflammatory, hepatoprotective, and other symptomatic medications were adequately decreased to completely stop during the weight loss treatment. Thus, the fast weight loss treatment may be beneficial for the COVID-19 patients with comorbid T2D, hypertension, and NASH over traditional medical treatment because, it improved clinical and laboratory/instrumental data on inflammation; glucose/lipid metabolism, systolic/diastolic BPs, and NASH biochemical outcomes, reactive oxygen species; and allowed patients to stop taking medications.ClinicalTrials.gov NCT05635539 (02/12/2022): https://clinicaltrials.gov/ct2/show/NCT05635539?term=NCT05635539&draw=2&rank=1 .},
	keywords = {HYPERTENSION; type 2 diabetes mellitus; RESTRICTED DIET; NASH; chest CT; COVID-19; Fast weight loss; Inflammation/glycemic/lipid profile; Lipid/protein oxidation},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Tordai, Attila/0000-0001-6966-1622}
}

@article{MTMT:34687517,
	title = {Microchimaerismus kimutatása nagy érzékenységű droplet digitális PCR technikával és szerepe a vérképzőőssejt-transzplantált betegek monitorozásában},
	url = {https://m2.mtmt.hu/api/publication/34687517},
	author = {Őrfi, Zoltán and Meggyesi, Nóra and Varga, Lívia and Bors, András and Gopcsa, László and Paksi, Melinda and Lakatos, Viktor and Kállay, Krisztián Miklós and Kriván, Gergely and Jónás, Alexa and Tordai, Attila and Vályi-Nagy, István and Reményi, Péter and Andrikovics, Hajnalka},
	doi = {10.1556/650.2024.32995},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34687517},
	issn = {0030-6002},
	keywords = {Autoimmune Diseases; Hematopoietic Stem Cell Transplantation; prenatal screening; CELL-FREE DNA; AUTOIMMUN BETEGSÉGEK; microchimerism; short tandem repeats; deletion insertion polymorphism; deletiós insertiós polimorfizmusok; haemopoeticusőssejt-transzplantáció; microchimaerismus; praenatalis szűrések; sejtmentes DNS; „short tandem repeats”},
	year = {2024},
	eissn = {1788-6120},
	pages = {297-308},
	orcid-numbers = {Kállay, Krisztián Miklós/0000-0002-4328-9612; Tordai, Attila/0000-0001-6966-1622; Reményi, Péter/0000-0003-3581-113X}
}

@article{MTMT:33731782,
	title = {Plasma membrane Ca2+ pump isoform 4 function in cell migration and cancer metastasis},
	url = {https://m2.mtmt.hu/api/publication/33731782},
	author = {Naffa, R. and Hegedűs, L. and Hegedűs, Tamás and Tóth, Sarolta and Papp, B. and Tordai, Attila and Enyedi, Ágnes},
	doi = {10.1113/JP284179},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {602},
	unique-id = {33731782},
	issn = {0022-3751},
	year = {2024},
	eissn = {1469-7793},
	pages = {1551-1564},
	orcid-numbers = {Hegedűs, Tamás/0000-0002-0331-9629; Tóth, Sarolta/0000-0002-0341-7675; Tordai, Attila/0000-0001-6966-1622; Enyedi, Ágnes/0000-0002-7366-9376}
}

@article{MTMT:34857190,
	title = {Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer.},
	url = {https://m2.mtmt.hu/api/publication/34857190},
	author = {Liedtke, Cornelia and Mazouni, Chafika and Hess, Kenneth R and André, Fabrice and Tordai, Attila and Mejia, Jaime A and Symmans, W Fraser and Gonzalez-Angulo, Ana M and Hennessy, Bryan and Green, Marjorie and Cristofanilli, Massimo and Hortobagyi, Gabriel N and Pusztai, Lajos},
	doi = {10.1200/JCO.22.02572},
	journal-iso = {J CLIN ONCOL},
	journal = {JOURNAL OF CLINICAL ONCOLOGY},
	volume = {41},
	unique-id = {34857190},
	issn = {0732-183X},
	abstract = {Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC.Analysis of a prospectively collected clinical database was performed. We included 1,118 patients who received neoadjuvant chemotherapy at M.D. Anderson Cancer Center for stage I-III breast cancer from 1985 to 2004 and for whom complete receptor information were available. Clinical and pathologic parameters, pathologic complete response rates (pCR), survival measurements, and organ-specific relapse rates were compared between patients with TNBC and non-TNBC.Two hundred fifty-five patients (23%) had TNBC. Patients with TNBC compared with non-TNBC had significantly higher pCR rates (22% v 11%; P = .034), but decreased 3-year progression-free survival rates (P < .0001) and 3-year overall survival (OS) rates (P < .0001). TNBC was associated with increased risk for visceral metastases (P = .0005), lower risk for bone recurrence (P = .027), and shorter postrecurrence survival (P < .0001). Recurrence and death rates were higher for TNBC only in the first 3 years. If pCR was achieved, patients with TNBC and non-TNBC had similar survival (P = .24). In contrast, patients with residual disease (RD) had worse OS if they had TNBC compared with non-TNBC (P < .0001).Patients with TNBC have increased pCR rates compared with non-TNBC, and those with pCR have excellent survival. However, patients with RD after neoadjuvant chemotherapy have significantly worse survival if they have TNBC compared with non-TNBC, particularly in the first 3 years.},
	year = {2023},
	eissn = {1527-7755},
	pages = {1809-1815},
	orcid-numbers = {Tordai, Attila/0000-0001-6966-1622}
}

@{MTMT:34043436,
	title = {Örökletes genetikai eltérések diagnosztikája az orvosi gyakorlatban},
	url = {https://m2.mtmt.hu/api/publication/34043436},
	author = {Andrikovics, Hajnalka and Csabán, Dóra and Tordai, Attila and Őrfi, Zoltán},
	booktitle = {Orvosi biotechnológia},
	unique-id = {34043436},
	year = {2022},
	pages = {99},
	orcid-numbers = {Csabán, Dóra/0000-0003-4602-6639; Tordai, Attila/0000-0001-6966-1622; Őrfi, Zoltán/0000-0001-6099-2206}
}

@article{MTMT:33261135,
	title = {SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa},
	url = {https://m2.mtmt.hu/api/publication/33261135},
	author = {Tarcsai, Katalin Réka and Corolciuc, Oliga and Tordai, Attila and Ongrádi, József},
	doi = {10.1007/s11357-022-00603-6},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {44},
	unique-id = {33261135},
	issn = {2509-2715},
	abstract = {A new variant of SARS-CoV-2 named Omicron (B.1.1.529) was isolated from an HIV-infected patient in Botswana, South Africa, in November 2021. Whole genome sequencing revealed a multitude of mutations and its relationship to the mutation-rich Alpha variant that had been isolated from a cancer patient. It is conceivable that very high prevalence of HIV-infected individuals as susceptible hosts in South Africa and their immunocompromised state may predispose for accumulation of coronavirus mutations. Coronaviruses uniquely code for an N-terminal 3′ to 5′exonuclease (ExoN, nsp14) that removes mismatched nucleotides paired by the RNA dependent RNA polymerase. Its activity depends preferably on Mg2+ and other divalent cations (manganese, cobalt and zinc). On the contrary, methyl transferase activity of non-structural protein (nsp) 14 and nsp16 both complexed with nsp10 requires Mn2+. Enzymes in successive stages of HIV infections require the same cations. In HIV-infected organisms, a subsequent coronavirus infection encounters with altered homeostasis of the body including relative starvation of divalent cations induced by interleukin production of HIV-infected cells. It is hypothesized that selective diminished efficacy of ExoN in the absence of sufficient amount of magnesium may result in the accumulation of mutations. Unusual mutations and recombinations of heterologous viruses detected in AIDS patients also suggest that long-lasting persistence of superinfecting viruses may also contribute to the selection of genetic variants. Non-nucleoside reverse transcriptase inhibitors partially restore divalent cations’ equilibrium. As a practical approach, implementation of highly active antiretroviral therapy against HIV replication and vaccination against coronaviruses may be a successful strategy to reduce the risk of selection of similar mutants.},
	year = {2022},
	eissn = {2509-2723},
	pages = {2337-2345},
	orcid-numbers = {Tarcsai, Katalin Réka/0000-0001-6088-0116; Tordai, Attila/0000-0001-6966-1622; Ongrádi, József/0000-0001-8099-8656}
}

@article{MTMT:32837228,
	title = {The Correlation Between Platelet Count and Survival in Prostate Cancer},
	url = {https://m2.mtmt.hu/api/publication/32837228},
	author = {Mezei, Tünde and Bőde, Imre and Tenke, Péter and Jósa, Valéria and Merkel, Keresztély and Szilasi, Zsuzsanna and Tordai, Attila and Máthé, Domokos and Baranyai, Zsolt},
	doi = {10.2147/RRU.S359715},
	journal-iso = {RESEARCH AND REPORTS IN UROLOGY},
	journal = {RESEARCH AND REPORTS IN UROLOGY},
	volume = {14},
	unique-id = {32837228},
	issn = {2253-2447},
	abstract = {A number of studies have confirmed that elevated platelet count accompanying various solid tumours is associated with worse survival. However, only meagre data are available on the relationship between thrombocytosis and survival in prostate cancer.We conducted a retrospective analysis on clinical-pathological data accumulated from 316 patients during on average 51 months of follow-up after laparoscopic prostatectomy performed for prostate cancer. We analyzed the relationship between platelet count, risk factors, prostate-specific antigen (PSA) and cancer stage with use the Tumor, Node, Metastase system (TNM), as well as surgical margin, and prognosis.Thrombocytosis occurred in only one out of the 316 patients. The multivariate Cox proportional hazard model showed that preoperative PSA, risk group, preoperative haemoglobin level, and surgical margin status were significant, independent predictors of biochemical progression-free survival. By contrast, age at diagnosis and thrombocytosis had no such predictive value.We could not demonstrate an association between elevated platelet count and worse survival in our study population of patients with prostate cancer.},
	keywords = {Prognosis; solid tumor; thrombocytosis; Pathomechanism; Prostate cancer},
	year = {2022},
	pages = {193-202},
	orcid-numbers = {Tordai, Attila/0000-0001-6966-1622}
}

@article{MTMT:32827541,
	title = {Correction to : Early Transfusion of Convalescent Plasma Improves the Clinical Outcome in Severe SARS-CoV2 Infection.},
	url = {https://m2.mtmt.hu/api/publication/32827541},
	author = {Fodor, Eszter and Müller, Veronika and Iványi, Zsolt and Berki, Tímea and Kuten Pella, Olga and Hornyák, István and Ambrus, Mira and Sárkány, Ágnes and Skázel, Árpád and Madár, Ágnes and Kardos, Dorottya and Kemenesi, Gábor and Földes, Fanni Vivien and Nagy, Sándor and Matusovits, Andrea and Nacsa, Janos and Tordai, Attila and Jakab, Ferenc and Lacza, Zsombor},
	doi = {10.1007/s40121-022-00637-5},
	journal-iso = {INFECT DIS THER},
	journal = {INFECTIOUS DISEASES AND THERAPY},
	volume = {11},
	unique-id = {32827541},
	issn = {2193-8229},
	year = {2022},
	eissn = {2193-6382},
	pages = {1767-1768},
	orcid-numbers = {Müller, Veronika/0000-0002-1398-3187; Iványi, Zsolt/0000-0002-6556-1330; Berki, Tímea/0000-0002-0134-8127; Hornyák, István/0000-0002-7183-8973; Kemenesi, Gábor/0000-0001-9775-3065; Tordai, Attila/0000-0001-6966-1622}
}

@article{MTMT:32691840,
	title = {Secondary primary malignancies after treatment with chemo-immunotherapy in treatment-naïve patients with CLL: a systematic literature review},
	url = {https://m2.mtmt.hu/api/publication/32691840},
	author = {Csanádi, Marcell and Ágh, Tamás and Tordai, Attila and Tapprich, Christoph and Vokó, Zoltán and Stamatopoulos, Kostas},
	doi = {10.1080/17474086.2022.2042246},
	journal-iso = {EXPERT REV HEMATOL},
	journal = {EXPERT REVIEW OF HEMATOLOGY},
	volume = {15},
	unique-id = {32691840},
	issn = {1747-4086},
	year = {2022},
	eissn = {1747-4094},
	pages = {273-284},
	orcid-numbers = {Ágh, Tamás/0000-0002-9609-0236; Tordai, Attila/0000-0001-6966-1622; Vokó, Zoltán/0000-0002-1004-1848}
}

@article{MTMT:32637858,
	title = {Association between COVID-19 morbidity, mortality, and gross domestic product, overweight/ obesity, non-communicable diseases, vaccination rate: A cross-sectional study},
	url = {https://m2.mtmt.hu/api/publication/32637858},
	author = {Oshakbayev, K. and Zhankalova, Z. and Gazaliyeva, M. and Mustafin, K. and Bedelbayeva, G. and Dukenbayeva, B. and Otarbayev, N. and Tordai, Attila},
	doi = {10.1016/j.jiph.2022.01.009},
	journal-iso = {J INFECT PUBLIC HEALTH},
	journal = {JOURNAL OF INFECTION AND PUBLIC HEALTH},
	volume = {15},
	unique-id = {32637858},
	issn = {1876-0341},
	year = {2022},
	eissn = {1876-035X},
	pages = {255-260},
	orcid-numbers = {Tordai, Attila/0000-0001-6966-1622}
}