@article{MTMT:2853634,
	title = {Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila},
	url = {https://m2.mtmt.hu/api/publication/2853634},
	author = {Márkus, Róbert and Lerner, Zita and Honti, Viktor and Csordás, Gábor and Zsámboki, János and Cinege, Gyöngyi Ilona and Párducz, Árpád and Lukacsovich, Tamás and Kurucz, Judit Éva and Andó, István},
	doi = {10.1159/000369618},
	journal-iso = {J INNATE IMMUN},
	journal = {JOURNAL OF INNATE IMMUNITY},
	volume = {7},
	unique-id = {2853634},
	issn = {1662-811X},
	abstract = {We identified and characterized a so far unrecognized cell type, dubbed the multinucleated giant hemocyte (MGH), in the ananassae subgroup of Drosophilidae. Here, we describe the functional and ultrastructural characteristics of this novel blood cell type as well as its characterization with a set of discriminative immunological markers. MGHs are encapsulating cells that isolate and kill the parasite without melanization. They share some properties with but differ considerably from lamellocytes, the encapsulating cells of Drosophila melanogaster, the broadly used model organism in studies of innate immunity. MGHs are nonproliferative effector cells that are derived from phagocytic cells of the sessile tissue and the circulation, but do not exhibit phagocytic activity. In contrast to lamellocytes, MGHs are gigantic cells with filamentous projections and contain many nuclei, which are the result of the fusion of several cells. Although the structure of lamellocytes and MGHs differ remarkably, their function in the elimination of parasites is similar, which is potentially the result of the convergent evolution of interactions between hosts and parasites in different geographic regions. MGHs are highly motile and share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. © 2015 S. Karger AG, Basel},
	year = {2015},
	eissn = {1662-8128},
	pages = {340-353},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@inbook{MTMT:2765598,
	title = {Vérsejt-differenciálódás vizsgálata a Drosophila melanogaster hematopoietikus kompartmentumaiban},
	url = {https://m2.mtmt.hu/api/publication/2765598},
	author = {Varga, Gergely István and Honti, Viktor and Csordás, Gábor and Jankovics, Ferenc and Márkus, Róbert and Lukacsovich, Tamás and Kurucz, Judit Éva and Andó, István},
	booktitle = {A biológia jövője, a jövő biológusai},
	unique-id = {2765598},
	year = {2014},
	pages = {103-113},
	orcid-numbers = {Varga, Gergely István/0000-0001-9073-5788; Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2372553,
	title = {The cell-mediated immunity of Drosophila melanogaster: Hemocyte lineages, immune compartments, microanatomy and regulation.},
	url = {https://m2.mtmt.hu/api/publication/2372553},
	author = {Honti, Viktor and Csordás, Gábor and Kurucz, Judit Éva and Márkus, Róbert and Andó, István},
	doi = {10.1016/j.dci.2013.06.005},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {42},
	unique-id = {2372553},
	issn = {0145-305X},
	abstract = {In the animal kingdom, innate immunity is the first line of defense against invading pathogens. The dangers of microbial and parasitic attacks are countered by similar mechanisms, involving the prototypes of the cell-mediated immune responses, the phagocytosis and encapsulation. Work on Drosophila has played an important role in promoting an understanding of the basic mechanisms of phylogenetically conserved modules of innate immunity. The aim of this review is to survey the developments in the identification and functional definition of immune cell types and the immunological compartments of Drosophila melanogaster. We focus on the molecular and developmental aspects of the blood cell types and compartments, as well as the dynamics of blood cell development and the immune response. Further advances in the characterization of the innate immune mechanisms in Drosophila will provide basic clues to the understanding of the importance of the evolutionary conserved mechanisms of innate immune defenses in the animal kingdom.},
	year = {2014},
	eissn = {1879-0089},
	pages = {47-56},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@inproceedings{MTMT:2519814,
	title = {A SZEPTIKUS SÉRÜLÉST KÖVETŐ IMMUNVÁLASZT SZABÁLYOZÓ GENETIKAI FAKTOROK AZONOSÍTÁSÁNAK MÓDSZEREI DROSOPHILÁBAN},
	url = {https://m2.mtmt.hu/api/publication/2519814},
	author = {Kari, Beáta and Zsámboki, János and Honti, Viktor and Csordás, Gábor and Márkus, Róbert and Andó, István and Kurucz, Judit Éva},
	booktitle = {Tudomány a vidék mindennapjaiban},
	unique-id = {2519814},
	year = {2013},
	pages = {43-47},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@inproceedings{MTMT:2519808,
	title = {AZ ECETMUSLICA (DROSOPHILA MELANOGASTER) VÉRSEJTKÉPZŐDÉSE},
	url = {https://m2.mtmt.hu/api/publication/2519808},
	author = {Csordás, Gábor and Honti, Viktor and Márkus, Róbert and Jankovics, Ferenc and Varga, Gergely István and Kurucz, Judit Éva and Andó, István},
	booktitle = {Tudomány a vidék mindennapjaiban},
	unique-id = {2519808},
	year = {2013},
	pages = {23-28},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Varga, Gergely István/0000-0001-9073-5788; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2490590,
	title = {A novel interplay between the ubiquitin-proteasome system and serine proteases during Drosophila development.},
	url = {https://m2.mtmt.hu/api/publication/2490590},
	author = {Lipinszki, Zoltán and Klement, Éva and Hunyadi-Gulyás Éva, Csilla and Medzihradszky F., Katalin and Márkus, Róbert and Pál, Margit and Deák, Péter and Udvardy, Andor},
	doi = {10.1042/BJ20130040},
	journal-iso = {BIOCHEM J},
	journal = {BIOCHEMICAL JOURNAL},
	volume = {454},
	unique-id = {2490590},
	issn = {0264-6021},
	abstract = {The concentrations of the Drosophila proteasomal and extraproteasomal polyubiquitin receptors fluctuate in a developmentally regulated fashion. This fluctuation is generated by a previously unidentified proteolytic activity. In the present paper, we describe the purification, identification and characterization of this protease (endoproteinase I). Its expression increases sharply at the L1-L2 larval stages, remains high until the second half of the L3 stage, then declines dramatically. This sharp decrease coincides precisely with the increase of polyubiquitin receptor concentrations in late L3 larvae, which suggests a tight developmental co-regulation. RNAi-induced down-regulation of endoproteinase I results in pupal lethality. Interestingly, we found a cross-talk between the 26S proteasome and this larval protease: transgenic overexpression of the in vivo target of endoproteinase I, the C-terminal half of the proteasomal polyubiquitin receptor subunit p54/Rpn10 results in transcriptional down-regulation of endoproteinase I and consequently a lower level of proteolytic elimination of the polyubiquitin receptors. Another larval protease, Jonah65A-IV, which degrades only unfolded proteins and exhibits similar cross-talk with the proteasome has also been purified and characterized. It may prevent the accumulation of polyubiquitylated proteins in larvae contrary to the low polyubiquitin receptor concentration.},
	keywords = {Animals; PROTEOLYSIS; Amino Acid Motifs; RNA, Small Interfering/genetics; Gene Expression Regulation, Developmental; Conserved Sequence; Enzyme Induction; Drosophila melanogaster/genetics/*growth & development/metabolism; Proteasome Endopeptidase Complex/*metabolism; Unfolded protein response; Gene Knockdown Techniques; *Ubiquitination; Serine Endopeptidases/*chemistry/genetics/*metabolism; Larva/genetics/growth & development/metabolism; Drosophila Proteins/*chemistry/genetics/*metabolism},
	year = {2013},
	eissn = {1470-8728},
	pages = {571-583},
	orcid-numbers = {Lipinszki, Zoltán/0000-0002-2067-0832}
}

@article{MTMT:2463198,
	title = {A novel method for the identification of factors involved in host-pathogen interactions in Drosophila melanogaster.},
	url = {https://m2.mtmt.hu/api/publication/2463198},
	author = {Kari, Beáta and Zsámboki, János and Honti, Viktor and Csordás, Gábor and Márkus, Róbert and Andó, István and Kurucz, Judit Éva},
	doi = {10.1016/j.jim.2013.09.011},
	journal-iso = {J IMMUNOL METHODS},
	journal = {JOURNAL OF IMMUNOLOGICAL METHODS},
	volume = {398-399},
	unique-id = {2463198},
	issn = {0022-1759},
	abstract = {A new method was established, standardized and validated for screening factors involved in the response to septic injury in Drosophila melanogaster. The method, based on inducing lesion by removing the tarsal segments of the first pair of legs of Drosophila adults and exposing them to different bacteria, imitates injury that often occurs in the natural habitat. The method is easy to perform, highly reproducible and suitable for large-scale genetic screens with the aim of identifying factors involved in host-pathogen interactions. The technique was validated by using mutant variations of different components of the immune response, blood clotting as well as the involvement of a number of genes known to be instrumental in the humoral and cell-mediated immune responses of Drosophila was confirmed. Moreover, the combination of the present method with antibiotic treatment allows the screening of potential antimicrobial drugs in vivo.},
	year = {2013},
	eissn = {1872-7905},
	pages = {76-82},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1921048,
	title = {Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1921048},
	author = {Honti, Viktor and Csordás, Gábor and Márkus, Róbert and Kurucz, Judit Éva and Jankovics, Ferenc and Andó, István},
	doi = {10.1016/j.molimm.2010.04.017},
	journal-iso = {MOL IMMUNOL},
	journal = {MOLECULAR IMMUNOLOGY},
	volume = {47},
	unique-id = {1921048},
	issn = {0161-5890},
	keywords = {Animals; Immunity, Innate; Immunity, Cellular; Receptors, Scavenger/genetics; Hemocytes/cytology/*physiology; *Hematopoiesis; Drosophila melanogaster/embryology/*immunology; Drosophila Proteins/genetics; *Cell Lineage},
	year = {2010},
	eissn = {1872-9142},
	pages = {1997-2004},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1920812,
	title = {In vivo detection of lamellocytes in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1920812},
	author = {Honti, Viktor and Kurucz, Judit Éva and Csordás, Gábor and Laurinyecz, Barbara and Márkus, Róbert and Andó, István},
	doi = {10.1016/j.imlet.2009.08.004},
	journal-iso = {IMMUNOL LETT},
	journal = {IMMUNOLOGY LETTERS},
	volume = {126},
	unique-id = {1920812},
	issn = {0165-2478},
	keywords = {Animals; Cell Differentiation; Mutagenesis, Insertional; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins/genetics/metabolism; DNA Transposable Elements/genetics; Larva/genetics/metabolism; Hemocytes/cytology/*metabolism; Drosophila melanogaster/*genetics/metabolism; Drosophila Proteins/*genetics},
	year = {2009},
	eissn = {1879-0542},
	pages = {83-84},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1920807,
	title = {Csodálatos apróságok a mikroszkóp alatt},
	url = {https://m2.mtmt.hu/api/publication/1920807},
	author = {Márkus, Róbert},
	journal-iso = {DIGITÁLIS FOTÓ MAGAZIN},
	journal = {DIGITÁLIS FOTÓ MAGAZIN},
	volume = {9},
	unique-id = {1920807},
	issn = {1587-7280},
	year = {2009},
	pages = {80-93}
}