TY - JOUR AU - Mirdamadi, Seyedmohsen AU - Schaffer, Annamária AU - Barna, Tamara AU - Samavati, Reza AU - Szűcs, Kálmán Ferenc AU - Szűcs, Edina AU - Benyhe, Sándor AU - Szécsi, Mihály AU - Gáspár, Róbert TI - Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study JF - EUROPEAN JOURNAL OF PHARMACOLOGY J2 - EUR J PHARMACOL VL - 935 PY - 2022 PG - 10 SN - 0014-2999 DO - 10.1016/j.ejphar.2022.175346 UR - https://m2.mtmt.hu/api/publication/33174887 ID - 33174887 N1 - Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund; Stipendium Hungaricum Scholarship; [TKP2021-EGA-32]; [TKP2021-EGA] Funding text: Project No. TKP2021-EGA-32 was implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund, financed under the TKP2021-EGA funding scheme. This work was also supported by the Stipendium Hungaricum Scholarship. Special thanks are due to ? Agnes Csisz ? arne ? for technical assistance in the experiments. LA - English DB - MTMT ER - TY - JOUR AU - Kulmány, Ágnes Erika AU - Herman, Bianka Edina AU - Zupkó, István AU - Sinreih, Masa AU - Rižner, Tea Lanišnik AU - Savić, Marina AU - Oklješa, Aleksandar AU - Nikolić, Andrea AU - Nagy, Viktória AU - Ocsovszki, Imre AU - Szécsi, Mihály AU - Jovanović-Šanta, Suzana TI - Heterocyclic androstane and estrane D-ring modified steroids. Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes TS - Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes JF - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY J2 - J STEROID BIOCHEM MOL BIOL VL - 214 PY - 2021 PG - 13 SN - 0960-0760 DO - 10.1016/j.jsbmb.2021.105997 UR - https://m2.mtmt.hu/api/publication/32196015 ID - 32196015 N1 - Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, H-6720, Hungary Department of Medicine, University of Szeged, Szeged, H-6720, Hungary Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, 21000, Serbia Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, H-6720, Hungary Export Date: 29 March 2022 CODEN: JSBBE Correspondence Address: Jovanović-Šanta, S.; University of Novi Sad, Trg Dositeja Obradovića 3, Serbia; email: suzana.jovanovic-santa@dh.uns.ac.rs Chemicals/CAS: estradiol, 50-28-2; estrone, 53-16-7; RNA, 63231-63-0; Androstanes; Enzyme Inhibitors; Estradiol; Estranes; Estrogens; Estrone; Fatty Acids; IDS 89 Sabal serrulata extract; Phytosterols; RNA; RNA, Messenger LA - English DB - MTMT ER - TY - JOUR AU - Mirdamadi, Seyedmohsen AU - Kothencz, Anna AU - Szűcs, Edina AU - Benyhe, Sándor AU - Szécsi, Mihály AU - Gáspár, Róbert TI - Non-genomic actions of sex hormones on pregnant uterine contractility in rats. An in vitro study at term TS - An in vitro study at term JF - LIFE SCIENCES J2 - LIFE SCI VL - 263 PY - 2020 PG - 9 SN - 0024-3205 DO - 10.1016/j.lfs.2020.118584 UR - https://m2.mtmt.hu/api/publication/31632111 ID - 31632111 N1 - Funding Agency and Grant Number: Ministry of Human Capacities [20391-3/2018/FEKUSTRAT]; Stipendium Hungaricum Scholarship Funding text: This work was supported by the Ministry of Human Capacities. [Hungary grant 20391-3/2018/FEKUSTRAT] and the Stipendium Hungaricum Scholarship. Special thanks are due to Agnes Csiszarne for technical assistance in the experiments. Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, Faculty of Medicine, University of Szeged, Hungary Institute of Biochemistry, Biological Research Center, Center of Excellence in European Union, Hungarian Academy of Sciences, Szeged, Hungary Department of Medicine, Faculty of Medicine, University of Szeged, Hungary Cited By :1 Export Date: 27 May 2021 CODEN: LIFSA Correspondence Address: Gáspár, R.; Department of Pharmacology and Pharmacotherapy, Hungary; email: gaspar.robert@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Herman, Bianka Edina AU - Gardi, János AU - Julesz, János AU - Tömböly, Csaba AU - Szánti-Pintér, Eszter AU - Fehér, Klaudia AU - Skodáné Földes, Rita AU - Szécsi, Mihály TI - Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis JF - BIOLOGIA FUTURA J2 - BIOL FUTURA VL - 71 PY - 2020 IS - 3 SP - 249 EP - 264 PG - 16 SN - 2676-8615 DO - 10.1007/s42977-020-00023-7 UR - https://m2.mtmt.hu/api/publication/31365295 ID - 31365295 N1 - 1st Department of Medicine, University of Szeged, Korányi fasor 8–10, P. O. Box 427, Szeged, 6720, Hungary Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvári körút 62, P. O. Box 521, Szeged, 6726, Hungary Department of Organic Chemistry, Institute of Chemistry, University of Pannonia, Egyetem utca 10, P. O. Box 158, Veszprém, 8200, Hungary Cited By :2 Export Date: 12 September 2022 Correspondence Address: Szécsi, M.; 1st Department of Medicine, Korányi fasor 8–10, P. O. Box 427, Hungary; email: szecsi.mihaly@med.u-szeged.hu Correspondence Address: Skoda-Földes, R.; Department of Organic Chemistry, Egyetem utca 10, P. O. Box 158, Hungary; email: skodane@almos.uni-pannon.hu LA - English DB - MTMT ER - TY - JOUR AU - Herman, Bianka Edina AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Szécsi, Mihály AU - Schneider, Gyula TI - Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1 JF - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY J2 - J ENZYM INHIB MED CH VL - 34 PY - 2019 IS - 1 SP - 1271 EP - 1286 PG - 16 SN - 1475-6366 DO - 10.1080/14756366.2019.1634064 UR - https://m2.mtmt.hu/api/publication/30747981 ID - 30747981 N1 - Export Date: 6 August 2019 LA - English DB - MTMT ER - TY - JOUR AU - Jójárt, Rebeka AU - Traj, Péter AU - Kovács, Édua AU - Horváth, Ágnes AU - Schneider, Gyula AU - Szécsi, Mihály AU - Pál, Attila AU - Paragi, Gábor AU - Mernyák, Erzsébet TI - Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 9 PG - 18 SN - 1420-3049 DO - 10.3390/molecules24091783 UR - https://m2.mtmt.hu/api/publication/30672179 ID - 30672179 N1 - WoS:hiba:000469518100142 2020-01-10 07:35 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - CONF AU - Jójárt, R AU - Pécsy, Sz AU - Szlávik, M AU - Szabó, V AU - Traj, P AU - Szécsi, Mihály AU - Laczkó-Rigó, Réka AU - Özvegy-Laczka, Cs AU - Mernyák, Erzsébet TI - Synthesis and biochemical evaluation of novel 13?-estrone derivatives for targeted intracrine modulation of estrogen biosynthesis and transport T2 - Serbian Biochemical Society - Eighth Conference PY - 2018 SP - 137 EP - 138 PG - 2 UR - https://m2.mtmt.hu/api/publication/30462098 ID - 30462098 LA - English DB - MTMT ER - TY - CHAP AU - Jovanović-Šanta, SS AU - Herman, Bianka Edina AU - Zupkó, István AU - Kulmány, Ágnes Erika AU - Ocsovszki, I AU - Nikolić, AR AU - Savić, M AU - Oklješa, A AU - Szécsi, Mihály ED - Dávis, Szüts ED - László, Buday ED - Róbert, Hohol ED - Gergely, Szakáts ED - Gabriella, Bánfalvi TI - Screening of Antihormonal and Anticancer Potential of Heterocyclic Estrane Steroids T2 - FEBS3+: From molecules to living systems PB - Diamond Congress Kft. CY - Veszprém SN - 9786155270475 PY - 2018 SP - 247 UR - https://m2.mtmt.hu/api/publication/30462091 ID - 30462091 LA - English DB - MTMT ER - TY - JOUR AU - Jójárt, Rebeka AU - Pécsy, S. AU - Keglevich, György AU - Szécsi, Mihály AU - Laczkó-Rigó, Réka AU - Laczka, Csilla AU - Kecskeméti, Gábor AU - Mernyák, Erzsébet TI - Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors JF - BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY J2 - BEILSTEIN J ORG CHEM VL - 14 ET - 0 PY - 2018 SP - 2838 EP - 2845 PG - 8 SN - 1860-5397 DO - 10.3762/bjoc.14.262 UR - https://m2.mtmt.hu/api/publication/30331520 ID - 30331520 N1 - Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1521, Hungary 1st Department of Medicine, University of Szeged, Korányi fasor 8-10, Szeged, H-6720, Hungary Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Cited By :9 Export Date: 26 August 2021 CODEN: BJOCB Correspondence Address: Mernyák, E.; Department of Organic Chemistry, Dóm tér 8, Hungary; email: bobe@chem.u-szeged.hu AB - Novel 2- or 4-phosphonated 13 alpha-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13 alpha-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh3)(4) as catalyst under microwave irradiation. The influence of the new compounds on the transport function of the organic anion transporting polypeptide OATP2B1 was investigated by measuring Cascade Blue uptake. Derivatives bearing a 3-benzyl ether function displayed substantial submicromolar OATP2B1 inhibitory activity. The inhibitory effects of the compounds on human placental steroid sulfatase (STS) and 17 beta-hydroxysteroid dehydrogenase type 1 isozyme (17 beta-HSD1) were investigated by in vitro radiosub-strate incubation methods. None of the test compounds inhibited the STS markedly. The structure-activity relationship evaluation revealed that 2-substituted 3-hydroxy derivatives are able to inhibit the 17 beta-HSD1 enzyme with submicromolar IC50 values. Dual OATP2B1 and 17 beta-HSD1 inhibitors have been identified. LA - English DB - MTMT ER - TY - JOUR AU - Bacsa, Ildikó AU - Herman, Bianka Edina AU - Jójárt, Rebeka AU - Herman, Kevin Stefan AU - Wölfling, János AU - Schneider, Gyula AU - Varga, Mónika AU - Tömböly, Csaba AU - Rizner, Tea Lanisnik AU - Szécsi, Mihály AU - Mernyák, Erzsébet TI - Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis JF - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY J2 - J ENZYM INHIB MED CH VL - 33 PY - 2018 IS - 1 SP - 1271 EP - 1282 PG - 12 SN - 1475-6366 DO - 10.1080/14756366.2018.1490731 UR - https://m2.mtmt.hu/api/publication/27701563 ID - 27701563 N1 - Department of Organic Chemistry, University of Szeged, Szeged, Hungary 1st Department of Medicine, University of Szeged, Szeged, Hungary Department of Microbiology, University of Szeged, University of Szeged, Szeged, Hungary Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Cited By :19 Export Date: 3 May 2022 CODEN: JEIMA Correspondence Address: Mernyák, E.; Department of Organic Chemistry, Dóm tér 8, Hungary; email: bobe@chem.u-szeged.hu Chemicals/CAS: aromatase, 9039-48-9; hydroxysteroid dehydrogenase, 9001-56-3; steryl sulfatase, 9025-62-1; estradiol 17beta dehydrogenase, 9028-61-9; estrone, 53-16-7; Aromatase; Enzyme Inhibitors; Estradiol Dehydrogenases; Estrogens; Estrone; HSD17B1 protein, human; Steryl-Sulfatase LA - English DB - MTMT ER -