@article{MTMT:33174887, title = {Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study}, url = {https://m2.mtmt.hu/api/publication/33174887}, author = {Mirdamadi, Seyedmohsen and Schaffer, Annamária and Barna, Tamara and Samavati, Reza and Szűcs, Kálmán Ferenc and Szűcs, Edina and Benyhe, Sándor and Szécsi, Mihály and Gáspár, Róbert}, doi = {10.1016/j.ejphar.2022.175346}, journal-iso = {EUR J PHARMACOL}, journal = {EUROPEAN JOURNAL OF PHARMACOLOGY}, volume = {935}, unique-id = {33174887}, issn = {0014-2999}, year = {2022}, eissn = {1879-0712}, orcid-numbers = {Szécsi, Mihály/0000-0002-4272-1362; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:32196015, title = {Heterocyclic androstane and estrane D-ring modified steroids. Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes}, url = {https://m2.mtmt.hu/api/publication/32196015}, author = {Kulmány, Ágnes Erika and Herman, Bianka Edina and Zupkó, István and Sinreih, Masa and Rižner, Tea Lanišnik and Savić, Marina and Oklješa, Aleksandar and Nikolić, Andrea and Nagy, Viktória and Ocsovszki, Imre and Szécsi, Mihály and Jovanović-Šanta, Suzana}, doi = {10.1016/j.jsbmb.2021.105997}, journal-iso = {J STEROID BIOCHEM MOL BIOL}, journal = {JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY}, volume = {214}, unique-id = {32196015}, issn = {0960-0760}, year = {2021}, eissn = {1879-1220}, orcid-numbers = {Zupkó, István/0000-0003-3243-5300; Savić, Marina/0000-0002-1019-3673; Ocsovszki, Imre/0000-0003-1290-996X; Szécsi, Mihály/0000-0002-4272-1362; Jovanović-Šanta, Suzana/0000-0002-4579-5762} } @article{MTMT:31632111, title = {Non-genomic actions of sex hormones on pregnant uterine contractility in rats. An in vitro study at term}, url = {https://m2.mtmt.hu/api/publication/31632111}, author = {Mirdamadi, Seyedmohsen and Kothencz, Anna and Szűcs, Edina and Benyhe, Sándor and Szécsi, Mihály and Gáspár, Róbert}, doi = {10.1016/j.lfs.2020.118584}, journal-iso = {LIFE SCI}, journal = {LIFE SCIENCES}, volume = {263}, unique-id = {31632111}, issn = {0024-3205}, year = {2020}, eissn = {1879-0631}, orcid-numbers = {Kothencz, Anna/0000-0003-4359-7049; Szécsi, Mihály/0000-0002-4272-1362; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:31365295, title = {Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis}, url = {https://m2.mtmt.hu/api/publication/31365295}, author = {Herman, Bianka Edina and Gardi, János and Julesz, János and Tömböly, Csaba and Szánti-Pintér, Eszter and Fehér, Klaudia and Skodáné Földes, Rita and Szécsi, Mihály}, doi = {10.1007/s42977-020-00023-7}, journal-iso = {BIOL FUTURA}, journal = {BIOLOGIA FUTURA}, volume = {71}, unique-id = {31365295}, issn = {2676-8615}, year = {2020}, eissn = {2676-8607}, pages = {249-264}, orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509; Szécsi, Mihály/0000-0002-4272-1362} } @article{MTMT:30747981, title = {Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1}, url = {https://m2.mtmt.hu/api/publication/30747981}, author = {Herman, Bianka Edina and Kiss, Anita and Wölfling, János and Mernyák, Erzsébet and Szécsi, Mihály and Schneider, Gyula}, doi = {10.1080/14756366.2019.1634064}, journal-iso = {J ENZYM INHIB MED CH}, journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY}, volume = {34}, unique-id = {30747981}, issn = {1475-6366}, year = {2019}, eissn = {1475-6374}, pages = {1271-1286}, orcid-numbers = {Kiss, Anita/0000-0003-3352-0996; Wölfling, János/0000-0002-3037-309X; Mernyák, Erzsébet/0000-0003-4494-1817; Szécsi, Mihály/0000-0002-4272-1362} } @article{MTMT:30672179, title = {Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors}, url = {https://m2.mtmt.hu/api/publication/30672179}, author = {Jójárt, Rebeka and Traj, Péter and Kovács, Édua and Horváth, Ágnes and Schneider, Gyula and Szécsi, Mihály and Pál, Attila and Paragi, Gábor and Mernyák, Erzsébet}, doi = {10.3390/molecules24091783}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30672179}, issn = {1420-3049}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Szécsi, Mihály/0000-0002-4272-1362; Paragi, Gábor/0000-0001-5408-1748; Mernyák, Erzsébet/0000-0003-4494-1817} } @CONFERENCE{MTMT:30462098, title = {Synthesis and biochemical evaluation of novel 13?-estrone derivatives for targeted intracrine modulation of estrogen biosynthesis and transport}, url = {https://m2.mtmt.hu/api/publication/30462098}, author = {Jójárt, R and Pécsy, Sz and Szlávik, M and Szabó, V and Traj, P and Szécsi, Mihály and Laczkó-Rigó, Réka and Özvegy-Laczka, Cs and Mernyák, Erzsébet}, booktitle = {Serbian Biochemical Society - Eighth Conference}, unique-id = {30462098}, year = {2018}, pages = {137-138}, orcid-numbers = {Szécsi, Mihály/0000-0002-4272-1362; Mernyák, Erzsébet/0000-0003-4494-1817} } @{MTMT:30462091, title = {Screening of Antihormonal and Anticancer Potential of Heterocyclic Estrane Steroids}, url = {https://m2.mtmt.hu/api/publication/30462091}, author = {Jovanović-Šanta, SS and Herman, Bianka Edina and Zupkó, István and Kulmány, Ágnes Erika and Ocsovszki, I and Nikolić, AR and Savić, M and Oklješa, A and Szécsi, Mihály}, booktitle = {FEBS3+: From molecules to living systems}, unique-id = {30462091}, year = {2018}, pages = {247}, orcid-numbers = {Zupkó, István/0000-0003-3243-5300; Kulmány, Ágnes Erika/0000-0003-3243-5300} } @article{MTMT:30331520, title = {Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors}, url = {https://m2.mtmt.hu/api/publication/30331520}, author = {Jójárt, Rebeka and Pécsy, S. and Keglevich, György and Szécsi, Mihály and Laczkó-Rigó, Réka and Laczka, Csilla and Kecskeméti, Gábor and Mernyák, Erzsébet}, doi = {10.3762/bjoc.14.262}, journal-iso = {BEILSTEIN J ORG CHEM}, journal = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY}, volume = {14}, unique-id = {30331520}, issn = {1860-5397}, abstract = {Novel 2- or 4-phosphonated 13 alpha-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13 alpha-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh3)(4) as catalyst under microwave irradiation. The influence of the new compounds on the transport function of the organic anion transporting polypeptide OATP2B1 was investigated by measuring Cascade Blue uptake. Derivatives bearing a 3-benzyl ether function displayed substantial submicromolar OATP2B1 inhibitory activity. The inhibitory effects of the compounds on human placental steroid sulfatase (STS) and 17 beta-hydroxysteroid dehydrogenase type 1 isozyme (17 beta-HSD1) were investigated by in vitro radiosub-strate incubation methods. None of the test compounds inhibited the STS markedly. The structure-activity relationship evaluation revealed that 2-substituted 3-hydroxy derivatives are able to inhibit the 17 beta-HSD1 enzyme with submicromolar IC50 values. Dual OATP2B1 and 17 beta-HSD1 inhibitors have been identified.}, keywords = {ENZYME; CATALYSIS; STS; Hirao reaction; OATP2B1; 13 alpha-estrone; 17 beta-HSD1 inhibition}, year = {2018}, eissn = {1860-5397}, pages = {2838-2845}, orcid-numbers = {Szécsi, Mihály/0000-0002-4272-1362; Kecskeméti, Gábor/0000-0002-5584-6869; Mernyák, Erzsébet/0000-0003-4494-1817} } @article{MTMT:27701563, title = {Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis}, url = {https://m2.mtmt.hu/api/publication/27701563}, author = {Bacsa, Ildikó and Herman, Bianka Edina and Jójárt, Rebeka and Herman, Kevin Stefan and Wölfling, János and Schneider, Gyula and Varga, Mónika and Tömböly, Csaba and Rizner, Tea Lanisnik and Szécsi, Mihály and Mernyák, Erzsébet}, doi = {10.1080/14756366.2018.1490731}, journal-iso = {J ENZYM INHIB MED CH}, journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY}, volume = {33}, unique-id = {27701563}, issn = {1475-6366}, year = {2018}, eissn = {1475-6374}, pages = {1271-1282}, orcid-numbers = {Bacsa, Ildikó/0000-0001-8277-631X; Wölfling, János/0000-0002-3037-309X; Szécsi, Mihály/0000-0002-4272-1362; Mernyák, Erzsébet/0000-0003-4494-1817} }