@article{MTMT:34854390, title = {„Agyfényesítés” vagy evidenciák nélküli gyógyszerabúzus? A piracetám alkalmazása Magyarországon [„Cognitive Enhancement" or non-evidence-based nootropic abuse? – Use of Piracetam in Hungary]}, url = {https://m2.mtmt.hu/api/publication/34854390}, author = {Érszegi, András and Vámos, Máté and Viola, Réka and Csupor, Dezső and Vágvölgyi, Anna}, doi = {10.26430/CHUNGARICA.2024.54.2.141}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {54}, unique-id = {34854390}, issn = {0133-5596}, year = {2024}, eissn = {1588-0230}, pages = {141-149}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333; Vágvölgyi, Anna/0000-0002-8810-700X} } @article{MTMT:34833996, title = {A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases}, url = {https://m2.mtmt.hu/api/publication/34833996}, author = {Gantsetseg, Garmaa and Bunduc, Stefania and Kói, Tamás and Hegyi, Péter and Csupor, Dezső and Dariimaa, Ganbat and Dembrovszky, Fanni and Meznerics, Fanni Adél and Ailar, Nasirzadeh and Cristina, Barbagallo and Kökény, Gábor}, doi = {10.3390/ncrna10030030}, journal-iso = {NON-CODING RNA}, journal = {NON-CODING RNA}, volume = {10}, unique-id = {34833996}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2311-553X}, orcid-numbers = {Gantsetseg, Garmaa/0000-0001-9631-8635; Hegyi, Péter/0000-0003-0399-7259; Csupor, Dezső/0000-0002-4088-3333; Dembrovszky, Fanni/0000-0001-6953-3591; Kökény, Gábor/0000-0002-0345-6914} } @article{MTMT:34824725, title = {Trends and regional differences in antidiabetic medication use: a nationwide retrospective observational study}, url = {https://m2.mtmt.hu/api/publication/34824725}, author = {Csatordai, Márta and Benkő, Ria and Matuz, Mária and Engi, Zsófia and Csupor, Dezső and Lengyel, Csaba Attila and Doró, Péter}, doi = {10.1186/s13098-024-01334-8}, journal-iso = {DIABETOL METAB SYNDR}, journal = {DIABETOLOGY AND METABOLIC SYNDROME}, volume = {16}, unique-id = {34824725}, issn = {1758-5996}, year = {2024}, eissn = {1758-5996}, orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333; Lengyel, Csaba Attila/0000-0002-0434-0067; Doró, Péter/0000-0001-7784-6010} } @article{MTMT:34796471, title = {Favipiravir does not improve viral clearance in mild to moderate COVID-19 – a systematic review and meta-analysis of randomized controlled trials}, url = {https://m2.mtmt.hu/api/publication/34796471}, author = {Bahar, Muhammad Akbar and Kusuma, Ikhwan Yuda and Visnyovszki, Ádám and Matuz, Mária and Benkő, Ria and Ferenci, Tamás and Szabó, Bálint Gergely and Hajdú, Edit and Pető, Zoltán and Csupor, Dezső}, doi = {10.1016/j.heliyon.2024.e29808}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34796471}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Matuz, Mária/0000-0002-7877-2399; Benkő, Ria/0000-0002-8009-8962; Ferenci, Tamás/0000-0001-6791-3080; Szabó, Bálint Gergely/0000-0003-1775-1356; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34791311, title = {Pain management: opioid use in hospitals}, url = {https://m2.mtmt.hu/api/publication/34791311}, author = {Dewi, Ni Made Amelia Ratnata and Benkő, Ria and Engi, Zsófia and Csupor, Dezső and Viola, Réka and Csatordai, Márta and Matuz, Mária}, doi = {10.1136/ejhpharm-2024-eahp.501}, journal-iso = {EUR J HOSP PHARM SCI PRACT}, journal = {EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE}, volume = {31}, unique-id = {34791311}, issn = {2047-9956}, year = {2024}, eissn = {2047-9964}, pages = {A242-A243}, orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Csupor, Dezső/0000-0002-4088-3333; Matuz, Mária/0000-0002-7877-2399} } @article{MTMT:34776969, title = {Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies}, url = {https://m2.mtmt.hu/api/publication/34776969}, author = {Gulyás, Eszter and Horváth, István László and Engh, Marie Anne and Bunduc, Stefania and Dembrovszky, Fanni and Fehérvári, Péter and Bánvölgyi, András and Csupor, Dezső and Hegyi, Péter and Karvaly, Gellért Balázs}, doi = {10.1038/s41598-024-58200-w}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34776969}, issn = {2045-2322}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Dembrovszky, Fanni/0000-0001-6953-3591; Bánvölgyi, András/0000-0002-7071-1364; Csupor, Dezső/0000-0002-4088-3333; Hegyi, Péter/0000-0003-0399-7259; Karvaly, Gellért Balázs/0000-0003-2468-5633} } @article{MTMT:34760472, title = {Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34760472}, author = {Bérczi, Bálint and Borbásné Farkas, Kornélia and Hegyi, Péter and Tóth, Barbara and Csupor, Dezső and Németh, Balázs and Lukács, Anita and Czumbel, László Márk and Kerémi, Beáta and Kiss, István and Szabó, Andrea and Varga, Gábor and Gerber, Gábor and Gyöngyi, Zoltán}, doi = {10.3390/jcm13061818}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {13}, unique-id = {34760472}, abstract = {Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2077-0383}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333; Németh, Balázs/0000-0002-4914-9872; Lukács, Anita/0000-0002-0746-8920; Czumbel, László Márk/0000-0002-5915-0383; Kerémi, Beáta/0000-0003-4000-9440; Szabó, Andrea/0000-0003-4949-9431; Varga, Gábor/0000-0002-5506-8198; Gerber, Gábor/0000-0003-0256-2608; Gyöngyi, Zoltán/0000-0001-9330-9119} } @article{MTMT:34728728, title = {Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials}, url = {https://m2.mtmt.hu/api/publication/34728728}, author = {Tóth, Barbara and Horváth, Attila and Jójártné Laczkovich, Orsolya and Biró, Dalma and Matuz, Mária and Csupor, Dezső}, doi = {10.1055/a-2283-8147}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, unique-id = {34728728}, issn = {0032-0943}, abstract = {Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.}, year = {2024}, eissn = {1439-0221}, orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34723194, title = {Reducing cardiovascular risk in immune‐mediated inflammatory diseases: Tumour necrosis factor inhibitors compared to conventional therapies—A systematic review and meta‐analysis}, url = {https://m2.mtmt.hu/api/publication/34723194}, author = {Galajda, Noémi Ágnes and Meznerics, Fanni Adél and Mátrai, P. and Fehérvári, Péter and Lengyel, Anna Sára and Kolonics, Mária Veronika and Sipos, Z. and Kemény, Lajos Vince and Csupor, Dezső and Hegyi, Péter and Bánvölgyi, András and Holló, Péter}, doi = {10.1111/jdv.19900}, journal-iso = {J EUR ACAD DERMATOL}, journal = {JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY}, unique-id = {34723194}, issn = {0926-9959}, abstract = {Immune‐mediated inflammatory disease (IMID) patients including psoriasis, inflammatory arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) diseases compared to the general population. The increased CV risk may be promoted by tumour necrosis factor (TNF)‐α‐mediated immunological processes, which are present both in the pathomechanism of IMIDs and atherosclerosis. Our objective was to comprehensively investigate the effect of TNF inhibitors (TNFi) on CV risk compared with conventional therapies in IMIDs. The systematic literature search was conducted in three databases (MEDLINE, EMBASE, Cochrane Library) on 14 November 2022. Randomized controlled trials, cohort and case–control studies were eligible for inclusion. Outcomes consisted of the incidence of CV events, with major adverse cardiovascular events (MACE) as a main endpoint. A random‐effects meta‐analysis was performed by pooling fully adjusted multivariate hazard ratios (HR) and incidence rate ratios (IRR) with a 95% confidence interval (CI) comparing TNFis with conventional systemic non‐biologicals (CSNBs). Of a total of 8724 search results, 56 studies were included overall, of which 29 articles were eligible for the meta‐analysis, and 27 were involved in the systematic review. Including all IMIDs, the TNFi group showed a significantly reduced risk of MACE compared with the CSNB group (HR = 0.74, 95% confidence interval (CI) 0.58–0.95, p = 0.025; IRR = 0.77, 95% CI 0.67–0.88, p < 0.001). Subgroup analysis of Pso, PsA patients by pooling IRRs also confirmed the significantly decreased risk of MACE in TNFi‐treated patients compared with CSNB groups (IRR = 0.79, 95% CI 0.64–0.98). The observational nature of most included studies leading to high heterogeneity represents a limitation. Based on the results, TNFis may reduce the risk of CV events compared to CSNBs. Therefore, earlier use of TNFis compared to conventional systemic agents in the therapeutic sequence may benefit CV risk in IMID patients.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1468-3083}, orcid-numbers = {Mátrai, P./0000-0001-5144-0733; Sipos, Z./0000-0001-7845-8116; Kemény, Lajos Vince/0000-0002-8233-1844; Csupor, Dezső/0000-0002-4088-3333; Hegyi, Péter/0000-0003-0399-7259; Bánvölgyi, András/0000-0002-7071-1364; Holló, Péter/0000-0002-0744-8989} } @article{MTMT:34577678, title = {Antibiotic knowledge assessment questionnaire in undergraduate pharmacy students: A Rasch analysis of validity evidence}, url = {https://m2.mtmt.hu/api/publication/34577678}, author = {Kusuma, Ikhwan Yuda and Bahar, Muhammad Akbar and Nuari, Doni Anshar and Prabandari, Rani and Soeharto, Soeharto and Csupor, Dezső and Benkő, Ria and Matuz, Mária}, doi = {10.46542/pe.2024.241.5478}, journal-iso = {PHARM EDUC}, journal = {PHARMACY EDUCATION}, volume = {24}, unique-id = {34577678}, issn = {1560-2214}, abstract = {Background: Antibiotic knowledge is crucial for undergraduate pharmacy students who are future healthcare professionals. However, a valid and reliable instrument to assess their knowledge is scarce. This study aimed to develop and validate an Antibiotic Knowledge Assessment Questionnaire (AKAQ).Methods: The AKAQ had three domains and 29 items, encompassing general antibiotic knowledge, antibiotic resistance, and antibiotic stewardship. Rasch analysis was used to assess psychometric properties, including validity parameters (item and person fit and structural validity), reliability (person and item reliability, Cronbach’s Alpha value), item-person interaction, and item bias, using differential item functioning (DIF) based on tems.Results: This study included 500 undergraduate pharmacy students from 90 Indonesian universities. The validity of the questionnaire was demonstrated, except for one item. Person means infit and outfit for MNSQ were 1.02 and 0.95, whereas ZSTD were 0.11 and 0.08, respectively. Items means infit and outfit for MNSQ were 1.01 and 0.96, while ZSTD were 0.11 and -0.23. Item and person reliabilities were acceptable at 0.99 and 0.68. Cronbach’s alpha reliability was acceptable at 0.71. Two items were biased by term.Conclusion: The AKAQ is a valid, reliable, and standard instrument for assessing the antibiotic knowledge levels of undergraduate pharmacy students.}, year = {2024}, eissn = {1477-2701}, pages = {54-78}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333; Benkő, Ria/0000-0002-8009-8962; Matuz, Mária/0000-0002-7877-2399} }