TY - JOUR AU - Murillo, Enrique AU - Nagy, Veronika AU - Menchaca, Dania AU - Deli, József AU - Agócs, Attila TI - Changes in the Carotenoids of Zamia dressleri Leaves during Development JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 13 PY - 2024 IS - 9 PG - 11 SN - 2223-7747 DO - 10.3390/plants13091251 UR - https://m2.mtmt.hu/api/publication/34832995 ID - 34832995 AB - It has been observed that the leaves of some Zamia species undergo a kind of “reverse ripening”; that is, they change from their original brown color to green during development. We assumed that this strange color change was due to the change in carotenoid composition, so we followed the changes for several weeks. The detailed carotenoid composition and content at different stages of development of the leaves was determined with HPLC-DAD focusing on the changes in red and yellow carotenoids. The total and relative amounts of red and yellow carotenoids were determined simultaneously from one measurement from a saponified and/or unsaponified extract. At the beginning of development, the concentration of red carotenoids was higher than that of the yellow ones; it decreased drastically until 22 days and continued to decrease slowly until they completely disappeared. The concentration of yellow carotenoids decreased at the beginning as well, but after 22 days it started to increase. The amount of red carotenoids started to decrease when the leaflet stopped growing. Lutein is the main component in old leaflets, which is not a red carotenoid precursor. Red carotenoids can always be found in their esterified form in the leaves. These findings support the hypothesis that red and yellow carotenoid accumulation are independent and probably have different functions in the leaflet. The strange color change was explained based on the compartmentalization of red and yellow carotenoids and on the changing activity of the enzyme capsanthin–capsorubin synthase responsible for the synthesis of red carotenoids capsorubin and capsanthin. LA - English DB - MTMT ER - TY - JOUR AU - Linzembold, I. AU - Gulyás, Gergely AU - Deli, József AU - Agócs, Attila AU - Nagy, Veronika TI - Synthesis of phenolic acids esters of carotenoids JF - CAROTENOID SCIENCE J2 - CAROTENOID SCI VL - 25 PY - 2023 SP - 156 EP - 156 PG - 1 SN - 1880-5671 UR - https://m2.mtmt.hu/api/publication/34833060 ID - 34833060 LA - English DB - MTMT ER - TY - JOUR AU - Czett, Dalma AU - Böddi, Katalin AU - Nagy, Veronika AU - Takátsy, Anikó AU - Deli, József AU - Paul, Tone AU - Balogh, T. György AU - Vincze, Anna AU - Agócs, Attila TI - Synthesis and antioxidant capacity of carotenoid succinates and their melatonin conjugates JF - CAROTENOID SCIENCE J2 - CAROTENOID SCI VL - 25 PY - 2023 SP - 118 EP - 118 PG - 1 SN - 1880-5671 UR - https://m2.mtmt.hu/api/publication/34833055 ID - 34833055 LA - English DB - MTMT ER - TY - JOUR AU - Czett, Dalma AU - Böddi, Katalin AU - Agócs, Attila AU - Deli, József AU - Nagy, Veronika TI - Effect of the aggregation behavior on the antioxidant capacity of carotenoids JF - CAROTENOID SCIENCE J2 - CAROTENOID SCI VL - 25 PY - 2023 SP - 68 EP - 68 PG - 1 SN - 1880-5671 UR - https://m2.mtmt.hu/api/publication/34833011 ID - 34833011 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Erzsébet AU - Balázs, Viktória Lilla AU - Sándor, Viktor AU - Agócs, Attila AU - Nagy, Veronika AU - Király, Sándor Balázs AU - Kurtán, Tibor AU - Molnár, Péter AU - Deli, József TI - Carotenoid Composition of Telekia speciosa JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 12 PY - 2023 IS - 24 PG - 12 SN - 2223-7747 DO - 10.3390/plants12244116 UR - https://m2.mtmt.hu/api/publication/34429989 ID - 34429989 N1 - Department of Pharmacognosy and Phytotherapy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Târgu Mureș, 540139, Romania Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, Rókus utca 2, Pécs, H-7624, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Department of Organic Chemistry, Faculty of Sciences, University of Debrecen, Debrecen, H-4032, Hungary Export Date: 8 January 2024 Correspondence Address: Deli, J.; Department of Pharmacognosy, Rókus utca 2, Hungary; email: jozsef.deli@aok.pte.hu AB - The carotenoid composition of the flower of Telekia speciosa was investigated for the first time by HPLC-DAD-MS. In addition to the main carotenoid lutein and its geometrical isomers, 5,6-epoxy-carotenoids, namely violaxanthin, lutein 5,6-epoxide and antheraxanthin, were detected in larger amounts. In addition, β-carotene 5,6-epoxide and β-carotene 5,6,5′,6′-diepoxide were found, which occurs very rarely in plants. For unambigous identification, β-carotene 5,6-epoxide and β-carotene 5,6,5′,6′-diepoxide were prepared semisynthetically, and they were characterized by 1H and 13C NMR and HPLC-CD methods. LA - English DB - MTMT ER - TY - JOUR AU - Balázs, Viktória Lilla AU - Gulyás, Gergely AU - Nagy, Veronika AU - Zubay, Péter AU - Szabó, Krisztina AU - Sándor, Viktor AU - Agócs, Attila AU - Deli, József TI - Carotenoid Composition of Calendula officinalis Flowers with Identification of the Configuration of 5,8-Epoxy-carotenoids JF - ACS AGRICULTURAL SCIENCE & TECHNOLOGY J2 - ACS AGRIC SCI TECHNOL VL - 3 PY - 2023 IS - 11 SP - 1092 EP - 1102 PG - 11 SN - 2692-1952 DO - 10.1021/acsagscitech.3c00367 UR - https://m2.mtmt.hu/api/publication/34274821 ID - 34274821 N1 - Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, Rókus u. 2., Pécs, H-7624, Hungary Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary Institute of Bioanalytics, Medical School, University of Pécs, Szigeti út 12., Pécs, H-7624, Hungary Department of Medicinal and Aromatic Plants, Institute of Sustainable Horticulture, Hungarian University of Agriculture and Life Sciences, Villányi str. 29-43., Budapest, H-1118, Hungary Export Date: 11 December 2023 Correspondence Address: Deli, J.; Department of Pharmacognosy, Rókus u. 2., Hungary; email: jozsef.deli@aok.pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Pap, Ramóna AU - Pandur, Edina AU - Jánosa, Gergely AU - Horváth, Adrienn AU - Sipos, Katalin AU - Agócs, Attila AU - Deli, József TI - Lutein and its metabolites modulate inflammation, oxidative stress, and lipid peroxidation at glutamate-induced neurotoxicity JF - CAROTENOID SCIENCE J2 - CAROTENOID SCI VL - 25 PY - 2023 SP - 187 EP - 187 PG - 1 SN - 1880-5671 UR - https://m2.mtmt.hu/api/publication/34122466 ID - 34122466 LA - English DB - MTMT ER - TY - JOUR AU - Pap, Ramóna AU - Pandur, Edina AU - Jánosa, Gergely AU - Sipos, Katalin AU - Fritz, Ferenc Rómeó AU - Nagy, Tamás AU - Agócs, Attila AU - Deli, József TI - Protective Effects of 3′-Epilutein and 3′-Oxolutein against Glutamate-Induced Neuronal Damage JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 15 PG - 24 SN - 1661-6596 DO - 10.3390/ijms241512008 UR - https://m2.mtmt.hu/api/publication/34082313 ID - 34082313 N1 - ISSN:1422-0067 AB - Dietary lutein can be naturally metabolized to 3′-epilutein and 3′-oxolutein in the human body. The epimerization of lutein can happen in acidic pH, and through cooking, 3′-epilutein can be the product of the direct oxidation of lutein in the retina, which is also present in human serum. The 3′-oxolutein is the main oxidation product of lutein. Thus, the allylic oxidation of dietary lutein can result in the formation of 3′-oxolutein, which may undergo reduction either to revert to dietary lutein or epimerize to form 3′-epilutein. We focused on the effects of 3′-epilutein and 3′-oxolutein itself and on glutamate-induced neurotoxicity on SH-SY5Y human neuroblastoma cells to identify the possible alterations in oxidative stress, inflammation, antioxidant capacity, and iron metabolism that affect neurological function. ROS measurements were performed in the differently treated cells. The inflammatory state of cells was followed by TNFα, IL-6, and IL-8 cytokine ELISA measurements. The antioxidant status of the cells was determined by the total antioxidant capacity kit assay. The alterations of genes related to ferroptosis and lipid peroxidation were followed by gene expression measurements; then, thiol measurements were performed. Lutein metabolites 3′-epilutein and 3′-oxolutein differently modulated the effect of glutamate on ROS, inflammation, ferroptosis-related iron metabolism, and lipid peroxidation in SH-SY5Y cells. Our results revealed the antioxidant and anti-inflammatory features of 3′-epilutein and 3′-oxolutein as possible protective agents against glutamate-induced oxidative stress in SH-SY5Y cells, with greater efficacy in the case of 3′-epilutein. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Veronika AU - Agócs, Attila AU - Balázs, Viktória Lilla AU - Purger, Dragica AU - Filep, Rita AU - Sándor, Viktor AU - Turcsi, Erika Margit AU - Gulyás, Gergely AU - Deli, József TI - Lutein Isomers: Preparation, Separation, Structure Elucidation, and Occurrence in 20 Medicinal Plants JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 3 PG - 18 SN - 1420-3049 DO - 10.3390/molecules28031187 UR - https://m2.mtmt.hu/api/publication/33597596 ID - 33597596 N1 - Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs, H-7624, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Cited By :2 Export Date: 3 May 2024 CODEN: MOLEF Correspondence Address: Deli, J.; Department of Biochemistry and Medical Chemistry, Szigeti út 12, Hungary; email: jozsef.deli@aok.pte.hu AB - Lutein and its cis-isomers occur in a lot of plants, including a variety of flowers. In this study, lutein isomers were produced via iodine-catalyzed isomerization, and four cis-isomers (9Z-, 9′Z-, 13Z-, and 13Z′) were isolated by means of column chromatography and semipreparative HPLC. The structures of the 9′Z- and 13′Z-isomers were elucidated via NMR measurements. These compounds were used as standards for the HPLC-DAD-MS determination of the carotenoid composition of the flowers of 20 plant species, in which lutein and its geometrical isomers are the main components. The flowers showed great variation in their cis- and trans-lutein content, and also in the presence or absence of other carotenoids, such as violaxanthin, neoxanthin, β-cryptoxanthin, and β-carotene. Some of the investigated flowers were found to be rich sources of lutein without zeaxanthin. LA - English DB - MTMT ER - TY - JOUR AU - Garai, János AU - Radnai, Balázs AU - Vámos, Eszter AU - Kovács, Dominika AU - Bagóné Vántus, Viola AU - Rumbus, Zoltán AU - Pákai, Eszter AU - Garami, András AU - Gulyás, Gergely AU - Agócs, Attila AU - Krekó, Marcell AU - Zaman, K. AU - Prókai, L. AU - Őrfi, László AU - Jakus, Péter AU - Lóránd, Tamás TI - Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 247 PY - 2023 PG - 11 SN - 0223-5234 DO - 10.1016/j.ejmech.2022.115050 UR - https://m2.mtmt.hu/api/publication/33546311 ID - 33546311 LA - English DB - MTMT ER -