TY - JOUR AU - Quemé Peña, Mayra AU - Ricci, Maria AU - Juhász, Tünde AU - Horváti, Kata AU - Bősze, Szilvia AU - Biri-Kovács, Beáta AU - Szeder, Bálint AU - Zsila, Ferenc AU - Beke-Somfai, Tamás TI - Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37 JF - ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE J2 - ACS PHARMACOL TRANS SCI VL - 4 PY - 2021 IS - 1 SP - 155 EP - 167 PG - 13 SN - 2575-9108 DO - 10.1021/acsptsci.0c00155 UR - https://m2.mtmt.hu/api/publication/31776326 ID - 31776326 N1 - Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Biomolecular Self-Assembly Research Group, Budapest, H-1117, Hungary MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, Budapest, H-1117, Hungary Institute of Chemistry, Eötvös Loránd University, Budapest, H-1117, Hungary Institute of Enzymology, Research Centre for Natural Sciences, Budapest, H-1117, Hungary Export Date: 23 February 2021 Correspondence Address: Beke-Somfai, T.; Institute of Materials and Environmental Chemistry, Hungary; email: beke-somfai.tamas@ttk.mta.hu Funding details: NKFIH-1157-8/2019-DT, NVKP_16-1-2016-0007 Funding details: 2018-1.2.1-NKP-2018-00005 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Eötvös Loránd Tudományegyetem, ELTE Funding text 1: This study was financially supported by the Momentum Program (LP2016-2), the National Competitiveness and Excellence Program (NVKP_16-1-2016-0007), and the BIONANO_GINOP-2.3.2-15-2016-00017 project. S.B., B.B.-K., and K.H. would like to thank the ELTE Institutional Excellence Program (NKFIH-1157-8/2019-DT), the Hungarian Ministry of Human Capacities, the ELTE Thematic Excellence Programme (Szint+), and the Hungarian Ministry for Innovation and Technology. The work was also supported by the National Research, Development and Innovation Fund of Hungary (2018-1.2.1-NKP-2018-00005). K.H. was supported by the Premium Post-Doctoral Fellowship of the Hungarian Academy of Sciences. AB - The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic activity ranging from immunological to anti-neoplastic functions. However, its overexpression has been associated with harmful inflammatory responses and apoptosis. Thus, for the latter cases, the development of strategies aiming to reduce LL-37 toxicity is highly desired as these have the potential to provide a viable solution. Here, we demonstrate that the reduction of LL-37 toxicity might be achieved by the impairment of its cell surface binding through interaction with small organic compounds that are able to alter the peptide conformation and minimize its cell penetration ability. In this regard, the performed cell viability and internalization studies showed a remarkable attenuation of LL-37 cytotoxicity toward colon and monocytic cells in the presence of the polysulfonated drug suramin. The mechanistic examinations of the molecular details indicated that this effect was coupled with the ability of suramin to alter LL-37 secondary structure via the formation of peptide-drug complexes. Moreover, a comparison with other therapeutic agents having common features unveiled the peculiar ability of suramin to optimize the binding to the peptide sequence. The newly discovered suramin action is hoped to inspire the elaboration of novel repurposing strategies aimed to reduce LL-37 cytotoxicity under pathological conditions. © LA - English DB - MTMT ER - TY - JOUR AU - Bobály, Balázs AU - Tóth, Eszter AU - Drahos, László AU - Zsila, Ferenc AU - Benéné Visy, Júlia AU - Fekete, Jenő AU - Vékey, Károly TI - Influence of acid-induced conformational variability on protein separation in reversed phase high performance liquid chromatography JF - JOURNAL OF CHROMATOGRAPHY A J2 - J CHROMATOGR A VL - 1325 PY - 2014 SP - 155 EP - 162 PG - 8 SN - 0021-9673 DO - 10.1016/j.chroma.2013.12.022 UR - https://m2.mtmt.hu/api/publication/2482487 ID - 2482487 N1 - WoS:hiba:000330256200020 2020-08-26 03:17 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - PAT AU - Finta, Zoltán AU - Soós, Tibor AU - Timári, Géza AU - Vlad, Gábor AU - Dalicsek, Zoltán TI - A NEW PALLADIUM CATALYST, METHOD FOR ITS PREPARATION AND ITS USE PY - 2013 UR - https://m2.mtmt.hu/api/publication/31970218 ID - 31970218 AB - The invention relates to palladium(0)-tetrakis{tri-[3,5-bis(trifluoromethyl)- phenylj-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results. LA - English DB - MTMT ER - TY - JOUR AU - Wang, JJ AU - Li, JZ AU - Jakus, Judit AU - Shim, YK TI - Synthesis of long-wavelength chlorins by chemical modification for methyl pyropheophorbide-a and their in vitro cell viabilities JF - JOURNAL OF PORPHYRINS AND PHTHALOCYANINES J2 - J PORPHYR PHTHALOCYA VL - 16 PY - 2012 IS - 1 SP - 122 EP - 129 PG - 8 SN - 1088-4246 DO - 10.1142/S1088424611004403 UR - https://m2.mtmt.hu/api/publication/2558905 ID - 2558905 AB - A series of novel chlorophyll-a homologs with long wavelength absorption were synthesized via modification of methyl pyropheophorbide-a used as starting material. For introducing electron-withdrawing group methylenemalononitrile moiety was established on the periphery of modified chlorin by Knoevenagel reaction of malononitrile with formyl group at 3-, 15-position and 13 1-carbonyl group on the exocyclic ring. All of chlorins containing the methylenemalononitrile structure show Qy-absorption at more than 700 nm. Moreover, we have examined a preliminary in vitro photodynamic anticancer effect of these new derivatives on mouse sarcoma S-180 cell line. © 2012 World Scientific Publishing Company. LA - English DB - MTMT ER - TY - JOUR AU - Sendula, Róbert AU - Orbán, Erika AU - Hudecz, Ferenc AU - Sagi, Gyula AU - Jablonkai, István TI - SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL 5-SUBSTITUTED-1-(beta-L-ARABINOFURANOSYL) PYRIMIDINE NUCLEOSIDES JF - NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS J2 - NUCLEOS NUCLEOT NUCL VL - 31 PY - 2012 IS - 6 SP - 482 EP - 500 PG - 19 SN - 1525-7770 DO - 10.1080/15257770.2012.689410 UR - https://m2.mtmt.hu/api/publication/2149101 ID - 2149101 AB - A series of new 5-halogeno-1-(beta-L-arabinofuranosyl)uracils and their cytosine analogues were synthesized by halogenation of ara-L-uridine and ara-L-cytidine, respectively. The 5-(2-thienyl) and 5-halogenothienyl derivatives of both series were also prepared in excellent yields by Stille coupling followed by halogenation. All of these syntheses were based on benzoyl-protected derivatives. In vitro cytotoxicity experiments carried out using L1210 mouse leukemia cells showed that 5-(2-thienyl)-ara-L-uridine was the most potent compound of the new compounds; the majority of the analogues were not effective up to 200 mu M concentrations. LA - English DB - MTMT ER - TY - JOUR AU - Nyitrai, Gabriella AU - Kékesi, Orsolya Sára AU - Pál, Ildikó AU - Keglevich, Péter AU - Csíki, Zsuzsanna AU - Fügedi, Péter AU - Simon, Ágnes AU - Fitos, Ilona AU - Németh, Krisztina AU - Benéné Visy, Júlia AU - Tárkányi, Gábor AU - Kardos, Julianna TI - Assessing toxicity of polyamidoamine dendrimers by neuronal signaling functions JF - NANOTOXICOLOGY J2 - NANOTOXICOLOGY VL - 6 PY - 2012 IS - 6 SP - 576 EP - 586 PG - 11 SN - 1743-5390 DO - 10.3109/17435390.2011.591511 UR - https://m2.mtmt.hu/api/publication/2060849 ID - 2060849 N1 - Early Online: pp. 1-13. (2011) Funding Agency and Grant Number: Nanotransport [CRC-HAS_2009]; NANOSEN9 [TECH-09-A1-2009-0117]; [GVOP-3.2.1.-2004-04-0210/3.0] Funding text: We thank Nanotransport (CRC-HAS_2009), NANOSEN9 (TECH-09-A1-2009-0117) and GVOP-3.2.1.-2004-04-0210/3.0 projects for financial support. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. LA - English DB - MTMT ER - TY - JOUR AU - Várhelyi, C. AU - Pokol, György AU - Izvekov, Vladiszlav AU - Gömöry, Ágnes AU - Várhelyi, C. AU - Kocsis, L. TI - Asymmetric Co(III)-complexes of ethyl-methyl-dioxime JF - STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA J2 - STUD UNIV BABES-BOLYAI CHEM VL - 2011 PY - 2011 IS - 1 SP - 275 EP - 284 PG - 10 SN - 1224-7154 UR - https://m2.mtmt.hu/api/publication/31910559 ID - 31910559 N1 - Babeş-Bolyai University, Faculty of Chemistry, 400 028 - Cluj-Napoca Arany J. str. 11, Romania Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Romania Hungarian Academy of Sciences, Chemical Research Center, H-1525 Budapest, Pf. 17, Pusztaszeri út 59-67, Romania Export Date: 11 March 2021 Correspondence Address: Várhelyi, C.; Babeş-Bolyai University, 400 028 - Cluj-Napoca Arany J. str. 11, Romania; email: vcaba@chem.ubbcluj.ro AB - There is abundant literature regarding the symmetric α-dioximes, R′-C(=NOH)-C(=NOH)-R″, (R′=R″) and their derivatives. However, this is not the case for asymmetric α-dioximes, and the goal of this research was to increase knowledge in this domain. The thermal stability of the asymmetric α-dioximes and their Co-complexes is lower than that of the similar symmetric derivatives. This difference has also been observed in spectroscopical analysis. In this study, the synthesis of a series of Co-complexes of the type [Co(Et-Me-DioxH)2L2]+, (L=amine) was described and characterized with thermoanalytical and spectroscopical methods. LA - English DB - MTMT ER - TY - CONF AU - Domonkos, Celesztina Diána AU - Szilvágyi, G AU - Bősze, Sz AU - Tobias, Bogner AU - Benedek, L AU - Harmat, V AU - Majer, Zs TI - Kétmagvú átmenetifém-komplexek előállítása, szerkezetvizsgálata és in vitro biológiai hatása T2 - Kálmán Erika Doktori Konferencia 2011. PB - MTA Kémiai Kutatóközpont C1 - Budapest PY - 2011 SP - 15 EP - 16 PG - 2 UR - https://m2.mtmt.hu/api/publication/2595085 ID - 2595085 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Wang, J-J AU - Wang, P AU - Li, J-Z AU - Jakus, Judit AU - Shim, Y-K TI - Synthesis of novel C12-nonmethylated chlorophyll derivatives from methyl pyropheophorbide-a by allomerization and functionalization JF - BULLETIN OF THE KOREAN CHEMICAL SOCIETY J2 - B KOR CHEM SOC VL - 32 PY - 2011 IS - 9 SP - 3473 EP - 3476 PG - 4 SN - 0253-2964 DO - 10.5012/bkcs.2011.32.9.3473 UR - https://m2.mtmt.hu/api/publication/2558906 ID - 2558906 LA - English DB - MTMT ER - TY - JOUR AU - Maksay, Gábor TI - Gondolatok a kémiaévealkalmából JF - BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA J2 - BIOKÉMIA VL - 35 PY - 2011 IS - 1 SP - 45 EP - 46 PG - 2 SN - 0133-8455 UR - https://m2.mtmt.hu/api/publication/2268377 ID - 2268377 LA - Hungarian DB - MTMT ER -