@article{MTMT:31776326,
	title = {Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37},
	url = {https://m2.mtmt.hu/api/publication/31776326},
	author = {Quemé Peña, Mayra and Ricci, Maria and Juhász, Tünde and Horváti, Kata and Bősze, Szilvia and Biri-Kovács, Beáta and Szeder, Bálint and Zsila, Ferenc and Beke-Somfai, Tamás},
	doi = {10.1021/acsptsci.0c00155},
	journal-iso = {ACS PHARMACOL TRANS SCI},
	journal = {ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE},
	volume = {4},
	unique-id = {31776326},
	abstract = {The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic activity ranging from immunological to anti-neoplastic functions. However, its overexpression has been associated with harmful inflammatory responses and apoptosis. Thus, for the latter cases, the development of strategies aiming to reduce LL-37 toxicity is highly desired as these have the potential to provide a viable solution. Here, we demonstrate that the reduction of LL-37 toxicity might be achieved by the impairment of its cell surface binding through interaction with small organic compounds that are able to alter the peptide conformation and minimize its cell penetration ability. In this regard, the performed cell viability and internalization studies showed a remarkable attenuation of LL-37 cytotoxicity toward colon and monocytic cells in the presence of the polysulfonated drug suramin. The mechanistic examinations of the molecular details indicated that this effect was coupled with the ability of suramin to alter LL-37 secondary structure via the formation of peptide-drug complexes. Moreover, a comparison with other therapeutic agents having common features unveiled the peculiar ability of suramin to optimize the binding to the peptide sequence. The newly discovered suramin action is hoped to inspire the elaboration of novel repurposing strategies aimed to reduce LL-37 cytotoxicity under pathological conditions. ©},
	keywords = {MOLECULAR MECHANISMS; SURAMIN; Cathelicidins; Helical folding; reduced cytotoxicity},
	year = {2021},
	eissn = {2575-9108},
	pages = {155-167},
	orcid-numbers = {Horváti, Kata/0000-0003-4092-6011; Biri-Kovács, Beáta/0000-0001-5803-9969}
}

@article{MTMT:2482487,
	title = {Influence of acid-induced conformational variability on protein separation in reversed phase high performance liquid chromatography},
	url = {https://m2.mtmt.hu/api/publication/2482487},
	author = {Bobály, Balázs and Tóth, Eszter and Drahos, László and Zsila, Ferenc and Benéné Visy, Júlia and Fekete, Jenő and Vékey, Károly},
	doi = {10.1016/j.chroma.2013.12.022},
	journal-iso = {J CHROMATOGR A},
	journal = {JOURNAL OF CHROMATOGRAPHY A},
	volume = {1325},
	unique-id = {2482487},
	issn = {0021-9673},
	keywords = {Protein Conformation; RP-HPLC; Protein separation mechanism; TFA-protein adduct},
	year = {2014},
	eissn = {1873-3778},
	pages = {155-162},
	orcid-numbers = {Drahos, László/0000-0001-9589-6652}
}

@{MTMT:31970218,
	title = {A NEW PALLADIUM CATALYST, METHOD FOR ITS PREPARATION AND ITS USE},
	url = {https://m2.mtmt.hu/api/publication/31970218},
	author = {Finta, Zoltán and Soós, Tibor and Timári, Géza and Vlad, Gábor and Dalicsek, Zoltán},
	unique-id = {31970218},
	abstract = {The invention relates to palladium(0)-tetrakis{tri-[3,5-bis(trifluoromethyl)- phenylj-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.},
	year = {2013}
}

@article{MTMT:2558905,
	title = {Synthesis of long-wavelength chlorins by chemical modification for methyl pyropheophorbide-a and their in vitro cell viabilities},
	url = {https://m2.mtmt.hu/api/publication/2558905},
	author = {Wang, JJ and Li, JZ and Jakus, Judit and Shim, YK},
	doi = {10.1142/S1088424611004403},
	journal-iso = {J PORPHYR PHTHALOCYA},
	journal = {JOURNAL OF PORPHYRINS AND PHTHALOCYANINES},
	volume = {16},
	unique-id = {2558905},
	issn = {1088-4246},
	abstract = {A series of novel chlorophyll-a homologs with long wavelength absorption were synthesized via modification of methyl pyropheophorbide-a used as starting material. For introducing electron-withdrawing group methylenemalononitrile moiety was established on the periphery of modified chlorin by Knoevenagel reaction of malononitrile with formyl group at 3-, 15-position and 13 1-carbonyl group on the exocyclic ring. All of chlorins containing the methylenemalononitrile structure show Qy-absorption at more than 700 nm. Moreover, we have examined a preliminary in vitro photodynamic anticancer effect of these new derivatives on mouse sarcoma S-180 cell line. © 2012 World Scientific Publishing Company.},
	keywords = {chemical modification; visible absorption; methyl pyropheophorbide-a; chlorin},
	year = {2012},
	eissn = {1099-1409},
	pages = {122-129}
}

@article{MTMT:2149101,
	title = {SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL 5-SUBSTITUTED-1-(beta-L-ARABINOFURANOSYL) PYRIMIDINE NUCLEOSIDES},
	url = {https://m2.mtmt.hu/api/publication/2149101},
	author = {Sendula, Róbert and Orbán, Erika and Hudecz, Ferenc and Sagi, Gyula and Jablonkai, István},
	doi = {10.1080/15257770.2012.689410},
	journal-iso = {NUCLEOS NUCLEOT NUCL},
	journal = {NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS},
	volume = {31},
	unique-id = {2149101},
	issn = {1525-7770},
	abstract = {A series of new 5-halogeno-1-(beta-L-arabinofuranosyl)uracils and their cytosine analogues were synthesized by halogenation of ara-L-uridine and ara-L-cytidine, respectively. The 5-(2-thienyl) and 5-halogenothienyl derivatives of both series were also prepared in excellent yields by Stille coupling followed by halogenation. All of these syntheses were based on benzoyl-protected derivatives. In vitro cytotoxicity experiments carried out using L1210 mouse leukemia cells showed that 5-(2-thienyl)-ara-L-uridine was the most potent compound of the new compounds; the majority of the analogues were not effective up to 200 mu M concentrations.},
	year = {2012},
	eissn = {1532-2335},
	pages = {482-500},
	orcid-numbers = {Orbán, Erika/0000-0002-8554-3922; Hudecz, Ferenc/0000-0001-5128-9498}
}

@article{MTMT:2060849,
	title = {Assessing toxicity of polyamidoamine dendrimers by neuronal signaling functions},
	url = {https://m2.mtmt.hu/api/publication/2060849},
	author = {Nyitrai, Gabriella and Kékesi, Orsolya Sára and Pál, Ildikó and Keglevich, Péter and Csíki, Zsuzsanna and Fügedi, Péter and Simon, Ágnes and Fitos, Ilona and Németh, Krisztina and Benéné Visy, Júlia and Tárkányi, Gábor and Kardos, Julianna},
	doi = {10.3109/17435390.2011.591511},
	journal-iso = {NANOTOXICOLOGY},
	journal = {NANOTOXICOLOGY},
	volume = {6},
	unique-id = {2060849},
	issn = {1743-5390},
	keywords = {Brain; CELLS; DELIVERY; GROWTH; CYTOTOXICITY; NANOPARTICLES; Phosphate; internalization; MOLECULAR SIMULATION; CARRIERS; PAMAM dendrimers; imaging cell death; beta-D-glucopyranose-conjugation; polycationic and polyanionic PAMAM dendrimers; Functional neurotoxicity indicators},
	year = {2012},
	eissn = {1743-5404},
	pages = {576-586},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}

@article{MTMT:31910559,
	title = {Asymmetric Co(III)-complexes of ethyl-methyl-dioxime},
	url = {https://m2.mtmt.hu/api/publication/31910559},
	author = {Várhelyi, C. and Pokol, György and Izvekov, Vladiszlav and Gömöry, Ágnes and Várhelyi, C. and Kocsis, L.},
	journal-iso = {STUD UNIV BABES-BOLYAI CHEM},
	journal = {STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA},
	volume = {2011},
	unique-id = {31910559},
	issn = {1224-7154},
	abstract = {There is abundant literature regarding the symmetric α-dioximes, R′-C(=NOH)-C(=NOH)-R″, (R′=R″) and their derivatives. However, this is not the case for asymmetric α-dioximes, and the goal of this research was to increase knowledge in this domain. The thermal stability of the asymmetric α-dioximes and their Co-complexes is lower than that of the similar symmetric derivatives. This difference has also been observed in spectroscopical analysis. In this study, the synthesis of a series of Co-complexes of the type [Co(Et-Me-DioxH)2L2]+, (L=amine) was described and characterized with thermoanalytical and spectroscopical methods.},
	keywords = {thermal decomposition; Spectroscopic measurements; Heterocyclic amines; α-dioxime; Co-complexes},
	year = {2011},
	eissn = {2065-9520},
	pages = {275-284},
	orcid-numbers = {Pokol, György/0000-0003-1597-9808; Gömöry, Ágnes/0000-0001-5216-0135}
}

@CONFERENCE{MTMT:2595085,
	title = {Kétmagvú átmenetifém-komplexek előállítása, szerkezetvizsgálata és in vitro biológiai hatása},
	url = {https://m2.mtmt.hu/api/publication/2595085},
	author = {Domonkos, Celesztina Diána and Szilvágyi, G and Bősze, Sz and Tobias, Bogner and Benedek, L and Harmat, V and Majer, Zs},
	booktitle = {Kálmán Erika Doktori Konferencia 2011.},
	unique-id = {2595085},
	year = {2011},
	pages = {15-16}
}

@article{MTMT:2558906,
	title = {Synthesis of novel C12-nonmethylated chlorophyll derivatives from methyl pyropheophorbide-a by allomerization and functionalization},
	url = {https://m2.mtmt.hu/api/publication/2558906},
	author = {Wang, J-J and Wang, P and Li, J-Z and Jakus, Judit and Shim, Y-K},
	doi = {10.5012/bkcs.2011.32.9.3473},
	journal-iso = {B KOR CHEM SOC},
	journal = {BULLETIN OF THE KOREAN CHEMICAL SOCIETY},
	volume = {32},
	unique-id = {2558906},
	issn = {0253-2964},
	keywords = {FUNCTIONALIZATION; CHLOROPHYLL; Pyropheophorbide-a; Formylation; Allomerization; chlorin},
	year = {2011},
	eissn = {1229-5949},
	pages = {3473-3476}
}

@article{MTMT:2268377,
	title = {Gondolatok a kémiaévealkalmából},
	url = {https://m2.mtmt.hu/api/publication/2268377},
	author = {Maksay, Gábor},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {35},
	unique-id = {2268377},
	issn = {0133-8455},
	year = {2011},
	eissn = {2060-8152},
	pages = {45-46}
}