TY - JOUR AU - Tresóné Takács, Virág AU - Bardóczi, Zsuzsanna AU - Orosz, Áron AU - Major, Ábel AU - Tar, Luca AU - Berki, Péter AU - Papp, Péter AU - Mayer, Márton István AU - Sebők, Hunor AU - Zsolt, Luca AU - Sós, Katalin Eszter AU - Káli, Szabolcs AU - Freund, Tamás AU - Nyíri, Gábor TI - Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 22 PY - 2024 IS - 3 PG - 54 SN - 1544-9173 DO - 10.1371/journal.pbio.3002539 UR - https://m2.mtmt.hu/api/publication/34749015 ID - 34749015 AB - GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal (HS) cells. These cell types show many similarities in their soma-dendritic architecture, but they have different axonal targets, display different activity patterns in vivo, and are thought to have distinct network functions. However, a complete understanding of the functional roles of these interneurons requires a precise description of their intrinsic computational properties and their synaptic interactions. In the current study we generated, analyzed, and make available several key data sets that enable a quantitative comparison of various anatomical and physiological properties of OLM and HS cells in mouse. The data set includes detailed scanning electron microscopy (SEM)-based 3D reconstructions of OLM and HS cells along with their excitatory and inhibitory synaptic inputs. Combining this core data set with other anatomical data, patch-clamp electrophysiology, and compartmental modeling, we examined the precise morphological structure, inputs, outputs, and basic physiological properties of these cells. Our results highlight key differences between OLM and HS cells, particularly regarding the density and distribution of their synaptic inputs and mitochondria. For example, we estimated that an OLM cell receives about 8,400, whereas an HS cell about 15,600 synaptic inputs, about 16% of which are GABAergic. Our data and models provide insight into the possible basis of the different functionality of OLM and HS cell types and supply essential information for more detailed functional models of these neurons and the hippocampal network. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Viktor AU - Petersen, Peter AU - Zutshi, Ipshita AU - Huszar, Roman AU - Zhang, Yiyao AU - Buzsáki, György TI - Working memory features are embedded in hippocampal place fields JF - CELL REPORTS J2 - CELL REP VL - 43 PY - 2024 IS - 3 SP - 113807 SN - 2211-1247 DO - 10.1016/j.celrep.2024.113807 UR - https://m2.mtmt.hu/api/publication/34714189 ID - 34714189 LA - English DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - Author Correction: The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 1 SN - 2041-1723 DO - 10.1038/s41467-023-43190-6 UR - https://m2.mtmt.hu/api/publication/34400320 ID - 34400320 LA - English DB - MTMT ER - TY - JOUR AU - Barth, Albert AU - Jelitai, Márta AU - Vasarhelyi-Nagy, Maria Flora AU - Varga, Viktor TI - Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 17 SN - 2041-1723 DO - 10.1038/s41467-023-42611-w UR - https://m2.mtmt.hu/api/publication/34237484 ID - 34237484 AB - Throughout life animals inevitably encounter unforeseen threatening events. Activity of principal cells in the hippocampus is tuned for locations and for salient stimuli in the animals’ environment thus forming a map known to be pivotal for guiding behavior. Here, we explored if a code of threatening stimuli exists in the CA1 region of the dorsal hippocampus of mice by recording neuronal response to aversive stimuli delivered at changing locations. We have discovered a rapidly emerging, location independent response to innoxious aversive stimuli composed of the coordinated activation of subgroups of pyramidal cells and connected interneurons. Activated pyramidal cells had higher basal firing rate, more probably participated in ripples, targeted more interneurons than place cells and many of them lacked place fields. We also detected aversive stimulus-coupled assemblies dominated by the activated neurons. Notably, these assemblies could be observed even before the delivery of the first aversive event. Finally, we uncovered the systematic shift of the spatial code from the aversive to, surprisingly, the reward location during the fearful stimulus. Our results uncovered components of the dorsal CA1 circuit possibly key for re-sculpting the spatial map in response to abrupt aversive events. LA - English DB - MTMT ER - TY - JOUR AU - Acsády, László AU - Mátyás, Ferenc TI - Several ways to wake you up by the thalamus JF - NEURON J2 - NEURON VL - 111 PY - 2023 IS - 20 SP - 3140 EP - 3142 PG - 3 SN - 0896-6273 DO - 10.1016/j.neuron.2023.09.020 UR - https://m2.mtmt.hu/api/publication/34207759 ID - 34207759 LA - English DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 25 SN - 2041-1723 DO - 10.1038/s41467-023-41746-0 UR - https://m2.mtmt.hu/api/publication/34188237 ID - 34188237 AB - Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. LA - English DB - MTMT ER - TY - JOUR AU - Nagy-Pál, Petra AU - Veres, Judit AU - Fekete, Zsuzsanna AU - Karlócai, Rita AU - Filippo, Weisz AU - Barabás, Bence AU - Reéb, Zsófia AU - Hájos, Norbert TI - Structural organisation of perisomatic inhibition in the mouse medial prefrontal cortex JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 43 PY - 2023 IS - 42 SP - 6972 EP - 6987 PG - 16 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0432-23.2023 UR - https://m2.mtmt.hu/api/publication/34125713 ID - 34125713 LA - English DB - MTMT ER - TY - CONF AU - Tóth, Katalin Zsófia AU - Szekeres-Paraczky, Cecília Kata AU - Erőss, Loránd AU - Fabó, Dániel AU - Orsolya, Salamonné Mihály AU - Maglóczky, Zsófia AU - Szocsics, Péter TI - Examination of the density of macro- and microglia coverage of the bloodbrain barrier in human patients with focal cortical dysplasia-associated epilepsy. T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 PG - 1 UR - https://m2.mtmt.hu/api/publication/34084378 ID - 34084378 LA - English DB - MTMT ER - TY - CONF AU - Farkas, Gábor AU - Tar, Luca AU - Sáray, Sára AU - Káli, Szabolcs TI - Modelling the intracellular biochemical mechanisms of long term potentiation in a CA1 pyramidal cell spine head T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 SP - 156 EP - 156 PG - 1 UR - https://m2.mtmt.hu/api/publication/34023858 ID - 34023858 LA - English DB - MTMT ER - TY - JOUR AU - Zichó, Krisztián AU - Sós, Katalin Eszter AU - Papp, Péter AU - Barth, Albert AU - Misák, Erik AU - Orosz, Áron AU - Mayer, Márton István AU - Sebestény, Réka Z. AU - Nyíri, Gábor TI - Fear memory recall involves hippocampal somatostatin interneurons JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 21 PY - 2023 IS - 6 PG - 38 SN - 1544-9173 DO - 10.1371/journal.pbio.3002154 UR - https://m2.mtmt.hu/api/publication/33833304 ID - 33833304 LA - English DB - MTMT ER -