TY - JOUR AU - Bodolay, Edit AU - Koch, A E AU - Kim, J AU - Szegedi, Gyula AU - Szekanecz, Zoltán TI - Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases JF - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J2 - J CELL MOL MED VL - 6 PY - 2002 IS - 3 SP - 357 EP - 376 PG - 20 SN - 1582-1838 DO - 10.1111/j.1582-4934.2002.tb00514.x UR - https://m2.mtmt.hu/api/publication/1472446 ID - 1472446 AB - Angiogenesis, the formation of new vessels, is important in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. Chemotactic cytokines termed chemokines mediate the ingress of leukocytes, including neutrophils and monocytes into the inflamed synovium. In this review, authors discuss the role of the most important angiogenic factors and angiogenesis inhibitors, as well as relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. RA was chosen as a prototype to discuss these issues, as the majority of studies on the role of angiogenesis and chemokines in inflammatory diseases were carried out in arthritis. However, other systemic inflammatory (autoimmune) diseases including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS), mixed connective tissue disease (MCTD), polymyositis/ dermatomyositis (PM/DM) and systemic vasculites are also discussed in this context. As a number of chemokines may also play a role in neovascularizaton, this issue is also described here. Apart from discussing the pathogenic role of angiogenesis and chemokines, authors also review the regulation of angiogenesis and chemokine production by other inflammatory meditors, as well as the important relevance of neovascularization and chemokines for antirheumatic intervention. LA - English DB - MTMT ER - TY - JOUR AU - Török, László AU - Dankó, Katalin AU - Cserni, Gábor AU - Szűcs, Gabriella TI - Polymyositis/scleroderma autoantitest pozitív scleroderma dermatomyositissel (scleromyositis). Polymyositis/scleroderma autoantibody-positive scleroderma with dermatomyositis (scleromyositis) TS - Polymyositis/scleroderma autoantibody-positive scleroderma with dermatomyositis (scleromyositis) JF - ORVOSI HETILAP J2 - ORV HETIL VL - 143 PY - 2002 IS - 45 SP - 2553 EP - 2556 PG - 4 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1387607 ID - 1387607 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Emese AU - Bhattoa Harjit, Pál AU - Bettembuk, P AU - Balogh, Ádám AU - Szegedi, Gyula TI - Pregnancy in Women With Systemic Lupus Erythematosus JF - EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY J2 - EUR J OBSTET GYN R B (EJOG) VL - 101 PY - 2002 IS - 2 SP - 129 EP - 134 PG - 6 SN - 0301-2115 DO - 10.1016/S0301-2115(01)00525-5 UR - https://m2.mtmt.hu/api/publication/1091679 ID - 1091679 AB - BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder which may be affected by hormonal changes, such as those of pregnancy. Women with SLE have increased adverse pregnancy outcomes. STUDY DESIGN: A retrospective analysis of the gynecologic and immunologic case history of 140 women with SLE and the outcome of 263 pregnancies in 99 women with SLE. RESULTS: In patients diagnosed with SLE, the proportion of pregnancies ending with live birth at term decreased to one-third compared with three quarters in those without a diagnosis of SLE and the incidence of pre-term deliveries and spontaneous abortions increased by 6.8 and 4.7 times, respectively. When SLE was associated with secondary antiphospholipid (APL) syndrome, and lupus anticoagulant (LA) or beta2-glycoprotein antibodies were present, a further increase in the incidence of pregnancy loss was observed. Pregnancy did not cause a flare-up of SLE in all cases, the disease remained stable in about 30% of the patients. Lupus was mild in the majority of the women who carried out their pregnancy to term. We also observed mothers with active SLE who successfully carried out pregnancies to term. CONCLUSION: These findings accord with previous literature and should inform rheumatologists, obstetricians and neonatologists who guide patients in their reproductive decisions. LA - English DB - MTMT ER - TY - JOUR AU - Soltész, Pál AU - Aleksza, Magdolna AU - Antal-Szalmás, Péter AU - Lakos, Gabriella AU - Szegedi, Gyula AU - Kiss, Emese TI - Plasmapheresis Modulates Th1/th2 Imbalance in Patients With Systemic Lupus Erythematosus According to Measurement of Intracytoplasmic Cytokines. JF - AUTOIMMUNITY J2 - AUTOIMMUNITY VL - 35 PY - 2002 IS - 1 SP - 51 EP - 56 PG - 6 SN - 0891-6934 DO - 10.1080/08916930290005909 UR - https://m2.mtmt.hu/api/publication/1091678 ID - 1091678 AB - To examine the possible effect of plasmapheresis on the ratio of Th1/Th2 type cytokine-secreting cells we recruited eight patients with active systemic lupus erythematosus into the present study. They all failed to respond to conventional therapy. A sensitive multiparametric flow cytometric analysis was used for the detection of intracellular IL-4, IL-10 and IFNgamma. Stimulated peripheral blood cells were analysed by this procedure. Plasmapheresis was performed every second day for three occasions, using a continuous flow type blood cell separator, and a total of 100 ml/body weight kg plasma was removed. Patients received 1 mg/kg/day methylprednisolone during this period. As a result of the procedure, the rate of IFNgamma positive Th cells increased, while the rate of IL-4 and IL-10 expressing CD4 positive cells decreased. Together with these observations the concentration of anti-ds-DNA antibodies decreased after plasmapheresis. A decrease in disease activity index (SLE-DAI) indicated the clinical effectiveness of the therapy. LA - English DB - MTMT ER - TY - JOUR AU - Pigniczkiné Rigó, Adrien AU - Gergely, P AU - Kiss, Emese AU - Szongoth, M TI - Fáradtság és alvászavar systemás lupus erythematosusban szenvedő betegek esetében. klinikai tanulmány TS - klinikai tanulmány JF - MAGYAR REUMATOLÓGIA J2 - MAGYAR REUMATOL VL - 43 PY - 2002 IS - 1 SP - 9 EP - 18 PG - 10 SN - 0139-4495 UR - https://m2.mtmt.hu/api/publication/151859 ID - 151859 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Emese AU - Sonkoly, I AU - Szegedi, Gyula TI - Szisztémás lupus erythematosusban szenvedő betegek követésével szerzett tapasztalataink JF - MAGYAR IMMUNOLÓGIA J2 - MAGYAR IMMUNOLÓGIA VL - 1 PY - 2002 IS - 1 SP - 28 EP - 34 PG - 7 SN - 1588-3280 UR - https://m2.mtmt.hu/api/publication/151857 ID - 151857 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Emese AU - Zeher, Margit AU - Szegedi, Gyula TI - A szisztémás lupus erythematosus diagnosztikája és klasszifikációja JF - MAGYAR IMMUNOLÓGIA J2 - MAGYAR IMMUNOLÓGIA VL - 1 PY - 2002 IS - 1 SP - 38 EP - 40 PG - 3 SN - 1588-3280 UR - https://m2.mtmt.hu/api/publication/151856 ID - 151856 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Emese AU - Facskó, Andrea AU - Dévényi, K AU - Dankó, Katalin AU - Zeher, Margit TI - Szemizomra lokalizált myositis JF - MAGYAR IMMUNOLÓGIA J2 - MAGYAR IMMUNOLÓGIA VL - 1 PY - 2002 IS - 2 SP - 25 EP - 28 PG - 4 SN - 1588-3280 UR - https://m2.mtmt.hu/api/publication/151855 ID - 151855 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dankó, Katalin AU - Simkovics, E AU - Nagymáté, O AU - Aleksza, Magdolna AU - Szegedi, Andrea TI - AMYOPATHIAS DERMATOMYOSITIS JF - ORVOSI HETILAP J2 - ORV HETIL VL - 143 PY - 2002 IS - 7 SP - 341 EP - 346 PG - 6 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/151854 ID - 151854 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ponyi, Andrea AU - Constantin, Tamás AU - Dankó, Katalin TI - ANTISZINTETÁZ SZINDRÓMA JF - MAGYAR IMMUNOLÓGIA J2 - MAGYAR IMMUNOLÓGIA VL - 1 PY - 2002 IS - 2 SP - 13 EP - 19 PG - 7 SN - 1588-3280 UR - https://m2.mtmt.hu/api/publication/151853 ID - 151853 LA - Hungarian DB - MTMT ER -