@article{MTMT:1472446, title = {Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases}, url = {https://m2.mtmt.hu/api/publication/1472446}, author = {Bodolay, Edit and Koch, A E and Kim, J and Szegedi, Gyula and Szekanecz, Zoltán}, doi = {10.1111/j.1582-4934.2002.tb00514.x}, journal-iso = {J CELL MOL MED}, journal = {JOURNAL OF CELLULAR AND MOLECULAR MEDICINE}, volume = {6}, unique-id = {1472446}, issn = {1582-1838}, abstract = {Angiogenesis, the formation of new vessels, is important in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. Chemotactic cytokines termed chemokines mediate the ingress of leukocytes, including neutrophils and monocytes into the inflamed synovium. In this review, authors discuss the role of the most important angiogenic factors and angiogenesis inhibitors, as well as relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. RA was chosen as a prototype to discuss these issues, as the majority of studies on the role of angiogenesis and chemokines in inflammatory diseases were carried out in arthritis. However, other systemic inflammatory (autoimmune) diseases including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS), mixed connective tissue disease (MCTD), polymyositis/ dermatomyositis (PM/DM) and systemic vasculites are also discussed in this context. As a number of chemokines may also play a role in neovascularizaton, this issue is also described here. Apart from discussing the pathogenic role of angiogenesis and chemokines, authors also review the regulation of angiogenesis and chemokine production by other inflammatory meditors, as well as the important relevance of neovascularization and chemokines for antirheumatic intervention.}, keywords = {Humans; metabolism; PATHOPHYSIOLOGY; ANGIOGENESIS; review; human; Autoimmune Diseases; autoimmune disease; POLYMYOSITIS; dermatomyositis; systemic lupus erythematosus; vasculitis; mixed connective tissue disease; systemic sclerosis; rheumatoid arthritis; Neovascularization, Pathologic; angiogenesis inhibitor; Angiogenesis Inhibitors; Chemokines; Sjogren's Syndrome; Arthritis, Rheumatoid; chemokine; neovascularization (pathology); Receptors, Chemokine; chemokine receptor; Growth Substances; growth promotor}, year = {2002}, eissn = {1582-4934}, pages = {357-376} } @article{MTMT:1387607, title = {Polymyositis/scleroderma autoantitest pozitív scleroderma dermatomyositissel (scleromyositis). Polymyositis/scleroderma autoantibody-positive scleroderma with dermatomyositis (scleromyositis)}, url = {https://m2.mtmt.hu/api/publication/1387607}, author = {Török, László and Dankó, Katalin and Cserni, Gábor and Szűcs, Gabriella}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {143}, unique-id = {1387607}, issn = {0030-6002}, keywords = {Female; Middle Aged; Humans; Diagnosis, Differential; Autoantibodies/*blood; Scleroderma, Systemic/*immunology/*pathology; Pulmonary Fibrosis/immunology/pathology; Dermatomyositis/*immunology/*pathology; CREST Syndrome/immunology}, year = {2002}, eissn = {1788-6120}, pages = {2553-2556}, orcid-numbers = {Cserni, Gábor/0000-0003-1344-7744} } @article{MTMT:1091679, title = {Pregnancy in Women With Systemic Lupus Erythematosus}, url = {https://m2.mtmt.hu/api/publication/1091679}, author = {Kiss, Emese and Bhattoa Harjit, Pál and Bettembuk, P and Balogh, Ádám and Szegedi, Gyula}, doi = {10.1016/S0301-2115(01)00525-5}, journal-iso = {EUR J OBSTET GYN R B (EJOG)}, journal = {EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY}, volume = {101}, unique-id = {1091679}, issn = {0301-2115}, abstract = {BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder which may be affected by hormonal changes, such as those of pregnancy. Women with SLE have increased adverse pregnancy outcomes. STUDY DESIGN: A retrospective analysis of the gynecologic and immunologic case history of 140 women with SLE and the outcome of 263 pregnancies in 99 women with SLE. RESULTS: In patients diagnosed with SLE, the proportion of pregnancies ending with live birth at term decreased to one-third compared with three quarters in those without a diagnosis of SLE and the incidence of pre-term deliveries and spontaneous abortions increased by 6.8 and 4.7 times, respectively. When SLE was associated with secondary antiphospholipid (APL) syndrome, and lupus anticoagulant (LA) or beta2-glycoprotein antibodies were present, a further increase in the incidence of pregnancy loss was observed. Pregnancy did not cause a flare-up of SLE in all cases, the disease remained stable in about 30% of the patients. Lupus was mild in the majority of the women who carried out their pregnancy to term. We also observed mothers with active SLE who successfully carried out pregnancies to term. CONCLUSION: These findings accord with previous literature and should inform rheumatologists, obstetricians and neonatologists who guide patients in their reproductive decisions.}, year = {2002}, eissn = {1872-7654}, pages = {129-134}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379; Bhattoa Harjit, Pál/0000-0002-4909-0065} } @article{MTMT:1091678, title = {Plasmapheresis Modulates Th1/th2 Imbalance in Patients With Systemic Lupus Erythematosus According to Measurement of Intracytoplasmic Cytokines.}, url = {https://m2.mtmt.hu/api/publication/1091678}, author = {Soltész, Pál and Aleksza, Magdolna and Antal-Szalmás, Péter and Lakos, Gabriella and Szegedi, Gyula and Kiss, Emese}, doi = {10.1080/08916930290005909}, journal-iso = {AUTOIMMUNITY}, journal = {AUTOIMMUNITY}, volume = {35}, unique-id = {1091678}, issn = {0891-6934}, abstract = {To examine the possible effect of plasmapheresis on the ratio of Th1/Th2 type cytokine-secreting cells we recruited eight patients with active systemic lupus erythematosus into the present study. They all failed to respond to conventional therapy. A sensitive multiparametric flow cytometric analysis was used for the detection of intracellular IL-4, IL-10 and IFNgamma. Stimulated peripheral blood cells were analysed by this procedure. Plasmapheresis was performed every second day for three occasions, using a continuous flow type blood cell separator, and a total of 100 ml/body weight kg plasma was removed. Patients received 1 mg/kg/day methylprednisolone during this period. As a result of the procedure, the rate of IFNgamma positive Th cells increased, while the rate of IL-4 and IL-10 expressing CD4 positive cells decreased. Together with these observations the concentration of anti-ds-DNA antibodies decreased after plasmapheresis. A decrease in disease activity index (SLE-DAI) indicated the clinical effectiveness of the therapy.}, year = {2002}, eissn = {1607-842X}, pages = {51-56}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:151859, title = {Fáradtság és alvászavar systemás lupus erythematosusban szenvedő betegek esetében. klinikai tanulmány}, url = {https://m2.mtmt.hu/api/publication/151859}, author = {Pigniczkiné Rigó, Adrien and Gergely, P and Kiss, Emese and Szongoth, M}, journal-iso = {MAGYAR REUMATOL}, journal = {MAGYAR REUMATOLÓGIA}, volume = {43}, unique-id = {151859}, issn = {0139-4495}, year = {2002}, pages = {9-18}, orcid-numbers = {Pigniczkiné Rigó, Adrien/0000-0003-2940-2110; Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:151857, title = {Szisztémás lupus erythematosusban szenvedő betegek követésével szerzett tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/151857}, author = {Kiss, Emese and Sonkoly, I and Szegedi, Gyula}, journal-iso = {MAGYAR IMMUNOLÓGIA}, journal = {MAGYAR IMMUNOLÓGIA}, volume = {1}, unique-id = {151857}, issn = {1588-3280}, year = {2002}, pages = {28-34}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:151856, title = {A szisztémás lupus erythematosus diagnosztikája és klasszifikációja}, url = {https://m2.mtmt.hu/api/publication/151856}, author = {Kiss, Emese and Zeher, Margit and Szegedi, Gyula}, journal-iso = {MAGYAR IMMUNOLÓGIA}, journal = {MAGYAR IMMUNOLÓGIA}, volume = {1}, unique-id = {151856}, issn = {1588-3280}, year = {2002}, pages = {38-40}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:151855, title = {Szemizomra lokalizált myositis}, url = {https://m2.mtmt.hu/api/publication/151855}, author = {Kiss, Emese and Facskó, Andrea and Dévényi, K and Dankó, Katalin and Zeher, Margit}, journal-iso = {MAGYAR IMMUNOLÓGIA}, journal = {MAGYAR IMMUNOLÓGIA}, volume = {1}, unique-id = {151855}, issn = {1588-3280}, year = {2002}, pages = {25-28}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:151854, title = {AMYOPATHIAS DERMATOMYOSITIS}, url = {https://m2.mtmt.hu/api/publication/151854}, author = {Dankó, Katalin and Simkovics, E and Nagymáté, O and Aleksza, Magdolna and Szegedi, Andrea}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {143}, unique-id = {151854}, issn = {0030-6002}, keywords = {Female; Male; Humans; Diagnosis, Differential; Sex Distribution; idegen nyelvű folyóiratközlemény hazai lapban; Klinikai orvostudományok; Orvostudományok; Neoplasms, Unknown Primary/complications; *Dermatomyositis/diagnosis/epidemiology/etiology/physiopathology/therapy}, year = {2002}, eissn = {1788-6120}, pages = {341-346} } @article{MTMT:151853, title = {ANTISZINTETÁZ SZINDRÓMA}, url = {https://m2.mtmt.hu/api/publication/151853}, author = {Ponyi, Andrea and Constantin, Tamás and Dankó, Katalin}, journal-iso = {MAGYAR IMMUNOLÓGIA}, journal = {MAGYAR IMMUNOLÓGIA}, volume = {1}, unique-id = {151853}, issn = {1588-3280}, year = {2002}, pages = {13-19}, orcid-numbers = {Ponyi, Andrea/0000-0001-9518-3193; Constantin, Tamás/0000-0002-0146-3045} }