TY - JOUR AU - Szilágyi, Ákos AU - Fenyvesi, Ferenc AU - Majercsik, Orsolya AU - Pelyvás Ferenczik, István AU - Bácskay, Ildikó AU - Siposné Fehér, Pálma AU - Váradi, Judit AU - Vecsernyés, Miklós AU - Herczegh, Pál TI - Synthesis and Cytotoxicity of Leinamycin Antibiotic Analogues JF - JOURNAL OF MEDICINAL CHEMISTRY J2 - J MED CHEM VL - 49 PY - 2006 IS - 18 SP - 5626 EP - 5630 PG - 5 SN - 0022-2623 DO - 10.1021/jm060471h UR - https://m2.mtmt.hu/api/publication/1163687 ID - 1163687 LA - English DB - MTMT ER - TY - JOUR AU - Gunda, Tamás AU - Batta, Gyula TI - Reactions of Cephalosporin Sulfones 3. Synthesis of 2-Phenylhydrazonocephem-sulfones. A New Potential Entry to 2-Aminocephems JF - JOURNAL OF HETEROCYCLIC CHEMISTRY J2 - J HETEROCYCLIC CHEM VL - 43 PY - 2006 SP - 183 EP - 186 PG - 4 SN - 0022-152X DO - 10.1002/jhet.5570430128 UR - https://m2.mtmt.hu/api/publication/1162292 ID - 1162292 AB - Reaction of cephem sulfones 1a-e with aryldiazonium salts gives the 2-azo compounds which immediately rearrange into the corresponding 2-hydrazono derivatives 2a-e. LA - English DB - MTMT ER - TY - JOUR AU - E Kövér, Katalin AU - Batta, Gyula AU - Fehér, Krisztina TI - Accurate measurement of long-range heteronuclear coupling constants from undistorted multiplets of an enhanced CPMG-HSQMBC experiment JF - JOURNAL OF MAGNETIC RESONANCE J2 - J MAGN RESON VL - 181 PY - 2006 IS - 1 SP - 89 EP - 97 PG - 9 SN - 1090-7807 DO - 10.1016/j.jmr.2006.03.015 UR - https://m2.mtmt.hu/api/publication/1154251 ID - 1154251 AB - Here, we present a modified CPMG-HSQMBC experiment which is capable to reduce the detrimental phase twists in the "longrange" connectivity multiplets caused by proton-proton couplings. We demonstrate that concerted CPMG pulse trains applied on both nuclei in the starting CPMG-INEPT transfer step can considerably be improved by composite pi pulses that compensate for pulse imperfections and off-resonance effects. Experimental optimization of the interpulse delay within the CPMG cycle was found to be crucial in order to achieve the best possible "decoupling" of homonuclear coupling modulation. (c) 2006 Elsevier Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Katona, K AU - Herczegh, Pál AU - Kappelmayer, János AU - Fésüs, László AU - Aradi, János TI - Deoxy-adenosine-monophospate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells JF - CANCER LETTERS J2 - CANCER LETT VL - 235 PY - 2006 IS - 2 SP - 281 EP - 290 PG - 10 SN - 0304-3835 DO - 10.1016/j.canlet.2005.04.027 UR - https://m2.mtmt.hu/api/publication/1101249 ID - 1101249 LA - English DB - MTMT ER - TY - JOUR AU - Kéki, Sándor AU - Batta, Gyula AU - Bakai-Bereczki, Ilona AU - Fejes, Zsolt AU - Nagy, Lajos AU - Zajacz, A AU - Kandra, Lili AU - Kiricsi, Imre AU - Deák, György AU - Zsuga, Miklós AU - Herczegh, Pál TI - New types of alpha-amylase enzyme-inhibitory polysaccharides from D-glucal JF - CARBOHYDRATE POLYMERS J2 - CARBOHYD POLYM VL - 63 PY - 2006 SP - 136 EP - 140 PG - 5 SN - 0144-8617 DO - 10.1016/j.carbpol.2005.07.036 UR - https://m2.mtmt.hu/api/publication/1067497 ID - 1067497 AB - We describe the synthesis of new types of alpha-amylase enzyme-inhibitory polysaccharides obtained by polycondensation of 3,6-Di-O-acetyl-D-glucal followed by deacetylation. The structure of the resulting new polysaccharides containing unique 2,3-unsaturated hexopyranose repeating units were unambiguously determined by NMR and MALDI-TOF MS methods. The deacetylated polysaccharides proved to be a semicompetitive inhibitor of the human salivary amylase enzyme. (c) 2005 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Sztaricskai, Ferenc AU - Batta, Gyula AU - Herczegh, Pál AU - Balázs, Attila AU - Jekő, József AU - Roth, E AU - Szabó, Pál Tamás AU - Kardos, Szilvia AU - Rozgonyi, Ferenc AU - Boda, Zoltán TI - A new series of glycopeptide antibiotics incorporating a squaric acid moiety - Synthesis, structural and antibacterial studies JF - JOURNAL OF ANTIBIOTICS J2 - J ANTIBIOT VL - 59 PY - 2006 IS - 9 SP - 564 EP - 582 PG - 19 SN - 0021-8820 DO - 10.1038/ja.2006.77 UR - https://m2.mtmt.hu/api/publication/112938 ID - 112938 AB - The aglycones of the antibiotics eremomycin, vancomycin and ristocetin (3, 4 and 6, respectively) were prepared by deglycosidation of the parent antibiotics with hydrogen fluoride, and complete assignation of their H-1, C-13 and N-15 spectra was performed. The squaric acid amide esters (11 similar to 14), were prepared from dimethyl squarate. The corresponding asymmetric diamides (16 similar to 19, 22, 23) were also synthesized using 4-phenylbenzylamine and triglycine. The advantage of the method is the high regioselectivity and that no protecting group strategy is required. Electrospray mass spectroscopic method was elaborated for the determination of the site of substitution of the modified antibiotics. The antibacterial activity of the prepared compounds is discussed in detail. LA - English DB - MTMT ER - TY - CONF AU - Kandra, Lili AU - Gálné Remenyik, Judit AU - Gyémánt, Gyöngyi AU - Zajácz, Á. AU - Batta, Gyula ED - Shigeyuki, Tajima ED - Yasuhiko, Asada TI - Synthesis of a novel inhibitor specific for human α-amylases T2 - RARE SUGARS PY - 2005 SP - 289 EP - 293 PG - 5 UR - https://m2.mtmt.hu/api/publication/34072230 ID - 34072230 LA - English DB - MTMT ER - TY - JOUR AU - Kandra, Lili AU - Gálné Remenyik, Judit AU - Batta, Gyula AU - Somsák, László AU - Gyémánt, Gyöngyi AU - Park, KH TI - Enzymatic synthesis of a new inhibitor of alpha-amylases: acarviosinyl-isomaltosyl-spirothiohidantoin JF - CARBOHYDRATE RESEARCH J2 - CARBOHYD RES VL - 340 PY - 2005 IS - 7 SP - 1311 EP - 1317 PG - 7 SN - 0008-6215 DO - 10.1016/j.carres.2005.03.003 UR - https://m2.mtmt.hu/api/publication/1336614 ID - 1336614 N1 - Department of Biochemistry, Faculty of Sciences, University of Debrecen, PO Box 55, 4010 Debrecen, Hungary Research Group for Carbohydrates, Hungarian Academy of Sciences, PO Box 55, 4010 Debrecen, Hungary Res. Grp. Antibiot. Hung. Acad. Sci., Dept. of Pharmaceutical Chemistry, University of Debrecen, PO Box 70, H-4010 Debrecen, Hungary University of Debrecen, Faculty of Sciences, Department of Organic Chemistry, PO Box 20, H-4010 Debrecen, Hungary Dept. of Food Science and Technology, Res. Center for New Bio-Materials, Seoul National University, Seoul 151-742, South Korea Cited By :21 Export Date: 13 July 2023 CODEN: CRBRA Correspondence Address: Kandra, L.; Department of Biochemistry, PO Box 55, 4010 Debrecen, Hungary; email: kandra@tigris.klte.hu AB - Synthesis of acarviosinyl-isomaltosyl-spiro-thiohydantoin in yields up to 20%, has been achieved by Bacillus stearothermophilus maltogenic amylase (BSMA). BSMA is capable of transferring the acarviosine-glucose residue from an acarbose donor onto glucopyranosylidene-spiro-thiohydantoin. Reactions were followed using HPLC and MALDI-TOF MS. (1H and 13C NMR studies revealed that the enzyme reserved its stereoselectivity. Glycosylation took place mainly at C-6 resulting in a-acarviosinyl-(14)-a-D-glucopyranosyl-(16)-D-glucopyranosylidene-spiro- thiohydantoin. This compound was found to be a much more efficient salivary amylase inhibitor than glucopyranosylidene-spiro-thiohydantoin with kinetic constants of K)(EI) (= 0.19 mM and K)(ESI) = 0.24 mM. 2005 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Miklós AU - Kéki, Sándor AU - Orosz, L AU - Deák, György AU - Herczegh, Pál AU - Lévai, A AU - Zsuga, Miklós TI - Novel and simple synthesis of carboxyl-terminated polyisobutylenes JF - MACROMOLECULES J2 - MACROMOLECULES VL - 38 PY - 2005 IS - 10 SP - 4043 EP - 4046 PG - 4 SN - 0024-9297 DO - 10.1021/ma050075t UR - https://m2.mtmt.hu/api/publication/1163684 ID - 1163684 N1 - Megjegyzés-22399488 WC: Polymer Science LA - English DB - MTMT ER - TY - JOUR AU - Palczewska, M AU - Batta, Gyula AU - Groves, P AU - Linse, S AU - Kuznicki, J TI - Characterization of calretinin I-II as an EF-hand, Ca2+, H+-sensing domain JF - PROTEIN SCIENCE J2 - PROTEIN SCI VL - 14 PY - 2005 SP - 1879 EP - 1887 PG - 9 SN - 0961-8368 DO - 10.1110/ps.051369805 UR - https://m2.mtmt.hu/api/publication/237595 ID - 237595 AB - Calretinin, a neuronal protein with well-defined calcium-binding properties, has a poorly defined function. The pH dependent properties of calretinin (CR), the N-terminal (CR I-II), and C-terminal (CR III-VI) domains were investigated. A drop in pH within the intracellular range (from pH 7.5 to pH 6.5) leads to an increased hydrophobicity of calcium-bound CR and its domains as reported by fluorescence spectroscopy with the hydrophobic probe 2-(p-toluidino)-6-naphthalenesulfonic acid (TNS). The TNS data for the N- and C-terminal domains of CR are additive, providing further support for their independence within the full-length protein. Our work concentrated on CR I-II, which was found to have hydrophobic properties similar to calmodulin at lower pH. The elution of CR I-II from a phenyl-Sepharose column was consistent with the TNS data. The pH-dependent structural changes were further localized to residues 13-28 and 44-51 using nuclear magnetic resonance spectroscopy chemical shift analysis, and there appear to be no large changes in secondary structure. Protonation of His12 and/or His27 side chains, coupled with calcium chelation, appears to lead to the organization of a hydrophobic pocket in the N-terminal domain. CR may sense and respond to calcium, proton, and other signals, contributing to conflicting data on the proteins role as a calcium sensor or calcium buffer. LA - English DB - MTMT ER -