@article{MTMT:37419601, title = {Structural transition in antimicrobial resistance dynamics of Corynebacterium striatum}, url = {https://m2.mtmt.hu/api/publication/37419601}, author = {Lorencz, Anna and Sajerli, Bence Szaniszló and Burián, Katalin and Orosz, László}, doi = {10.1016/j.idm.2026.07.002}, journal-iso = {INFECT DIS MODEL}, journal = {INFECTIOUS DISEASE MODELLING}, volume = {12}, unique-id = {37419601}, issn = {2468-2152}, year = {2027}, eissn = {2468-0427}, pages = {83-93}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Orosz, László/0000-0002-5268-6134} } @article{MTMT:36267570, title = {Urinary bacterial spectrum and antibiotic resistance trends at a Urology Clinic in Hungary between 2012 and 2023}, url = {https://m2.mtmt.hu/api/publication/36267570}, author = {Fehér, Ádám Miklós and Safikhani, Milad and Bajory, Zoltán and Lázár, Andrea and Burián, Katalin and Rárosi, Ferenc and Köves, Béla}, doi = {10.1007/s11255-025-04683-z}, journal-iso = {INT UROL NEPHROL}, journal = {INTERNATIONAL UROLOGY AND NEPHROLOGY}, volume = {58}, unique-id = {36267570}, issn = {0301-1623}, year = {2026}, eissn = {1573-2584}, pages = {517-525}, orcid-numbers = {Fehér, Ádám Miklós/0000-0003-3438-4375; Bajory, Zoltán/0000-0003-3835-2549; Burián, Katalin/0000-0003-1300-2374; Rárosi, Ferenc/0000-0002-1014-9242} } @article{MTMT:36319640, title = {Vernomigeodiins A–D, highly oxygenated stigmastane-type steroids isolated from Vernoniastrum migeodii with anti-herpes simplex virus activity}, url = {https://m2.mtmt.hu/api/publication/36319640}, author = {Yazdani, Morteza and Barta, Anita and Hetényi, Anasztázia and Saidu, Muhammad Bello and Gallah, Umar Shehu and Berkecz, Róbert and Csámpai, Antal and Burián, Katalin and Paróczai, Dóra and AHMED, Sara Hassan Hassan and Hohmann, Judit}, doi = {10.1016/j.phytochem.2025.114659}, journal-iso = {PHYTOCHEMISTRY}, journal = {PHYTOCHEMISTRY}, volume = {241}, unique-id = {36319640}, issn = {0031-9422}, year = {2026}, eissn = {1873-3700}, orcid-numbers = {Yazdani, Morteza/0000-0001-6569-5681; Barta, Anita/0000-0003-0606-2766; Hetényi, Anasztázia/0000-0001-8080-6992; Berkecz, Róbert/0000-0002-9076-2177; Csámpai, Antal/0000-0003-2107-7309; Burián, Katalin/0000-0003-1300-2374; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:36386190, title = {Co-encapsulated Apigenin and Clove Oil in Nanostructured Lipid Carriers for Enhanced Periodontal Disease Therapy}, url = {https://m2.mtmt.hu/api/publication/36386190}, author = {Ashfaq, Rabia and Kovács, Anita and Berkó, Szilvia and Katona, Gábor and Paróczai, Dóra and Szécsényi, Mária and Burián, Katalin and Vályi, Péter and Veres, Katalin and Girst, Gábor and Hunyadi, Attila and Polgár, Tamás Ferenc and Budai-Szűcs, Mária}, doi = {10.1016/j.jddst.2025.107644}, journal-iso = {J DRUG DELIV SCI TEC}, journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}, volume = {115}, unique-id = {36386190}, issn = {1773-2247}, year = {2026}, eissn = {2588-8943}, orcid-numbers = {Kovács, Anita/0000-0001-5593-1329; Berkó, Szilvia/0000-0002-3842-8876; Katona, Gábor/0000-0003-1564-4813; Burián, Katalin/0000-0003-1300-2374; Vályi, Péter/0000-0002-9594-2038; Veres, Katalin/0000-0001-7108-3622; Girst, Gábor/0000-0003-0582-5215; Hunyadi, Attila/0000-0003-0074-3472; Polgár, Tamás Ferenc/0000-0002-6287-1093; Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:36464703, title = {Cutibacterium acnes induces skin region-specific innate immune memory alterations in human keratinocytes}, url = {https://m2.mtmt.hu/api/publication/36464703}, author = {Balogh, Fanni and Magyari, Anett and Erdei, Lilla and Bolla, Beáta Szilvia and Koncz, Balázs and Bagi, Laura and Manczinger, Máté and Toldi, Blanka and Baráth, Bálint and Burián, Katalin and Gyulai, Rolland Péter and Kemény, Lajos and Szabó, Kornélia Ágnes}, doi = {10.1016/j.jid.2025.10.610}, journal-iso = {J INVEST DERMATOL}, journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY}, volume = {146}, unique-id = {36464703}, issn = {0022-202X}, year = {2026}, eissn = {1523-1747}, pages = {1605-1616.e6}, orcid-numbers = {Balogh, Fanni/0000-0002-3330-919X; Erdei, Lilla/0000-0001-8129-2364; Manczinger, Máté/0000-0003-0831-9617; Baráth, Bálint/0000-0001-8837-2375; Burián, Katalin/0000-0003-1300-2374; Gyulai, Rolland Péter/0000-0002-3286-8846; Kemény, Lajos/0000-0002-2119-9501; Szabó, Kornélia Ágnes/0000-0002-6231-3251} } @article{MTMT:36871909, title = {Sequence variability of Hungarian RSV G and F proteins between 2017 and 2023: single-center study}, url = {https://m2.mtmt.hu/api/publication/36871909}, author = {Juhász, Hajnalka and Burián, Katalin and Bukva, Mátyás and Terhes, Gabriella}, doi = {10.1016/j.ijmm.2026.151700}, journal-iso = {INT J MED MICROBIOL}, journal = {INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY}, volume = {322}, unique-id = {36871909}, issn = {1438-4221}, year = {2026}, eissn = {1618-0607}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Bukva, Mátyás/0000-0002-5225-0285; Terhes, Gabriella/0000-0002-7301-9672} } @article{MTMT:36876458, title = {Structure and solution biospeciation on tricarbonylrhenium(I) complexes of mercaptopyrimidines with multifaceted biological activity}, url = {https://m2.mtmt.hu/api/publication/36876458}, author = {Rapuš, Uroš and Pivarcsik, Tamás and Dömötör, Orsolya and Nové, Márta and Nyári, József and Bogdanov, Anita and Spengler, Gabriella and Turel, Iztok and Kljun, Jakob and Enyedy, Éva Anna}, doi = {10.1093/mtomcs/mfag002}, journal-iso = {METALLOMICS}, journal = {METALLOMICS}, volume = {18}, unique-id = {36876458}, issn = {1756-5901}, abstract = {In this study, we report the synthesis and detailed characterization of four novel bidentate (N, N) ligands incorporating a 2-(methylthio)pyrimidine moiety and their fac-tricarbonylrhenium(I) complexes (ReB1—ReB4 and ReB1Aq) with the general formula fac-[Re(CO)3(N, N)X]n+, with X = Cl—or H2O and n = 0 or 1. Designed to integrate biologically relevant functionalities, these complexes exhibited promising multifunctional bioactivity. Cytotoxicity assays demonstrated moderate activity (IC50 = 11–78 µM) on various human cancer cell lines, with certain derivatives showing notable selectivity toward the Colo205 line. Most of the chlorido complexes effectively inhibited the replication of Herpes simplex virus type 2, while ReB4 displayed significant antibacterial activity against Staphylococcus aureus, including methicillin-resistant strains (MIC = 12.5–25 µM), and demonstrated biofilm inhibition. Aqueous stability of these organometallic complexes was thoroughly investigated, and complexes ReB2 and ReB3 containing a pyrimidine and a thiazole ring, respectively, gradually decompose in aqueous media, correlating with a decline in anticancer activity. Ligand-exchange processes were observed, in which the chlorido co-ligands were replaced by water, thus affecting the solubility and lipophilicity. The aqua complex ReB1Aq exhibited a low chloride affinity, and the pKa of the coordinated water molecule was obtained to be ∼8. Its interaction with human serum albumin was investigated in detail and was found to be dominated by non-covalent interactions, indicating that no coordination bond formation occurs with the protein.}, year = {2026}, eissn = {1756-591X}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; Bogdanov, Anita/0000-0003-3067-8835; Spengler, Gabriella/0000-0001-8085-0950; Turel, Iztok/0000-0001-6776-4062; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:36888550, title = {Exploring Chemical Composition of the Aerial Parts of Vernoniastrum migeodii and Anti-Inflammatory Activity of the Compounds}, url = {https://m2.mtmt.hu/api/publication/36888550}, author = {Yazdani, Morteza and Paróczai, Dóra and Barta, Anita and Burián, Katalin and Hohmann, Judit}, doi = {10.3390/plants15020321}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {15}, unique-id = {36888550}, abstract = {Therapeutic strategies that fine-tune epithelial inflammatory responses are highly sought after in respiratory and mucosal disorders, but few molecules selectively target these pathways. Vernoniastrum migeodii (S. Moore) Isawumi (Asteraceae) represents a chemically promising but understudied source of bioactive small molecules. This study aimed to define the metabolite profile of V. migeodii and evaluate the modulation of inflammatory epithelial signaling of the constituents. From the methanolic extract of V. migeodii, five germacranolide sesquiterpenes, vernolide (1), 3′-hydroxylvernolide (2), pectorolide (3), 4′-hydroxypectorolide-14-O-acetate (4) and 4′-hydroxypectorolide (5), together with (6S,9R)-vomifoliol (6), eucarvone (7), luteolin (8), and luteolin-7-O-glucoside (9) were isolated by multiple chromatographic separations. The structures were determined by comprehensive 1D and 2D NMR spectroscopy. Isolated compounds 1 to 9 together with previously reported steroids (10–17) and tripeptide (18) were evaluated in LPS-activated A549 cells by quantitative PCR for interleukin-6 (IL6), interleukin-1β (IL1β), and prostaglandin-endoperoxide synthase 2 (PTGS2) and by enzyme-linked immunosorbent assay (ELISA) for IL-6 and IL-8. Compounds 2, 7, steroids 10–17 and aurantiamide acetate (18) reduced IL6 mRNA relative to the LPS control, while (6S,9R)-vomifoliol (6) increased IL-6 and elevated IL-8. In the assay IL1β and PTGS2 transcripts were not significantly altered. These findings highlight the potential of V. migeodii metabolites as modulators of epithelial inflammatory pathways. Combining chemical and biological evidence provides a clear basis for structure–activity- and pathway-focused studies.}, year = {2026}, eissn = {2223-7747}, orcid-numbers = {Yazdani, Morteza/0000-0001-6569-5681; Paróczai, Dóra/0000-0001-6792-6789; Barta, Anita/0000-0003-0606-2766; Burián, Katalin/0000-0003-1300-2374; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:36911370, title = {Design and Biological Evaluation of Mannich-Modified 8-Hydroxyquinoline–Phthalimide Hybrids Against Drug-Resistant Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/36911370}, author = {Mohamed, Moamen Awad Hassanin and Nové, Márta and Spengler, Gabriella and Szatmári, István and Simon, Péter}, doi = {10.3390/ph19020230}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {19}, unique-id = {36911370}, abstract = {Background: 8-Hydroxyquinoline and phthalimide are two significant heterocyclic scaffolds in medicinal chemistry due to their pharmacological profiles. Hybridizing these pharmacophores and further modifying them via modified Mannich reactions provides a strategy to improve their physicochemical parameters and selectivity toward multidrug-resistant (MDR) cancer cells. Objectives: To synthesize a series of 8-hydroxyquinoline–phthalimide hybrids and their Mannich base derivatives and evaluate their cytotoxic activity and resistance-selective properties against sensitive Colo205 and resistant Colo320 cancer cell lines. Methods: Four hybrid compounds were synthesized by reacting 5-amino-8-hydroxyquinoline with different phthalic anhydride derivatives. Twelve fine-tuned derivatives were prepared by using the modified Mannich reaction. Cytotoxic activity was measured using the MTT assay, and relative resistance (RR) was calculated to determine selectivity toward the resistant cell line. P-glycoprotein (Pgp) ATPase activity was evaluated for the most active compounds. Results: All derivatives displayed cytotoxic activity, with higher potency toward the resistant Colo320 cell line. Compounds 2 and 4 showed the strongest activity against both cell lines (IC50 down to 4.88 µM). Compounds 5, 8a, 9a, and 9c retained potent activity against Colo320 (IC50 = 9.89–22.79 µM). Incorporating a CH2–N group at position C7 substantially enhanced the selectivity for MDR cells. Compounds 9c, 9a, and 8a exhibited the highest selectivity, with RR values of 0.29, 0.33, and 0.35, respectively. Compounds 2, 4, 5, 8a, and 9a showed inhibitory effects on Pgp ATPase activity. Conclusion: The newly synthesized HQ–phthalimide hybrids represent promising candidates for targeting MDR in colorectal cancer, with Mannich modification enhancing the selectivity toward resistant cells.}, year = {2026}, eissn = {1424-8247}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229} } @article{MTMT:36932837, title = {Beta-lactamases in anaerobic, intestinal bacteria: a narrative review}, url = {https://m2.mtmt.hu/api/publication/36932837}, author = {Dutkiewicz, Marion and Sóki, József and Ruppe, Etienne}, doi = {10.1016/j.anaerobe.2026.103024}, journal-iso = {ANAEROBE}, journal = {ANAEROBE}, volume = {97}, unique-id = {36932837}, issn = {1075-9964}, abstract = {Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of beta-lactamases. This narrative review explores the diversity of beta-lactamases found in intestinal anaerobes, their functional characteristics, and clinical implications. Species of the genus Bacteroides are major producers, harboring enzymes from Ambler classes A (e.g. CepA, CfxA and CblA), B (e.g. CfiA and CcrA) and D (e.g. OXA-347), with activity ranging from cephalosporinases to carbapenemases and oxacillinases. Other gut members, including Clostridioides difficile, Fusobacterium nucleatum, and Acidaminococcus fermentans, also encode specific beta-lactamases. These enzymes contribute to microbiota resilience following beta-lactam exposure and can protect neighboring bacteria via extracellular degradation. This protective mechanism has inspired therapeutic applications, such as recombinant beta-lactamases (ribaxamase, SYN-006) designed to preserve gut integrity during antibiotic therapy. Understanding these intrinsic resistance mechanisms is essential for optimizing antibiotic stewardship and mitigating the spread of resistance genes. Copyright © 2026. Published by Elsevier Ltd.}, keywords = {bacteroides; Antibiotic resistance; gut microbiota; carbapenemases; microbiota protection}, year = {2026}, eissn = {1095-8274}, orcid-numbers = {Sóki, József/0000-0001-9230-8907} }