TY - JOUR AU - Takács, Tímea AU - Berki, Ádám József AU - Böjti, Péter Pál AU - Stang, Rita AU - Fritz-Ruenes, Pablo Antonio AU - Schnekenberg, Luiz AU - Siepmann, Timo AU - Pintér, Alexandra AU - Szatmári, Szabolcs AU - Bereczki, Dániel AU - Gunda, Bence TI - The impact of SARS-CoV-2 infection on the outcome of acute ischemic stroke - A retrospective cohort study. JF - PLOS ONE J2 - PLOS ONE VL - 18 PY - 2023 IS - 3 PG - 15 SN - 1932-6203 DO - 10.1371/journal.pone.0282045 UR - https://m2.mtmt.hu/api/publication/33682398 ID - 33682398 AB - Acute ischemic stroke (AIS) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection (COVID-19), but the prognosis of these patients is poorly understood.To explore the impact of COVID-19 on neurological outcomes in AIS patients.A comparative retrospective cohort study was conducted in 32 consecutive AIS patients with and 51 without COVID-19 between the 1st of March 2020 and 1st of May 2021. The evaluation was based on a detailed chart review for demographic data, medical history, stroke severity, cranial and vessel imaging results, laboratory parameters, COVID-19 severity, hospitalization time, in-hospital mortality, and functional deficits at discharge (modified Rankin Scale, mRS).COVID-19 AIS patients showed tendency to worse initial neurological deficit (NIHSS 9 (3-13) vs. 4 (2-10); p = 0.06), higher rate of large vessel occlusion (LVO; 13/32 vs. 14/51; p = 0.21), had prolonged hospitalization (19.4 ± 17.7 vs. 9.7 ± 7 days; p = 0.003), had lower chance of functional independence (mRS≤2) (12/32 vs. 32/51; p = 0.02) and showed higher in-hospital mortality (10/32 vs. 6/51; p = 0.02). In COVID-19 AIS patients, LVO was more common with COVID-19 pneumonia than without (55.6% vs. 23.1%; p = 0.139).COVID-19-related AIS carries a worse prognosis. COVID-19 with pneumonia seems to be associated with a higher rate of LVO. LA - English DB - MTMT ER - TY - JOUR AU - Bereczki, Dániel AU - Csiba, László TI - Stroke • Stroke JF - MAGYAR TUDOMÁNY J2 - MAGYAR TUDOMÁNY VL - 184 PY - 2023 IS - 1 SP - 18 EP - 29 PG - 12 SN - 0025-0325 DO - 10.1556/2065.184.2023.1.3 UR - https://m2.mtmt.hu/api/publication/33652738 ID - 33652738 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Takács, Tímea AU - Böjti, Péter Pál AU - Stang, Rita AU - Fritz-Ruenes, Pablo Antonio AU - Sipos, Ildikó AU - Szatmári, Szabolcs AU - Bereczki, Dániel AU - Gunda, Bence TI - A SARS-CoV-2-fertőzés hatásai az akut ischaemiás stroke betegek rövid távú kimenetelére a Semmelweis Egyetem Neurológiai Klinikáján JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 3 SP - 189 EP - 190 PG - 2 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33147165 ID - 33147165 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Böjti, Péter Pál AU - Szilágyi, Géza AU - Dobi, Balázs AU - Stang, Rita AU - Takács, Tímea AU - Elad, Merose AU - Both, Levente AU - Szikora, István AU - Óváry, Csaba AU - Erőss, Loránd AU - Banczerowski, Péter AU - Bereczki, Dániel TI - A Covid-19-járvány alatti endovascularis akut ischaemiás stroke ellátás visszaesésének országos elemzése JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 3 SP - 188 EP - 189 PG - 2 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33146947 ID - 33146947 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Böjti, Péter Pál AU - Safouris, Apostolos AU - Czencz, Máté AU - Kondor, Máté AU - Szikora, István AU - Bereczki, Dániel TI - A logisztikai paradigmák hatása az akut stroke ellátást érintő változásokra a Covid-19 pandémia során JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 3 SP - 188 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33146876 ID - 33146876 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bereczki, Dániel AU - Bálint, M. AU - Ajtay, András AU - Oberfrank, F. AU - Vastagh, Ildikó TI - Pregestational neurological disorders among women of childbearing age-Nationwide data from a 13-year period in Hungary JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 9 PG - 14 SN - 1932-6203 DO - 10.1371/journal.pone.0274873 UR - https://m2.mtmt.hu/api/publication/33132870 ID - 33132870 N1 - János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary Department of Neurology, Bajcsy-Zsilinszky Hospital and Clinics, Budapest, Hungary Centre for Economic and Regional Studies, Budapest, Hungary Department of Neurology, Semmelweis University, Budapest, Hungary MTA-SE Neuroepidemiological Research Group, ELKH, Budapest, Hungary Hungarian Academy of Sciences, Budapest, Hungary Export Date: 18 April 2023 CODEN: POLNC Correspondence Address: Bereczki, D.; János Szentágothai Doctoral School of Neurosciences, Hungary; email: bereczki.daniel@hotmail.com LA - English DB - MTMT ER - TY - BOOK ED - Bereczki, Dániel ED - Ajtay, András TI - Magyarország neurológiai ellátása 2004-2020 PB - Semmelweis Kiadó CY - Budapest PY - 2022 SN - 9789633315576 UR - https://m2.mtmt.hu/api/publication/32909887 ID - 32909887 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hajnóczky, Nóra AU - Bereczki, Dániel TI - A malignus daganatok és az ischaemiás stroke kapcsolata. II. A diagnózisok időrendje és a stroke kezelése TS - II. A diagnózisok időrendje és a stroke kezelése JF - ORVOSI HETILAP J2 - ORV HETIL VL - 163 PY - 2022 IS - 2 SP - 43 EP - 51 PG - 9 SN - 0030-6002 DO - 10.1556/650.2022.32329 UR - https://m2.mtmt.hu/api/publication/32643078 ID - 32643078 N1 - Neurológiai Klinika, Semmelweis Egyetem, Általános Orostudományi Kar, Budapest, Hungary MTA-SE Neuroepidemiologiai Kutatocsoport - Eotvos Lorand Kutatasi Halozat, Budapest, Hungary Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, United States Balassa u. 6., Budapest, 1083, Hungary Export Date: 27 March 2023 CODEN: ORHEA AB - Cancer and stroke occur in similar patient populations, and they have similar traditional risk factors (hypertension, hyperlipidemia, obesity, diabetes, and smoking), therefore, it is beneficial to study the relationship between cancer and stroke. Patients diagnosed with cancer have an increased incidence of acute ischemic cerebral events within the first 6 months up to a year post diagnosis. The reverse relationship is also true for patients diagnosed with stroke and then cancer. Interestingly, patients may have a stroke as their first indication to an underlying developing cancer and will most often be diagnosed with cancer sometime within six months to a year after the cerebral incident. When cancer is diagnosed immediately after a cryptogenic stroke (unknown etiology), the stroke may be a result of cancer -associated hypercoagulability. The most common malignancies observed in the cancer-stroke patients are lung, breast and melanoma. Currently, there are no pharmacologic recommendations for primary stroke prevention in cancer patients. For acute ischemic stroke, life expectancy and the potential for hemorrhagic complications should be con -sidered when deciding on thrombolytic treatment. Only a few case series have been reported on mechanical thrombectomy in malignancies, and there are no guideline recommendations yet. Secondary prevention is advised through low molecular weight heparin. Understanding cancer-associated hypercoagulability and the ways we can prevent the combined effects of cancer and stroke is a crucial gap that requires further studies. Additionally, guides to aid in the recognition of underlying malignancy in patients suffering from cryptogenic stroke need to be estab-lished. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hajnóczky, Nóra AU - Bereczki, Dániel TI - A malignus daganatok és az ischaemiás stroke kapcsolata. I. A thrombosis kialakulása, átfedő kockázati tényezők TS - I. A thrombosis kialakulása, átfedő kockázati tényezők JF - ORVOSI HETILAP J2 - ORV HETIL VL - 163 PY - 2022 IS - 1 SP - 3 EP - 11 PG - 9 SN - 0030-6002 DO - 10.1556/650.2022.32328 UR - https://m2.mtmt.hu/api/publication/32630109 ID - 32630109 AB - Cancer and stroke have long been studied individually, but their detrimental forces together have also been a strong point of focus. The occurrence of both cancer and stroke in a patient is often a reflection of their similar risk factors (hypertension, hyperlipidemia, diabetes, obesity, and smoking), however, a subgroup of the cancer stroke population is believed to occur due to cancer-associated hypercoagulability. A deeper look into the cancer-associated hypercoagulable environment has indicated that thrombosis may be explained by cancer's role in several factors, including activation of platelets and tissue factor, elevated expression of heparanase and influence on neutrophilic extracellular traps. When a cryptogenic stroke (stroke lacking the aforementioned risk factors) occurs due to the cancer-induced hypercoagulation state, patient serum D-dimer levels have been found elevated, and CT/MRI images of the brain have shown multivascular infarctions compared to stroke patients with traditional risk factors. Additionally, cancer treatment - chemotherapy and radiation - have also been found to increase the occurrence of cerebral vascular thrombosis. Further investigations are required to better understand cancer-associated vascular pathophysiologic changes and how to discern their unique strokes compared to strokes from other etiologies. With these insights, the prevalence of strokes in the cancer population could be decreased. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bereczki, Dániel AU - Nagy, Béla AU - Kerenyi, Adrienne AU - Nagy, Gábor AU - Szarka, Krisztina Zsuzsanna AU - Kristóf, Katalin AU - Szalay, Balázs AU - Vásárhelyi, Barna AU - Bhattoa Harjit, Pál AU - Kappelmayer, János TI - EDTA-Induced Pseudothrombocytopenia Up to 9 Months After Initial COVID-19 Infection Associated with Persistent Anti-SARS-CoV-2 IgM/IgG Seropositivity JF - LABORATORY MEDICINE J2 - LAB MED VL - 53 PY - 2022 IS - 2 SP - 206 EP - 209 PG - 4 SN - 0007-5027 DO - 10.1093/labmed/lmab050 UR - https://m2.mtmt.hu/api/publication/32478261 ID - 32478261 AB - Platelets have a role in vascular complications of COVID-19-related viral coagulopathy. Although immune-induced thrombocytopenia has been described mostly in moderate-to-severe COVID-19, the prognostic role of platelet count in COVID-19 is still controversial. Pseudothrombocytopenia has been reported to represent COVID-19-associated coagulopathy in critical illness, and transient EDTA-dependent pseudothrombocytopenia lasting less than 3 weeks was described in a patient with severe acute COVID-19 pneumonia. In our case study, EDTA-induced pseudothrombocytopenia was still present at 9 months after an initial SARS-CoV-2 virus infection in an apparently recovered 60 year old man. The persistence of antinucleocapside and antispike antibodies 9 months after the initial infection suggests that EDTA-induced pseudothrombocytopenia may be related to anti-SARS-CoV-2 IgG or IgM antibodies. We should acknowledge the possibility that pseudothrombocytopenia may also appear in some patients after seroconversion after the launch of large-scale vaccination programs. LA - English DB - MTMT ER -