TY - JOUR AU - OKAMOTO, MASAHIRO AU - SHIMODA, RYO AU - AMAYA, YUKI AU - SOYA, SHINGO AU - SOYA, MARIKO AU - KOIZUMI, HIKARU AU - NAKAMURA, KENGO AU - HIRAGA, TAICHI AU - Torma, Ferenc Gergely AU - SOYA, HIDEAKI TI - Accelerated Fear Extinction by Regular Light-Intensity Exercise: A Possible Role of Hippocampal BDNF-TrkB Signaling JF - MEDICINE AND SCIENCE IN SPORTS AND EXERCISE J2 - MED SCI SPORT EXER VL - 56 PY - 2024 IS - 2 SP - 221 EP - 229 PG - 9 SN - 0195-9131 DO - 10.1249/MSS.0000000000003312 UR - https://m2.mtmt.hu/api/publication/34776881 ID - 34776881 LA - English DB - MTMT ER - TY - JOUR AU - Ayaz, Asma AU - Zaman, Wajid AU - Radák, Zsolt AU - Gu, Yaodong TI - Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 13 PY - 2024 IS - 4 SP - 437 SN - 2076-3921 DO - 10.3390/antiox13040437 UR - https://m2.mtmt.hu/api/publication/34775640 ID - 34775640 AB - The intricate interplay between plant-based nutrition, antioxidants, and their impact on athletic performance forms the cornerstone of this comprehensive review. Emphasizing the pivotal importance of dietary choices in the realm of sports, this paper sets the stage for an in-depth exploration of how stress and physical performance are interconnected through the lens of nutrition. The increasing interest among athletes in plant-based diets presents an opportunity with benefits for health, performance, and recovery. It is essential to investigate the connection between sports, plants, and antioxidants. Highlighting the impact of nutrition on recovery and well-being, this review emphasizes how antioxidants can help mitigate oxidative stress. Furthermore, it discusses the growing popularity of plant-based diets among athletes. It elaborates on the importance of antioxidants in combating radicals addressing stress levels while promoting cellular health. By identifying rich foods, it emphasizes the role of a balanced diet in ensuring sufficient intake of these beneficial compounds. Examining stress within the context of sports activities, this review provides insights into its mechanisms and its impact on athletic performance as well as recovery processes. This study explores the impact of plant-based diets on athletes including their types, potential advantages and challenges. It also addresses the drawbacks of relying on plant-based diets, concerns related to antioxidant supplementation and identifies areas where further research is needed. Furthermore, the review suggests directions for research and potential innovations in sports nutrition. Ultimately it brings together the aspects of sports, plant-based nutrition, and antioxidants to provide a perspective for athletes, researchers and practitioners. By consolidating existing knowledge, it offers insights that can pave the way for advancements in the ever-evolving field of sports nutrition. LA - English DB - MTMT ER - TY - JOUR AU - Kolonics, Attila AU - Kawamura, Takuji AU - Szipőcs, Róbert AU - Radák, Zsolt TI - Combined NAD(P)H and lipofuscin FLIM revealed the development of metabolic syndrome in the liver of epigenetically altered rats JF - PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING J2 - PROCEEDINGS OF SPIE VL - 12849 PY - 2024 PG - 9 SN - 0277-786X DO - 10.1117/12.3005632 UR - https://m2.mtmt.hu/api/publication/34743288 ID - 34743288 LA - English DB - MTMT ER - TY - JOUR AU - Olek, Robert A. AU - Kujach, Sylwester AU - Radák, Zsolt TI - Current knowledge about pyruvate supplementation: A brief review JF - SPORTS MEDICINE AND HEALTH SCIENCE J2 - SPORTS MED HEALTH SCI VL - 2024 PY - 2024 SN - 2666-3376 DO - 10.1016/j.smhs.2024.02.007 UR - https://m2.mtmt.hu/api/publication/34718895 ID - 34718895 LA - English DB - MTMT ER - TY - JOUR AU - Oroszi, Tamás AU - Felszeghy, Klára AU - Luiten, Paul G.M. AU - Schoemaker, Regien G. AU - van der Zee, Eddy A. AU - Nyakas, Csaba TI - Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 4 PG - 11 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e26608 UR - https://m2.mtmt.hu/api/publication/34714793 ID - 34714793 N1 - Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, Netherlands Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary Department of Morphology and Physiology, Health Science Faculty, Semmelweis University, Budapest, Hungary Export Date: 10 April 2024 Correspondence Address: Oroszi, T.; Department of Molecular Neurobiology, Netherlands; email: t.oroszi@rug.nl LA - English DB - MTMT ER - TY - JOUR AU - Torma, Ferenc Gergely AU - Kerepesi, Csaba AU - Jókai, Mátyás AU - Bábszky, Gergely AU - Koltai, Erika AU - Ligeti, Balázs AU - Kalcsevszki, Regina AU - McGreevy, Kristen M. AU - Horvath, Steve AU - Radák, Zsolt TI - Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness JF - AGING CELL J2 - AGING CELL PY - 2024 SN - 1474-9718 DO - 10.1111/acel.14101 UR - https://m2.mtmt.hu/api/publication/34693196 ID - 34693196 N1 - Funding Agency and Grant Number: European Union; National Research, Development and Innovation Office, Hungary; National Excellence Program [126823]; National Science and Research Found [OTKA142192, TKP2021-EGA-37]; Hungarian University Sport Science, Innovation and Technology Ministry, Hungary [2021-28]; National Academy of Science, Hungary; [RRF-2.3.1-21-2022-00004]; [OTKA146113] Funding text: CK was supported by the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory, and the National Excellence Program (OTKA146113) of the National Research, Development and Innovation Office, Hungary. ZR acknowledges support from the National Excellence Program (126823) National Science and Research Found (OTKA142192) and Scientific Excellence Program TKP2021-EGA-37 at the Hungarian University Sport Science, Innovation and Technology Ministry, Hungary, as well as Post-Covid 2021-28 grant by National Academy of Science, Hungary. We thank to Szilvia Farkas (Semmelweis University, Hungary) for the valuable discussions. AB - Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness. LA - English DB - MTMT ER - TY - GEN AU - Takuji, Kawamura AU - Mitsuru, Higuchi AU - Tomoko, Ito AU - Ryoko, Kawakami AU - Chiyoko, Usui AU - Kristen, M. McGreevy AU - Steve, Horvath AU - Radák, Zsolt AU - Suguru, Torii AU - Katsuhiko, Suzuki AU - Kaori, Ishii AU - Shizuo, Sakamoto AU - Koichiro, Oka AU - Isao, Muraoka AU - Kumpei, Tanisawa TI - Healthy Japanese Dietary Pattern Is Associated with Slower Biological Aging in Older Men: WASEDA’S Health Study PY - 2024 SP - 2024.01.20.24300981 UR - https://m2.mtmt.hu/api/publication/34539499 ID - 34539499 AB - Aging is the greatest risk factor for numerous diseases and mortality, and establishing geroprotective interventions targeting aging is required. Previous studies have suggested that healthy dietary patterns, such as the Mediterranean diet, are associated with delayed biological aging; however, these associations depend on nationality and sex. Therefore, this study aimed to investigate the relationship between dietary patterns identified through principal component analysis and biological aging in older men of Japan, one of the countries with the longest life expectancies. Principal component analysis identified two dietary patterns: a healthy Japanese dietary pattern and a Western-style dietary pattern. Eight epigenetic clocks, some of the most accurate aging biomarkers, were identified using DNA methylation data from whole-blood samples. Correlation analyses revealed that healthy Japanese dietary patterns were significantly negatively or positively correlated with multiple epigenetic age accelerations (AgeAccel), including AgeAccelGrim, FitAgeAccel, and age-adjusted DNAm-based telomere length (DNAmTLAdjAge). Conversely, the Western-style dietary pattern showed no significant correlation with any of the examined epigenetic AgeAccels or age-adjusted values. After adjusting for confounders, the healthy Japanese dietary pattern remained significantly negatively correlated with AgeAccelPheno and AgeAccelGrim and positively correlated with DNAmTLAdjAge. These findings suggest that a Western-style dietary pattern is not associated with biological aging, whereas a healthy Japanese dietary pattern is associated with delayed biological aging in older Japanese men. Our findings provide evidence that healthy dietary patterns may have beneficial effects on delayed biological aging in older Japanese men.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was supported by Grant-in-Aid for Early-Career Scientists (20K19520) from the Japan Society for the Promotion of Science. This project is a collaborative research project with the Institute of Stress Science, Public Health Research Foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Research Ethics Committee of Waseda University (approval numbers: 2014-G002 and 2018-G001)I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.Yes LA - English DB - MTMT ER - TY - JOUR AU - Mozaffaritabar, Soroosh AU - Koltai, Erika AU - Zhou, Lei AU - Bori, Zoltán AU - Kolonics, Attila AU - Kujach, Sylwester AU - Gu, Yaodong AU - Koike, Atsuko AU - Boros, Anita AU - Radák, Zsolt TI - PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle JF - JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY J2 - J PHYSIOL BIOCHEM VL - 2024 PY - 2024 SN - 1138-7548 DO - 10.1007/s13105-024-01006-1 UR - https://m2.mtmt.hu/api/publication/34539479 ID - 34539479 N1 - Received25 August 2023 Accepted10 January 2024 Published23 January 2024 AB - The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling. LA - English DB - MTMT ER - TY - JOUR AU - Zhou, Lei AU - Mozaffaritabar, Soroosh AU - Kolonics, Attila AU - Kawamura, Takuji AU - Koike, Atsuko AU - Kéringer, Johanna AU - Gu, Yaodong AU - Karabanov, Roman AU - Radák, Zsolt TI - Long-term iron supplementation combined with vitamin B6 enhances maximal oxygen uptake and promotes skeletal muscle-specific mitochondrial biogenesis in rats JF - FRONTIERS IN NUTRITION J2 - FRONT NUTR VL - 10 PY - 2024 SN - 2296-861X DO - 10.3389/fnut.2023.1335187 UR - https://m2.mtmt.hu/api/publication/34504451 ID - 34504451 N1 - Received: 08 November 2023; Accepted: 30 December 2023; Published: 15 January 2024. LA - English DB - MTMT ER - TY - JOUR AU - Zhou, Lei AU - Mozaffaritabar, Soroosh AU - Kawamura, Takuji AU - Koike, Atsuko AU - Kolonics, Attila AU - Kéringer, Johanna AU - Pinho, Ricardo A. AU - Sun, Jingquan AU - Shangguan, Ruonan AU - Radák, Zsolt TI - The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 2 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e24421 UR - https://m2.mtmt.hu/api/publication/34503809 ID - 34503809 LA - English DB - MTMT ER -