@article{MTMT:34776881, title = {Accelerated Fear Extinction by Regular Light-Intensity Exercise: A Possible Role of Hippocampal BDNF-TrkB Signaling}, url = {https://m2.mtmt.hu/api/publication/34776881}, author = {OKAMOTO, MASAHIRO and SHIMODA, RYO and AMAYA, YUKI and SOYA, SHINGO and SOYA, MARIKO and KOIZUMI, HIKARU and NAKAMURA, KENGO and HIRAGA, TAICHI and Torma, Ferenc Gergely and SOYA, HIDEAKI}, doi = {10.1249/MSS.0000000000003312}, journal-iso = {MED SCI SPORT EXER}, journal = {MEDICINE AND SCIENCE IN SPORTS AND EXERCISE}, volume = {56}, unique-id = {34776881}, issn = {0195-9131}, year = {2024}, eissn = {1530-0315}, pages = {221-229} } @article{MTMT:34775640, title = {Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance}, url = {https://m2.mtmt.hu/api/publication/34775640}, author = {Ayaz, Asma and Zaman, Wajid and Radák, Zsolt and Gu, Yaodong}, doi = {10.3390/antiox13040437}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {13}, unique-id = {34775640}, abstract = {The intricate interplay between plant-based nutrition, antioxidants, and their impact on athletic performance forms the cornerstone of this comprehensive review. Emphasizing the pivotal importance of dietary choices in the realm of sports, this paper sets the stage for an in-depth exploration of how stress and physical performance are interconnected through the lens of nutrition. The increasing interest among athletes in plant-based diets presents an opportunity with benefits for health, performance, and recovery. It is essential to investigate the connection between sports, plants, and antioxidants. Highlighting the impact of nutrition on recovery and well-being, this review emphasizes how antioxidants can help mitigate oxidative stress. Furthermore, it discusses the growing popularity of plant-based diets among athletes. It elaborates on the importance of antioxidants in combating radicals addressing stress levels while promoting cellular health. By identifying rich foods, it emphasizes the role of a balanced diet in ensuring sufficient intake of these beneficial compounds. Examining stress within the context of sports activities, this review provides insights into its mechanisms and its impact on athletic performance as well as recovery processes. This study explores the impact of plant-based diets on athletes including their types, potential advantages and challenges. It also addresses the drawbacks of relying on plant-based diets, concerns related to antioxidant supplementation and identifies areas where further research is needed. Furthermore, the review suggests directions for research and potential innovations in sports nutrition. Ultimately it brings together the aspects of sports, plant-based nutrition, and antioxidants to provide a perspective for athletes, researchers and practitioners. By consolidating existing knowledge, it offers insights that can pave the way for advancements in the ever-evolving field of sports nutrition.}, year = {2024}, eissn = {2076-3921}, pages = {437}, orcid-numbers = {Ayaz, Asma/0000-0002-7596-8513; Zaman, Wajid/0000-0001-6864-2366; Radák, Zsolt/0000-0003-1297-6804; Gu, Yaodong/0000-0003-2187-9440} } @article{MTMT:34743288, title = {Combined NAD(P)H and lipofuscin FLIM revealed the development of metabolic syndrome in the liver of epigenetically altered rats}, url = {https://m2.mtmt.hu/api/publication/34743288}, author = {Kolonics, Attila and Kawamura, Takuji and Szipőcs, Róbert and Radák, Zsolt}, doi = {10.1117/12.3005632}, journal-iso = {PROCEEDINGS OF SPIE}, journal = {PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING}, volume = {12849}, unique-id = {34743288}, issn = {0277-786X}, year = {2024}, eissn = {1996-756X}, orcid-numbers = {Kolonics, Attila/0000-0003-3990-5336; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:34718895, title = {Current knowledge about pyruvate supplementation: A brief review}, url = {https://m2.mtmt.hu/api/publication/34718895}, author = {Olek, Robert A. and Kujach, Sylwester and Radák, Zsolt}, doi = {10.1016/j.smhs.2024.02.007}, journal-iso = {SPORTS MED HEALTH SCI}, journal = {SPORTS MEDICINE AND HEALTH SCIENCE}, volume = {2024}, unique-id = {34718895}, issn = {2666-3376}, year = {2024}, orcid-numbers = {Olek, Robert A./0000-0002-3714-7386; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:34714793, title = {Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats}, url = {https://m2.mtmt.hu/api/publication/34714793}, author = {Oroszi, Tamás and Felszeghy, Klára and Luiten, Paul G.M. and Schoemaker, Regien G. and van der Zee, Eddy A. and Nyakas, Csaba}, doi = {10.1016/j.heliyon.2024.e26608}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34714793}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Oroszi, Tamás/0000-0003-2327-9959; Felszeghy, Klára/0000-0002-3539-1457; van der Zee, Eddy A./0000-0002-6471-7938; Nyakas, Csaba/0000-0003-3756-0186} } @article{MTMT:34693196, title = {Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness}, url = {https://m2.mtmt.hu/api/publication/34693196}, author = {Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt}, doi = {10.1111/acel.14101}, journal-iso = {AGING CELL}, journal = {AGING CELL}, unique-id = {34693196}, issn = {1474-9718}, abstract = {Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.}, year = {2024}, eissn = {1474-9726}, orcid-numbers = {Kerepesi, Csaba/0000-0001-9541-246X; Bábszky, Gergely/0000-0002-5939-8434; Koltai, Erika/0000-0002-1370-2955; Horvath, Steve/0000-0002-4110-3589; Radák, Zsolt/0000-0003-1297-6804} } @misc{MTMT:34539499, title = {Healthy Japanese Dietary Pattern Is Associated with Slower Biological Aging in Older Men: WASEDA’S Health Study}, url = {https://m2.mtmt.hu/api/publication/34539499}, author = {Takuji, Kawamura and Mitsuru, Higuchi and Tomoko, Ito and Ryoko, Kawakami and Chiyoko, Usui and Kristen, M. McGreevy and Steve, Horvath and Radák, Zsolt and Suguru, Torii and Katsuhiko, Suzuki and Kaori, Ishii and Shizuo, Sakamoto and Koichiro, Oka and Isao, Muraoka and Kumpei, Tanisawa}, unique-id = {34539499}, abstract = {Aging is the greatest risk factor for numerous diseases and mortality, and establishing geroprotective interventions targeting aging is required. Previous studies have suggested that healthy dietary patterns, such as the Mediterranean diet, are associated with delayed biological aging; however, these associations depend on nationality and sex. Therefore, this study aimed to investigate the relationship between dietary patterns identified through principal component analysis and biological aging in older men of Japan, one of the countries with the longest life expectancies. Principal component analysis identified two dietary patterns: a healthy Japanese dietary pattern and a Western-style dietary pattern. Eight epigenetic clocks, some of the most accurate aging biomarkers, were identified using DNA methylation data from whole-blood samples. Correlation analyses revealed that healthy Japanese dietary patterns were significantly negatively or positively correlated with multiple epigenetic age accelerations (AgeAccel), including AgeAccelGrim, FitAgeAccel, and age-adjusted DNAm-based telomere length (DNAmTLAdjAge). Conversely, the Western-style dietary pattern showed no significant correlation with any of the examined epigenetic AgeAccels or age-adjusted values. After adjusting for confounders, the healthy Japanese dietary pattern remained significantly negatively correlated with AgeAccelPheno and AgeAccelGrim and positively correlated with DNAmTLAdjAge. These findings suggest that a Western-style dietary pattern is not associated with biological aging, whereas a healthy Japanese dietary pattern is associated with delayed biological aging in older Japanese men. Our findings provide evidence that healthy dietary patterns may have beneficial effects on delayed biological aging in older Japanese men.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was supported by Grant-in-Aid for Early-Career Scientists (20K19520) from the Japan Society for the Promotion of Science. This project is a collaborative research project with the Institute of Stress Science, Public Health Research Foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Research Ethics Committee of Waseda University (approval numbers: 2014-G002 and 2018-G001)I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.Yes}, year = {2024}, pages = {2024.01.20.24300981}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:34539479, title = {PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle}, url = {https://m2.mtmt.hu/api/publication/34539479}, author = {Mozaffaritabar, Soroosh and Koltai, Erika and Zhou, Lei and Bori, Zoltán and Kolonics, Attila and Kujach, Sylwester and Gu, Yaodong and Koike, Atsuko and Boros, Anita and Radák, Zsolt}, doi = {10.1007/s13105-024-01006-1}, journal-iso = {J PHYSIOL BIOCHEM}, journal = {JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY}, volume = {2024}, unique-id = {34539479}, issn = {1138-7548}, abstract = {The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.}, keywords = {skeletal muscle; lipid metabolism; Exercise; Mitochondrial function; PGC-1α overexpression}, year = {2024}, eissn = {1877-8755}, orcid-numbers = {Mozaffaritabar, Soroosh/0000-0003-1052-7140; Koltai, Erika/0000-0002-1370-2955; Zhou, Lei/0000-0002-8152-7896; Bori, Zoltán/0000-0003-1253-060X; Kolonics, Attila/0000-0003-3990-5336; Kujach, Sylwester/0000-0001-5520-1748; Koike, Atsuko/0009-0002-2668-7114; Boros, Anita/0000-0001-5330-9050; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:34504451, title = {Long-term iron supplementation combined with vitamin B6 enhances maximal oxygen uptake and promotes skeletal muscle-specific mitochondrial biogenesis in rats}, url = {https://m2.mtmt.hu/api/publication/34504451}, author = {Zhou, Lei and Mozaffaritabar, Soroosh and Kolonics, Attila and Kawamura, Takuji and Koike, Atsuko and Kéringer, Johanna and Gu, Yaodong and Karabanov, Roman and Radák, Zsolt}, doi = {10.3389/fnut.2023.1335187}, journal-iso = {FRONT NUTR}, journal = {FRONTIERS IN NUTRITION}, volume = {10}, unique-id = {34504451}, issn = {2296-861X}, year = {2024}, eissn = {2296-861X}, orcid-numbers = {Zhou, Lei/0000-0002-8152-7896; Mozaffaritabar, Soroosh/0000-0003-1052-7140; Kolonics, Attila/0000-0003-3990-5336; Kéringer, Johanna/0009-0001-8379-0866; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:34503809, title = {The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice}, url = {https://m2.mtmt.hu/api/publication/34503809}, author = {Zhou, Lei and Mozaffaritabar, Soroosh and Kawamura, Takuji and Koike, Atsuko and Kolonics, Attila and Kéringer, Johanna and Pinho, Ricardo A. and Sun, Jingquan and Shangguan, Ruonan and Radák, Zsolt}, doi = {10.1016/j.heliyon.2024.e24421}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34503809}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Zhou, Lei/0000-0002-8152-7896; Mozaffaritabar, Soroosh/0000-0003-1052-7140; Kawamura, Takuji/0000-0003-2110-8718; Kolonics, Attila/0000-0003-3990-5336; Kéringer, Johanna/0009-0001-8379-0866; Pinho, Ricardo A./0000-0003-3116-4553; Radák, Zsolt/0000-0003-1297-6804} }