@article{MTMT:34797483,
	title = {Birthweight trends and their explanatory factors in Hungary between 1999 and 2018. an analysis of the Hungarian Tauffer registry},
	url = {https://m2.mtmt.hu/api/publication/34797483},
	author = {Zsirai, László and Kun, Attila and Visolyi, Gergely and Svébis, Márk Márton and Domján, Beatrix Annamária and Tabák, Ádám},
	doi = {10.1186/s12978-024-01787-0},
	journal-iso = {REPROD HEALTH},
	journal = {REPRODUCTIVE HEALTH},
	volume = {21},
	unique-id = {34797483},
	abstract = {The increasing birthweight trend stopped and even reversed in several high income countries in the last 20 years, however the reason for these changes is not well characterized. We aimed to describe birthweight trends of term deliveries in Hungary between 1999 and 2018 and to investigate potential maternal and foetal variables that could drive these changes.We analysed data from the Hungarian Tauffer registry, a compulsory anonymized data collection of each delivery. We included all singleton term deliveries in 1999-2018 (n = 1,591,932). We modelled birthweight trends separately in 1999-2008 and 2008-2018 in hierarchical multiple linear regression models adjusted for calendar year, newborn sex, maternal age, gestational age at delivery, and other important determinants.Median birthweights increased from 3250/3400 g (girl/boy) to 3300/3440 g from 1999 to 2008 and decreased to 3260/3400 g in 2018. When we adjusted for gestational age at delivery the increase in the first period became more pronounced (5.4 g/year). During the second period, similar adjustment substantially decreased the rate of decline from 2.5 to 1.4 g/year. Further adjustment for maternal age halved the rate of increase to 2.4 g/year in the first period. During the second period, adjustment for maternal age had little effect on the estimate.Our findings of an increasing birthweight trend (mostly related to the aging of the mothers) in 1999-2008 may forecast an increased risk of cardiometabolic diseases in offsprings born in this period. In contrast, the decreasing birthweight trends after 2008 may reflect some beneficial effects on perinatal morbidity. However, the long-term effect cannot be predicted, as the trend is mostly explained by the shorter pregnancies.},
	keywords = {pregnancy; Gestational Age; parity; Maternal Age; Caesarean section; labor induction; Population-based study; birthweight; Obstetrical database; Week of delivery},
	year = {2024},
	eissn = {1742-4755},
	orcid-numbers = {Visolyi, Gergely/0000-0003-3677-7682; Svébis, Márk Márton/0000-0002-6624-9621; Tabák, Ádám/0000-0002-6234-3936}
}

@article{MTMT:34795043,
	title = {Analysis of SIRT1 Gene SNPs and Clinical Characteristics in Medication-Related Osteonecrosis of the Jaw},
	url = {https://m2.mtmt.hu/api/publication/34795043},
	author = {Bojtor, Bence and Vaszilkó, Mihály Tamás and Ármós, Richárd Levente and Tóbiás, Bálint and Podani, János and Szentpéteri, Szófia Katalin and Balla, Bernadett and Lengyel, Balazs and Pikó, Henriett and Illés, Anett and Kiss, András and Putz, Zsuzsanna and Takács, István and Kósa, János and Lakatos, Péter},
	doi = {10.3390/ijms25073646},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34795043},
	issn = {1661-6596},
	abstract = {Certain genetic factors, including single-nucleotide polymorphisms (SNPs) in the SIRT1 gene, have been linked to medication-related osteonecrosis of the jaw (MRONJ). This study examined four SNPs in the SIRT1 gene and implemented multivariate statistical analysis to analyze genetic and clinical factors in MRONJ patients. Genomic DNA was isolated from peripheral blood samples of 63 patients of European origin treated for MRONJ, and four SNP genotypes in the gene encoding the SIRT-1 protein were determined by Sanger sequencing. The allele frequencies measured in the MRONJ population were compared with allele frequencies measured in the European population in the National Center for Biotechnology Information Allele Frequency Aggregator (NCBI ALFA) database. Genetic and clinical factors were examined with multivariate statistical analysis. A C:A allele distribution ratio of 77.8:22.2 was measured in the rs932658 SNP. In the ALFA project, a C:A allele distribution ratio of 59.9:40.1 was detected in the European population, which was found to be a significant difference (p = 4.5 × 10−5). Multivariate statistical analysis revealed a positive correlation (0.275) between the genotype of SNP rs932658 and the number of stages improved during appropriate MRONJ therapy. It is concluded that allele A in SNP rs932658 in the SIRT1 gene acts as a protective factor in MRONJ.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Vaszilkó, Mihály Tamás/0000-0002-2570-0009; Tóbiás, Bálint/0000-0003-4343-1866; Podani, János/0000-0002-1452-1486; Szentpéteri, Szófia Katalin/0000-0003-0073-4154; Balla, Bernadett/0000-0003-2465-1804; Pikó, Henriett/0000-0002-3579-5451; Illés, Anett/0000-0001-5351-9015; Putz, Zsuzsanna/0000-0002-0674-337X; Takács, István/0000-0002-7810-4833; Lakatos, Péter/0000-0002-7652-3671}
}

@article{MTMT:34784033,
	title = {A diabeteses neuropathia jelentősége és diagnosztikája a klinikai gyakorlatban},
	url = {https://m2.mtmt.hu/api/publication/34784033},
	author = {Sztanek, Ferenc and Hernyák, Marcell and Kempler, Péter},
	doi = {10.33616/lam.34.0111},
	journal-iso = {LEGE ART MED},
	journal = {LEGE ARTIS MEDICINAE},
	volume = {34},
	unique-id = {34784033},
	issn = {0866-4811},
	abstract = {A diabeteses neuropathia a cukorbetegség korán kimutatható microvascularis szövődménye. Leggyakrabban a distalis típusú szimmetrikus polyneuropathia tünetei alapján gondolhatunk jelenlétére, az autonóm idegrendszer károsodása pedig fokozott cardiovascularis mortalitással jár. A diabeteses neuropathia szűrése lényeges a klinikai gyakorlatban, mivel a cukorbetegséghez köthető idegi károsodás jelei már korai szakaszban kimutathatók és terápiás beavatkozásra is lehetőséget adnak. A betegellátásban szintén fontos a diabeteses neuropathia megfelelő diagnózisa és folyamatos követése. Az összefoglaló a diabeteses neuropathia jelentőségét és diagnosztikai lehetőségeit tárgyalja a klinikai gyakorlat szempontjából.},
	year = {2024},
	eissn = {2063-4161},
	pages = {111-116},
	orcid-numbers = {Kempler, Péter/0000-0002-6072-8832}
}

@article{MTMT:34781507,
	title = {Letter to the Editor From Tőke and Tóth: “Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia”},
	url = {https://m2.mtmt.hu/api/publication/34781507},
	author = {Tőke, Judit and Tóth, Miklós},
	doi = {10.1210/clinem/dgae077},
	journal-iso = {J CLIN ENDOCR METAB},
	journal = {JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM},
	volume = {In press},
	unique-id = {34781507},
	issn = {0021-972X},
	year = {2024},
	eissn = {1945-7197},
	pages = {In press},
	orcid-numbers = {Tóth, Miklós/0000-0002-8701-408X}
}

@article{MTMT:34780698,
	title = {Az első hazai tapasztalatok összegzése kromoszomális microarray-analízis és teljesexom-szekvenálás módszerekkel a magzati diagnosztikában},
	url = {https://m2.mtmt.hu/api/publication/34780698},
	author = {Pikó, Henriett and Illés, Anett and Nagy, Sándor and Beke, Artúr and Árvai, Kristóf and Elekes, Tibor and Ferdinandyné Horváth, Emese and Ferenczy, Miklós and Mosonyi, Péter and Lukács, Valéria and Klujber, Valéria and Török, Olga and Kiss, Zsuzsanna and P Tardy, Erika and Tidrenczel, Zsolt and Tóbiás, Bálint and Balla, Bernadett and Lakatos, Péter and Kósa, János and Takács, István},
	doi = {10.1556/650.2024.33028},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34780698},
	issn = {0030-6002},
	abstract = {Bevezetés: Az elmúlt évtized egyik jelentős technológiai újdonsága az ún. ’high-throughput’ molekuláris genetikai vizsgálati módszerek – mint a kromoszomális microarray-analízis (chromosomal microarray analysis, CMA) és a teljesexom-szekvenálás (whole-exome sequencing, WES) – elterjedése a praenatalis diagnosztikában. Célkitűzés: Az elmúlt 5 évben munkacsoportunk több mint 252 praenatalis vizsgálatot végzett hazai laboratóriumi háttérrel, amelyek indikációját különböző súlyosságú strukturális magzati ultrahangeltérések képezték. A klasszikus citogenetikai vizsgálatok eredményétől függően végeztük el a nagy felbontású CMA- és WES-analíziseket a praenatalis diagnosztika érdekében. Módszer: A CMA-vizsgálatokat a „GeneChip System 3000 Instrument” platformmal végeztük az SNP-alapú komparatív hibridizálás módszerével. Az általunk elvégzett újgenerációs szekvenálás során a teljes humán exom szekvenciájának meghatározása IonTorrent és Illumina platformokkal történt. Eredmények: Összesen 252 magzati CMA-vizsgálatot végeztünk, és 42%-ban mutattunk ki valamilyen hiányt vagy többletet, ebből 22%-ban igazoltunk kóros eltérést. 42 esetben végeztünk WES-t, amelyből 9 esetben (21,4%) azonosítottunk kóros eltérést az öröklésmenetet támogató, a magzati fenotípussal feltételezhetően összefüggésben lévő, a ClinVar adatbázis vagy az ACMG-klasszifikáció alapján. Megbeszélés: Tekintettel arra, hogy a magzati fenotípus értékelése közvetett, a praenatalis CMA- és WES-elemzésnek elsősorban a magzati ultrahangvizsgálat során azonosítható strukturális anomáliákkal összefüggő génekre, kromoszomális régiókra kell korlátozódnia. A szülők vizsgálata mind a CMA-, mind a WES-analízisek során kiemelt jelentőséggel bír, főleg azokban az esetekben, amelyeknél a kapott eltérés nem hozható egyértelmű összefüggésbe az ultrahangeltérésekkel. Következtetés: Fontos meghatározni azokat a paramétereket, amelyek alapján a magzati mintában talált kópiaszám-eltéréseket és WES-vizsgálattal igazolt variánsokat a leletben közöljük (figyelembe véve a nemzetközi ajánlásokat). Ezek alapján a praenatalis klinikai genetikai tanácsadáskor sokkal használhatóbb információk adhatók. Orv Hetil. 2024; 165(14): 523–530.},
	year = {2024},
	eissn = {1788-6120},
	pages = {523-530},
	orcid-numbers = {Pikó, Henriett/0000-0002-3579-5451; Illés, Anett/0000-0001-5351-9015; Beke, Artúr/0000-0002-6826-7751; Árvai, Kristóf/0000-0001-8774-937X; Tidrenczel, Zsolt/0000-0001-7223-1551; Tóbiás, Bálint/0000-0003-4343-1866; Balla, Bernadett/0000-0003-2465-1804; Lakatos, Péter/0000-0002-7652-3671; Takács, István/0000-0002-7810-4833}
}

@article{MTMT:34775042,
	title = {Novel and potential future therapeutic options in systemic autoimmune diseases},
	url = {https://m2.mtmt.hu/api/publication/34775042},
	author = {Balogh, Lili and Olah, Katalin and Santa, Soma and Majerhoffer, Nora and Németh, Tamás},
	doi = {10.3389/fimmu.2024.1249500},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34775042},
	issn = {1664-3224},
	abstract = {Autoimmune inflammation is caused by the loss of tolerance to specific self-antigens and can result in organ-specific or systemic disorders. Systemic autoimmune diseases affect a significant portion of the population with an increasing rate of incidence, which means that is essential to have effective therapies to control these chronic disorders. Unfortunately, several patients with systemic autoimmune diseases do not respond at all or just partially respond to available conventional synthetic disease-modifying antirheumatic drugs and targeted therapies. However, during the past few years, some new medications have been approved and can be used in real-life clinical settings. Meanwhile, several new candidates appeared and can offer promising novel treatment options in the future. Here, we summarize the newly available medications and the most encouraging drug candidates in the treatment of systemic lupus erythematosus, rheumatoid arthritis, Sjogren's disease, systemic sclerosis, systemic vasculitis, and autoimmune myositis.},
	keywords = {INHIBITOR; SAFETY; RHEUMATOID-ARTHRITIS; ANTIBODY; EFFICACY; placebo; autoimmune disease; DOUBLE-BLIND; treatment; PRIMARY SJOGRENS-SYNDROME; Pathomechanism; LUPUS-ERYTHEMATOSUS; PHASE-2 TRIAL; EOSINOPHILIC GRANULOMATOSIS},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Németh, Tamás/0000-0001-6854-4301}
}

@article{MTMT:34773876,
	title = {Corrigendum: Comorbidities and outcomes of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a real-world, nationwide, retrospective study from Hungary},
	url = {https://m2.mtmt.hu/api/publication/34773876},
	author = {Batar, Peter and Alizadeh, Hussain and Rokszin, Gyorgy and Abonyi-Toth, Zsolt and Demeter, Judit},
	doi = {10.3389/pore.2024.1611758},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {30},
	unique-id = {34773876},
	issn = {1219-4956},
	year = {2024},
	eissn = {1532-2807},
	orcid-numbers = {Demeter, Judit/0000-0001-8745-0757}
}

@article{MTMT:34765047,
	title = {Evaluation of Office and Ambulatory Central Blood Pressure and Augmentation Index by Two Methods and Their Changes After Lifestyle or Medical Interventions in Hypertension},
	url = {https://m2.mtmt.hu/api/publication/34765047},
	author = {Gyöngyösi, Helga and Batta, Dóra and László, Andrea and Torzsa, Péter and Kőrösi, Beáta Zita and Nemcsik-Bencze, Zsófia and Cseprekál, Orsolya and Tislér, András and Nemcsik, János},
	doi = {10.1007/s44200-024-00045-9},
	journal-iso = {ARTERY RES},
	journal = {ARTERY RESEARCH},
	volume = {30},
	unique-id = {34765047},
	issn = {1872-9312},
	year = {2024},
	eissn = {1876-4401},
	orcid-numbers = {Batta, Dóra/0000-0001-7207-8665; Torzsa, Péter/0000-0002-8148-4961; Kőrösi, Beáta Zita/0000-0003-4995-6401; Cseprekál, Orsolya/0000-0003-2867-3875; Tislér, András/0000-0002-1265-1869; Nemcsik, János/0000-0002-3573-0287}
}

@article{MTMT:34763500,
	title = {Research autopsy programmes in oncology. shared experience from 14 centres across the world},
	url = {https://m2.mtmt.hu/api/publication/34763500},
	author = {Geukens, Tatjana and Maetens, Marion and Hooper, Jody E and Oesterreich, Steffi and Lee, Adrian V and Miller, Lori and Atkinson, Jenny M and Rosenzweig, Margaret and Puhalla, Shannon and Thorne, Heather and Devereux, Lisa and Bowtell, David and Loi, Sherene and Bacon, Eliza R and Ihle, Kena and Song, Mihae and Rodriguez-Rodriguez, Lorna and Welm, Alana L and Gauchay, Lisa and Murali, Rajmohan and Chanda, Pharto and Karacay, Ali and Naceur-Lombardelli, Cristina and Bridger, Hayley and Swanton, Charles and Jamal-Hanjani, Mariam and Kollath, Lori and True, Lawrence and Morrissey, Colm and Chambers, Meagan and Chinnaiyan, Arul M and Wilson, Allecia and Mehra, Rohit and Reichert, Zachery and Carey, Lisa A and Perou, Charles M and Kelly, Erin and Maeda, Daichi and Goto, Akiteru and Kulka, Janina and Székely, Borbála and Szász, Attila Marcell and Tőkés, Anna-Mária and Van Den Bogaert, Wouter and Floris, Giuseppe and Desmedt, Christine},
	doi = {10.1002/path.6271},
	journal-iso = {J PATHOL},
	journal = {JOURNAL OF PATHOLOGY},
	volume = {Mar 29},
	unique-id = {34763500},
	issn = {0022-3417},
	abstract = {While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field through synchronous, extensive, and high-volume sample collection. However, it remains an underused strategy in translational research. Via an extensive questionnaire, we collected information on the study design, enrolment strategy, study conduct, sample and data management, and challenges and opportunities of research autopsy programmes in oncology worldwide. Fourteen programmes participated in this study. Eight programmes operated 24 h/7 days, resulting in a lower median postmortem interval (time between death and start of the autopsy, 4 h) compared with those operating during working hours (9 h). Most programmes (n = 10) succeeded in collecting all samples within a median of 12 h after death. A large number of tumour sites were sampled during each autopsy (median 15.5 per patient). The median number of samples collected per patient was 58, including different processing methods for tumour samples but also non-tumour tissues and liquid biopsies. Unique biological insights derived from these samples included metastatic progression, treatment resistance, disease heterogeneity, tumour dormancy, interactions with the tumour micro-environment, and tumour representation in liquid biopsies. Tumour patient-derived xenograft (PDX) or organoid (PDO) models were additionally established, allowing for drug discovery and treatment sensitivity assays. Apart from the opportunities and achievements, we also present the challenges related with postmortem sample collections and strategies to overcome them, based on the shared experience of these 14 programmes. Through this work, we hope to increase the transparency of postmortem tissue donation, to encourage and aid the creation of new programmes, and to foster collaborations on these unique sample collections. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.},
	keywords = {liquid biopsy; metastatic cancer; tissue donation; research autopsy; tumour model},
	year = {2024},
	eissn = {1096-9896},
	orcid-numbers = {Kulka, Janina/0000-0001-6498-5943; Szász, Attila Marcell/0000-0003-2739-4196; Tőkés, Anna-Mária/0000-0002-9581-7536}
}

@article{MTMT:34763005,
	title = {Burden of Mental Health among Patients with Inflammatory Bowel Disease—A Cross-Sectional Study from a Tertiary IBD Center in Hungary},
	url = {https://m2.mtmt.hu/api/publication/34763005},
	author = {Lontai, Livia and Elek, Lívia Priyanka and Balogh, Fruzsina and Angyal, Dorottya and Pajkossy, Péter and Gönczi, Lóránt and Lakatos, Péter László and Iliás, Ákos},
	doi = {10.3390/jcm13072002},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34763005},
	abstract = {Background: Inflammatory bowel diseases (IBDs) are chronic conditions that negatively affect the patient’s quality of life. With the spread of the biopsychosocial model, the role of mental health in the activity and course of inflammatory bowel disease is becoming more and more recognized. Our study aimed to assess the prevalence of anxiety and depression in IBD patients in our tertiary referral center and determine the predictive factors of these mental conditions. Methods: A total of 117 patients were included consecutively between 1 December 2021 and 28 February 2022. We used a questionnaire to gather demographic information, disease course, and IBD-specific symptoms. We assessed anxiety symptoms using the GAD-7 and depressive complaints using the PHQ-9 questionnaire. We evaluated disease activity using CDAI and pMayo scores. Results: Of the 117 patients (male/female: 63/54), 88 suffered from Crohn’s disease, and 29 were diagnosed with ulcerative colitis. Only 6 patients were taking medication for mood disorders, and 38 individuals sought mental support during their lifetime. A total of 15% of the population suffered from moderate–severe anxiety disorder, and 22% were affected by moderate–severe depression. The GAD-7 and PHQ9 values showed a significant correlation between the number of stools, bloody stools, abdominal pain, number of flare-ups, and CDAI scores. Conclusions: Our study confirmed that there is a high incidence of anxiety and depressive symptoms among IBD patients. Our results highlighted the symptoms that could be associated with mental disorders. It is important to assess the mental status of IBD patients to improve their quality of life.},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Balogh, Fruzsina/0000-0003-4623-4024; Gönczi, Lóránt/0000-0002-8819-6460; Lakatos, Péter László/0000-0002-3948-6488; Iliás, Ákos/0000-0002-9865-2642}
}