TY - GEN AU - Erdelyi-Hamza, Berta AU - Török, Dóra AU - Gál, Zsófia AU - Gyorik, Dorka AU - Eszlári, Nóra AU - Bagdy, György AU - Juhász, Gabriella AU - Gonda, Xénia TI - CLOCK gene plays role in the genetic background of depression after stressful life events – a GWAS study PY - 2023 UR - https://m2.mtmt.hu/api/publication/34091453 ID - 34091453 LA - English DB - MTMT ER - TY - BOOK ED - Smirnova, Daria ED - Fountoulakis, Konstantinos N ED - Gonda, Xénia ED - Morgado, Pedro TI - COVID-19 Pandemic: Mental health, life habit changes and social phenomena T3 - Frontiers Research Topics, ISSN 1664-8714 PB - Frontiers Media S.A. CY - Lausanne PY - 2023 SP - 1399 SN - 9782832511756 DO - 10.3389/978-2-83251-175-6 UR - https://m2.mtmt.hu/api/publication/33577345 ID - 33577345 LA - English DB - MTMT ER - TY - JOUR AU - Vas, Szilvia AU - Papp, Rege Sugárka AU - Könczöl, Katalin AU - Bogáthy, Emese AU - Papp, Noémi AU - Ádori, Csaba AU - Durst, Máté AU - Sípos, Klaudia AU - Ocskay, Klementina AU - Farkas, Imre AU - Bálint, Flóra AU - Ferenczi, Szilamér AU - Török, Bibiána AU - Kovács, Anita AU - Szabó, Evelin AU - Zelena, Dóra AU - Kovács, Krisztina AU - Földes, Anna AU - Kató, Erzsébet AU - Köles, László AU - Bagdy, György AU - Palkovits, Miklós AU - Tóth, Zsuzsanna TI - Prolactin-releasing peptide contributes to stress-related mood disorders and inhibits sleep/mood regulatory melanin-concentrating hormone neurons in rats. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 43 PY - 2023 IS - 5 SP - 846 EP - 862 PG - 17 SN - 0270-6474 DO - 10.1523/JNEUROSCI.2139-21.2022 UR - https://m2.mtmt.hu/api/publication/33543493 ID - 33543493 AB - Stress disorders impair sleep, quality of life, however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator, therefore, we hypothesised that PrRP may be involved in the development of stress disorders. PrRP is produced by the medullary A1/A2 noradrenaline (NA) cells, which transmit stress signals to forebrain centers, and by non-NA cells in the hypothalamic dorsomedial nucleus. We found in male rats that both PrRP and PrRP-NA cells innervate melanin-concentrating hormone (MCH) producing neurons in the dorsolateral hypothalamus (DLH). These cells serve as a key hub for regulating sleep and affective states. Ex vivo, PrRP hyperpolarized MCH neurons and further increased the hyperpolarization caused by NA. Following sleep deprivation, intracerebroventricular PrRP injection reduced the number of REM sleep-active MCH cells. PrRP expression in the dorsomedial nucleus was up-regulated by sleep deprivation, while down-regulated by REM sleep rebound. Both in learned helplessness paradigm and after peripheral inflammation, impaired coping with sustained stress was associated with (i) overactivation of PrRP cells, (ii) PrRP protein and receptor depletion in the DLH, and (iii) dysregulation of MCH expression. Exposure to stress in PrRP insensitive period led to increased passive coping with stress. Normal PrRP signaling, therefore, seems to protect animals against stress-related disorders. PrRP signaling in the DLH is important component of the PrRP's action, which may be mediated by MCH neurons. Moreover, PrRP receptors were downregulated in the DLH of human suicidal victims. As stress-related mental disorders are the leading cause of suicide, our findings may have particular translational relevance.SIGNIFICANCE STATEMENT:Treatment resistance to monoaminergic antidepressants is a major problem. Neuropeptides that modulate the central monoaminergic signaling are promising targets for developing alternative therapeutic strategies. We found that stress-responsive prolactin-releasing peptide (PrRP) cells innervated melanin-concentrating hormone (MCH) neurons that are crucial in the regulation of sleep and mood. PrRP inhibited MCH cell activity and enhanced the inhibitory effect evoked by noradrenaline, a classic monoamine, on MCH neurons. We observed that impaired PrRP signaling led to failure in coping with chronic/repeated stress and was associated with altered MCH expression. We found alterations of the PrRP system also in suicidal human subjects. PrRP dysfunction may underlie stress disorders, and fine-tuning MCH activity by PrRP may be an important part of the mechanism. LA - English DB - MTMT ER - TY - JOUR AU - Fico, Giovanna AU - Janiri, Delfina AU - Pinna, Marco AU - Sagué-Vilavella, Maria AU - Palomo, Anna Gimenez AU - Oliva, Vincenzo AU - De Prisco, Michele AU - Cortez, Pablo Guzmán AU - Anmella, Gerard AU - Gonda, Xénia AU - Sani, Gabriele AU - Tondo, Leonardo AU - Vieta, Eduard AU - Murru, Andrea TI - Affective temperaments mediate aggressive dimensions in bipolar disorders. A cluster analysis from a large, cross-sectional, international study TS - A cluster analysis from a large, cross-sectional, international study JF - JOURNAL OF AFFECTIVE DISORDERS J2 - J AFFECT DISORDERS VL - 323 PY - 2023 SP - 327 EP - 335 PG - 9 SN - 0165-0327 DO - 10.1016/j.jad.2022.11.084 UR - https://m2.mtmt.hu/api/publication/33296256 ID - 33296256 N1 - Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova, 143, Barcelona, 08036, Spain Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, Barcelona, 08036, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, Barcelona, 08036, Spain Institute of Neurosciences (UBNeuro), p. de la Vall d'Hebron, 171, Barcelona, 08035, Spain CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain Department of Neuroscience, Section of Psychiatry, Catholic University of the Sacred Hearth, Roma, Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy Lucio Bini Mood Disorders Center, Cagliari, Italy Section of Psychiatry, Department of Medical Science and Public Health, University of Cagliari, Italy Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy Institut Clínic de Neurociències, Psychiatry and Psychology Service, Grup Recerca Addiccions Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic de Barcelona, Barcelona, Spain Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary McLean Hospital–Harvard Medical School, Boston, United States NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, Russian Federation Export Date: 16 January 2023 CODEN: JADID Correspondence Address: Vieta, E.; Bipolar and Depressive Disorders Unit, 170 Villarroel St, Catalonia, Spain; email: evieta@clinic.cat AB - Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB.Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership.799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership.Recall bias might have affected the recollection of AB.Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB. LA - English DB - MTMT ER - TY - JOUR AU - Gonda, Xénia AU - Döme, Péter AU - Neill, Joanna C. AU - Tarazi, Frank I. TI - Novel antidepressant drugs: Beyond monoamine targets JF - CNS SPECTRUMS J2 - CNS SPECTRUMS VL - 28 PY - 2023 IS - 1 SP - 6 EP - 15 PG - 10 SN - 1092-8529 DO - 10.1017/S1092852921000791 UR - https://m2.mtmt.hu/api/publication/32259137 ID - 32259137 N1 - Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary Nyiro Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom Medical Psychedelics Working Group, Drug Science, Manchester, United Kingdom Department of Psychiatry and Neuroscience Program, Harvard Medical School, McLean Hospital, Belmont, MA, United States Export Date: 25 November 2021 CODEN: CNSPF Correspondence Address: Tarazi, F.I.; Department of Psychiatry and Neuroscience Program, United States; email: ftarazi@hms.harvard.edu LA - English DB - MTMT ER - TY - JOUR AU - Török, Dóra AU - Gál, Zsófia AU - Gecse, Kinga AU - Eszlári, Nóra AU - Juhász, Gabriella AU - Petschner, Péter TI - INVESTIGATING THE POLYGENIC SIGNAL OF MIGRAINE: COMPARISON OF DIFFERENT COHORTS JF - EUROPEAN NEUROPSYCHOPHARMACOLOGY J2 - EUR NEUROPSYCHOPHARM VL - 63 PY - 2022 SP - e249 EP - e250 SN - 0924-977X DO - 10.1016/j.euroneuro.2022.07.446 UR - https://m2.mtmt.hu/api/publication/33648554 ID - 33648554 LA - English DB - MTMT ER - TY - GEN AU - Gecse, Kinga AU - Tamás, Nagy AU - Bagdy, György AU - Juhász, Gabriella TI - Alterations of tryptophan pathway and cytokine profile in migraine patients PY - 2022 UR - https://m2.mtmt.hu/api/publication/33643403 ID - 33643403 LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Kinga AU - Nagy, T. AU - Környei, Z. AU - Dénes, Á. AU - Bagdy, György AU - Juhász, Gabriella TI - Decreased plasma RANTES/CCL5 concentration in headache-free episodic migraine patients JF - JOURNAL OF HEADACHE AND PAIN J2 - J HEADACHE PAIN VL - 23 PY - 2022 IS - Suppl. 1. SN - 1129-2369 UR - https://m2.mtmt.hu/api/publication/33643393 ID - 33643393 LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Kinga AU - K., Norbert AU - Dobos, Dóra AU - Baksa, Dániel AU - C., Aranyi AU - M., Emri AU - Kökönyei, Gyöngyi AU - Bagdy, György AU - Juhász, Gabriella TI - Why is my headache different? Functional connectivity alterations of periaqueductal gray matter in migraine and tension-type headache patients JF - NEUROSCIENCE APPLIED J2 - NEUROSCI APPL VL - 1 PY - 2022 IS - Suppl. 2. SN - 2772-4085 DO - 10.1016/j.nsa.2022.100552 UR - https://m2.mtmt.hu/api/publication/33641776 ID - 33641776 N1 - Abstracts of the 35th ECNP Congress 2022 LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Kinga AU - Dobos, Dóra AU - N., Károlyi AU - Baksa, Dániel AU - C.S., Aranyi AU - M., Emri AU - Kökönyei, Gyöngyi AU - Bagdy, György AU - Juhász, Gabriella TI - Tension-type headache frequency correlates with periaqueductal gray matter functional connectivity JF - NEUROSCIENCE APPLIED J2 - NEUROSCI APPL VL - 1 PY - 2022 IS - Suppl. 1. SN - 2772-4085 DO - 10.1016/j.nsa.2022.100082 UR - https://m2.mtmt.hu/api/publication/33641764 ID - 33641764 N1 - ECNP Workshop for Early Career Scientists in Europe 2022 LA - English DB - MTMT ER -