TY - CHAP AU - Czeiter, Endre AU - Amrein, Krisztina ED - Vámos, Zoltán TI - Az agyi neurobiomarkerek diagnosztikus és prognosztikus értéke T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269177 PY - 2024 SP - 63 EP - 66 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823697 ID - 34823697 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Czeiter, Endre AU - Fazekas, Bálint AU - Amrein, Krisztina ED - Vámos, Zoltán TI - Az agysérülés neuroanatómiája T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269177 PY - 2024 SP - 33 EP - 46 PG - 14 UR - https://m2.mtmt.hu/api/publication/34823375 ID - 34823375 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csiszar, Anna AU - Ungvári, Anna Sára AU - Patai, Roland AU - Gulej, Rafal AU - Yabluchanskiy, Andriy AU - Benyó, Zoltán AU - Kovács, Illés AU - Sótonyi, Péter AU - Kirkpartrick, Angelia C AU - Prodan, Calin I AU - Liotta, Eric M AU - Zhang, Xin A AU - Tóth, Péter József AU - Tarantini, Stefano AU - Sorond, Farzaneh A AU - Ungvári, Zoltán István TI - Atherosclerotic burden and cerebral small vessel disease : exploring the link through microvascular aging and cerebral microhemorrhages JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - in press PY - 2024 PG - 30 SN - 2509-2715 DO - 10.1007/s11357-024-01139-7 UR - https://m2.mtmt.hu/api/publication/34804161 ID - 34804161 N1 - * Megosztott szerzőség AB - Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health. LA - English DB - MTMT ER - TY - JOUR AU - Trivedi, Dhanisha Trivedi AU - Forssten, Maximilian Peter AU - Cao, Yang AU - Mohammad Ismail, Ahmad AU - Czeiter, Endre AU - Amrein, Krisztina AU - Kobeissy, Firas AU - Wang, Kevin K W AU - DeSoucy, Erik AU - Büki, András AU - Mohseni, Shahin TI - Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 41 PY - 2024 IS - 3-4 SP - 349 EP - 358 PG - 10 SN - 0897-7151 DO - 10.1089/neu.2023.0322 UR - https://m2.mtmt.hu/api/publication/34477399 ID - 34477399 N1 - * Megosztott szerzőség AB - The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Hossain, I. AU - Marklund, N. AU - Czeiter, Endre AU - Hutchinson, P. AU - Büki, András TI - Blood biomarkers for traumatic brain injury: A narrative review of current evidence JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 4 PY - 2024 PG - 9 SN - 2772-5294 DO - 10.1016/j.bas.2023.102735 UR - https://m2.mtmt.hu/api/publication/34474356 ID - 34474356 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Lendvai-Emmert, Dominika AU - Magyar-Sümegi, Zsófia Dina AU - Hegedüs, Emőke AU - Szarka, Nikolett AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Ungvári, Zoltán István AU - Tóth, Péter József TI - Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 PG - 9 SN - 1664-2295 DO - 10.3389/fneur.2023.1252796 UR - https://m2.mtmt.hu/api/publication/34392087 ID - 34392087 N1 - This work was supported by grants from the National Research, Development and Innovation Office (OTKA K-134555 and OTKA FK-123798 to PT), the Hungarian Academy of Sciences Bolyai Research Scholarship (to PT), National Clinical Neuroscience Laboratory (RRF-2.3.1-21-2022-00011), the Thematic Excellence Program 2021 Health sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the University of Pecs (to PT), the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295, and K01-AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782), the National Cancer Institute (R01CA255840). LA - English DB - MTMT ER - TY - JOUR AU - Richter, Sophie AU - Czeiter, Endre AU - Amrein, Krisztina AU - Mikolic, Ana AU - Verheyden, Jan AU - Wang, Kevin K AU - Maas, Andrew AU - Steyerberg, Ewout AU - Büki, András AU - Menon, David AU - Newcombe, Virginia TI - Prognostic Value of Serum Biomarkers in Patients With Moderate-Severe Traumatic Brain Injury, Differentiated by Marshall Computer Tomography Classification JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 40 PY - 2023 IS - 21-22 SP - 2297 EP - 2310 PG - 14 SN - 0897-7151 DO - 10.1089/neu.2023.0029 UR - https://m2.mtmt.hu/api/publication/34050791 ID - 34050791 N1 - University Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary ELKH-PTE Clinical Neuroscience MR Research Group, University of Pécs, Pécs, Hungary Department of Psychology, University of British Columbia, Vancouver, BC, Canada Rehabilitation Research Program, GF Strong Rehabilitation Centre, Vancouver, BC, Canada Research and Development, icometrix, Leuven, Belgium Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, FL, United States Department of Neurosurgery, Antwerp University Hospital, University of Antwerp, Edegem, Belgium Department of Biomedical Data Sciences, University Medical Centre, Leiden, Netherlands Örebro University, School of Medical Sciences, Örebro, Sweden Export Date: 1 February 2024 CODEN: JNEUE Correspondence Address: Richter, S.; University Division of Anaesthesia, Box 93, Hills Road, United Kingdom; email: sr773@cam.ac.uk Correspondence Address: Newcombe, V.F.J.; University Division of Anaesthesia, Box 93, Hills Road, United Kingdom; email: vfjn2@cam.ac.uk AB - Prognostication is challenging in traumatic brain injury (TBI) patients in whom the CT fails to fully explain a low level of consciousness. Serum biomarkers reflect the extent of structural damage in a different way than CT does, but it is unclear if biomarkers provide additional prognostic value across the range of CT abnormalities. This study aimed to determine the added predictive value of biomarkers, differentiated by imaging severity. This prognostic study used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study (2014-2017). The analysis included patients aged ≥16 years with a moderate-severe TBI (Glasgow Coma Scale, GCS < 13) who had an acute CT and serum biomarkers obtained ≤24h of injury. Out of six protein biomarkers (GFAP, NFL, NSE, S100B, Tau, UCH-L1) the most prognostic panel was selected using lasso regression. The performance of established prognostic models (CRASH and IMPACT) was assessed before and after the addition of the biomarker panel, and compared between patients with different CT Marshall scores (Marshall score <3 versus Marshall score ≥3). Outcome was assessed at 6 months post-injury using the extended Glasgow Outcome Scale (GOSE), and dichotomized into favorable and unfavourable (GOSE <5). We included 872 patients with moderate-severe TBI. The mean age was 47 years (range 16 - 95), 647 (74%) were male and 438 (50%) had a Marshall CT score <3. The serum biomarkers GFAP, NFL, S100B and UCH-L1 provided complementary prognostic information, NSE and Tau showed no added value. The addition of the biomarker panel to established prognostic models increased the area under the curve (AUC) by 0.08 and 0.03, and the explained variation in outcome by 13-14% and 7-8%, for patients with a Marshall score of <3 and ≥3, respectively. The incremental AUC of biomarkers for individual models was significantly greater when the Marshall score was <3 compared to ≥3 (p < 0.001). Serum biomarkers improve outcome prediction after moderate-severe TBI across the range of imaging severities and especially in patients with a Marshall score <3. LA - English DB - MTMT ER - TY - CONF AU - Kolozsvári, Áron AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Hernádi, István TI - Alleviation of longterm cognitive impairment with memantine combined with alfa7 nicotic receptor ligand after repetitive mild traumatic brain injury in rats T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 SP - 136 UR - https://m2.mtmt.hu/api/publication/33704639 ID - 33704639 LA - English DB - MTMT ER - TY - JOUR AU - Kovács-Öller, Tamás AU - Zempléni, Renáta AU - Balogh, Boglárka AU - Szarka, Gergely AU - Fazekas, Bálint AU - Tengölics, Ádám Jonatán AU - Amrein, Krisztina AU - Czeiter, Endre AU - Hernádi, István AU - Büki, András AU - Völgyi, Béla TI - Traumatic Brain Injury Induces Microglial and Caspase3 Activation in the Retina JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 5 PG - 16 SN - 1661-6596 DO - 10.3390/ijms24054451 UR - https://m2.mtmt.hu/api/publication/33695777 ID - 33695777 AB - Traumatic brain injury (TBI) is among the main causes of sudden death after head trauma. These injuries can result in severe degeneration and neuronal cell death in the CNS, including the retina, which is a crucial part of the brain responsible for perceiving and transmitting visual information. The long-term effects of mild-repetitive TBI (rmTBI) are far less studied thus far, even though damage induced by repetitive injuries occurring in the brain is more common, especially amongst athletes. rmTBI can also have a detrimental effect on the retina and the pathophysiology of these injuries is likely to differ from severe TBI (sTBI) retinal injury. Here, we show how rmTBI and sTBI can differentially affect the retina. Our results indicate an increase in the number of activated microglial cells and Caspase3-positive cells in the retina in both traumatic models, suggesting a rise in the level of inflammation and cell death after TBI. The pattern of microglial activation appears distributed and widespread but differs amongst the various retinal layers. sTBI induced microglial activation in both the superficial and deep retinal layers. In contrast to sTBI, no significant change occurred following the repetitive mild injury in the superficial layer, only the deep layer (spanning from the inner nuclear layer to the outer plexiform layer) shows microglial activation. This difference suggests that alternate response mechanisms play a role in the case of the different TBI incidents. The Caspase3 activation pattern showed a uniform increase in both the superficial and deep layers of the retina. This suggests a different action in the course of the disease in sTBI and rmTBI models and points to the need for new diagnostic procedures. Our present results suggest that the retina might serve as such a model of head injuries since the retinal tissue reacts to both forms of TBI and is the most accessible part of the human brain. LA - English DB - MTMT ER - TY - JOUR AU - Emmert, Vanessza AU - Lendvai-Emmert, Dominika AU - Eklicsné Lepenye, Katalin AU - Prémusz, Viktória AU - Tóth, Gergely Péter TI - Current Practice in Pediatric Cow's Milk Protein Allergy-Immunological Features and Beyond. JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 5 PG - 12 SN - 1661-6596 DO - 10.3390/ijms24055025 UR - https://m2.mtmt.hu/api/publication/33695775 ID - 33695775 N1 - * Megosztott szerzőség AB - Cow's milk protein allergy is one of the most common pediatric food allergies. It poses a significant socioeconomic burden in industrialized countries and has a profound effect on the quality of life of affected individuals and their families. Diverse immunologic pathways can lead to the clinical symptoms of cow's milk protein allergy; some of the pathomechanisms are known in detail, but others need further elucidation. A comprehensive understanding of the development of food allergies and the features of oral tolerance could have the potential to unlock more precise diagnostic tools and novel therapeutic approaches for patients with cow's milk protein allergy. LA - English DB - MTMT ER -