@CONFERENCE{MTMT:34688594, title = {Learning-dependent occipital NREM sleep-spindle clustering following extensive training in a visual perceptual task}, url = {https://m2.mtmt.hu/api/publication/34688594}, author = {Gerván, Patrícia and Gombos, Ferenc and Bocskai, Gábor and Berencsi, Andrea and Kovács, Ilona}, booktitle = {International Neuroscience Conference, Pécs 2024}, unique-id = {34688594}, abstract = {Sleep spindles have been implicated to contribute to brain plasticity and the consolidation of pro- cedural memories. More recently, research by Boutin and colleagues (Boutin & Doyon, 2020; Boutin et al., 2023) suggests that the clustering of spindles into groups, referred to as trains, plays a critical role in motor learning. However, the association of clustered sleep spindles with perceptual learning has not yet been investigated. In this study, we aimed to explore how spindle clustering contributes to visual perceptual mem- ory consolidation by applying a contour integration task in humans. Perceptual learning in contour integration specifically addresses the long-range horizontal connections in the primary visual cortex (Kovacs & Julesz, 1993; Angelucci et al., 2002) and together with its documented sleep-dependent (Gerván et al., 2007) manner, this paradigm offers a well-established investigation of learning-de- pendent changes in electroencephalographic activity during sleep. As it is also detailed in the abstract by Gombos et al., we invited a developmental cohort (between 12 and 20 years of age) to spend an adaptation, and two consecutive nights under polysomno- graphic recording of full-night sleep. At least three weeks preceding the experimental sessions, and also three times between the two analyzed sleep recordings, participants practiced in the contour integration task. There was a retest session after the third night. Since perceptual performance of 16- and 20-year-olds was very similar, we collapsed these two age-groups for further analysis (n=39, female=20). Based on contour integration performance improvement between the first and last ses- sions, we divided the participants into two distinct groups: non-learners (n=17) and learners (n=22). To explore the connection between memory consolidation and sleep spindles, we compared the operating characteristics of aggregated occipital channels before and after training. We found an elevated level of spindle clustering by the second night in the ’learner’ group as it is reflected in the significant change in the ratio of fast spindles organized into trains, an increase in the number of fast spindle trains, and a decrease in the inter-spindle-interval within trains. No such pattern of cluster- ing was found in the ’non-learner’ group. These findings suggest that the clustering of sleep spindles into trains may support the efficient reactivation and consolidation of perceptual memories. The project was funded by the National Research, Development and Innovation Office of Hungary (Grants NRLN NK- 104481 and K-134370 to I.K.) and by the Hungarian Research Network (HUN-REN- ELTE-PPKE Adolescent Development Research Group)}, year = {2024}, pages = {207-207}, orcid-numbers = {Berencsi, Andrea/0000-0002-2330-7895} } @article{MTMT:32791005, title = {The adolescent pattern of sleep spindle development revealed by HD‐EEG}, url = {https://m2.mtmt.hu/api/publication/32791005}, author = {Bocskai, Gábor and Pótári, Adrián and Gombos, Ferenc and Kovács, Ilona}, doi = {10.1111/jsr.13618}, journal-iso = {J SLEEP RES}, journal = {JOURNAL OF SLEEP RESEARCH}, volume = {32}, unique-id = {32791005}, issn = {0962-1105}, abstract = {Sleep spindles are developmentally relevant cortical oscillatory patterns; however, they have mostly been studied by considering the entire spindle frequency range (11–15 Hz) without a distinction between the functionally and topographically different slow and fast spindles, using relatively few electrodes and analysing wide age ranges. Here, we employ high-density night sleep electroencephalography in three age-groups between 12 and 20 years of age (30 females and 30 males) and analyse the adolescent developmental pattern of the four major parameters of slow and fast sleep spindles. Most of our findings corroborate those very few previous studies that also make a distinction between slow and fast spindles in their developmental analysis. We find spindle frequency increasing with age. A spindle density change is not obvious in our study. We confirm the declining tendencies for amplitude and duration, although within narrower, more specific age-windows than previously determined. Spindle frequency seems to be higher in females in the oldest age-group. Based on the pattern of our findings, we suggest that high-density electroencephalography, specifically targeting slow and fast spindle ranges and relatively narrow age-ranges would advance the understanding of both adolescent cortical maturation and development and the functional relevance of sleep spindles in general.}, year = {2023}, eissn = {1365-2869} } @article{MTMT:33122833, title = {Scale-free and oscillatory spectral measures of sleep stages in humans}, url = {https://m2.mtmt.hu/api/publication/33122833}, author = {Schneider, Bence and Szalárdy, Orsolya and Ujma, Przemyslaw Péter and Simor, Péter Dániel and Gombos, Ferenc and Kovács, Ilona and Dresler, Martin and Bódizs, Róbert}, doi = {10.3389/fninf.2022.989262}, journal-iso = {FRONT NEUROINFORM}, journal = {FRONTIERS IN NEUROINFORMATICS}, volume = {16}, unique-id = {33122833}, abstract = {Power spectra of sleep electroencephalograms (EEG) comprise two main components: a decaying power-law corresponding to the aperiodic neural background activity, and spectral peaks present due to neural oscillations. “Traditional” band-based spectral methods ignore this fundamental structure of the EEG spectra and thus are susceptible to misrepresenting the underlying phenomena. A fitting method that attempts to separate and parameterize the aperiodic and periodic spectral components called “fitting oscillations and one over f” (FOOOF) was applied to a set of annotated whole-night sleep EEG recordings of 251 subjects from a wide age range (4–69 years). Most of the extracted parameters exhibited sleep stage sensitivity; significant main effects and interactions of sleep stage, age, sex, and brain region were found. The spectral slope (describing the steepness of the aperiodic component) showed especially large and consistent variability between sleep stages (and low variability between subjects), making it a candidate indicator of sleep states. The limitations and arisen problems of the FOOOF method are also discussed, possible solutions for some of them are suggested.}, year = {2022}, eissn = {1662-5196}, orcid-numbers = {Szalárdy, Orsolya/0000-0001-9171-1147; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Simor, Péter Dániel/0000-0003-0695-166X; Bódizs, Róbert/0000-0001-5341-060X} } @article{MTMT:33096870, title = {Maturation-dependent vulnerability of emotion regulation as a response to COVID-19 related stress in adolescents}, url = {https://m2.mtmt.hu/api/publication/33096870}, author = {Gerván, Patrícia and Bunford, Nóra and Utczás, Katinka and Tróznai, Zsófia and Oláh, Gyöngyi and Szakács, Hanna and Kriston, Pálma and Gombos, Ferenc and Kovács, Ilona}, doi = {10.1016/j.pedn.2022.08.017}, journal-iso = {J PEDIATR NURS}, journal = {JOURNAL OF PEDIATRIC NURSING: NURSING CARE OF CHILDREN AND FAMILIES}, volume = {67}, unique-id = {33096870}, issn = {0882-5963}, abstract = {Background The COVID-19 pandemic created unpredictable circumstances resulting in increased psychological strain. Here we investigate pandemic-related alterations in emotion regulation in adolescents assessed before and during the pandemic. We also take biological age into account in the response to the pandemic. Methods Mann-Whitney U tests were conducted to compare baseline data on the Difficulties in Emotion Regulation Scale (DERS) total scores of a pre-pandemic adolescent cohort (n = 241) with those obtained during the second wave of the pandemic (n = 266). We estimated biological age based on an ultrasonic boneage assessment procedure in a subgroup of males, including grammar school and vocational school students in the 9th and 10th grades, and analyzed their data independently. Findings There is a gender difference in the timing of vulnerability for pandemic-related stress in grammar school students: females are affected a year earlier than males. Vocational school male students mature faster than grammar school male students, and the timing of emotional vulnerability also precedes that of the grammar school students'. Discussion We interpret our findings within a developmental model suggesting that there might be a window of highest vulnerability in adolescent emotion regulation. The timing of the window is determined by both chronological and biological age, and it is different for females and males. Application to practice Defining the exact temporal windows of vulnerability for different adolescent cohorts allows for the timely integration of preventive actions into adolescent care to protect mental health during future chronic stressful situations.}, year = {2022}, eissn = {1532-8449}, pages = {132-138}, orcid-numbers = {Bunford, Nóra/0000-0002-9645-604X; Utczás, Katinka/0000-0001-5734-2018; Tróznai, Zsófia/0000-0002-4020-6447; Oláh, Gyöngyi/0000-0003-3433-9160; Szakács, Hanna/0000-0001-5081-7535} } @article{MTMT:33048975, title = {Sleep EEG spectral exponents and maximal peak frequencies in consecutive NREM periods: possible markers for sleep regulation}, url = {https://m2.mtmt.hu/api/publication/33048975}, author = {G. Horváth, Csenge and Szalárdy, O. and Ujma, Przemyslaw Péter and Simor, Péter Dániel and Gombos, Ferenc and Kovács, Ilona and Dresler, M. and Bódizs, Róbert}, doi = {10.1016/j.sleep.2022.05.080}, journal-iso = {SLEEP MED}, journal = {SLEEP MEDICINE}, volume = {100}, unique-id = {33048975}, issn = {1389-9457}, abstract = {Introduction: According to Borbély (1982) a homeostatic and a circadian process define the main aspects of sleep regulation. Although slow wave activity of the sleep EEG is a widely accepted marker of sleep homeostasis, high frequency activity is also changing throughout the night (in the opposite direction). Thus, the ratio of lower to higher frequencies in the EEG power spectrum seems to be a more accurate indicator of sleep homeostasis. In addition, sleep spindle frequency could be a suitable marker of the circadian process since it was shown to follow a U-shaped overnight dynamic and its dampening in aged subjects. Given the linear association between the logarithm of frequency and logarithm of amplitude the Fourier spectrum can be described by an approximation of the parameters of the following function: P(f) =CfαPPeak(f), where P is power as a function of frequency, C is the constant, α is the spectral exponent which shows the ratio of different frequencies in the signal, and PPeak is the peak power at frequency f. We hypothesized that (i) Ppeak(f) values of the sleep spindle range (9-18 Hz) are higher in the last and first sleep cycles than in the middle parts of night sleep records, (ii) spindle deceleration in the middle of the night is modulated by age, while (iii) α is decreasing linearly across the night as the sleep pressure decays (spectral slope flattening). Materials and Methods: Artefact-free NREM sleep periods of successive cycles in the Budapest-Munich database of sleep records (N = 251 healthy subjects, 122 females, age range: 4–69 years) were analysed by FFT routine and power spectrum obtained for selected EEG derivations. Furthermore, the log-log power was fitted with a linear, and a peak detection was applied in the 9-18 Hz (broad sleep spindle) range at derivations O2, O1, P4, P3, C4, C3, F4, F3, Fp2, Fp1. Statistical analysis was based on general linear models. Results: The NREM sleep EEG spectral exponents (α) increased in consecutive sleep cycles (absolute values decreased), and this effect was significant at all derivations. The maximum peak frequency was significantly modulated by age at all derivations and by cycle at O2, P4, P3, C4, F4, F3, Fp1. There was a cycle x age group interaction at derivations O2 and F3. A tendency for the U-shaped dynamic throughout the sleep cycles was seen at all derivations. Conclusions:Our results show that the spectral exponent is a potent marker of the homeostatic process of sleep regulation which supports earlier findings about the associations between this exponent and sleep depth. Furthermore, the maximum spectral peak frequencies could reflect the circadian modulation of sleep. The latter index could be a useful measure in future studies, potentially substituting complicated protocols like melatonin or core body temperature measurements, with assumed applicability in retrospective investigations. Finally, the spectral exponent can serve as a link between sleep regulation and consciousness.}, year = {2022}, eissn = {1878-5506}, pages = {S24-S25}, orcid-numbers = {G. Horváth, Csenge/0000-0003-2609-5565; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Simor, Péter Dániel/0000-0003-0695-166X; Bódizs, Róbert/0000-0001-5341-060X} } @article{MTMT:33039914, title = {Visual imagery vividness declines across the lifespan}, url = {https://m2.mtmt.hu/api/publication/33039914}, author = {Gulyás, Erzsébet and Gombos, Ferenc and Sütöri, Sára and Lovas, Andrea and Ziman, Gergő and Kovács, Ilona}, doi = {10.1016/j.cortex.2022.06.011}, journal-iso = {CORTEX}, journal = {CORTEX: A JOURNAL DEVOTED TO THE STUDY OF THE NERVOUS SYSTEM AND BEHAVIOR}, volume = {154}, unique-id = {33039914}, issn = {0010-9452}, abstract = {The capacity to elicit vivid visual mental images varies within an extensive range across individuals between hyper- and aphantasia. It is not clear, however, whether imagery vividness is constant across the lifespan or changes during development and later in life. Without enforcing the constraints of strict experimental procedures and representativity across the entire population, our purpose was to explore the self-reported level of imagery vividness and determine the relative proportions of aphantasic/hyperphantasic participants in different age groups. Relying on the frequently used Vividness of Visual Imagery Questionnaire, we collected data on a random sample of 2252 participants between the ages of 12–60 years. We found a novel developmental pattern that describes a declining ability to elicit vivid visual mental images in the group averages of different age groups from adolescence to middle age. This effect involves both a decreasing proportion of individuals with vivid visual imagery vividness and an increasing proportion of individuals with low imagery vividness as maturation (based on bone age assessments in adolescents) and ageing progress. These findings may shed some light on the developmental mechanisms of our internal, stimulus-independent processes, and might also help to determine genetic, maturational, and age-dependent factors in the cases of hyper- and aphantasia.}, year = {2022}, eissn = {1973-8102}, pages = {365-374}, orcid-numbers = {Ziman, Gergő/0000-0002-6397-6882} } @article{MTMT:32800032, title = {Topographical relocation of adolescent sleep spindles reveals a new maturational pattern in the human brain}, url = {https://m2.mtmt.hu/api/publication/32800032}, author = {Gombos, Ferenc and Bódizs, Róbert and Pótári, Adrián and Bocskai, Gábor and Berencsi, Andrea and Szakács, Hanna and Kovács, Ilona}, doi = {10.1038/s41598-022-11098-8}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {32800032}, issn = {2045-2322}, abstract = {Current theories of human neural development emphasize the posterior-to-anterior pattern of brain maturation. However, this scenario leaves out significant brain areas not directly involved with sensory input and behavioral control. Suggesting the relevance of cortical activity unrelated to sensory stimulation, such as sleep, we investigated adolescent transformations in the topography of sleep spindles. Sleep spindles are known to be involved in neural plasticity and in adults have a bimodal topography: slow spindles are frontally dominant, while fast spindles have a parietal/precuneal origin. The late functional segregation of the precuneus from the frontoparietal network during adolescence suggests that spindle topography might approach the adult state relatively late in development, and it may not be a result of the posterior-to-anterior maturational pattern. We analyzed the topographical distribution of spindle parameters in HD-EEG polysomnographic sleep recordings of adolescents and found that slow spindle duration maxima traveled from central to anterior brain regions, while fast spindle density, amplitude and frequency peaks traveled from central to more posterior brain regions. These results provide evidence for the gradual posteriorization of the anatomical localization of fast sleep spindles during adolescence and indicate the existence of an anterior-to-posterior pattern of human brain maturation.}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Bódizs, Róbert/0000-0001-5341-060X; Berencsi, Andrea/0000-0002-2330-7895; Szakács, Hanna/0000-0001-5081-7535} } @article{MTMT:32787547, title = {Musical training improves fine motor function in adolescents}, url = {https://m2.mtmt.hu/api/publication/32787547}, author = {Berencsi, Andrea and Gombos, Ferenc and Gerván, Patrícia and Tróznai, Zsófia and Utczás, Katinka and Oláh, Gyöngyi and Kovács, Ilona}, doi = {10.1016/j.tine.2022.100176}, journal-iso = {TRENDS NEUROSCI EDUC}, journal = {TRENDS IN NEUROSCIENCE AND EDUCATION}, volume = {27}, unique-id = {32787547}, issn = {2211-9493}, year = {2022}, orcid-numbers = {Berencsi, Andrea/0000-0002-2330-7895; Tróznai, Zsófia/0000-0002-4020-6447; Utczás, Katinka/0000-0001-5734-2018; Oláh, Gyöngyi/0000-0003-3433-9160} } @article{MTMT:32763750, title = {Ultrasonic bone age fractionates cognitive abilities in adolescence}, url = {https://m2.mtmt.hu/api/publication/32763750}, author = {Kovács, Ilona and Kovács, Kristóf and Gerván, Patrícia and Utczás, Katinka and Oláh, Gyöngyi and Tróznai, Zsófia and Berencsi, Andrea and Szakács, Hanna and Gombos, Ferenc}, doi = {10.1038/s41598-022-09329-z}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {32763750}, issn = {2045-2322}, abstract = {Adolescent development is not only shaped by the mere passing of time and accumulating experience, but it also depends on pubertal timing and the cascade of maturational processes orchestrated by gonadal hormones. Although individual variability in puberty onset confounds adolescent studies, it has not been efficiently controlled for. Here we introduce ultrasonic bone age assessment to estimate biological maturity and disentangle the independent effects of chronological and biological age on adolescent cognitive abilities. Comparing cognitive performance of female participants with different skeletal maturity we uncover the impact of biological age on both IQ and specific abilities. We find that biological age has a selective effect on abilities: more mature individuals within the same age group have higher working memory capacity and processing speed, while those with higher chronological age have better verbal abilities, independently of their maturity. Based on our findings, bone age is a promising biomarker of adolescent maturity.}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Utczás, Katinka/0000-0001-5734-2018; Oláh, Gyöngyi/0000-0003-3433-9160; Tróznai, Zsófia/0000-0002-4020-6447; Berencsi, Andrea/0000-0002-2330-7895; Szakács, Hanna/0000-0001-5081-7535} } @article{MTMT:32637286, title = {Alternative female and male developmental trajectories in the dynamic balance of human visual perception}, url = {https://m2.mtmt.hu/api/publication/32637286}, author = {Ziman, Gergő and Aleshin, Stepan and Unoka, Zsolt and Braun, Jochen and Kovács, Ilona}, doi = {10.1038/s41598-022-05620-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {32637286}, issn = {2045-2322}, abstract = {Choosing between alternatives is the stuff of everyday life. Many choices require trades between competing objectives, such as between capitalizing on past experience ('exploitation') and updating this experience ('exploration'). In visual perception, where speed is important, there are tensions between stability of appearance, sensitivity to visual detail, and exploration of fundamental alternatives. Presumably, a 'sweet spot' balancing these objectives attains the highest degree of adaptive function. Here, we employ a no-report binocular rivalry paradigm combined with stochastic dynamic modeling to estimate how the visual system balances the objectives of stability, sensitivity, and exploration throughout the lifespan. Observed and simulated results reveal characteristic age- and sex-specific developmental and maturational lifespan trajectories that quantify important aspects of our neurocognitive phenotype. As we also reveal aspects of atypical development underlying mental health disorders, our cognitive modeling may inspire the field of developmental computational psychiatry, in addition to developmental and evolutionary cognitive neuroscience.}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Ziman, Gergő/0000-0002-6397-6882; Unoka, Zsolt/0000-0003-0103-5064} }