@article{MTMT:34133721,
	title = {Effect of pituitary adenylate cyclase-activating polypeptide supplementation, applied during or after vitrification on mouse embryo},
	url = {https://m2.mtmt.hu/api/publication/34133721},
	author = {Török, Dóra and Somoskői, Bence and Bordás, Lilla and Reglődi, Dóra and Cseh, Sándor},
	doi = {10.1556/004.2023.00903},
	journal-iso = {ACTA VET HUNG},
	journal = {ACTA VETERINARIA HUNGARICA},
	volume = {71},
	unique-id = {34133721},
	issn = {0236-6290},
	abstract = {Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse functions. It occurs in high levels in the gonads suggesting a potential central role in reproduction. The aim of our study was to assess the effect of PACAP treatment during embryo vitrification on the developmental rate and the expression of the heparin-binding EGF-like growth factor gene (Hbegf). Mouse embryos, obtained from superovulated females were allocated into the four treatment groups. In EM1 and EM2, the embryos were prepared for vitrification in an Equilibration Solution that was supplemented with 1 or 2 μM PACAP1-38, respectively. The embyos in groups CM1 and CM2 were not treated prior to vitrification but were cultured in a medium supplemented with 1 or 2 μM PACAP1-38 after thawing. The Vitrified Control group consisted of embryos vitrified and thawed then cultured without PACAP1-38 treatment. A non-vitrified, non-treated Fresh Control group was also used. After 24 h of culture, the developmental rate of the embryos, as well as the relative expression level of the Hbegf gene, as determined by qPCR, were compared among groups. Higher developmental rate and Hbegf gene expression level were found in the embryos treated with a higher concentration of PACAP. These results indicate that PACAP treatment has a beneficial effect on the survival and development of vitrified/thawed mouse embryos.},
	keywords = {PACAP; embryo; Vitrification; cryoprotectant; HB-EGF},
	year = {2023},
	eissn = {1588-2705},
	pages = {112-118}
}

@article{MTMT:34067933,
	title = {Diagnostic and Prognostic Value of PACAP in Multiple Myeloma},
	url = {https://m2.mtmt.hu/api/publication/34067933},
	author = {Tóth, Tünde and Alizadeh, Hussain and Polgár, Beáta and Csalódi, Renáta and Reglődi, Dóra and Tamás, Andrea},
	doi = {10.3390/ijms241310801},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34067933},
	issn = {1661-6596},
	abstract = {Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide with well-known anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects. PACAP regulates the production of various proinflammatory factors and may influence the complex cytokine network of the bone marrow microenvironment altered by plasma cells, affecting the progression of multiple myeloma (MM) and the development of end-organ damage. The aim of our study was to investigate the changes in PACAP-38 levels in patients with MM to explore its value as a potential biomarker in this disease. We compared the plasma PACAP-38 levels of MM patients with healthy individuals by ELISA method and examined its relationship with various MM-related clinical and laboratory parameters. Lower PACAP-38 levels were measured in MM patients compared with the healthy controls, however, this difference vanished if the patient achieved any response better than partial response. In addition, lower peptide levels were found in elderly patients. Significantly higher PACAP-38 levels were seen in patients with lower stage, lower plasma cell infiltration in bone marrow, lower markers of tumor burden in serum, lower total urinary and Bence-Jones protein levels, and in patients after lenalidomide therapy. Higher PACAP-38 levels in newly diagnosed MM patients predicted longer survival and a higher probability of complete response to treatment. Our findings confirm the hypothesis that PACAP plays an important role in the pathomechanism of MM. Furthermore, our results suggest that PACAP might be used as a valuable, non-invasive, complementary biomarker in diagnosis, and may be utilized for prognosis prediction and response monitoring.},
	keywords = {PACAP; ELISA; multiple myeloma; diagnostic and prognostic factor},
	year = {2023},
	eissn = {1422-0067}
}

@article{MTMT:33453105,
	title = {Modulatory activity of ADNP on the hypoxia‑induced angiogenic process in glioblastoma},
	url = {https://m2.mtmt.hu/api/publication/33453105},
	author = {D'Amico, Agata Grazia and Maugeri, Grazia and Magrì, Benedetta and Giunta, Salvatore and Saccone, Salvatore and Federico, Concetta and Pricoco, Elisabetta and Broggi, Giuseppe and Caltabiano, Rosario and Musumeci, Giuseppe and Reglődi, Dóra and D'Agata, Velia},
	doi = {10.3892/ijo.2022.5462},
	journal-iso = {INT J ONCOL},
	journal = {INTERNATIONAL JOURNAL OF ONCOLOGY},
	volume = {62},
	unique-id = {33453105},
	issn = {1019-6439},
	abstract = {Glioblastoma multiforme (GBM) is a brain cancer with a poor prognosis that affects adults. This is a solid tumor characterized by a high rate of cell migration and invasion. The uncontrolled cell proliferation creates hypoxic niches in the tumor mass, which leads to the overexpression of hypoxia‑inducible factors (HIFs). This induces the activation of the vascular endothelial growth factor (VEGF), which is responsible for uncontrolled neoangiogenesis. Recent studies have demonstrated the anti‑invasive effect of pituitary adenylate cyclase‑activating peptide (PACAP) in GBM. PACAP effects on the central nervous system are also mediated through the activity‑dependent neuroprotective protein (ADNP) activation. To date, no evidence exists regarding its role in GBM. Therefore, the ADNP involvement in GBM was investigated. By analyzing ADNP expression in a human GBM sample through confocal microscopy, a high ADNP immunoreactivity was detected in most glial cells and its predominant expression in hypoxic areas overexpressing HIF‑1α was highlighted. To investigate the role of ADNP on the HIF‑VEGF axis in GBM, a human U87MG GBM cell line was cultured with a hypoxic mimetic agent, deferoxamine, and cells were treated with the smallest active fragment of ADNP, known as NAP. The protein expression and distribution of HIF‑1α and VEGF was detected using western blot analysis and immunofluorescence assay. Results demonstrated that ADNP modulates the hypoxic‑angiogenic pathway in GBM cells by reducing VEGF secretion, detected through ELISA assay, as well as modulating their migration, assessed through wound healing assay. Although deeper investigation is necessary, the present study suggested that ADNP could be involved in PACAP anti‑invasive effects in GBM.},
	keywords = {ANGIOGENESIS; HYPOXIA; Vascular endothelial growth factor; glioblastoma multiforme; activity‑dependent neuroprotective protein},
	year = {2023},
	eissn = {1791-2423}
}

@{MTMT:33551214,
	title = {The protective effects of PACAP1-38 on the retinal vasculature and hypoxic molecules in rat glaucoma model},
	url = {https://m2.mtmt.hu/api/publication/33551214},
	author = {Patkó, Evelin Viktória and Szabó, Edina and Váczy, Alexandra and Molitor, Dorottya and Eniko, Tari and Lina, Li and Adrienne, Csutak and Gabor, Toth and Reglődi, Dóra and Atlasz, Tamás},
	booktitle = {XI. Interdiszciplináris Doktorandusz Konferencia 2022. november 25-26 = 11th Interdisciplinary Doctoral Conference 25-26th of November 2022},
	unique-id = {33551214},
	year = {2022},
	pages = {130-131},
	orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633}
}

@{MTMT:32831203,
	title = {Terhesség alatti dohányzás hatása a koraszülött retinopáthiára = The effects of maternal smoking on retinopathy of prematurity},
	url = {https://m2.mtmt.hu/api/publication/32831203},
	author = {Mérész, Balázs and Molitor, Dorottya and Schimdth, Anne and Patkó, Evelin Viktória and Szabó, Edina and Li, Lina and Reglődi, Dóra and Atlasz, Tamás and Váczy, Alexandra},
	booktitle = {XX. Szentágothai János Mutidiszciplináris Konferencia és Hallgatói Verseny Absztrakt kötet = XX. János Szentágothai Multidisciplinary Conference and Student Competition},
	unique-id = {32831203},
	year = {2022},
	pages = {161-162},
	orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633}
}

@{MTMT:32831178,
	title = {A PACAP 1-38 potenciális védőhatása a retina erezettségére patkány glaukóma modellben = The possible protective effects of PACAP 1-38 on the retinal vasculature in glaucomatous rat model},
	url = {https://m2.mtmt.hu/api/publication/32831178},
	author = {Tari, Enikő and Patkó, Evelin Viktória and Szabó, Edina and Váczy, Alexandra and Molitor, Dorottya and Lina, Li and Csutak, Adrienne and Tóth, Gábor and Reglődi, Dóra and Atlasz, Tamás},
	booktitle = {XX. Szentágothai János Mutidiszciplináris Konferencia és Hallgatói Verseny Absztrakt kötet = XX. János Szentágothai Multidisciplinary Conference and Student Competition},
	unique-id = {32831178},
	year = {2022},
	pages = {153-154},
	orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633}
}

@article{MTMT:32799467,
	title = {Effects of Pituitary Adenylate Cyclase Activating Polypeptide on Cell Death},
	url = {https://m2.mtmt.hu/api/publication/32799467},
	author = {Horváth-Opper, Gabriella and Reglődi, Dóra and Fábián, Eszter and Opper, Balázs},
	doi = {10.3390/ijms23094953},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32799467},
	issn = {1661-6596},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated as a hypothalamic peptide based on its efficacy to increase adenylate cyclase (AC) activity. It has a widespread distribution throughout the body including the nervous system and peripheral organs, where PACAP exerts protective effects both in vivo and in vitro through its anti-apoptotic, anti-inflammatory, and antioxidant functions. The aim of the present paper was to review the currently available literature regarding the effects of PACAP on cell death in vitro in neural and non-neural cells. Among others, its effect on apoptosis can be detected in cerebellar granule cells against different toxic stimuli. Different neural cell types from the cerebral cortex are also prevented from cell death. PACAP also shows effects on cell death in cells belonging to the peripheral nervous system and protects both neural and non-neural cells of sensory organs. In addition, cell survival-promoting effect can be observed in different peripheral organ systems including cardiovascular, immune, respiratory, gastrointestinal, urinary, and reproductive systems. The studies summarized here indicate its noteworthy effect on cell death in different in vitro models, suggesting PACAP's potential therapeutic usage in several pathological conditions.},
	keywords = {APOPTOSIS; PACAP; In Vitro; Cell Death},
	year = {2022},
	eissn = {1422-0067}
}

@article{MTMT:32785459,
	title = {Endometrium as Control of Endometriosis in Experimental Research: Assessment of Sample Suitability},
	url = {https://m2.mtmt.hu/api/publication/32785459},
	author = {Szegeczki, Vince and Fazekas, László Ádám and Kulcsár, Máté and Reglődi, Dóra and Török, Péter and Orlik, Brigitta and Laganà, Antonio S. and Jakab, Attila and Juhász, Tamás},
	doi = {10.3390/diagnostics12040970},
	journal-iso = {DIAGNOSTICS},
	journal = {DIAGNOSTICS},
	volume = {12},
	unique-id = {32785459},
	issn = {2075-4418},
	abstract = {Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel therapeutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were analysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were also detailed. Only a small number of the harvested endometrial samples was suitable for further molecular analysis, while preoperative screening protocol could enlarge this fraction. Applying clinical and histopathological selection and exclusion criteria for tissue screening and histopathological examination of samples could ensure the comparability of healthy endometrium with endometriosis. The present study could be useful for researchers who intend to perform molecular experiments to compare endometriosis with the physiological processes of the endometrium.},
	keywords = {Curettage; Endometrium; Hysteroscopy; endometrial sampling; in vitro endometrial culturing},
	year = {2022},
	eissn = {2075-4418}
}

@article{MTMT:32776007,
	title = {Effects of pituitary adenylate cyclase activating polypeptide (PACAP) in corneal epithelial regeneration and signal transduction in rats},
	url = {https://m2.mtmt.hu/api/publication/32776007},
	author = {Kiss, Péter and Farkas, József and Kovács, Krisztina and Gaál, Valéria and Biró, Zsolt and Szabó, Aliz and Atlasz, Tamás and Bosnyak, Inez and Tóth, Gábor and Tamás, Andrea and Reglődi, Dóra},
	doi = {10.1007/s10989-022-10405-1},
	journal-iso = {INT J PEPT RES THER},
	journal = {INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS},
	volume = {28},
	unique-id = {32776007},
	issn = {1573-3149},
	year = {2022},
	eissn = {1573-3904},
	orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633}
}

@article{MTMT:32763181,
	title = {PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients},
	url = {https://m2.mtmt.hu/api/publication/32763181},
	author = {Szabó, Dóra and Sárszegi, Zsolt and Polgár, Beáta and Sághy, Éva and Reglődi, Dóra and Tóth, Tünde and Onódi, Zsófia and Leszek, Przemyslaw and Varga, Zoltán and Helyes, Zsuzsanna and Kemény, Ágnes and Ferdinandy, Péter and Tamás, Andrea},
	doi = {10.3390/ijms23073715},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32763181},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Onódi, Zsófia/0000-0002-3746-8016; Varga, Zoltán/0000-0002-2758-0784; Kemény, Ágnes/0000-0002-4523-3938; Ferdinandy, Péter/0000-0002-6424-6806}
}