@article{MTMT:34774937,
	title = {Changes in public attitude toward epilepsy in Hungary since 1994. A multicriteria weighting analysis},
	url = {https://m2.mtmt.hu/api/publication/34774937},
	author = {Biresaw, Mengesha and Vitrai, József and Halász, Péter and Miranda Corréa, Vivian and Szűcs, Anna},
	doi = {10.1002/epi4.12935},
	journal-iso = {EPILEPSIA OPEN},
	journal = {EPILEPSIA OPEN},
	unique-id = {34774937},
	issn = {2470-9239},
	abstract = {Objective To assess the adult Hungarian population's knowledge about and attitude toward epilepsy and compare the present findings with previous ones in 1994 and 2000. Methods We performed a cross-sectional survey of the Hungarian adult population from 28th February to 8th March 2023. A non-probability quota sampling with a random walk method was used. We applied the computer-assisted personal interviewing (CAPI) method and used a multicriteria weighting procedure to correct for bias along the main sociodemographic variables. To detect changes over time, we used chi-squared tests, and to analyze the effect of sociodemographic characteristics, we applied multivariate logistic regression. Results One thousand participants (53.1% women, mean age 48.1 +/- 16.75 years) representing Hungary's population were interviewed yielding a response rate of 80.3%. 26.3% knew someone with epilepsy (55.9% in 1994 and 51.9% in 2000), and 30.8% saw an epileptic seizure (58% in 1994 and 55.3% in 2000). Compared to the young, fewer adults and elderly people knew someone with epilepsy or had seen a seizure. Like in 1994 and 2000, 16.6% reported objection to their children's interaction with people with epilepsy; however, in the present study, significantly fewer people opposed their children marrying or working together with epileptic people, indicating a change in attitude (p < 0.0001). Rural residents had less objection to their children's interaction with people with epilepsy (p < 0.05). People with secondary education objected significantly more often than those with primary education to their children's interaction (p = 0.037), marriage to people with epilepsy (p = 0.043), or their having equal employment (p = 0.008). Higher education people were as "permissive" as those with primary education. Significance Certain parameters of familiarity and attitude markers of the Hungarian population toward epilepsy have improved. These tendencies are promising, but work is still needed; our results will hopefully evoke educational programs and campaigns against negative attitudes. Plain Language Summary The knowledge of the Hungarian population about epilepsy and their attitude toward people with epilepsy has been improved since 1994. People from rural areas have shown more acceptance for people with epilepsy. Those people who completed secondary education were significantly more prone to stigmatization than those with primary education.},
	keywords = {EPILEPSY; KNOWLEDGE; KNOWLEDGE; PERCEPTION; Hungary; POPULATIONS; COUNTRIES; attitude; EXPERIENCES; STIGMA; Clinical Neurology; Beliefs; RURAL-COMMUNITY},
	year = {2024},
	eissn = {2470-9239},
	orcid-numbers = {Biresaw, Mengesha/0000-0002-6486-3732; Vitrai, József/0000-0001-9267-806X; Miranda Corréa, Vivian/0000-0003-1677-2171; Szűcs, Anna/0000-0002-9990-5787}
}

@article{MTMT:34720200,
	title = {Reference data on estrogen metabolome in healthy pregnancy},
	url = {https://m2.mtmt.hu/api/publication/34720200},
	author = {Karvaly, Gellért Balázs and Kovács, Krisztián and Gyarmati, Marcell and Gerszi, Dóra and Nagy, Sándor and Jalal, Dlovan Ali and Tóth, Zoltán and Vásárhelyi, Barna and Gyarmati, Béla},
	doi = {10.1016/j.mcp.2024.101953},
	journal-iso = {MOL CELL PROBE},
	journal = {MOLECULAR AND CELLULAR PROBES},
	volume = {74},
	unique-id = {34720200},
	issn = {0890-8508},
	year = {2024},
	eissn = {1096-1194},
	orcid-numbers = {Karvaly, Gellért Balázs/0000-0003-2468-5633; Kovács, Krisztián/0000-0002-7867-0528; Gerszi, Dóra/0000-0001-9883-7367; Vásárhelyi, Barna/0000-0003-0055-7346}
}

@article{MTMT:34689879,
	title = {Peer education program to improve fluid consumption in primary schools—lessons learned from an innovative pilot study},
	url = {https://m2.mtmt.hu/api/publication/34689879},
	author = {Soósné Kiss, Zsuzsanna and Vitrai, József and Takács, Johanna and Lukács, Ágnes and Falus, András and Feith, Helga Judit},
	doi = {10.1016/j.heliyon.2024.e26769},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34689879},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Soósné Kiss, Zsuzsanna/0000-0002-2080-807X; Vitrai, József/0000-0001-9267-806X; Takács, Johanna/0000-0002-8709-8826; Falus, András/0000-0002-6843-6789; Feith, Helga Judit/0000-0001-8855-5059}
}

@article{MTMT:34669504,
	title = {Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/34669504},
	author = {Gál, Luca and Fóthi, Ábel and Orosz, Gergő and Nagy, Sándor and Than, Nándor Gábor and Orbán, Tamás I.},
	doi = {10.3389/fimmu.2024.1321191},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34669504},
	issn = {1664-3224},
	abstract = {Introduction: Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset hypertension and proteinuria and it is often associated with fetal intrauterine growth restriction (IUGR). PE leads to long-term health complications, so early diagnosis would be crucial for timely prevention. There are multiple etiologies and subtypes of PE, and this heterogeneity has hindered accurate identification in the presymptomatic phase. Recent investigations have pointed to the potential role of small regulatory RNAs in PE, and these species, which travel in extracellular vesicles (EVs) in the circulation, have raised the possibility of non-invasive diagnostics. The aim of this study was to investigate the behavior of exosomal regulatory small RNAs in the most severe subtype of PE with IUGR.
		
		Methods: We isolated exosomal EVs from first-trimester peripheral blood plasma samples of women who later developed preterm PE with IUGR (n=6) and gestational age-matched healthy controls (n=14). The small RNA content of EVs and their differential expression were determined by next-generation sequencing and further validated by quantitative real-time PCR. We also applied the rigorous exceRpt bioinformatics pipeline for small RNA identification, followed by target verification and Gene Ontology analysis.
		
		Results: Overall, >2700 small RNAs were identified in all samples and, of interest, the majority belonged to the RNA interference (RNAi) pathways. Among the RNAi species, 16 differentially expressed microRNAs were up-regulated in PE, whereas up-regulated and down-regulated members were equally found among the six identified Piwi-associated RNAs. Gene ontology analysis of the predicted small RNA targets showed enrichment of genes in pathways related to immune processes involved in decidualization, placentation and embryonic development, indicating that dysregulation of the induced small RNAs is connected to the impairment of immune pathways in preeclampsia development. Finally, the subsequent validation experiments revealed that the hsa_piR_016658 piRNA is a promising biomarker candidate for preterm PE associated with IUGR.
		
		Discussion: Our rigorously designed study in a homogeneous group of patients unraveled small RNAs in circulating maternal exosomes that act on physiological pathways dysregulated in preterm PE with IUGR. Therefore, our small RNA hits are not only suitable biomarker candidates, but the revealed biological pathways may further inform us about the complex pathology of this severe PE subtype.},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Orbán, Tamás I./0000-0002-3424-3428}
}

@article{MTMT:34563187,
	title = {Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value},
	url = {https://m2.mtmt.hu/api/publication/34563187},
	author = {Tóth, Eszter and Györffy, Dániel and Posta, Máté and Hupuczi, Petronella and Balogh, Andrea and Szalai, Gábor and Orosz, Gergő Balázs and Orosz, László and Szilágyi, András and Oravecz, Orsolya and Veress, Lajos and Nagy, Sándor and Török, Olga and Murthi, Padma and Erez, Offer and Papp, Zoltán and Ács, Nándor and Than, Nándor Gábor},
	doi = {10.3390/ijms25031865},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34563187},
	issn = {1661-6596},
	abstract = {Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pathophysiology of RPL is incomplete, and thus, reliable diagnostic/preventive tools are not yet available. Here, we aimed to define the diagnostic value of three placental proteins for RPL: human chorionic gonadotropin free beta-subunit (free-β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF). Blood samples were collected from women with RPL (n = 14) and controls undergoing elective termination of pregnancy (n = 30) at the time of surgery. Maternal serum protein concentrations were measured by BRAHMS KRYPTOR Analyzer. Daily multiple of median (dMoM) values were calculated for gestational age-specific normalization. To obtain classifiers, logistic regression analysis was performed, and ROC curves were calculated. There were differences in changes of maternal serum protein concentrations with advancing healthy gestation. Between 6 and 13 weeks, women with RPL had lower concentrations and dMoMs of free β-hCG, PAPP-A, and PlGF than controls. PAPP-A dMoM had the best discriminative properties (AUC = 0.880). Between 9 and 13 weeks, discriminative properties of all protein dMoMs were excellent (free β-hCG: AUC = 0.975; PAPP-A: AUC = 0.998; PlGF: AUC = 0.924). In conclusion, free-β-hCG and PAPP-A are valuable biomarkers for RPL, especially between 9 and 13 weeks. Their decreased concentrations indicate the deterioration of placental functions, while lower PlGF levels indicate problems with placental angiogenesis after 9 weeks.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Tóth, Eszter/0000-0001-7149-1482; Balogh, Andrea/0000-0003-0322-1522; Szilágyi, András/0000-0002-1773-6861; Murthi, Padma/0000-0003-2535-5134; Ács, Nándor/0000-0002-1919-1869}
}

@article{MTMT:34520558,
	title = {Az egészségkárosodás társadalmi költségei a munkaképes korú lakosság körében 2019-ben Magyarországon},
	url = {https://m2.mtmt.hu/api/publication/34520558},
	author = {Joó, Tamás and Fadgyas-Freyler, Petra and Vitrai, József and Kollányi, Zsófia Katalin},
	doi = {10.1556/650.2024.32955},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34520558},
	issn = {0030-6002},
	abstract = {Bevezetés: Hazánkban a várható egészséges életévek száma alacsonyabb, mint a nyugdíjkorhatár, vagyis a 30 és 64 éves kor közötti magyar lakosság megromlott egészségi állapota jelentős termeléskiesést okoz. A gazdasági szempontokon túl a munkaképes korú korosztály romlott egészségi állapotát más társadalmi szereplő nézőpontjából is lehet vizsgálni, a közvetett költségeket az emberitőke-megközelítésnek megfelelően kalkulálva. Célkitűzés: Becslésünk célja az volt, hogy megvilágítsuk, mekkora veszteségeket okoz Magyarország számára évről évre az, hogy lakosai jelentősen rövidebb és betegebb életre számíthatnak, mint más országok hasonló helyzetű lakosai. Módszer: Az elemzés első részében a 30–64 éves korosztályra vonatkozóan 2019-re összesítettük a megromlott egészség és a betegségek okozta korlátozottság miatt elvesztett, egészségben eltöltött időt. A vizsgált korosztályra vonatkozó magyar értékeket a visegrádi országok, Ausztria és az Európai Unió megfelelő értékeivel vetettük össze. Az elemzés második részében a betegségben töltött időhöz kapcsolódó társadalmi költségeket mutattuk be, melyek között megkülönböztettünk közvetlen, pénzmozgással járó költségeket, valamint közvetett, az elmaradt bevételekben vagy termelésben megtestesülő költségeket. Eredmények: Az eredmények alapján megállapítható, hogy 2019-ben Magyarországon a munkanapok egyhetedében az egészségproblémák miatt csökkent a termelékenység és a teljesített munkaidő. Átlagosan 51 naptári nap, ennek megfelelően 35 munkanap elveszett egészséges idő jutott minden 30–64 éves munkaképes magyarra. A közvetlen költségek, vagyis az Egészségbiztosítási Alap természetbeni kiadásainak, valamint a betegek és az önkéntes (magán)biztosítás által finanszírozott kiadásainak összege 1446 milliárd Ft-ot tett ki. A közvetett költségek, amelyek a korai halálozásnak és a betegségeknek betudható munkaévveszteség következtében fellépő kiadásokat jelentik, további 2279 milliárd Ft terhet jelentettek. Következtetés: A 30–64 évesek közvetlen és közvetett kiadásainak összege 2019-ben 3425 milliárd Ft-ot tett ki, a GDP 7,21%-át. Jól ismert, hogy a fejlett országokban, így Magyarországon is azok a nem fertőző, krónikus betegségek okozzák a legnagyobb egészségveszteséget, amelyek egészséges életmóddal megelőzhetők. Az ország versenyképességének javításához emiatt elengedhetetlen az egészséges életmód előmozdítása és az azt elősegítő fizikai és szociális környezet kialakítása. Orv Hetil. 2024; 165(3): 110–120.},
	keywords = {társadalmi költség; munkaévveszteség; munkaképes korú; jövedelemveszteség},
	year = {2024},
	eissn = {1788-6120},
	pages = {110-120},
	orcid-numbers = {Joó, Tamás/0000-0002-3551-6125; Fadgyas-Freyler, Petra/0000-0002-0858-8924; Vitrai, József/0000-0001-9267-806X; Kollányi, Zsófia Katalin/0000-0003-1261-6745}
}

@article{MTMT:34504823,
	title = {High prevalence of burnout among midwives in Hungary: High job demands and low resources as potential persistent stressors, a focus on prevention},
	url = {https://m2.mtmt.hu/api/publication/34504823},
	author = {Soósné Kiss, Zsuzsanna and Vitrai, József and Dió, Mihály and Lipienné Krémer, Ibolya and Ádám, Szilvia},
	doi = {10.1016/j.heliyon.2024.e24495},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34504823},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Soósné Kiss, Zsuzsanna/0000-0002-2080-807X; Vitrai, József/0000-0001-9267-806X; Dió, Mihály/0000-0003-4307-3114; Ádám, Szilvia/0000-0003-0052-3525}
}

@article{MTMT:34477407,
	title = {Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention},
	url = {https://m2.mtmt.hu/api/publication/34477407},
	author = {Than, Nándor Gábor and Romero, Roberto and Posta, Máté and Györffy, Dániel and Szalai, Gábor and Rossi, Simona W and Szilágyi, András and Hupuczi, Petronella and Nagy, Sándor and Török, Olga and Tarca, Adi L and Erez, Offer and Ács, Nándor and Papp, Zoltán},
	doi = {10.1016/j.jri.2023.104172},
	journal-iso = {J REPROD IMMUNOL},
	journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY},
	volume = {161},
	unique-id = {34477407},
	issn = {0165-0378},
	abstract = {The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings.},
	keywords = {proteomics; personalized medicine; Screening; Prenatal Diagnosis; liquid biopsy; Extracellular matrix-related pre-eclampsia; Maternal anti-fetal rejection-type pre-eclampsia; Metabolic pre-eclampsia; Placental pre-eclampsia},
	year = {2024},
	eissn = {1872-7603},
	orcid-numbers = {Szilágyi, András/0000-0002-1773-6861; Ács, Nándor/0000-0002-1919-1869}
}

@article{MTMT:34433970,
	title = {Parasomnias manifest different phenotypes of sleep-related behaviors in age and sex groups. A YouTube-based video research highlighting the age slope of sleepwalking},
	url = {https://m2.mtmt.hu/api/publication/34433970},
	author = {Miranda Corréa, Vivian and Vitrai, József and Szűcs, Anna},
	doi = {10.1016/j.jocn.2023.11.016},
	journal-iso = {J CLIN NEUROSCI},
	journal = {JOURNAL OF CLINICAL NEUROSCIENCE},
	unique-id = {34433970},
	issn = {0967-5868},
	year = {2024},
	eissn = {1532-2653},
	orcid-numbers = {Miranda Corréa, Vivian/0000-0003-1677-2171; Vitrai, József/0000-0001-9267-806X; Szűcs, Anna/0000-0002-9990-5787}
}

@inbook{MTMT:34450403,
	title = {Mozgásos programok hatása a motoros és a kognitív tulajdonságokra},
	url = {https://m2.mtmt.hu/api/publication/34450403},
	author = {Thür, Antal and Kertész , Tamás},
	booktitle = {XXVI. Tavaszi Szél Konferencia 2023 - Tanulmánykötet II.},
	unique-id = {34450403},
	year = {2023},
	pages = {69-80}
}