@article{MTMT:34832111,
	title = {QbD Approach-Based Preparation and Optimization of Hydrophobic Ion-Pairing Complex of Lysozyme with Sodium Dodecyl Sulphate to Enhance Stability in Lipid-Based Carriers},
	url = {https://m2.mtmt.hu/api/publication/34832111},
	author = {Hassan, Alharith A. A. and Sovány, Tamás and Pamlényi, Krisztián and Deák, Martin and Varga, Viktória and Csapó, Edit and Regdon, Géza (ifj.) and Pannonhalminé Csóka, Ildikó and Kristó, Katalin},
	doi = {10.3390/pharmaceutics16050589},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {34832111},
	issn = {1999-4923},
	abstract = {Hydrophobic ion pairing (HIP) complexation was found to be an efficient approach in modulating the release and enhancing the stability and encapsulation of hydrophilic macromolecules such as proteins in hydrophobic nano/microcarriers. The present work strives to develop and optimize the preparation of the HIP complex of the antimicrobial enzyme lysozyme (LYZ) with the ion-pairing agent (IPA) sodium dodecyl sulphate (SDS) relying on the quality-by-design (QbD) approach. The quality target product profile (QTPP) includes the achievement of maximal lipophilicity in a reversible manner to enable the maintenance of biological activity. The related critical quality attributes (CQAs) were defined as complexation efficacy, complex stability, enzyme recovery and activity. Three risk assessment (RA) tools were used to identify and rank the critical process parameters (CPPs) and critical material attributes (CMAs). From this assessment, the pH of the medium, LYZ:SDS molar ratio and drying conditions were determined as high-risk factors that need to be investigated. To the best of our knowledge, for the first time, electrostatic titration was used as a smart approach to determine the optimum molar ratio at different pH values. Based on the predefined CQAs, pH 8 with an LYZ/SDS molar ratio of 1:8 was found to be the optimal condition for complexation efficiency and recovery (%) of a biologically active enzyme. A cost-effective drying process based on a ventilated oven was developed, which resulted in complex qualities comparable to those obtained by the commonly used freeze-drying method. In a nutshell, the optimum conditions for the preparation of the LYZ/SDS HIP complex were efficiently facilitated by the rational application of QbD principles and the utilization of efficient electrostatic titration and ventilated oven-drying methods.},
	year = {2024},
	eissn = {1999-4923},
	pages = {589},
	orcid-numbers = {Sovány, Tamás/0000-0003-3392-7788; Varga, Viktória/0000-0001-9933-7604; Csapó, Edit/0000-0002-6980-9524; Regdon, Géza (ifj.)/0000-0002-6921-3069; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:34830531,
	title = {Preparation and Investigation of a Nanosized Piroxicam Containing Orodispersible Lyophilizate},
	url = {https://m2.mtmt.hu/api/publication/34830531},
	author = {Party, Petra and Sümegi, Sándor Soma and Ambrus, Rita},
	doi = {10.3390/mi15040532},
	journal-iso = {MICROMACHINES-BASEL},
	journal = {MICROMACHINES},
	volume = {15},
	unique-id = {34830531},
	abstract = {Non-steroidal anti-inflammatory piroxicam (PRX) is a poorly water-soluble drug that provides relief in different arthritides. Reducing the particle size of PRX increases its bioavailability. For pediatric, geriatric, and dysphagic patients, oral dispersible systems ease administration. Moreover, fast disintegration followed by drug release and absorption through the oral mucosa can induce rapid systemic effects. We aimed to produce an orodispersible lyophilizate (OL) consisting of nanosized PRX. PRX was solved in ethyl acetate and then sonicated into a poloxamer-188 solution to perform spray-ultrasound-assisted solvent diffusion-based nanoprecipitation. The solid form was formulated via freeze drying in blister sockets. Mannitol and sodium alginate were applied as excipients. Dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) were used to determine the particle size. The morphology was characterized by scanning electron microscopy (SEM). To establish the crystallinity, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) were used. A disintegration and in vitro dissolution test were performed. DLS and NTA presented a nanosized PRX diameter. The SEM pictures showed a porous structure. PRX became amorphous according to the XRPD and DSC curves. The disintegration time was less than 1 min and the dissolution profile improved. The final product was an innovative anti-inflammatory drug delivery system.},
	year = {2024},
	eissn = {2072-666X},
	pages = {532}
}

@article{MTMT:34791444,
	title = {Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions},
	url = {https://m2.mtmt.hu/api/publication/34791444},
	author = {Mardikasari, Sandra Aulia and Katona, Gábor and Sipos, Bence and Pannonhalminé Csóka, Ildikó},
	doi = {10.1080/17425247.2024.2341184},
	journal-iso = {EXPERT OPIN DRUG DELIV},
	journal = {EXPERT OPINION ON DRUG DELIVERY},
	unique-id = {34791444},
	issn = {1742-5247},
	year = {2024},
	eissn = {1744-7593},
	pages = {1-15},
	orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:34770849,
	title = {Development of functionalized protein-based nanoparticles for improved drug delivery of antineurodegenerative drugs},
	url = {https://m2.mtmt.hu/api/publication/34770849},
	author = {Mohammad, Hanan and Katona, Gábor and Pannonhalminé Csóka, Ildikó},
	booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.61},
	unique-id = {34770849},
	year = {2024},
	pages = {61-61},
	orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:34770843,
	title = {Formulation and optimization of rifampicin-loaded niosomes for ocular delivery system},
	url = {https://m2.mtmt.hu/api/publication/34770843},
	author = {Salamah, Maryana and Balogh, György Tibor and Katona, Gábor},
	booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.48},
	unique-id = {34770843},
	year = {2024},
	pages = {48-48},
	orcid-numbers = {Balogh, György Tibor/0000-0001-8273-1760; Katona, Gábor/0000-0003-1564-4813}
}

@CONFERENCE{MTMT:34770823,
	title = {Design, development and investigation of dexamethasone sodium phosphate-containing dissolving microneedle arrays},
	url = {https://m2.mtmt.hu/api/publication/34770823},
	author = {Cseh, Martin and Katona, Gábor and Berkó, Szilvia and Pannonhalminé Csóka, Ildikó},
	booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.24},
	unique-id = {34770823},
	year = {2024},
	pages = {24-24},
	orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Berkó, Szilvia/0000-0002-3842-8876; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:34770795,
	title = {Development of in situ ionic-sensitive nasal gels of amoxicillin-loaded albumin nanoparticle applying QbD-based optimization for improved local delivery},
	url = {https://m2.mtmt.hu/api/publication/34770795},
	author = {Mardikasari, Sandra Aulia and Katona, Gábor and Budai-Szűcs, Mária and Sipos, Bence and Orosz, László and Burián, Katalin and Rovó, László and Pannonhalminé Csóka, Ildikó},
	booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.18},
	unique-id = {34770795},
	year = {2024},
	pages = {18-18},
	orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Sipos, Bence/0000-0002-0131-4728; Burián, Katalin/0000-0003-1300-2374; Rovó, László/0000-0003-1782-1756; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:34762705,
	title = {Nasal polymeric nanoparticles for enhanced therapeutic effects},
	url = {https://m2.mtmt.hu/api/publication/34762705},
	author = {Rajab, Fatima and Sipos, Bence and Pannonhalminé Csóka, Ildikó},
	booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.50},
	unique-id = {34762705},
	year = {2024},
	pages = {50-50},
	orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:34728728,
	title = {Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials},
	url = {https://m2.mtmt.hu/api/publication/34728728},
	author = {Tóth, Barbara and Horváth, Attila and Jójártné Laczkovich, Orsolya and Biró, Dalma and Matuz, Mária and Csupor, Dezső},
	doi = {10.1055/a-2283-8147},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	unique-id = {34728728},
	issn = {0032-0943},
	abstract = {Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.},
	year = {2024},
	eissn = {1439-0221},
	orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333}
}

@{MTMT:34723711,
	title = {Factorial design of injectable chlorhexidine in situ gelling system for the treatment of periodontitis},
	url = {https://m2.mtmt.hu/api/publication/34723711},
	author = {Ashfaq, Rabia and Budai-Szűcs, Mária},
	booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2024.19},
	unique-id = {34723711},
	year = {2024},
	pages = {19-19},
	orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702}
}