TY - JOUR AU - Kissné Hatala, Patrícia AU - Lajos, Andrea AU - Mackei, Máté AU - Sebők, Csilla AU - Tráj, Patrik AU - Vörösházi, Júlia AU - Neogrády, Zsuzsa AU - Mátis, Gábor TI - Feline Uroepithelial Cell Culture as a Novel Model of Idiopathic Cystitis: Investigations on the Effects of Norepinephrine on Inflammatory Response, Oxidative Stress, and Barrier Function JF - VETERINARY SCIENCES J2 - VET SCI VL - 10 PY - 2023 IS - 2 SN - 2306-7381 DO - 10.3390/vetsci10020132 UR - https://m2.mtmt.hu/api/publication/33630893 ID - 33630893 AB - Feline idiopathic cystitis (FIC) is one of the most common urinary tract disorders in domestic cats. As stress is suggested to play a key role in the pathogenesis of FIC, the effects of norepinephrine (NE) as a stress mediator were investigated on a novel feline primary uroepithelial cell culture, serving as an in vitro model of the disease. The uroepithelial cells gained from the mucosa of the bladder of a euthanized cat were cultured for 6 days and were acutely exposed to NE (10, 100, and 1000 µM) for 1 h. NE increased the metabolic activity of the cultured cells and elevated the extracellular concentrations of the pro-inflammatory mediators interleukin-6 (IL-6) and stromal cell derived factor 1 (SDF-1), confirming that NE can trigger an inflammatory response in the uroepithelium. Cellular protein carbonyl levels were increased by NE exposure, while malondialdehyde and glucose regulated protein 78 concentrations remained unchanged, indicating that NE may provoke the oxidative damage of proteins without inducing lipid peroxidation or endoplasmic reticulum stress. Further, it can be strongly suggested that an acute NE challenge might diminish the barrier function of uroepithelial cells, as reflected by the decreased glycosaminoglycan concentration, claudin-4 protein expression, and reduced TER values of the NE-treated cell cultures. Based on these results, short-term NE exposure mimicking acute stress can provoke an inflammatory response and decrease the barrier integrity of cultured feline uroepithelial cells. Hence, it is highly expected that stress-associated NE release may play an important mediatory role in the pathogenesis of FIC. LA - English DB - MTMT ER - TY - JOUR AU - Sebők, Csilla AU - Tráj, Patrik AU - Vörösházi, Júlia AU - Mackei, Máté AU - Papp, Márton AU - Gálfi, Péter AU - Neogrády, Zsuzsa AU - Mátis, Gábor TI - Two Sides to Every Question: Attempts to Activate Chicken Innate Immunity in 2D and 3D Hepatic Cell Cultures JF - CELLS J2 - CELLS-BASEL VL - 10 PY - 2021 IS - 8 PG - 17 SN - 2073-4409 DO - 10.3390/cells10081910 UR - https://m2.mtmt.hu/api/publication/32153465 ID - 32153465 LA - English DB - MTMT ER - TY - JOUR AU - Kissné Hatala, Patrícia AU - Lajos, Andrea AU - Orbán, Kata AU - Mátis, Gábor AU - Neogrády, Zsuzsa TI - Macskák idiopatikus húgyhólyaggyulladásának neurohumorális és biokémiai háttere : Irodalmi összefoglaló JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 142 PY - 2020 IS - 6 SP - 367 EP - 376 PG - 10 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/31801543 ID - 31801543 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mackei, Máté AU - Orbán, Kata AU - Molnár, Andor AU - Pál, László AU - Dublecz, Károly AU - Husvéth, Ferenc AU - Neogrády, Zsuzsa AU - Mátis, Gábor TI - Cellular Effects of T-2 Toxin on Primary Hepatic Cell Culture Models of Chickens JF - TOXINS J2 - TOXINS VL - 12 PY - 2020 IS - 1 PG - 14 SN - 2072-6651 DO - 10.3390/toxins12010046 UR - https://m2.mtmt.hu/api/publication/31125302 ID - 31125302 N1 - This research was supported by the NKFIH grant No 124586 of the Hungarian National Research, Development and Innovation Office. The work was also supported by the EFOP-3.6.3-VEKOP-16-2017-00008 project, co-financed by the European Union and the European Social Fund. LA - English DB - MTMT ER - TY - CHAP AU - Mátis, Gábor AU - Kulcsár, Anna AU - Kissné Hatala, Patrícia AU - Mackei, Máté AU - Neogrády, Zsuzsanna ED - Estella, Prukner-Radovcic ED - Helga, Medic TI - Investigations on the effects of heat stress on hepatic cell culture models of chicken origin T2 - WORLD'S POULTRY SCIENCE JOURNAL PB - World's Poultry Science Association (WPSA) CY - Dubrovnik SN - 9789082915709 PY - 2018 SP - 581 PG - 1 UR - https://m2.mtmt.hu/api/publication/32490517 ID - 32490517 N1 - poszter absztrakt LA - English DB - MTMT ER - TY - JOUR AU - Kulcsárné Petrilla, Janka AU - Mátis, Gábor AU - Kulcsár, Anna AU - Talapka, Petra AU - Bíró, Enikő AU - Mackei, Máté AU - Fébel, Hedvig AU - Neogrády, Zsuzsa TI - Effect of dietary cereal type, crude protein and butyrate supplementation on metabolic parameters of broilers JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 66 ET - 0 PY - 2018 IS - 3 SP - 408 EP - 425 PG - 18 SN - 0236-6290 DO - 10.1556/004.2018.037 UR - https://m2.mtmt.hu/api/publication/3408257 ID - 3408257 LA - English DB - MTMT ER - TY - JOUR AU - Kurucz, Á AU - Nagy, Cs. AU - Kulcsár, Anna AU - Orbán, Kata AU - Neogrády, Zsuzsa AU - Mátis, Gábor TI - Méregtelenítő folyamatok vizsgálata vadon élő állatfajokban JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 140 PY - 2018 IS - 9 SP - 551 EP - 562 PG - 12 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/3408242 ID - 3408242 N1 - Állatorvostudományi Egyetem, Élettani és Biokémiai Tanszék, Biokémiai Osztály, István utca 2, Budapest, H-1078, Hungary Roth Gyula Erdészeti, Faipari Szakképzo Iskola és Kollegium, Szent György utca 9, Sopron, H-9400, Hungary Export Date: 29 April 2020 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Dávid Sándor AU - Ioja, E AU - Tóth, István AU - Bárány, Zoltán Balázs AU - Jócsák, Gergely AU - Bartha, Tibor AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TR alpha) and Beta (TR beta) Expression in Rat Primary Cerebellar Cell Cultures JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 19 PY - 2018 IS - 5 PG - 17 SN - 1661-6596 DO - 10.3390/ijms19051440 UR - https://m2.mtmt.hu/api/publication/3393033 ID - 3393033 LA - English DB - MTMT ER - TY - CONF AU - Tóth, István TI - Hallgatói elégedettség mérése az élettani előadásokkal kapcsolatban T2 - Akadémiai beszámolók : Élettan és Biokémia Patológia Gyógyszertan és Toxikológia Morfológia PB - Állatorvostudományi Egyetem Doktori Iskola C1 - Budapest PY - 2018 SP - 7 UR - https://m2.mtmt.hu/api/publication/3376006 ID - 3376006 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Tóth, István AU - Barbara, Kerekes AU - Bartha, Tibor AU - Mándoki, Míra ED - Österreichische, Gesellschaft für Hochschuldidaktik (ÖGHD) TI - Students’ feedback on lectures in a multinational environment: primary experiences T2 - 22. Grazer Konferenz PB - Österreichische Gesellschaft für Hochschuldidaktik (ÖGHD) CY - Vienna SN - 9783200056541 PY - 2018 UR - https://m2.mtmt.hu/api/publication/3357055 ID - 3357055 LA - English DB - MTMT ER -