@article{MTMT:33630893, title = {Feline Uroepithelial Cell Culture as a Novel Model of Idiopathic Cystitis: Investigations on the Effects of Norepinephrine on Inflammatory Response, Oxidative Stress, and Barrier Function}, url = {https://m2.mtmt.hu/api/publication/33630893}, author = {Kissné Hatala, Patrícia and Lajos, Andrea and Mackei, Máté and Sebők, Csilla and Tráj, Patrik and Vörösházi, Júlia and Neogrády, Zsuzsa and Mátis, Gábor}, doi = {10.3390/vetsci10020132}, journal-iso = {VET SCI}, journal = {VETERINARY SCIENCES}, volume = {10}, unique-id = {33630893}, issn = {2306-7381}, abstract = {Feline idiopathic cystitis (FIC) is one of the most common urinary tract disorders in domestic cats. As stress is suggested to play a key role in the pathogenesis of FIC, the effects of norepinephrine (NE) as a stress mediator were investigated on a novel feline primary uroepithelial cell culture, serving as an in vitro model of the disease. The uroepithelial cells gained from the mucosa of the bladder of a euthanized cat were cultured for 6 days and were acutely exposed to NE (10, 100, and 1000 µM) for 1 h. NE increased the metabolic activity of the cultured cells and elevated the extracellular concentrations of the pro-inflammatory mediators interleukin-6 (IL-6) and stromal cell derived factor 1 (SDF-1), confirming that NE can trigger an inflammatory response in the uroepithelium. Cellular protein carbonyl levels were increased by NE exposure, while malondialdehyde and glucose regulated protein 78 concentrations remained unchanged, indicating that NE may provoke the oxidative damage of proteins without inducing lipid peroxidation or endoplasmic reticulum stress. Further, it can be strongly suggested that an acute NE challenge might diminish the barrier function of uroepithelial cells, as reflected by the decreased glycosaminoglycan concentration, claudin-4 protein expression, and reduced TER values of the NE-treated cell cultures. Based on these results, short-term NE exposure mimicking acute stress can provoke an inflammatory response and decrease the barrier integrity of cultured feline uroepithelial cells. Hence, it is highly expected that stress-associated NE release may play an important mediatory role in the pathogenesis of FIC.}, keywords = {NOREPINEPHRINE; Urinary Bladder; Claudin-4; Gag; SDF-1; Pro-inflammatory cytokines; Ter; Oxidative stress; bladder barrier; feline idiopathic cystitis}, year = {2023}, orcid-numbers = {Mackei, Máté/0000-0001-5992-6797} } @article{MTMT:32153465, title = {Two Sides to Every Question: Attempts to Activate Chicken Innate Immunity in 2D and 3D Hepatic Cell Cultures}, url = {https://m2.mtmt.hu/api/publication/32153465}, author = {Sebők, Csilla and Tráj, Patrik and Vörösházi, Júlia and Mackei, Máté and Papp, Márton and Gálfi, Péter and Neogrády, Zsuzsa and Mátis, Gábor}, doi = {10.3390/cells10081910}, journal-iso = {CELLS-BASEL}, journal = {CELLS}, volume = {10}, unique-id = {32153465}, year = {2021}, eissn = {2073-4409}, orcid-numbers = {Mackei, Máté/0000-0001-5992-6797; Papp, Márton/0000-0003-4975-253X} } @article{MTMT:31801543, title = {Macskák idiopatikus húgyhólyaggyulladásának neurohumorális és biokémiai háttere : Irodalmi összefoglaló}, url = {https://m2.mtmt.hu/api/publication/31801543}, author = {Kissné Hatala, Patrícia and Lajos, Andrea and Orbán, Kata and Mátis, Gábor and Neogrády, Zsuzsa}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {142}, unique-id = {31801543}, issn = {0025-004X}, year = {2020}, pages = {367-376} } @article{MTMT:31125302, title = {Cellular Effects of T-2 Toxin on Primary Hepatic Cell Culture Models of Chickens}, url = {https://m2.mtmt.hu/api/publication/31125302}, author = {Mackei, Máté and Orbán, Kata and Molnár, Andor and Pál, László and Dublecz, Károly and Husvéth, Ferenc and Neogrády, Zsuzsa and Mátis, Gábor}, doi = {10.3390/toxins12010046}, journal-iso = {TOXINS}, journal = {TOXINS}, volume = {12}, unique-id = {31125302}, issn = {2072-6651}, year = {2020}, eissn = {2072-6651}, orcid-numbers = {Mackei, Máté/0000-0001-5992-6797} } @{MTMT:32490517, title = {Investigations on the effects of heat stress on hepatic cell culture models of chicken origin}, url = {https://m2.mtmt.hu/api/publication/32490517}, author = {Mátis, Gábor and Kulcsár, Anna and Kissné Hatala, Patrícia and Mackei, Máté and Neogrády, Zsuzsanna}, booktitle = {WORLD'S POULTRY SCIENCE JOURNAL}, unique-id = {32490517}, year = {2018}, pages = {581-582}, orcid-numbers = {Mackei, Máté/0000-0001-5992-6797} } @article{MTMT:3408257, title = {Effect of dietary cereal type, crude protein and butyrate supplementation on metabolic parameters of broilers}, url = {https://m2.mtmt.hu/api/publication/3408257}, author = {Kulcsárné Petrilla, Janka and Mátis, Gábor and Kulcsár, Anna and Talapka, Petra and Bíró, Enikő and Mackei, Máté and Fébel, Hedvig and Neogrády, Zsuzsa}, doi = {10.1556/004.2018.037}, journal-iso = {ACTA VET HUNG}, journal = {ACTA VETERINARIA HUNGARICA}, volume = {66}, unique-id = {3408257}, issn = {0236-6290}, year = {2018}, eissn = {1588-2705}, pages = {408-425}, orcid-numbers = {Mackei, Máté/0000-0001-5992-6797} } @article{MTMT:3408242, title = {Méregtelenítő folyamatok vizsgálata vadon élő állatfajokban}, url = {https://m2.mtmt.hu/api/publication/3408242}, author = {Kurucz, Á and Nagy, Cs. and Kulcsár, Anna and Orbán, Kata and Neogrády, Zsuzsa and Mátis, Gábor}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {140}, unique-id = {3408242}, issn = {0025-004X}, year = {2018}, pages = {551-562} } @article{MTMT:3393033, title = {Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TR alpha) and Beta (TR beta) Expression in Rat Primary Cerebellar Cell Cultures}, url = {https://m2.mtmt.hu/api/publication/3393033}, author = {Kiss, Dávid Sándor and Ioja, E and Tóth, István and Bárány, Zoltán Balázs and Jócsák, Gergely and Bartha, Tibor and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.3390/ijms19051440}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {19}, unique-id = {3393033}, issn = {1661-6596}, year = {2018}, eissn = {1422-0067}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @CONFERENCE{MTMT:3376006, title = {Hallgatói elégedettség mérése az élettani előadásokkal kapcsolatban}, url = {https://m2.mtmt.hu/api/publication/3376006}, author = {Tóth, István}, booktitle = {Akadémiai beszámolók : Élettan és Biokémia Patológia Gyógyszertan és Toxikológia Morfológia}, unique-id = {3376006}, year = {2018}, pages = {7}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @{MTMT:3357055, title = {Students’ feedback on lectures in a multinational environment: primary experiences}, url = {https://m2.mtmt.hu/api/publication/3357055}, author = {Tóth, István and Barbara, Kerekes and Bartha, Tibor and Mándoki, Míra}, booktitle = {22. Grazer Konferenz}, unique-id = {3357055}, year = {2018}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} }