TY - JOUR AU - Török, Dóra AU - Gonda, Xénia AU - Gál, Zsófia AU - Eszlári, Nóra AU - Bagdy, György AU - Juhász, Gabriella AU - Petschner, Péter TI - Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 65 PY - 2022 IS - S1 SP - S148 EP - S148 SN - 0924-9338 DO - 10.1192/j.eurpsy.2022.398 UR - https://m2.mtmt.hu/api/publication/33088384 ID - 33088384 LA - English DB - MTMT ER - TY - CHAP AU - Gonda, Xénia AU - Gecse, Kinga AU - Gál, Zsófia AU - Juhász, Gabriella ED - Hasanzad, Mandana TI - Precision Medicine in Psychiatric Disorders T2 - Precision Medicine in Clinical Practice PB - Springer-Verlag Singapore CY - Singapore SN - 9789811950810 PY - 2022 SP - 93 EP - 112 PG - 20 DO - 10.1007/978-981-19-5082-7_6 UR - https://m2.mtmt.hu/api/publication/33061562 ID - 33061562 N1 - NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary TRAJECTOME Research Group, Budapest, Hungary Export Date: 5 July 2023 Correspondence Address: Juhasz, G.; Department of Pharmacodynamics, Hungary; email: juhasz.gabriella@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Fountoulakis, K.N. AU - Gonda, Xénia TI - Sex differences in maturation and aging of human personality on the basis of a recently developed complex hierarchical model of temperament and character JF - INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE J2 - INT J PSYCHIAT CLIN VL - 26 PY - 2022 IS - 1 SP - 58 EP - 71 PG - 14 SN - 1365-1501 DO - 10.1080/13651501.2020.1804941 UR - https://m2.mtmt.hu/api/publication/31526985 ID - 31526985 N1 - 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary NAP-A-SE New Antidepressant Target Research Group, Semmelweis University, Budapest, Hungary Export Date: 23 May 2022 CODEN: IJPCF Correspondence Address: Fountoulakis, K.N.; 3rd Department of Psychiatry, 6, Odysseos street (1st Parodos Ampelonon street), Greece; email: kfount@med.auth.gr LA - English DB - MTMT ER - TY - JOUR AU - Gonda, Xénia AU - Eszlári, Nóra AU - Török, Dóra AU - Gál, Zsófia AU - Bokor, János AU - Millinghoffer, Andras AU - Baksa, Dániel AU - Petschner, Péter AU - Antal, Péter AU - Breen, Gerome AU - Juhász, Gabriella AU - Bagdy, György TI - Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 11 PY - 2021 IS - 1 PG - 15 SN - 2158-3188 DO - 10.1038/s41398-021-01436-1 UR - https://m2.mtmt.hu/api/publication/32064502 ID - 32064502 N1 - These authors contributed equally: Xenia Gonda, Nora Eszlari AB - Y Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings. We carried out a pilot GWAS with in-depth phenotyping of affective temperaments, considered as subclinical manifestations and high-risk states for affective disorders, in a general population sample of European origin. Affective temperaments were measured by TEMPS-A. SNP-level association was assessed by linear regression models, assuming an additive genetic effect, using PLINK1.9. Gender, age, the first ten principal components (PCs) and the other four temperaments were included in the regression models as covariates. SNP-level relevances (p-values) were aggregated to gene level using the PEGASUS method(1). In SNP-based tests, a Bonferroni-corrected significance threshold of p <= 5.0 x 10(-8) and a suggestive significance threshold of p <= 1.0 x 10(-5), whereas in gene-based tests a Bonferroni-corrected significance of 2.0 x 10(-6) and a suggestive significance of p <= 4.0 x 10(-4) was established. To explore known functional effects of the most significant SNPs, FUMA v1.3.5 was used. We identified 1 significant and 21 suggestively significant SNPs in ADGRB3, expressed in the brain, for anxious temperament. Several other brain-relevant SNPs and genes emerged at suggestive significance for the other temperaments. Functional analyses reflecting effect on gene expression and participation in chromatin interactions also pointed to several genes expressed in the brain with potentially relevant phenotypes regulated by our top SNPs. Our findings need to be tested in larger GWA studies and candidate gene analyses in well-phenotyped samples in relation to affective disorders and related phenotypes. LA - English DB - MTMT ER - TY - JOUR AU - Sharma, Samata R AU - Gonda, Xénia AU - Döme, Péter AU - Tarazi, Frank I TI - What's Love Got to do with it. Role of oxytocin in trauma, attachment and resilience TS - Role of oxytocin in trauma, attachment and resilience JF - PHARMACOLOGY & THERAPEUTICS J2 - PHARMACOL THERAPEUT VL - 214 PY - 2020 PG - 15 SN - 0163-7258 DO - 10.1016/j.pharmthera.2020.107602 UR - https://m2.mtmt.hu/api/publication/31383651 ID - 31383651 AB - Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the hypothalamus and released by the pituitary gland. It has multiple physiological roles including stimulation of parturition and lactation, and promotion of pro-adaptive social behaviors necessary for mammalian survival. OT interacts with one receptor subtype: the OT receptor (OTR), which, upon stimulation, triggers different intracellular signal transduction cascades to mediate its physiological actions. Preclinical studies show that OT regulates social behaviors such as pair bonding, recognition and social interaction. It also coordinates the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of corticotrophin-releasing hormone. Further evidence suggests that OT plays an important role in regulating caloric intake and metabolism, and in maintaining electrolyte and cardiovascular homeostasis. OT is also involved in attenuating the neurophysiological and neurochemical effects of trauma on the brain and body by facilitating both physical attachment such as wound healing, and psychological/social attachment, thereby increasing resilience to subsequent traumatic events. Clinical trials have reported that intranasal administration of OT provides therapeutic benefits for patients diagnosed with traumatic stress-related diseases such as major depressive disorders and post-traumatic stress disorder. OT's therapeutic benefits may result from context-dependent interactions with key neural pathways (social, cognitive, and reward), neurotransmitters (dopamine, norepinephrine, serotonin, and endogenous opioids), and biomarkers (adrenocorticotropic hormone, cortisol, and dehydroepiandrosterone sulfate), that lead to a decrease in stress associated behaviors, and facilitate post-traumatic growth, ultimately leading to increased resilience, through improved social cohesion and attachment. OT induced-augmentation of physical and cognitive resilience may play a significant role in both the prevention of, and improved clinical outcomes for, traumatic stress-related disorders following either acute or enduring traumatic experiences. LA - English DB - MTMT ER - TY - GEN AU - Gonda, Xénia AU - Eszlári, Nóra AU - Sütöri, Sára AU - Gál, Zsófia AU - Török, Dóra AU - Petschner, Péter AU - Juhász, Gabriella AU - Bagdy, György TI - GABA-A and CB1 receptor variants mediate different types of stress in the development of depression and anxiety - O0122 PY - 2020 UR - https://m2.mtmt.hu/api/publication/31368877 ID - 31368877 LA - English DB - MTMT ER - TY - JOUR AU - Serafini, Gianluca AU - Aguglia, Andrea AU - Santi, Francesca AU - Canepa, Giovanna AU - Gonda, Xénia AU - Rihmer, Zoltán AU - Pompili, Maurizio AU - Amore, Mario TI - Depressive polarity at illness onset is associated with lifetime suicide attempts in euthymic bipolar outpatients - O0009 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 63 PY - 2020 IS - Spec. Issue.1 SP - S4 EP - S5 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/31368870 ID - 31368870 LA - English DB - MTMT ER - TY - JOUR AU - Kőrösi, Beáta Zita AU - Batta, Dóra AU - Vecsey-Nagy, Milán AU - Gonda, Xénia AU - Rihmer, Zoltán AU - Nemcsik-Bencze, Zsófia AU - László, Andrea AU - Nemcsik, János TI - P43 The Association of Irritable Affective Temperament with 24-Hour Brachial and Central Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Men JF - ARTERY RESEARCH J2 - ARTERY RES VL - 25 PY - 2020 IS - Supplement 1 SP - S83 SN - 1872-9312 DO - 10.2991/artres.k.191224.074 UR - https://m2.mtmt.hu/api/publication/31270854 ID - 31270854 LA - English DB - MTMT ER - TY - JOUR AU - Vecsey-Nagy, Milán AU - Kőrösi, Beáta Zita AU - Batta, Dóra AU - Gonda, Xénia AU - Rihmer, Zoltán AU - Nemcsik-Bencze, Zsófia AU - László, Andrea AU - Nemcsik, János TI - P92 The Association of Agreeableness and Conscientiousness with 24-Hour Brachial Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Patients JF - ARTERY RESEARCH J2 - ARTERY RES VL - 25 PY - 2020 IS - Supplement 1 SP - S134 SN - 1872-9312 DO - 10.2991/artres.k.191224.121 UR - https://m2.mtmt.hu/api/publication/31270815 ID - 31270815 LA - English DB - MTMT ER - TY - JOUR AU - Hargittay, Csenge AU - Eőry, Ajándék AU - Gonda, Xénia AU - Márkus, Bernadett AU - Szélvári, Ágnes AU - Vörös, Krisztián AU - Rihmer, Zoltán AU - Kalabay, László AU - Torzsa, Péter TI - A DEPRESSZIÓ, SZORONGÁS ÉS AZ AFFEKTÍV TEMPERAMENTUM-TÍPUSOK HATÁSA A 2-ES TÍPUSÚ CUKORBETEGEK SZÉNHIDRÁTHÁZTARTÁSÁRA JF - MEDICUS UNIVERSALIS J2 - MED UNIV VL - 53 PY - 2020 IS - 1 SP - 41 SN - 0133-1973 UR - https://m2.mtmt.hu/api/publication/31266667 ID - 31266667 LA - Hungarian DB - MTMT ER -